LOCUS       NM_207261               3032 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus potassium channel, subfamily K, member 18 (Kcnk18),
            mRNA.
ACCESSION   NM_207261 XM_285304
VERSION     NM_207261.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3032)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3032)
  AUTHORS   Ruck,T., Bock,S., Pfeuffer,S., Schroeter,C.B., Cengiz,D.,
            Marciniak,P., Lindner,M., Herrmann,A., Liebmann,M., Kovac,S.,
            Gola,L., Rolfes,L., Pawlitzki,M., Opel,N., Hahn,T., Dannlowski,U.,
            Pap,T., Luessi,F., Schreiber,J.A., Wunsch,B., Kuhlmann,T.,
            Seebohm,G., Tackenberg,B., Seja,P., Doring,F., Wischmeyer,E.,
            Chasan,A.I., Roth,J., Klotz,L., Meyer Zu Horste,G., Wiendl,H.,
            Marschall,T., Floess,S., Huehn,J., Budde,T., Bopp,T., Bittner,S.
            and Meuth,S.G.
  TITLE     K2P18.1 translates T cell receptor signals into thymic regulatory T
            cell development
  JOURNAL   Cell Res 32 (1), 72-88 (2022)
   PUBMED   34702947
REFERENCE   3  (bases 1 to 3032)
  AUTHORS   Liu,P., Cheng,Y., Xu,H., Huang,H., Tang,S., Song,F. and Zhou,J.
  TITLE     TRESK Regulates Gm11874 to Induce Apoptosis of Spinal Cord Neurons
            via ATP5i Mediated Oxidative Stress and DNA Damage
  JOURNAL   Neurochem Res 46 (8), 1970-1980 (2021)
   PUBMED   33973102
  REMARK    GeneRIF: TRESK Regulates Gm11874 to Induce Apoptosis of Spinal Cord
            Neurons via ATP5i Mediated Oxidative Stress and DNA Damage.
REFERENCE   4  (bases 1 to 3032)
  AUTHORS   Huang,W., Ke,Y., Zhu,J., Liu,S., Cong,J., Ye,H., Guo,Y., Wang,K.,
            Zhang,Z., Meng,W., Gao,T.M., Luhmann,H.J., Kilb,W. and Chen,R.
  TITLE     TRESK channel contributes to depolarization-induced shunting
            inhibition and modulates epileptic seizures
  JOURNAL   Cell Rep 36 (3), 109404 (2021)
   PUBMED   34289346
  REMARK    GeneRIF: TRESK channel contributes to depolarization-induced
            shunting inhibition and modulates epileptic seizures.
REFERENCE   5  (bases 1 to 3032)
  AUTHORS   Kim,G.T., Siregar,A.S., Kim,E.J., Lee,E.S., Nyiramana,M.M.,
            Woo,M.S., Hah,Y.S., Han,J. and Kang,D.
  TITLE     Upregulation of TRESK Channels Contributes to Motor and Sensory
            Recovery after Spinal Cord Injury
  JOURNAL   Int J Mol Sci 21 (23), 8997 (2020)
   PUBMED   33256222
  REMARK    GeneRIF: Upregulation of TRESK Channels Contributes to Motor and
            Sensory Recovery after Spinal Cord Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3032)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   7  (bases 1 to 3032)
  AUTHORS   Czirjak,G. and Enyedi,P.
  TITLE     Targeting of calcineurin to an NFAT-like docking site is required
            for the calcium-dependent activation of the background K+ channel,
            TRESK
  JOURNAL   J Biol Chem 281 (21), 14677-14682 (2006)
   PUBMED   16569637
  REMARK    GeneRIF: the PQIVID sequence is a docking site for calcineurin, and
            its occupancy is required for the calcium-dependent regulation of
            TRESK
REFERENCE   8  (bases 1 to 3032)
  AUTHORS   Augustin,M., Sedlmeier,R., Peters,T., Huffstadt,U., Kochmann,E.,
            Simon,D., Schoniger,M., Garke-Mayerthaler,S., Laufs,J., Mayhaus,M.,
            Franke,S., Klose,M., Graupner,A., Kurzmann,M., Zinser,C., Wolf,A.,
            Voelkel,M., Kellner,M., Kilian,M., Seelig,S., Koppius,A.,
            Teubner,A., Korthaus,D., Nehls,M. and Wattler,S.
  TITLE     Efficient and fast targeted production of murine models based on
            ENU mutagenesis
  JOURNAL   Mamm Genome 16 (6), 405-413 (2005)
   PUBMED   16075367
REFERENCE   9  (bases 1 to 3032)
  AUTHORS   Kang,D., Mariash,E. and Kim,D.
  TITLE     Functional expression of TRESK-2, a new member of the tandem-pore
            K+ channel family
  JOURNAL   J Biol Chem 279 (27), 28063-28070 (2004)
   PUBMED   15123670
  REMARK    GeneRIF: TRESK-2 is a functional member of the K(2P) channel family
            and contributes to the background K+ conductance in many types of
            cells [TRESK-2]
REFERENCE   10 (bases 1 to 3032)
  AUTHORS   Czirjak,G., Toth,Z.E. and Enyedi,P.
  TITLE     The two-pore domain K+ channel, TRESK, is activated by the
            cytoplasmic calcium signal through calcineurin
  JOURNAL   J Biol Chem 279 (18), 18550-18558 (2004)
   PUBMED   14981085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107710.5.
            
            On Nov 17, 2006 this sequence version replaced NM_207261.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162136.1, AK139600.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               AC107710.5         152739-153080
            343-471             AC107710.5         158502-158630
            472-3032            AC107710.5         167901-170461
FEATURES             Location/Qualifiers
     source          1..3032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 54.63 cM"
     gene            1..3032
                     /gene="Kcnk18"
                     /gene_synonym="Gm781; Tresk; Tresk-2; Trik"
                     /note="potassium channel, subfamily K, member 18"
                     /db_xref="GeneID:332396"
                     /db_xref="MGI:MGI:2685627"
     exon            1..342
                     /gene="Kcnk18"
                     /gene_synonym="Gm781; Tresk; Tresk-2; Trik"
                     /inference="alignment:Splign:2.1.0"
     exon            343..471
                     /gene="Kcnk18"
                     /gene_synonym="Gm781; Tresk; Tresk-2; Trik"
                     /inference="alignment:Splign:2.1.0"
     exon            472..3032
                     /gene="Kcnk18"
                     /gene_synonym="Gm781; Tresk; Tresk-2; Trik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccactccc accttcctct cccaggctgt atgctccagc ctcctctaca cactcctcct
       61 gtcctgccct cagctgctcc aagaggatgg aggctgagga gccacctgag gccaggagat
      121 gctgtcccga ggccctgggg aaggccaggg gatgctgccc cgaagccctg ggcaagcttc
      181 tgcccggcct ctgcttcctt tgctgcctgg tgacctatgc gctggtgggt gctgctctct
      241 tctccgctgt cgagggccgc cctgacccag aagcagagga gaaccctgag ttgaagaagt
      301 tcctggacga tctgtgcaac atcctgaaat gtaacctgac agtggttgaa ggtagcagga
      361 agaacttgtg tgagcatctg caacacctca agccccagtg gctcaaggcg ccccaggact
      421 ggtccttcct gagcgctctc ttcttctgct gcacagtgtt cagcacagtg ggttatggcc
      481 acatgtaccc tgtcaccagg ctcggtaagt tcctgtgcat gctgtatgcg ctctttggaa
      541 tccctctaat gttcctggtc ctcacagaca taggagatat cctggccacc atcttatcca
      601 gggcttacag tcggttccag gctctccttt gcctccccca cgatatcttc aaatggcgct
      661 ccctcccgct ctgccggaag cagcctgaca gcaaaccggt ggaggaagcc atccctcaga
      721 ttgtcattga tgctggtgtg gatgaactcc taaacccgca gcccagcaag gaccccccct
      781 ctccgagctg caatgtggag ctgtttgaga gattagttgc ccgtgagaaa aagaacaagc
      841 tacaaccacc cacgcgtccc gtggagagga gcaactcctg tcccgagctg gtgctggggc
      901 gactgtcctg ttctattctc agcaatctgg atgaagtggg ccagcaggtg gagaggctgg
      961 acatccctct ccccgtcatc gccctggtcg tctttgcata catctcctgc gcggctgcta
     1021 tcctcccctt ctgggagacc gagctaggct tcgaggatgc tttctacttc tgctttgtga
     1081 cactgaccac catcgggttt ggggacatcg tgctggtgca ccctcatttc ttcctcttct
     1141 tctccatcta catcatcgtg ggcatggaga tcctgttcat tgccttcaag ctgatgcaga
     1201 accggctcct gcacacctac aaaaccctca tgctgtttgt ttgccaaagg gaagtttcgc
     1261 taccttggta aatggagagg gttccggcat ttccgtgacc tacagatgtg agccccacaa
     1321 gcttcccaca ccttggtttt atacagggtt agaagctggg ccctggtaat ctgccatcca
     1381 agctaccgag gcttggggaa acaacctact tgagggccaa attcagcgtc aaggtccctc
     1441 aggaacctgg ccatgccatt acacatgaca agaggaaagg tcatctccat tgttcccagt
     1501 cgaattagca tccctgtctg tctgaaaggc accattttaa gaatatgaaa gaactagtga
     1561 tgtcactgct ttttgtgtgt gtgacaggaa gaaaagaaaa aaaagacctt tgtttttggc
     1621 atttatactt tgagggaagt taaaatcttc ccaagtggcc ccagcttccc cccccccccc
     1681 cccatgagtc aaagtgtatc taggtaacct gtttccctga atgactgcat ggatgcactt
     1741 gacacctgcc ctaccccggg ctgctgacgt caccaagcag agttgttacc tgggagaagt
     1801 cttcatggct ggattctagt agagcacctg tctcattgct tagcccgtgg atggtgccac
     1861 ttgtgtgaat tcgatgtaac actgttgtca catcagagat ggattggtca cccctcaccc
     1921 caggtagaga cactcaagag ctgcccccga gtggctgatg tggagtagat attccacctg
     1981 tgtcttggca acttacttcc tctgtggact gtctttggac agtgaggtgt gggtctgtgc
     2041 tggaccagct agaaatgtca cggagggagc acccttcatc catgacaatg ccttgccttt
     2101 cctatgcaac agctctgggc tatgctgtat accatctccc ctcttcgcag ccagcttcag
     2161 gtgatcatta gcatactcat ttcagagtct ccctagtctc tgctcctcct catccaccct
     2221 gcccctcccc ccatcaggct ctctggggtc ccctcctata gaacataccc tgttcacatc
     2281 tgtctccaag cagcttttga ggaccaagaa aaggacagtg acagatgaca cggagatctg
     2341 gttggcaagg tcggggaagg acacacatcc tttattttat tattgtttct tttatttgaa
     2401 ggttatttga aatacctcac ggctgtatct tgtctccctg agcttgcaag cttagaaaca
     2461 tgagtcctgc aattagcaaa gttagttcct gggtgagtgg tggctggtgt tgcagagggg
     2521 agccacaggg ggaatgctgt gaggtggtag tttgaaagca gctgctggcc cttaggggct
     2581 cactattctg tcttagattc cagccgttgc caaaagcggc ttctcaggag ggtcttcagt
     2641 ttctccttct gggtccttct ccctcttccc tgcaaggatt aaattctaaa ttcctccaac
     2701 ccttgaagat ctacctcagg cactggaatc aacaaggtgt gagcaagaac cattgcaaag
     2761 acaaagtgcc ccagggtgaa ccttcaggcc agtgctcctg gttttgccat ctggcattcc
     2821 tcaagctttg tttatactgg taaggtgtgg caaagccctg caaacccaaa ttcattgaca
     2881 gcttcgccct tcaaggggct cgccatgggg ctggaggagg ttgcctagag gttctacaga
     2941 tacccaccaa acactgggca tttatccaga ttggcacaaa gcaaacctga accaagtgaa
     3001 tcctcagagc attagtgact tcatgaaagg ta
//
