LOCUS       NM_001403913            1872 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus potassium channel, subfamily K, member 4 (Kcnk4),
            transcript variant 3, mRNA.
ACCESSION   NM_001403913 XM_006526716
VERSION     NM_001403913.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Glogowska,E., Arhatte,M., Chatelain,F.C., Lesage,F., Xu,A.,
            Grashoff,C., Discher,D.E., Patel,A. and Honore,E.
  TITLE     Piezo1 and Piezo2 foster mechanical gating of K2P channels
  JOURNAL   Cell Rep 37 (9), 110070 (2021)
   PUBMED   34852225
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Brohawn,S.G., Wang,W., Handler,A., Campbell,E.B., Schwarz,J.R. and
            MacKinnon,R.
  TITLE     The mechanosensitive ion channel TRAAK is localized to the
            mammalian node of Ranvier
  JOURNAL   Elife 8, e50403 (2019)
   PUBMED   31674909
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1872)
  AUTHORS   Zhang,X.T., Xu,Z., Shi,K.P., Guo,D.L., Li,H., Wang,L. and Zhu,X.B.
  TITLE     Elevated expression of TREK-TRAAK K2P channels in the retina of
            adult rd1 mice
  JOURNAL   Int J Ophthalmol 12 (6), 924-929 (2019)
   PUBMED   31236347
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1872)
  AUTHORS   Gomez-Gonzalo,M., Zehnder,T., Requie,L.M., Bezzi,P. and
            Carmignoto,G.
  TITLE     Insights into the release mechanism of astrocytic glutamate evoking
            in neurons NMDA receptor-mediated slow depolarizing inward currents
  JOURNAL   Glia 66 (10), 2188-2199 (2018)
   PUBMED   30144319
REFERENCE   5  (bases 1 to 1872)
  AUTHORS   Schwingshackl,A., Lopez,B., Teng,B., Luellen,C., Lesage,F.,
            Belperio,J., Olcese,R. and Waters,C.M.
  TITLE     Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is
            associated with a reduction in surfactant proteins
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 313 (6), L1030-L1046 (2017)
   PUBMED   28839101
  REMARK    GeneRIF: Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice
            is associated with a reduction in surfactant proteins
REFERENCE   6  (bases 1 to 1872)
  AUTHORS   Heurteaux,C., Guy,N., Laigle,C., Blondeau,N., Duprat,F.,
            Mazzuca,M., Lang-Lazdunski,L., Widmann,C., Zanzouri,M., Romey,G.
            and Lazdunski,M.
  TITLE     TREK-1, a K+ channel involved in neuroprotection and general
            anesthesia
  JOURNAL   EMBO J 23 (13), 2684-2695 (2004)
   PUBMED   15175651
REFERENCE   7  (bases 1 to 1872)
  AUTHORS   Bockenhauer,D., Nimmakayalu,M.A., Ward,D.C., Goldstein,S.A. and
            Gallagher,P.G.
  TITLE     Genomic organization and chromosomal localization of the murine 2 P
            domain potassium channel gene Kcnk8: conservation of gene structure
            in 2 P domain potassium channels
  JOURNAL   Gene 261 (2), 365-372 (2000)
   PUBMED   11167025
REFERENCE   8  (bases 1 to 1872)
  AUTHORS   Tarantino,L.M., Feiner,L., Alavizadeh,A., Wiltshire,T., Hurle,B.,
            Ornitz,D.M., Webber,A.L., Raper,J., Lengeling,A., Rowe,L.B. and
            Bucan,M.
  TITLE     A high-resolution radiation hybrid map of the proximal portion of
            mouse chromosome 5
  JOURNAL   Genomics 66 (1), 55-64 (2000)
   PUBMED   10843805
REFERENCE   9  (bases 1 to 1872)
  AUTHORS   Patel,A.J., Honore,E., Lesage,F., Fink,M., Romey,G. and
            Lazdunski,M.
  TITLE     Inhalational anesthetics activate two-pore-domain background K+
            channels
  JOURNAL   Nat Neurosci 2 (5), 422-426 (1999)
   PUBMED   10321245
REFERENCE   10 (bases 1 to 1872)
  AUTHORS   Fink,M., Lesage,F., Duprat,F., Heurteaux,C., Reyes,R., Fosset,M.
            and Lazdunski,M.
  TITLE     A neuronal two P domain K+ channel stimulated by arachidonic acid
            and polyunsaturated fatty acids
  JOURNAL   EMBO J 17 (12), 3297-3308 (1998)
   PUBMED   9628867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120557.12.
            
            On Apr 5, 2022 this sequence version replaced XM_006526716.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.30052.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               AC120557.12        64764-65040
            278-543             AC120557.12        66010-66275
            544-670             AC120557.12        70570-70696
            671-831             AC120557.12        70824-70984
            832-1018            AC120557.12        71174-71360
            1019-1158           AC120557.12        71748-71887
            1159-1872           AC120557.12        72603-73316
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.08 cM"
     gene            1..1872
                     /gene="Kcnk4"
                     /gene_synonym="Catsperz; MLZ-622; Tex40; TRAAK; TRAAKt"
                     /note="potassium channel, subfamily K, member 4"
                     /db_xref="GeneID:16528"
                     /db_xref="MGI:MGI:1298234"
     exon            1..277
                     /gene="Kcnk4"
                     /gene_synonym="Catsperz; MLZ-622; Tex40; TRAAK; TRAAKt"
                     /inference="alignment:Splign:2.1.0"
     exon            278..543
                     /gene="Kcnk4"
                     /gene_synonym="Catsperz; MLZ-622; Tex40; TRAAK; TRAAKt"
                     /inference="alignment:Splign:2.1.0"
     exon            544..670
                     /gene="Kcnk4"
                     /gene_synonym="Catsperz; MLZ-622; Tex40; TRAAK; TRAAKt"
                     /inference="alignment:Splign:2.1.0"
     exon            671..831
                     /gene="Kcnk4"
                     /gene_synonym="Catsperz; MLZ-622; Tex40; TRAAK; TRAAKt"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1018
                     /gene="Kcnk4"
                     /gene_synonym="Catsperz; MLZ-622; Tex40; TRAAK; TRAAKt"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1158
                     /gene="Kcnk4"
                     /gene_synonym="Catsperz; MLZ-622; Tex40; TRAAK; TRAAKt"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1872
                     /gene="Kcnk4"
                     /gene_synonym="Catsperz; MLZ-622; Tex40; TRAAK; TRAAKt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1830..1835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnk4"
                     /gene_synonym="Catsperz; MLZ-622; Tex40; TRAAK; TRAAKt"
                     /note="hexamer: AACAAA"
     polyA_site      1872
                     /gene="Kcnk4"
                     /gene_synonym="Catsperz; MLZ-622; Tex40; TRAAK; TRAAKt"
                     /note="major polyA site"
ORIGIN      
        1 agacggccgc cggcggctcg gtctctgggc tgccgccggc acctccttgg ctcagcccgc
       61 acaccctcga ggcggcgcgg gagacctggc cgcagccaaa gccgcagcca cagagtgggc
      121 agacagtaag tgcggagcag gcgcgggaat gtgggctgga tctcaggccc tgggagctgg
      181 gagaaaccgg cagggcggga cacttcccgc gcgtggatgc cttcctcgag tggtgtgacc
      241 gtgcgtcccg tcgccggtca cgctcggagg cgtcggctga ccactgctcc ccaggagctc
      301 cctgctcctt cttcccaggc aggaagtgga gctggacctg cctctggaag gaccatgcgc
      361 agcaccacac tcctggctct gctggcactg gtgctgcttt acttggtatc tggggctcta
      421 gtgttccagg ctctggagca gcctcacgag cagcaggctc agaagaaaat ggatcatggc
      481 cgagaccagt ttctgaggga ccatccctgt gtgagccaga agagcctgga ggatttcatc
      541 aagctcctgg ttgaagccct gggagggggc gcaaacccag aaaccagctg gaccaatagc
      601 agcaaccact catcagcttg gaacctgggc agcgccttct ttttctcggg gaccatcatc
      661 actaccatcg gctatggcaa tatagtctta cacacagatg ccgggcgtct cttttgtatc
      721 ttctatgcac tggtggggat cccactgttc gggatgctgc tggcgggagt cggggaccgg
      781 ctgggctcct ctctgcgccg gggcatcggc cacatcgaag caatcttctt gaagtggcat
      841 gtgccaccgg ggctggtgag aagtctgtcc gcagtgctct tcctgctgat cggctgcctg
      901 ctctttgtcc tcactcctac cttcgtgttc tcctacatgg agagctggag caagttagaa
      961 gccatctact ttgttatagt gactctcacc actgtaggct ttggcgatta tgtacccggc
     1021 gatggcaccg ggcagaactc tccagcctac cagccgctgg tgtggttctg gatcttgttt
     1081 ggcctagcct acttcgcctc agtgctcacc accatcggca actggttgcg agcagtgtcc
     1141 cgccgaactc gggcagagat gggtggccta acggcacagg ctgctagctg gaccggcaca
     1201 gtgacagcgc gagtgaccca gcgaactggg cccagcgccc cgccgccaga gaaggagcaa
     1261 ccactcctgc cctcctcttt gccggcaccg cctgctgttg ttgagccagc cggcaggccc
     1321 ggctcccctg cacccgcaga gaaggttgag actccgtccc cgcccacggc ctcagctctg
     1381 gattacccca gtgagaatct ggccttcatc gacgagtcct cagacacgca gagtgagcgt
     1441 ggctgtgccc tgcctcgggc tcctcggggt cgccgccgac ccaacccatc caaaaagcct
     1501 tccagacccc ggggtcctgg gcgactccga gacaaggccg tgccggtgta ggggcaggat
     1561 ctctggaccc ggatcccacg ccagggcttt cgctcttgct gatgctcagg catgcttggc
     1621 ttatttgacc aaagagccgt ccctcttttg ttccacgtgg ttgcaaccct gacaggagtc
     1681 cagtggttgc caaatgccac cgctcttccc tggctggttc ttcacatcca atcatttcca
     1741 aagcccacca tccaaggctt tctgcctcgc tcccctgccg gttttgaccc tcacacctca
     1801 caactgtgcc tcaaaacctg caccaataaa acaaaaactc tgcactaccg agtgcatgct
     1861 cctgggtccc aa
//
