LOCUS       NM_010608               3810 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus potassium channel, subfamily K, member 3 (Kcnk3),
            mRNA.
ACCESSION   NM_010608 XM_990938
VERSION     NM_010608.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3810)
  AUTHORS   Huang,D., Shang,W., Xu,M., Wan,Q., Zhang,J., Tang,X., Shen,Y.,
            Wang,Y. and Yu,Y.
  TITLE     Genome-Wide Methylation Analysis Reveals a KCNK3-Prominent Causal
            Cascade on Hypertension
  JOURNAL   Circ Res 135 (3), e76-e93 (2024)
   PUBMED   38841840
  REMARK    GeneRIF: Genome-Wide Methylation Analysis Reveals a KCNK3-Prominent
            Causal Cascade on Hypertension.
REFERENCE   2  (bases 1 to 3810)
  AUTHORS   Song,H.C., Zhang,Y., Ma,Z.X., Yao,Q.L. and Ma,X.J.
  TITLE     TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3
            may participate in the process of the coexistence of asthma and OSA
  JOURNAL   Sleep Breath 28 (1), 123-131 (2024)
   PUBMED   37428352
  REMARK    GeneRIF: TWIK-related acid-sensitive potassium channels TASK-1 and
            TASK-3 may participate in the process of the coexistence of asthma
            and OSA.
REFERENCE   3  (bases 1 to 3810)
  AUTHORS   Russell,N.X., Burra,K., Shah,R.M., Bottasso-Arias,N.,
            Mohanakrishnan,M., Snowball,J., Ediga,H.H., Madala,S.K. and
            Sinner,D.
  TITLE     Wnt signaling regulates ion channel expression to promote smooth
            muscle and cartilage formation in developing mouse trachea
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (6), L788-L802 (2023)
   PUBMED   37873566
REFERENCE   4  (bases 1 to 3810)
  AUTHORS   Wang,Z., Zhao,X., Bu,L., Liu,K., Li,Z., Zhang,H., Zhang,X.,
            Yuan,F., Wang,S., Guo,Z. and Shi,L.
  TITLE     Low sodium intake ameliorates hypertension and left ventricular
            hypertrophy in mice with primary aldosteronism
  JOURNAL   Front Physiol 14, 1136574 (2023)
   PUBMED   36875038
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3810)
  AUTHORS   Matsuoka,H., Harada,K., Sugawara,A., Kim,D. and Inoue,M.
  TITLE     Expression of p11 and heteromeric TASK channels in mouse adrenal
            cortical cells and H295R cells
  JOURNAL   Acta Histochem 124 (5), 151898 (2022)
   PUBMED   35526370
  REMARK    GeneRIF: Expression of p11 and heteromeric TASK channels in mouse
            adrenal cortical cells and H295R cells.
REFERENCE   6  (bases 1 to 3810)
  AUTHORS   Lopes,C.M., Gallagher,P.G., Buck,M.E., Butler,M.H. and
            Goldstein,S.A.
  TITLE     Proton block and voltage gating are potassium-dependent in the
            cardiac leak channel Kcnk3
  JOURNAL   J Biol Chem 275 (22), 16969-16978 (2000)
   PUBMED   10748056
REFERENCE   7  (bases 1 to 3810)
  AUTHORS   Manjunath,N.A., Bray-Ward,P., Goldstein,S.A. and Gallagher,P.G.
  TITLE     Assignment of the 2P domain, acid-sensitive potassium channel OAT1
            gene KCNK3 to human chromosome bands 2p24.1-->p23.3 and murine 5B
            by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 242-243 (1999)
   PUBMED   10575216
REFERENCE   8  (bases 1 to 3810)
  AUTHORS   Fujita,A., Horio,Y., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Kurachi,Y.
  TITLE     Assignment of mouse cardiac two-pore background K+ channel gene
            (Kcnk4) to the proximal region of mouse chromosome 5
  JOURNAL   Genomics 54 (1), 183-184 (1998)
   PUBMED   9806851
REFERENCE   9  (bases 1 to 3810)
  AUTHORS   Kim,D., Fujita,A., Horio,Y. and Kurachi,Y.
  TITLE     Cloning and functional expression of a novel cardiac two-pore
            background K+ channel (cTBAK-1)
  JOURNAL   Circ Res 82 (4), 513-518 (1998)
   PUBMED   9506712
REFERENCE   10 (bases 1 to 3810)
  AUTHORS   Duprat,F., Lesage,F., Fink,M., Reyes,R., Heurteaux,C. and
            Lazdunski,M.
  TITLE     TASK, a human background K+ channel to sense external pH variations
            near physiological pH
  JOURNAL   EMBO J 16 (17), 5464-5471 (1997)
   PUBMED   9312005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105298.21 and AEKQ02160270.1.
            
            On Jul 30, 2020 this sequence version replaced NM_010608.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032047.1, AB008537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               AC105298.21        144461-144890       c
            431-678             AC105298.21        110922-111169       c
            679-3810            AEKQ02160270.1     30001-33132
FEATURES             Location/Qualifiers
     source          1..3810
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.68 cM"
     gene            1..3810
                     /gene="Kcnk3"
                     /gene_synonym="cTBAK-1; TASK; Task-1"
                     /note="potassium channel, subfamily K, member 3"
                     /db_xref="GeneID:16527"
                     /db_xref="MGI:MGI:1100509"
     exon            1..430
                     /gene="Kcnk3"
                     /gene_synonym="cTBAK-1; TASK; Task-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1377
                     /gene="Kcnk3"
                     /gene_synonym="cTBAK-1; TASK; Task-1"
                     /note="two pore potassium channel KT3.1; cardiac two pore
                     background K(+) channel; TWIK-related acid-sensitive K(+)
                     channel 1; acid-sensitive potassium channel protein
                     TASK-1; two pore K(+) channel KT3.1"
                     /codon_start=1
                     /product="potassium channel subfamily K member 3"
                     /protein_id="NP_034738.1"
                     /db_xref="CCDS:CCDS19160.1"
                     /db_xref="GeneID:16527"
                     /db_xref="MGI:MGI:1100509"
                     /translation="MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRLELR
                     QLELRARYNLSEGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPS
                     TDGGKVFCMFYALLGIPLTLVMFQSLGERINTFVRYLLHRAKRGLGMRHAEVSMANMV
                     LIGFVSCISTLCIGAAAFSYYERWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQP
                     QYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTHNGQAVGLGGL
                     SCLSGSLGDGVRPRDPVTCAAAAGGVGVGVGGSGFRNVYAEVLHFQSMCSCLWYKSRE
                     KLQYSIPMIIPRDLSTSDTCVEHSHSSPGGGGRYSDTPSHPCLCSGTQRSAISSVSTG
                     LHSLAAFRGLMKRRSSV"
     exon            431..3810
                     /gene="Kcnk3"
                     /gene_synonym="cTBAK-1; TASK; Task-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3785..3790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnk3"
                     /gene_synonym="cTBAK-1; TASK; Task-1"
                     /note="hexamer: AATAAA"
     polyA_site      3810
                     /gene="Kcnk3"
                     /gene_synonym="cTBAK-1; TASK; Task-1"
                     /note="major polyA site"
ORIGIN      
        1 ccccggggtg cggagctggt gcccggcgtg gagatccgcg agcgcagcca tgccccaggc
       61 cgcctccggg gcagcagcgg cggcggcggc cggggccggg gcgcgggccg gagacgccgg
      121 agggccggcg aggacccggg agggacgatg aagcggcaga atgtgcgcac gttggctctc
      181 atcgtgtgca ccttcaccta cctgctggtg ggcgccgcgg tgttcgacgc actggagtcg
      241 gagccggaga tgatcgagcg gcagcggctg gagctgcggc agctggagct gcgggcgcgc
      301 tacaacctca gcgagggcgg ctacgaggag ctggagcgcg tcgtgctgcg cctcaagccg
      361 cacaaggccg gcgtgcagtg gcgcttcgcc ggctccttct acttcgccat caccgtcatc
      421 accaccatcg gctatggtca tgcggcgccc agcacggacg gaggcaaggt gttctgcatg
      481 ttctacgcgc tgctgggcat cccgctcaca ctagtcatgt tccagagcct gggtgaacgc
      541 atcaacacct tcgtgaggta cctgctgcac cgtgccaaga gggggctggg catgcggcac
      601 gccgaggtgt ccatggccaa catggtgctc atcggtttcg tgtcgtgcat cagcacgctg
      661 tgcatcggcg cagctgcctt ctcctactac gagcgctgga ctttcttcca ggcctattac
      721 tactgcttca tcaccctcac caccatcggc ttcggcgact atgtggcgct gcagaaggac
      781 caggcgctgc agacgcagcc gcagtatgtg gccttcagct tcgtgtacat cctcacgggc
      841 ctcacggtca tcggcgcctt cctcaacctc gtggtgctgc gattcatgac catgaacgcc
      901 gaggacgaga agcgtgatgc ggagcaccgc gccctgctca cgcacaacgg ccaggctgtc
      961 ggcctgggtg gcctgagctg cctgagcggt agcctgggcg acggcgtgcg tccccgcgac
     1021 ccagtcacat gcgctgcggc cgcgggaggc gtgggcgtgg gcgtcggtgg cagcggcttc
     1081 cgcaacgtct atgccgaggt gctgcacttc cagtccatgt gctcgtgcct ctggtacaag
     1141 agccgcgaga agctgcagta ctccatcccc atgatcatcc cgcgggacct ctccacgtcc
     1201 gacacctgcg tggagcacag ccactcgtcg ccgggaggcg gcggccgcta cagcgacacg
     1261 ccctcacacc cctgcctgtg cagcgggacg cagcgctcgg ccatcagctc ggtgtccacg
     1321 ggcctgcaca gcctggctgc cttccgcggc ctcatgaagc gcaggagctc ggtgtgaacc
     1381 acagccagac ctggagcacc tgtgagccag aggggtaggg gacctgcctg cagaagccgc
     1441 aggagttggc cagaaggccc cccaaagacg ccttcgggcc ccatgggaag tccccagccc
     1501 atcaccacca ccaccacctc tactcttccc cagcccctaa atctccaact gtgcaggcta
     1561 tcactagcca gcaggaggcg gggctctgag gacccctgga gcccccatcg gagccgaaga
     1621 attccgagaa atgtgaaact tagggggtgg ggagcccgga aagcagccac ggggagctgc
     1681 tgagaagccc ccagtcctca gaggccctac gggggcccca gacccctcac ctccggaggg
     1741 aactaatgtt ctcgggtttt gttttctgtt ttctgttttg gtttggttct ctctctctct
     1801 ctctctctct ctctctctct ctctctctcc ctccctccct ccctccttct ctctctctct
     1861 tctacttaca cctcctctgg gttctccaaa gcccaaggtg tttttgtcca ggtcaccccc
     1921 actcagtccc acctggctct catccccagc catgtctccc agccttccac taccttacgt
     1981 gtccactccc ttctgttttt tgcatggcta tgcagttatg gaagaaaaaa aaaaaaaagg
     2041 aaaccccagc agcccctaaa gctagtcccc agagggcaag ataaaaaaga aagaaagaaa
     2101 aaaaaaaaaa agaagaagaa aaaaaaaggg caggccacag atgttagagc agagtgtgtg
     2161 cagaaactgt ggcttccacc tctgcggggt ggacatctgt aggtgagcca cctggagtct
     2221 gggaacattc tcaggggctc ctgagagact ccagccttca ggactgccct tggaatctaa
     2281 aacatggact cccctttgct gtccctggct gcagctgctc attcactcgt ccataggttg
     2341 tttttttttg tttgtttgtt tttttgtttt ttgttttttt gtcccagaaa ccctgtgcca
     2401 cctccgtatt catttgagtg taataacact ctagttaagt cacctgggca gttcttatgg
     2461 ccatttttca gaagaggaaa acaggtaaaa aaaaaaaaat tttttttttt acttgcccgg
     2521 ggtgtcttga aggggaacag cctgccggct tgttcccagc ccaagtgctc tttcttcagg
     2581 ctcagcctgc cctcagaagc gaagcccctg caggcaacac cccagctttg tgtaggcagc
     2641 tggggtttaa accagaatca aaagccccag cctgagccac tgccagggct ctgcctctgg
     2701 tactctttag cccagagact gaggctctaa atggaccctt gtctctgttc acaagcaggg
     2761 aagtccttgg gaccaaggta agaaggactg agtctcatgg actacaagcc agcagttggc
     2821 actcttgaga gttcagggac tgggcagagc agcccagaca gctgacaggt atatcctggg
     2881 acgttttccc tggcctagaa gccaggataa atgcatccta agttgctaga gtaacttcca
     2941 ctgcagccag gaacacccct ctggagggaa ggaggtattg ggcctgctat gccttctacc
     3001 tcctctacct gcaacccagt ggagggtggc ttgctactgg ggacaagctg gaggtggaaa
     3061 ccaggacaac agaagggtat gtgtggggct atgggtatag ccccaagttt tattcccagt
     3121 accatgaaaa gggaaacctt tcccctgcag agctgccttc tgctcactgt tcccaggcct
     3181 agctccatac tgctgagtaa ggccaatgtg accatttggg gaggtagaga gagagcccca
     3241 ccatgtcctc caggtcctgg gaaatcctta ggtggaagga atctggcctg tgtgtatccc
     3301 atgtccgtgt ggaggagctg gcccctgtgt caagggggaa tggaacccag cagctggaga
     3361 ggtgctgtct gtgtttatgt tgggctggag gcagtgctgg ctgcctctgt cctgtgtgtg
     3421 accctgccct cgaggggtca agtcccgtca gatccgaggg agccacaacc aaagttacag
     3481 agagggtggg gaaggcagca gagtggccct agggtctaag catgggggac tgctggtctc
     3541 ctgtagggtc tttgcctagg gaactagaag gccactgtca cttcctgtct caccccctcc
     3601 catgcaggca gcctttctgc ttccccaatg ccttatgcct gggcacactg ccacagaata
     3661 tgcaatatgt gtgggtgaca tccccacacc cacccgggca gcccctaagt ccccaggctg
     3721 tggctgccct ggcccccttt tcagcagctc ctgcccatct gtcttcacac tgagaatggc
     3781 gcctaataaa tgctgtccat ggagaccagg
//
