LOCUS       NM_001316665            7491 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus potassium channel, subfamily K, member 10 (Kcnk10),
            transcript variant 3, mRNA.
ACCESSION   NM_001316665 XM_006516254
VERSION     NM_001316665.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7491)
  AUTHORS   Kim SS, Park J, Kim E, Hwang EM and Park JY.
  TITLE     beta-COP Suppresses the Surface Expression of the TREK2
  JOURNAL   Cells 12 (11), 1500 (2023)
   PUBMED   37296621
  REMARK    GeneRIF: beta-COP Suppresses the Surface Expression of the TREK2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7491)
  AUTHORS   Glogowska E, Arhatte M, Chatelain FC, Lesage F, Xu A, Grashoff C,
            Discher DE, Patel A and Honore E.
  TITLE     Piezo1 and Piezo2 foster mechanical gating of K2P channels
  JOURNAL   Cell Rep 37 (9), 110070 (2021)
   PUBMED   34852225
REFERENCE   3  (bases 1 to 7491)
  AUTHORS   Choi SW, Woo J, Park KS, Ko J, Jeon YK, Choi SW, Yoo HY, Kho I, Kim
            TJ and Kim SJ.
  TITLE     Higher expression of KCNK10 (TREK-2) K+ channels and their
            functional upregulation by lipopolysaccharide treatment in mouse
            peritoneal B1a cells
  JOURNAL   Pflugers Arch 473 (4), 659-671 (2021)
   PUBMED   33586023
  REMARK    GeneRIF: Higher expression of KCNK10 (TREK-2) K(+) channels and
            their functional upregulation by lipopolysaccharide treatment in
            mouse peritoneal B1a cells.
REFERENCE   4  (bases 1 to 7491)
  AUTHORS   Lengyel M, Czirjak G, Jacobson DA and Enyedi P.
  TITLE     TRESK and TREK-2 two-pore-domain potassium channel subunits form
            functional heterodimers in primary somatosensory neurons
  JOURNAL   J Biol Chem 295 (35), 12408-12425 (2020)
   PUBMED   32641496
  REMARK    GeneRIF: TRESK and TREK-2 two-pore-domain potassium channel
            subunits form functional heterodimers in primary somatosensory
            neurons.
REFERENCE   5  (bases 1 to 7491)
  AUTHORS   Zhang XT, Xu Z, Shi KP, Guo DL, Li H, Wang L and Zhu XB.
  TITLE     Elevated expression of TREK-TRAAK K2P channels in the retina of
            adult rd1 mice
  JOURNAL   Int J Ophthalmol 12 (6), 924-929 (2019)
   PUBMED   31236347
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7491)
  AUTHORS   Zheng H, Nam JH, Pang B, Shin DH, Kim JS, Chun YS, Park JW, Bang H,
            Kim WK, Earm YE and Kim SJ.
  TITLE     Identification of the large-conductance background K+ channel in
            mouse B cells as TREK-2
  JOURNAL   Am J Physiol Cell Physiol 297 (1), C188-C197 (2009)
   PUBMED   19439530
  REMARK    GeneRIF: Identification of the large-conductance background K+
            channel in mouse B cells as TREK-2.
REFERENCE   7  (bases 1 to 7491)
  AUTHORS   Guyon A, Tardy MP, Rovere C, Nahon JL, Barhanin J and Lesage F.
  TITLE     Glucose inhibition persists in hypothalamic neurons lacking
            tandem-pore K+ channels
  JOURNAL   J Neurosci 29 (8), 2528-2533 (2009)
   PUBMED   19244527
REFERENCE   8  (bases 1 to 7491)
  AUTHORS   Czirjak G and Enyedi P.
  TITLE     Zinc and mercuric ions distinguish TRESK from the other
            two-pore-domain K+ channels
  JOURNAL   Mol Pharmacol 69 (3), 1024-1032 (2006)
   PUBMED   16354767
REFERENCE   9  (bases 1 to 7491)
  AUTHORS   Chemin J, Patel A, Duprat F, Zanzouri M, Lazdunski M and Honore E.
  TITLE     Lysophosphatidic acid-operated K+ channels
  JOURNAL   J Biol Chem 280 (6), 4415-4421 (2005)
   PUBMED   15572365
  REMARK    GeneRIF: TREK-1, TREK-2, and TRAAK are lysophosphatidic
            acid-operated K+ channels
            Erratum:[J Biol Chem. 2013 Sep 6;288(36):26178]
REFERENCE   10 (bases 1 to 7491)
  AUTHORS   Kang D, Choe C and Kim D.
  TITLE     Functional expression of TREK-2 in insulin-secreting MIN6 cells
  JOURNAL   Biochem Biophys Res Commun 323 (1), 323-331 (2004)
   PUBMED   15351740
  REMARK    GeneRIF: TREK-2 contributes to the background K+ conductance in
            MIN6 cells, and may regulate depolarization-induced secretion of
            insulin
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019376.1, AK031904.1, AC124516.4 and AC134249.4.
            
            On Oct 20, 2015 this sequence version replaced XM_006516254.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ185134.1, SRR10662774.1201352.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-556               AK019376.1         3-558
            557-736             AK031904.1         88-267
            737-737             AC124516.4         199087-199087
            738-3098            AK031904.1         268-2628
            3099-7491           AC134249.4         117511-121903       c
FEATURES             Location/Qualifiers
     source          1..7491
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 49.86 cM"
     gene            1..7491
                     /gene="Kcnk10"
                     /gene_synonym="1700024D23Rik; 3010005K24Rik; Trek2"
                     /note="potassium channel, subfamily K, member 10"
                     /db_xref="GeneID:72258"
                     /db_xref="MGI:MGI:1919508"
     exon            1..556
                     /gene="Kcnk10"
                     /gene_synonym="1700024D23Rik; 3010005K24Rik; Trek2"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..2121
                     /gene="Kcnk10"
                     /gene_synonym="1700024D23Rik; 3010005K24Rik; Trek2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     TREK-2 two-pore-domain K+ channel; outward rectifying
                     potassium channel TREK2"
                     /codon_start=1
                     /product="potassium channel subfamily K member 10 isoform
                     3"
                     /protein_id="NP_001303594.1"
                     /db_xref="GeneID:72258"
                     /db_xref="MGI:MGI:1919508"
                     /translation="MKFPIETPRKQVNWDPKVAVPAAAPPVCQPKSATNGHHPVPRLS
                     ISSRATVVARMEGASQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQK
                     NTIALEKAEFLRDHICVSPQELETLIQHALDADNAGVSPVGNSSNSSSHWDLGSAFFF
                     AGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVE
                     KVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTT
                     VGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVG
                     EIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDML
                     SPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLTKHGQGASEDNIINKFGST
                     SKLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEDETEKMCNSDNSSTAMLTECI
                     QQQAEMENGMVPTDTKDQGLENNSLLEDRN"
     exon            557..891
                     /gene="Kcnk10"
                     /gene_synonym="1700024D23Rik; 3010005K24Rik; Trek2"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1009
                     /gene="Kcnk10"
                     /gene_synonym="1700024D23Rik; 3010005K24Rik; Trek2"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1170
                     /gene="Kcnk10"
                     /gene_synonym="1700024D23Rik; 3010005K24Rik; Trek2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1357
                     /gene="Kcnk10"
                     /gene_synonym="1700024D23Rik; 3010005K24Rik; Trek2"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1500
                     /gene="Kcnk10"
                     /gene_synonym="1700024D23Rik; 3010005K24Rik; Trek2"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..7491
                     /gene="Kcnk10"
                     /gene_synonym="1700024D23Rik; 3010005K24Rik; Trek2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgcgcgc ctgtgtgtgt gtgtgtgcgt gtatgtatgg atgtgtgtgt atgtgtgtgt
       61 gcgtgtgtgt ggatgcgaga gagggggtac gaacacgcct ttggggaccc gagggacgct
      121 gcggtgggct tcactccggc ctccgcccgg cggctgctca gcctcgcatc tgcctaccgc
      181 gcttttgcag aagcagcccg gctctttgat cctctcggaa ccaccctcag catccgatct
      241 tactttttct ttcacccaca agggcagcag ctggccaccc ccttaaccgg tgcaaacacc
      301 caaccaagcc agtgctcggt gctttcctct gctagtattt tccccgcttg tctttctctg
      361 gggctcccca cgagccactt cagtgctcct ccatcctcac aaattgttcc gttggtctgt
      421 ttaaccgacg agttgtaaat cttgaagact ttattattat tattttgatt cttttcattt
      481 catccccctg tgggcaacgg agcaatgaaa tttccaatcg agacgccaag aaagcaggtg
      541 aactgggatc ctaaagtggc cgtgcctgca gcagccccac cagtgtgcca gcccaagagt
      601 gccactaacg ggcatcaccc tgttcctcga ctctccattt cctctcgagc cacggtggta
      661 gccaggatgg aaggcgcctc ccagggaggc ctgcaaacag ttatgaagtg gaaaacagtg
      721 gttgccatct tcgtggtggt cgtggtctac ctcgtcactg gtggccttgt cttccgggcc
      781 ttggaacagc ccttcgagag cagtcagaag aacacaatcg ccttggagaa ggcagaattc
      841 ttgagagatc acatctgtgt gagtccccag gaactagaga cactgattca gcatgcactc
      901 gatgctgata acgcgggagt cagcccagta ggaaactctt ccaacagcag cagtcactgg
      961 gaccttggaa gtgccttctt ctttgctggg acagtcatca caaccatagg gtatgggaat
     1021 attgctccga gcactgaagg aggcaaaatc ttttgtattt tatatgccat ctttgggatc
     1081 ccgctttttg gtttcttatt ggctggaatt ggagaccaac ttggaaccat ctttggcaaa
     1141 agcattgcaa gagtggaaaa ggtttttcga aagaagcaag tgagccagac caagatccgg
     1201 gtcatctcca cgattctctt catcttggct ggctgcatcg tgtttgtgac catccctgct
     1261 gtcatcttta aatacatcga gggttggacc gccttggagt ccatctactt tgtggtagtc
     1321 acgctgacca cagtaggctt tggtgatttt gtggcagggg gaaatgctgg catcaattac
     1381 cgagagtggt acaagccgct ggtgtggttt tggatccttg ttggccttgc ctactttgca
     1441 gctgtcctca gtatgatcgg agactggctg cgggttttat ccaaaaagac aaaagaagag
     1501 gttggtgaga tcaaagccca cgcagctgag tggaaggcta atgtcactgc tgagttccgg
     1561 gagacgagaa ggcggctcag cgttgagatc catgacaagc tgcaacgggc agccactatc
     1621 cgaagtatgg agcgccggag gctgggcttg gaccagaggg cccactcact ggacatgcta
     1681 tcccctgaga agcgttctgt ctttgcagcc ctggacacag gccgtttcaa ggcctcatcg
     1741 caggagagta tcaacaacag acccaacaac ctacgcctta aggggccaga acagcttacc
     1801 aaacatgggc agggcgcttc tgaggacaac atcatcaaca agtttgggtc cacctccaaa
     1861 ctcacaaaga ggaaaaacaa agatctcaaa aagaccttac ccgaggatgt tcagaaaatc
     1921 tacaaaacct tccggaatta ctctctggat gaagagaaga aagaggacga gacagaaaag
     1981 atgtgtaact ccgacaactc cagcacagcc atgctgacag agtgtataca gcagcaagct
     2041 gagatggaga acggaatggt acccacggac accaaagacc aggggctgga gaacaattct
     2101 ttacttgaag acagaaacta aatgttaaag acattggaat tggactatgt gttgtcttgt
     2161 ttttgttgtt ttgtttttgt cttgtttttg ttttaatatt cacactgaga cacgtgcctt
     2221 aaatagactt ctttttagtc caaaattaca tagcattgaa gaagatattt cactgtgcca
     2281 tacacaactg aaagcttgct ctgccaaaat gaaccaagca agagcttcat ttcagacagt
     2341 ggcggcagga cagttggggg agcatttgca caggtagcag gtgtcagctg tccctgtgag
     2401 ggggagttcc agtggcaacg ctatagttct cacacagtgt cactctggca tggcgcacag
     2461 gcaagggcag ctttccctta gaccagcccc tgagaggaca ggtttgtctt ttgaatcgag
     2521 tctcctttcc ccaaccagcc ctcagtgata ggtggtgcac agatagggcg gctgtttgtg
     2581 agggacccgg tggcggctct agcaagggtt tgagtggaca ttttgacagg ccacagtgca
     2641 aaacgcctac tccaaaatga atgtccctgg gacccaagag tacctggaat ttgttggaaa
     2701 ctgatcagag cacacacgtt ttataaggtg caattgcttt ctcataaaaa gacaaatcac
     2761 agacacaccc cactgtggct atctccttaa ccaatggcag aggcccgcta aactttatcc
     2821 ttctcatggg ataggtagtg taggtgggca agcgagcatt ggtgattaca ccgcctcagc
     2881 cgctgccttg ttggaaggca gatcatgcat ttttcttcag tgggtgtgaa ggttaaaaaa
     2941 aaaaaaacaa ctgattttgg aacattcata gtcacttttc tacgggaact ttaattataa
     3001 cttgttttga taggagggaa gaaataccaa aattattgcc tttgcatgat gccagtggct
     3061 tgctgttctg tctagctgat cctatttttc ttttttttaa ataaaagata aaaatagaca
     3121 tcttgcgttt gtgggacaca ccgaggagga ccatggcatc tttccatctc agggtttcct
     3181 gtccttttgg gtgttgtaga cttagctacg agcctcactc ttgtgatttc tatacaaagg
     3241 aaaaggagtc tctcaccaaa cccttgtaag actgaaatgg tttaagttgt ttgcaggtta
     3301 agtgccatta acacattgac aacaacactg gaaaggaata tgtaaaagat ttcactttgt
     3361 ccttgtgttt cgtggatgcc ttcatcaagt tcttggtatg attagatttc cttatgcctt
     3421 tagtatggga acatagcctt ccttatctat tcacctcaca cctgttatac accaaaaacg
     3481 gtaactcccg cagcattgtt tctagccgag cggtgatcaa catgtgattg ctatgattgt
     3541 ttaaccttct tttataatgt tcagagcatc gtagaaaaga gtgagttgta gggtttggga
     3601 ggctgattta atggagtttt gtttttttaa tcagaaagga gaaattcata gtaggcctta
     3661 tttcgcctgt gtgtatgtca actttaacca gacttggctg catgttggtt cagctagcag
     3721 ccccctgcca ttaaacattt gcatcctata tcatgaggaa actgctggct gtgggtcttc
     3781 aagactcagt accacttttt ggggattttc atggagtttt cctataacta attaacaaag
     3841 catatttaac aagagatcac agcacaagtg gagacttcca gaaatggtct accattttct
     3901 aaccgagggg gaaattatgt ccacggcctc gctggtacca tggaagactc atgccccctg
     3961 cccatttccc tgaaatgtac tgcttccagc tgtcccctac ttggagcaca gaagccctcg
     4021 tttcccagct ctcagggaaa ccttcaggat cttgttaaat atttgagaag tcaaataggc
     4081 atcactatgg tgaggccttt cctgtcaagg gtttgtctgg gatcagtcca tcatcagagc
     4141 agaatactgg ctcattggtg ttccacatag ttctgtagac ttggagaata taatgtgtat
     4201 gcaggcgcag atgctgggtt tttattatgg gtagggtcca gcctggctca ttgtgtttta
     4261 aggaacagat agataagtgg gacttagata agtgggactt ccctattctg acaagtttcc
     4321 tgatgaaact gcacatggat ctcacccgta ttctgttgta tggtacctcg gtacatcttt
     4381 gtggttgtgt taaaactgca ggcactagat gtatgtctgg caaagaacca gccctgctgt
     4441 ttgttctgtg ccagacttgg tactggattg gacattttac agcactcatt gaaacctcac
     4501 cctgtcaagt tggaagtatt tgcaaactct ctgtatagaa gaggtcacag agactcaggg
     4561 aggctaagca acttaccagt agagcacagc aagaatgtgg gaaaagtcga caacctgcac
     4621 ccttgtgact gagagtacat gtggttgtgt gtgtgacttt atgcgtgcac acgtcttgca
     4681 agcttcatga gcacagttga cagaggtgag gagaagatag actttttttt tcttttcttt
     4741 tttctttttt ttttttttac ccctaagagg gactgaaatt taggaggtaa aactggccta
     4801 aagggttgcc cctgaagcta tctactgcat gcttttgaca gcaccttttc tgtattgcca
     4861 gaaatgcccc tctaaagcac tcctttgcac tttactcgat tttcttgcag gaactcttca
     4921 tacagcagga actagacagc tctgcagtct tagatgcata atcaaccaaa tggaacaggt
     4981 atacgaatca gtgtgtgcac agatgtattc gtgagaatca aaccacagta atactaagac
     5041 tcaaacataa ccttggattg agagtgtgta acccattccc tgattgttgg aaaaaggttc
     5101 tgaatgacgt caaagacgac cctcaatgaa gactgtatat gtagacaacg tgttccaaga
     5161 gctaaactat gaggtactct ccaagggaga ggccgatggg tgcacgagag gtttcatccc
     5221 atgtatacat gctaactaag cctcaaggtg ctgggtgttt ggaagtcact cgactgtcac
     5281 ccctgtaagc aggggagcaa acagtatgca gaacatgtgt gtgataagac agctgctaca
     5341 tgttacgtac aaacatcagc ccagcctacc ctttctcctc agtaaccctt gcccttctta
     5401 agacatggaa agagcacatg tttggtatct taggtgggca gttttgtgct tcgtttggcg
     5461 gctgagttca gaattgttat tttgtttgga ggtttactag tgagagtcaa gggatagttg
     5521 ggaggaggtt attacacaca cacacacaca cacaaatata tatatatatg tgtatatata
     5581 tatatatata tatatatata tatatacata cacacatact tggctatcag gcttgtgcag
     5641 tgtgtatgtg tgtggcatgt gtggtgtgaa aggagtcctt ggcctataat tcaggcatct
     5701 gggaccacta ttgcttgagc tcttccaccc ccacagcttg tgctcacagg catactgttt
     5761 tttttccctg tacctcatct gcacaccaag ggaatggcgt acagattatt accaaaaccc
     5821 ttttccaatt gtacagttct ctgaggacac attccctagt ctgtgagtta atcagatgat
     5881 tattaagttg gatttctgca tattgattaa tggccccatt cccaccccta gtgtttgttt
     5941 tctgcatggt tgatggagac cagatgtatt tgaaagactg gtgtccaaat taggaataca
     6001 ccctatacag ggtctatcca ccactgtcct agctagttct tagcatgctg ttgttctaca
     6061 cagcacacga tgcagagggc ttcttttgtt ttgcagggcg gggtggggtc atcagggcaa
     6121 tggtgttaag gctagtcaaa gacctgtaag ccattgctat ctacactcag ttgtactaaa
     6181 cgttccgttg actgcattat gaattcctgt cctcccccgt cctgtcctgc tggtactcaa
     6241 aggcacccat gtgcaggcaa tgacttctct ggtcccacgg ggacaacttc aggtgggaat
     6301 ttctagttgt gctaagcatt agcaaacaac ccttcttcag ttctgaggca tcatttcctg
     6361 gggagtcaaa gctgccattt acgtgcttgg tctgggacca gggttctggt tgaagcactt
     6421 gtggctcact ggactgggga atgatgttag ccatccagtg tgcagagtga tttcaacatc
     6481 agagaaagga aaagaagcaa aaacaagctc ggagagactc tctataaaag aaaacgtgcc
     6541 ccatcgtctt ctgccctttg gctttctgca ttttgccaat gcttcatgtc tgtttttttg
     6601 ttttgttttt ccctcactgt taggatacag ctgtatgcaa agacaagagg ctgagggtgg
     6661 gcatgggaag cctcagctga tattaataat ggcttcaaaa agacacaact gagctctaaa
     6721 acgaaggcca ctttcacttg gcatttcgaa tgctgttgag tctgcataca gtgtggcagc
     6781 taccgggctc tgaaaatctc ctgcagtctg tcctggtgtg gtagccatgt tacaccacac
     6841 actgtgaccc cttccttgtt ccatgtgctt cttggtcctt ccatgctggt agatcacatg
     6901 acaccagctg agtggtatgg agaagtgaga ggtgtctctg atttactggg tgtagttatt
     6961 ttcacaggta tgggaggttg gggaccccct tgtgttcttt gtccttaagt tctctgttct
     7021 ttgtcccgtg cattacaaaa taaacccttc tgagaaagtt ccagcccatc agctcagtca
     7081 acttgtgcca tagatgctgc ttcatggtct gtcccacgtg cggggctcta gctgaaaggg
     7141 agatgcctag atgggctatg caaactaccc cgaaggaatg gaggttactc cagttcttcc
     7201 tgtcccagag ctgcaggcaa gggacccagt gatgaccaac catagatcca agtgtggaga
     7261 tgttttacat attctttttt tctgtaggat ttcatggtgc tttttttttt cttttaaagg
     7321 cattttacag ttaatgcgtt gggggagggg catttcatat tgttcttagg agaagtgggg
     7381 atttgcttgt aacatttcaa aaagctgtgc tgctattgcc cttatttgaa gatgtaattt
     7441 tttttttcaa tgatggagaa cattgcaaca aagaccttct ggaagatcca a
//
