LOCUS       NM_021542               3364 bp    mRNA    linear   ROD 23-JAN-2024
DEFINITION  Mus musculus potassium channel, subfamily K, member 5 (Kcnk5),
            mRNA.
ACCESSION   NM_021542
VERSION     NM_021542.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3364)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   2  (bases 1 to 3364)
  AUTHORS   Zhang,J., Chen,J., Lu,Y., Yang,Y., Chen,W., Shen,B., Hu,J., Jia,P.,
            Xu,S., Shi,Y., Ning,Y., Wang,J., Fang,Y., Zhao,S., Li,Y., Dai,Y.,
            Zhang,X., Xiang,M., Tian,Y., Liu,Z., Song,N. and Ding,X.
  TITLE     TWIK-related acid-sensitive K+ channel 2 promotes renal fibrosis by
            inducing cell-cycle arrest
  JOURNAL   iScience 25 (12), 105620 (2022)
   PUBMED   36465115
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3364)
  AUTHORS   Fernandez-Orth,J., Rolfes,L., Gola,L., Bittner,S., Andronic,J.,
            Sukhorukov,V.L., Sisario,D., Landgraf,P., Dieterich,D.C.,
            Cerina,M., Smalla,K.H., Kahne,T., Budde,T., Kovac,S., Ruck,T.,
            Sauer,M. and Meuth,S.G.
  TITLE     A role for TASK2 channels in the human immunological synapse
  JOURNAL   Eur J Immunol 51 (2), 342-353 (2021)
   PUBMED   33169379
  REMARK    GeneRIF: A role for TASK2 channels in the human immunological
            synapse.
REFERENCE   4  (bases 1 to 3364)
  AUTHORS   Li,B., Rietmeijer,R.A. and Brohawn,S.G.
  TITLE     Structural basis for pH gating of the two-pore domain K+ channel
            TASK2
  JOURNAL   Nature 586 (7829), 457-462 (2020)
   PUBMED   32999458
  REMARK    GeneRIF: Structural basis for pH gating of the two-pore domain K(+)
            channel TASK2.
REFERENCE   5  (bases 1 to 3364)
  AUTHORS   Endo,K., Kito,H., Tanaka,R., Kajikuri,J., Tanaka,S., Elboray,E.E.,
            Suzuki,T. and Ohya,S.
  TITLE     Possible Contribution of Inflammation-Associated Hypoxia to
            Increased K2P5.1 K+ Channel Expression in CD4+ T cells of the Mouse
            Model for Inflammatory Bowel Disease
  JOURNAL   Int J Mol Sci 21 (1), 38 (2019)
   PUBMED   31861667
  REMARK    GeneRIF: Results suggest a mechanism for K2P5.1 up-regulation via
            HIF-1 in the CD4(+) T cells of the mouse model for inflammatory
            bowel.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3364)
  AUTHORS   Gerstin,K.M., Gong,D.H., Abdallah,M., Winegar,B.D., Eger,E.I. 2nd
            and Gray,A.T.
  TITLE     Mutation of KCNK5 or Kir3.2 potassium channels in mice does not
            change minimum alveolar anesthetic concentration
  JOURNAL   Anesth Analg 96 (5), 1345-1349 (2003)
   PUBMED   12707131
  REMARK    GeneRIF: results do not support the notion that KCNK5 potassium
            channel mediates the capacity of inhaled anesthetics to produce
            immobility
REFERENCE   7  (bases 1 to 3364)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3364)
  AUTHORS   Niemeyer,M.I., Cid,L.P., Barros,L.F. and Sepulveda,F.V.
  TITLE     Modulation of the two-pore domain acid-sensitive K+ channel TASK-2
            (KCNK5) by changes in cell volume
  JOURNAL   J Biol Chem 276 (46), 43166-43174 (2001)
   PUBMED   11560934
REFERENCE   9  (bases 1 to 3364)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 3364)
  AUTHORS   Reyes,R., Duprat,F., Lesage,F., Fink,M., Salinas,M., Farman,N. and
            Lazdunski,M.
  TITLE     Cloning and expression of a novel pH-sensitive two pore domain K+
            channel from human kidney
  JOURNAL   J Biol Chem 273 (47), 30863-30869 (1998)
   PUBMED   9812978
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC126275.3.
            
            On Apr 29, 2007 this sequence version replaced NM_021542.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085330.1, AK132172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               AC126275.3         35723-36238
            517-628             AC126275.3         70893-71004
            629-795             AC126275.3         72383-72549
            796-964             AC126275.3         72702-72870
            965-3364            AC126275.3         75048-77447
FEATURES             Location/Qualifiers
     source          1..3364
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.43 cM"
     gene            1..3364
                     /gene="Kcnk5"
                     /gene_synonym="KCNK5b; TASK-2"
                     /note="potassium channel, subfamily K, member 5"
                     /db_xref="GeneID:16529"
                     /db_xref="MGI:MGI:1336175"
     exon            1..516
                     /gene="Kcnk5"
                     /gene_synonym="KCNK5b; TASK-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1839
                     /gene="Kcnk5"
                     /gene_synonym="KCNK5b; TASK-2"
                     /note="potassium inwardly-rectifying channel, subfamily K,
                     member 5; potassium channel, subfamily, member 5 (KCNK5)"
                     /codon_start=1
                     /product="potassium channel subfamily K member 5"
                     /protein_id="NP_067517.1"
                     /db_xref="CCDS:CCDS26841.1"
                     /db_xref="GeneID:16529"
                     /db_xref="MGI:MGI:1336175"
                     /translation="MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLH
                     LLKEFPCLSQEGLDKILQVVSDAADQGVAITGNQTFNNWNWPNAMIFAATVITTIGYG
                     NVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTRRGVSLRKAQI
                     TCTAIFIVWGVLVHLVIPPFVFMVTEEWNYIEGLYYSFITISTIGFGDFVAGVNPSAN
                     YHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKA
                     LQMAGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGERVPGPGHGLGPQGD
                     RLPTIPASLAPLVVYSKNRVPSLEEVSQTLKNKGHVSRPLGEEAGAQAPKDSYQTSEV
                     FINQLDRISEEGEPWEALDYHPLIFQNANITFENEETGLSDEETSKSSVEDNLTSKEQ
                     PEQGPMAEAPLSSTGEFPSSDESTFTSTESELSVPYEQLMNEYNKADNPRGT"
     exon            517..628
                     /gene="Kcnk5"
                     /gene_synonym="KCNK5b; TASK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..795
                     /gene="Kcnk5"
                     /gene_synonym="KCNK5b; TASK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..964
                     /gene="Kcnk5"
                     /gene_synonym="KCNK5b; TASK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            965..3364
                     /gene="Kcnk5"
                     /gene_synonym="KCNK5b; TASK-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtactgtcgc gcgcgcagag gcggcacacg tgtctgctgg tgtgggtcct gagtttcacc
       61 ctacccttca ggatcgagag attggggtgg ccccaacccc cttttgatgt gcgctcaccc
      121 tggcctgtga gaacgtgatc cacgcagttc cccgcgttca gggagccaac ttggccaagc
      181 aactgtcccg ggagcggcgc gcgggggtac cgggcactgc gcatgcggag ctccaaattc
      241 aaacagctgt gtccagggct gcaggacgag tgaacccgga gctgctggaa ttaggggact
      301 ctttctccag gaggtggcca ttccagagtc atggtggacc ggggtccttt actcacctcg
      361 gccatcatat tctacctggc catcggggca gcgatcttcg aagtgctgga ggagccacac
      421 tggaaggagg ccaagaaaaa ctactataca cagaaactgc atctactcaa ggagtttccg
      481 tgcctgagtc aggagggact ggacaagatc ctacaggtgg tgtctgatgc tgcggatcag
      541 ggtgtggcca tcaccgggaa ccagactttc aacaactgga actggcccaa tgcaatgatt
      601 tttgctgcca cagtcatcac caccatcggt tatggcaatg tggctcccaa gaccccagct
      661 gggcgcctct tctgtgtctt ctacggcctc ttcggggtgc cgctgtgcct gacatggatc
      721 agtgccctgg gcaagttctt cgggggacgt gcaaagaggt tgggccagtt tcttaccagg
      781 agaggagtga gcctgaggaa ggctcagatc acgtgtacag ccatcttcat cgtgtggggt
      841 gtcctggtcc atctggtgat cccgcccttt gtgttcatgg tgacagaaga atggaactac
      901 attgagggcc tctactattc cttcatcacc atctccacca ttggctttgg ggactttgtg
      961 gccggtgtga accccagtgc caactaccac gccctatacc gatactttgt ggagctttgg
     1021 atctacctgg ggctggcttg gctgtccctc tttgtcaact ggaaggtgag catgtttgtg
     1081 gaagtacaca aagccattaa aaagaggcgg cggcggcgca aggaatcctt tgagagctct
     1141 ccacactccc ggaaggccct acagatggct ggaagtacag catccaagga cgtcaacatc
     1201 ttcagcttcc tatccaaaaa ggaggagacc tacaatgacc tcatcaaaca gattgggaag
     1261 aaggcaatga aaacaagtgg gggaggggag agggtcccag gacctggaca cgggctggga
     1321 cctcaagggg atagactacc caccatccct gcatccctgg cacctttggt ggtctattcc
     1381 aagaatcggg tgcccagctt ggaagaggta tctcagactc taaaaaacaa gggacatgtg
     1441 tcaaggccac ttggtgagga ggctggggca caggccccca aggatagtta ccaaacctct
     1501 gaagtgttta ttaaccaact ggaccgtatc agtgaggagg gagagccgtg ggaagccctg
     1561 gactaccacc cgctcatctt ccaaaatgcc aacattacct ttgaaaatga agaaaccggc
     1621 ctctcagacg aggagacctc taagtcttct gtggaggaca acctgacctc aaaggagcag
     1681 cctgaacagg gacccatggc tgaggcaccc ttgagcagca cgggtgaatt cccttcatcc
     1741 gatgagtcca ccttcaccag caccgagtca gagctctccg tgccttacga gcagctgatg
     1801 aacgaataca acaaggcaga taaccccagg ggcacgtgag gtgggcctgg ctccccactt
     1861 gctttccagt ggcttcctct cacgaggatt gtcctgtgat ggccagaccc cagggagaag
     1921 gctctggaaa tgagatgggg agccagggac ctgcctttcc ttctgtcctc tccacttggt
     1981 tgcttccatg ggatgtggtg ttggcccagg acaggcctcc gttctgtggc ccagtaggga
     2041 ggctgctgtc ctgggcctgc ccggcaggtg tattgctgat tcaggcacgt aggccgcaac
     2101 actcaccctg gaggtcctgg gtttgctgct tgtgtcttcc cccatcactc ggttgactgt
     2161 tgtacggttc tctgaggcca ggagcttcag ctgagttcac cagtgttaat gggcaacgcc
     2221 cttgtgcctt gcactaagct agacatttgg aaggaggagc tcataagacc caggtttggc
     2281 atgtggttct cgggtgttct gggaaagcac agatatgatg gggtttgggg cctctcagta
     2341 ccccagcagt agcaggacct gcttgcccaa gtaggcatca ctgcccagca agccccttac
     2401 tgcaaacctc agggcagggg atgtagggga gagctatgtg tgtcctctgt gtggagtcat
     2461 gcccacctca gattccctct gaacaacaac agcaggccaa agggtccctg tgccccgaaa
     2521 gtgcagaaga aagatggagc ctccggatgt ggtcagggag ctcagagatg aggtgcaggc
     2581 ccctcagccc cagcctaggc acccatactc ccagcccacc gtctcatttc agagagattc
     2641 tctcactgcc tctccctcct ctcttagtgg gggccaaatt gttcttggct catagaactg
     2701 tgaattgagc ccccccctcc agccactata tggtattagc atgtgtaact gccaatcaat
     2761 gggcatgcgt gtgcacattt gggctgggga gaaaagaaaa tgtgaatctt actggtccag
     2821 ttcctagcga ggtctgggaa ctagctgctg tatatgtcct tgatgctcag cccactctgg
     2881 cctaaatgct ttttgttatt aatatttttt aatgaactgt tatttttata cccagagcca
     2941 gtaaagaaca gggtccctgc cattagaatg gaggtctgtc aggcactctg ttgtccttcc
     3001 aactcagctt gtcctttgtc aagccaaggt ctagctacgg aggggcaggc gcaggtctcg
     3061 ggtgaggggc agctgataac ctgcctcagc cccttcccct gctgtgtgca tttgcggagg
     3121 ggcatatagg gccagagccc ccacacgtta ggacagtgag aggtgtgtat ccatacctcc
     3181 accattatca aagcggttgt agaggccaca gcagcctcgg tggggggaag agccaggctc
     3241 ctgtgagagg acctcagctg aatgtcctgg cggcacacca accacgctgt gtgcatgtgc
     3301 cgatggtgaa ggcagatgta atttatttta acattttttt acaataaaac acatgaacaa
     3361 gccc
//
