LOCUS       NM_029006               2367 bp    mRNA    linear   ROD 15-DEC-2024
DEFINITION  Mus musculus potassium channel, subfamily K, member 16 (Kcnk16),
            mRNA.
ACCESSION   NM_029006 XM_138942 XM_907162
VERSION     NM_029006.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2367)
  AUTHORS   Nakhe,A.Y., Dadi,P.K., Kim,J., Dickerson,M.T., Behera,S.,
            Dobson,J.R., Shrestha,S., Cartailler,J.P., Sampson,L.,
            Magnuson,M.A. and Jacobson,D.A.
  TITLE     The MODY-associated KCNK16 L114P mutation increases islet glucagon
            secretion and limits insulin secretion resulting in transient
            neonatal diabetes and glucose dyshomeostasis in adults
  JOURNAL   Elife 12, 89967 (2024)
   PUBMED   38700926
  REMARK    GeneRIF: The MODY-associated KCNK16 L114P mutation increases islet
            glucagon secretion and limits insulin secretion resulting in
            transient neonatal diabetes and glucose dyshomeostasis in adults.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2367)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2367)
  AUTHORS   Graff,S.M., Nakhe,A.Y., Dadi,P.K., Dickerson,M.T., Dobson,J.R.,
            Zaborska,K.E., Ibsen,C.E., Butterworth,R.B., Vierra,N.C. and
            Jacobson,D.A.
  TITLE     TALK-1-mediated alterations of beta-cell mitochondrial function and
            insulin secretion impair glucose homeostasis on a diabetogenic diet
  JOURNAL   Cell Rep 43 (1), 113673 (2024)
   PUBMED   38206814
  REMARK    GeneRIF: TALK-1-mediated alterations of beta-cell mitochondrial
            function and insulin secretion impair glucose homeostasis on a
            diabetogenic diet.
REFERENCE   4  (bases 1 to 2367)
  AUTHORS   Zhang,J., Jin,H., Zhang,W., Ding,C., O'Keeffe,S., Ye,M. and
            Zuker,C.S.
  TITLE     Sour Sensing from the Tongue to the Brain
  JOURNAL   Cell 179 (2), 392-402 (2019)
   PUBMED   31543264
REFERENCE   5  (bases 1 to 2367)
  AUTHORS   Vierra,N.C., Dickerson,M.T., Jordan,K.L., Dadi,P.K., Katdare,K.A.,
            Altman,M.K., Milian,S.C. and Jacobson,D.A.
  TITLE     TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic
            calcium levels limiting somatostatin secretion
  JOURNAL   Mol Metab 9, 84-97 (2018)
   PUBMED   29402588
  REMARK    GeneRIF: TALK-1 reduces delta-cell cytosolic Ca2+ elevations and
            somatostatin release by limiting delta-cell Ca2+-induced Ca2+
            release.
REFERENCE   6  (bases 1 to 2367)
  AUTHORS   Vierra,N.C., Dadi,P.K., Milian,S.C., Dickerson,M.T., Jordan,K.L.,
            Gilon,P. and Jacobson,D.A.
  TITLE     TALK-1 channels control beta cell endoplasmic reticulum Ca2+
            homeostasis
  JOURNAL   Sci Signal 10 (497) (2017)
   PUBMED   28928238
  REMARK    GeneRIF: data establish TALK-1 channels as key regulators of beta
            cell ER Ca(2+) and suggest that TALK-1 may be a therapeutic target
            to reduce ER Ca(2+) handling defects in beta cells during the
            pathogenesis of diabetes.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2367)
  AUTHORS   Dickerson,M.T., Vierra,N.C., Milian,S.C., Dadi,P.K. and
            Jacobson,D.A.
  TITLE     Osteopontin activates the diabetes-associated potassium channel
            TALK-1 in pancreatic beta-cells
  JOURNAL   PLoS One 12 (4), e0175069 (2017)
   PUBMED   28403169
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2367)
  AUTHORS   Vierra,N.C., Dadi,P.K., Jeong,I., Dickerson,M., Powell,D.R. and
            Jacobson,D.A.
  TITLE     Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates beta-Cell
            Electrical Excitability, Second-Phase Insulin Secretion, and
            Glucose Homeostasis
  JOURNAL   Diabetes 64 (11), 3818-3828 (2015)
   PUBMED   26239056
REFERENCE   9  (bases 1 to 2367)
  AUTHORS   Han,J., Kang,D. and Kim,D.
  TITLE     Functional properties of four splice variants of a human pancreatic
            tandem-pore K+ channel, TALK-1
  JOURNAL   Am J Physiol Cell Physiol 285 (3), C529-C538 (2003)
   PUBMED   12724142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159106.3.
            
            On Jun 20, 2019 this sequence version replaced NM_029006.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164143
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AC159106.3         105676-105995       c
            321-435             AC159106.3         101892-102006       c
            436-602             AC159106.3         100886-101052       c
            603-768             AC159106.3         99975-100140        c
            769-2367            AC159106.3         98101-99699         c
FEATURES             Location/Qualifiers
     source          1..2367
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.49 cM"
     gene            1..2367
                     /gene="Kcnk16"
                     /gene_synonym="4731413G05Rik; TALK-1; TALK1"
                     /note="potassium channel, subfamily K, member 16"
                     /db_xref="GeneID:74571"
                     /db_xref="MGI:MGI:1921821"
     exon            1..320
                     /gene="Kcnk16"
                     /gene_synonym="4731413G05Rik; TALK-1; TALK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..986
                     /gene="Kcnk16"
                     /gene_synonym="4731413G05Rik; TALK-1; TALK1"
                     /note="2P domain potassium channel Talk-1; TWIK-related
                     alkaline pH-activated K(+) channel 1"
                     /codon_start=1
                     /product="potassium channel, subfamily K, member 16"
                     /protein_id="NP_083282.1"
                     /db_xref="CCDS:CCDS49407.1"
                     /db_xref="GeneID:74571"
                     /db_xref="MGI:MGI:1921821"
                     /translation="MPRAGVCGCWGGQVLPLLLAYICYLLLGATIFQLLEKQAEAQSR
                     DQFQLEKLRFLENYTCLDQQALEQFVQVILEAWVKGVNPKGNSTNPSNWDFGSSFFFA
                     GTVVTTIGYGNLAPSTEAGQVFCVFYALMGIPLNVVFLNHLGTGLRAHLTTLDRWEDH
                     PRHSQLLQVLGLALFLTLGTLVILIFPPMFFSHVEGWSFREGFYFAFITLSTIGFGDY
                     VVGTDPSKHYIAVYRSLAAIWILLGLAWLAVVLSLGSLLLHRCSRLWQLIRGLDLKDG
                     AAPDSEPRSQKIPISA"
     exon            321..435
                     /gene="Kcnk16"
                     /gene_synonym="4731413G05Rik; TALK-1; TALK1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..602
                     /gene="Kcnk16"
                     /gene_synonym="4731413G05Rik; TALK-1; TALK1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..768
                     /gene="Kcnk16"
                     /gene_synonym="4731413G05Rik; TALK-1; TALK1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..2367
                     /gene="Kcnk16"
                     /gene_synonym="4731413G05Rik; TALK-1; TALK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2338..2343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnk16"
                     /gene_synonym="4731413G05Rik; TALK-1; TALK1"
                     /note="hexamer: AATAAA"
     polyA_site      2367
                     /gene="Kcnk16"
                     /gene_synonym="4731413G05Rik; TALK-1; TALK1"
                     /note="major polyA site"
ORIGIN      
        1 gcagacacct gtgcggtgga ggacagggca ggcagtggca ggggctctca cctcttccaa
       61 ctctttcaca gccaccctga cagctgctgc agagtcctgg ccacatcatg ccccgtgctg
      121 gggtctgcgg ctgctggggt ggccaagtat tgcccctgct tctggcctat atctgctacc
      181 tactgcttgg ggccaccatc ttccagctgc tggagaagca ggcagaggct caatccaggg
      241 accagttcca gctggaaaag ctacgcttct tagagaacta cacctgccta gaccagcagg
      301 ccctggagca gtttgtacag gtcatcctgg aagcctgggt gaagggtgtg aaccccaaag
      361 gcaactccac caatcccagc aactgggact tcgggagcag cttcttcttt gcaggcacag
      421 tggtcaccac cataggttat ggaaacctgg cccccagcac ggaggcaggg caggtcttct
      481 gtgtcttcta tgctctgatg gggatcccac tcaatgtggt cttcctcaac catctgggca
      541 cagggctgcg ggcccacctg accacattgg acaggtggga ggaccacccc aggcattccc
      601 agctcctgca ggtcctgggc ctggctctgt tcctgacctt ggggaccctg gtcattctca
      661 tcttcccacc catgttcttc agccacgtgg agggctggag cttccgtgag ggcttctact
      721 tcgcgtttat caccctcagc accattggct tcggggacta tgttgttggc acagacccca
      781 gcaagcatta catcgctgtg tatcggagct tggcagctat atggatcctc ctaggactgg
      841 catggctggc ggtggtcctc agcctgggat ccctgcttct gcacaggtgc tcccggctct
      901 ggcagctcat cagaggcctg gaccttaagg atggagcagc ccctgactct gagcctagat
      961 cacagaaaat ccccatctct gcatgagacc caagtgtcct gacctcccca aacccatgcc
     1021 attccctgcc cttccccttt cttctcaacc cacacacttc ccagcaactt tccagagaga
     1081 gaaaggagac agatgtgcct acaaagtgac tggggcgggg gggggggggg cggtgaggag
     1141 acaaagatca aagatctgca tggatggaga tgtgaagttt gcccttggcg cttttcccat
     1201 ctcccaaaga gaacctggat cgtggttgcc aaatcactac tgccatctta acatggtcat
     1261 gggagccctt aggctgcagg caaaggtgga cttgactttt gtattattta ctacatacac
     1321 agtaggctct taacaggtcc ctactaggta gcacatagtg gtggtttctg ccttcattgt
     1381 gtcagtgtgt cagtcttgaa ggagctccaa ggcagcatcc tcatctttga tgggaataaa
     1441 cctggggaga atgaaagttc agggcggtgg ctggaggaag ggagctggac acacaccagg
     1501 ggatgccttt gatgcataca ggaagccgtc ctcaggagtc tcacagctga ggaacaagaa
     1561 ggctgccagt cagaattccc cagctctcct tgcccacaag tggagaggaa tcctagaaca
     1621 acactggggg cccctttcag gggtcccacc actttcttga acatgacctc ctctgaccct
     1681 cagagcacac ttagacctct ttactccccc gcccccagag aagctggggg tggggggagc
     1741 agcagatccc aagggcttca tagcctgtca tctctccggt ggcatggact cccaccgagc
     1801 ctggttcttc tgccagatcg tgacattgtg ggccagaagg caggaaaggt tcgtcccaga
     1861 ctcacaagac taggaactaa tttttgtttg gacttccttt acctctccag tggcaggggt
     1921 gtccccaagt tctgtgtcct ctttatagca ttaagggtgg gggtgggact gtgagcccca
     1981 gaggttgagg ggagtccctg agaaggaccc gcattggcag agggttccca gcacccaagt
     2041 cttactgcca cccaggaaag gattgaaata tgacgtctct aacaccccga cacctgctgg
     2101 accccacttc ttttctgggt ggatggagat gcagggactt ccctccaaag cagcaaggaa
     2161 aatttgggtc cggtcttctt gcctgctagc ctcccagccc gggacagcac agacaaacca
     2221 tacccccctc cccattttat ttcttatagt acactggctg tagcgagatc tagggtgata
     2281 caaggaagca ctcggaggaa gtccccagcc cctcagctta ggcaggagtc ctgtgacaat
     2341 aaacttggct gctgtttctt ctctgca
//
