LOCUS       NM_008430               2306 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus potassium channel, subfamily K, member 1 (Kcnk1),
            mRNA.
ACCESSION   NM_008430
VERSION     NM_008430.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Kim,S.S., Bae,Y., Kwon,O., Kwon,S.H., Seo,J.B., Hwang,E.M. and
            Park,J.Y.
  TITLE     beta-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated
            Passive Conductance in Astrocytes
  JOURNAL   Cells 11 (20), 3322 (2022)
   PUBMED   36291187
  REMARK    GeneRIF: beta-COP Regulates TWIK1/TREK1 Heterodimeric
            Channel-Mediated Passive Conductance in Astrocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2306)
  AUTHORS   Kwon,O., Yang,H., Kim,S.C., Kim,J., Sim,J., Lee,J., Hwang,E.M.,
            Shim,S. and Park,J.Y.
  TITLE     TWIK-1 BAC-GFP Transgenic Mice, an Animal Model for TWIK-1
            Expression
  JOURNAL   Cells 10 (10), 2751 (2021)
   PUBMED   34685731
  REMARK    GeneRIF: TWIK-1 BAC-GFP Transgenic Mice, an Animal Model for TWIK-1
            Expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2306)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2306)
  AUTHORS   Mao,Q., Wu,S., Gu,X., Du,S., Mo,K., Sun,L., Cao,J., Bekker,A.,
            Chen,L. and Tao,Y.X.
  TITLE     DNMT3a-triggered downregulation of K2p 1.1 gene in primary sensory
            neurons contributes to paclitaxel-induced neuropathic pain
  JOURNAL   Int J Cancer 145 (8), 2122-2134 (2019)
   PUBMED   30684388
  REMARK    GeneRIF: Findings suggest that DNA methyltransferase 3A
            (DNMT3a)-triggered downregulation of dorsal root ganglia (DRG)
            potassium channel subfamily K member 1 (KCNK1; K2p 1.1) may
            contribute to chemotherapy-induced neuropathic pain.
REFERENCE   5  (bases 1 to 2306)
  AUTHORS   Zhang,J., Jin,H., Zhang,W., Ding,C., O'Keeffe,S., Ye,M. and
            Zuker,C.S.
  TITLE     Sour Sensing from the Tongue to the Brain
  JOURNAL   Cell 179 (2), 392-402 (2019)
   PUBMED   31543264
REFERENCE   6  (bases 1 to 2306)
  AUTHORS   Nicolas,M.T., Barhanin,J., Reyes,R. and Dememes,D.
  TITLE     Cellular localization of TWIK-1, a two-pore-domain potassium
            channel in the rodent inner ear
  JOURNAL   Hear Res 181 (1-2), 20-26 (2003)
   PUBMED   12855359
  REMARK    GeneRIF: Specifically localized in 'non-sensory' cells of inner
            ear, in dark cells of vestibule and in strial marginal cells of
            cochlea. May have role in regulation of K(+) homeostasis in dark
            cells and in strial marginal cells.
REFERENCE   7  (bases 1 to 2306)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2306)
  AUTHORS   Arrighi,I., Lesage,F., Scimeca,J.C., Carle,G.F. and Barhanin,J.
  TITLE     Structure, chromosome localization, and tissue distribution of the
            mouse twik K+ channel gene
  JOURNAL   FEBS Lett 425 (2), 310-316 (1998)
   PUBMED   9559671
REFERENCE   9  (bases 1 to 2306)
  AUTHORS   Kim,D., Fujita,A., Horio,Y. and Kurachi,Y.
  TITLE     Cloning and functional expression of a novel cardiac two-pore
            background K+ channel (cTBAK-1)
  JOURNAL   Circ Res 82 (4), 513-518 (1998)
   PUBMED   9506712
REFERENCE   10 (bases 1 to 2306)
  AUTHORS   Lesage,F., Lauritzen,I., Duprat,F., Reyes,R., Fink,M., Heurteaux,C.
            and Lazdunski,M.
  TITLE     The structure, function and distribution of the mouse TWIK-1 K+
            channel
  JOURNAL   FEBS Lett 402 (1), 28-32 (1997)
   PUBMED   9013852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY240683.1, AK137224.1, BG088333.2, AC102420.10 and AF033017.1.
            
            On Nov 16, 2007 this sequence version replaced NM_008430.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF033017.1, SRR1660815.50861.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                BY240683.1         1-89
            90-349              AK137224.1         2-261
            350-726             AK137224.1         263-639
            727-765             AK137224.1         641-679
            766-1293            BG088333.2         56-583
            1294-1389           AK137224.1         1208-1303
            1390-2290           AC102420.10        114180-115080
            2291-2306           AF033017.1         2225-2240
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 73.67 cM"
     gene            1..2306
                     /gene="Kcnk1"
                     /gene_synonym="TWIK-1"
                     /note="potassium channel, subfamily K, member 1"
                     /db_xref="GeneID:16525"
                     /db_xref="MGI:MGI:109322"
     exon            1..713
                     /gene="Kcnk1"
                     /gene_synonym="TWIK-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..1369
                     /gene="Kcnk1"
                     /gene_synonym="TWIK-1"
                     /note="inward rectifying potassium channel protein TWIK-1"
                     /codon_start=1
                     /product="potassium channel subfamily K member 1"
                     /protein_id="NP_032456.2"
                     /db_xref="CCDS:CCDS22783.1"
                     /db_xref="GeneID:16525"
                     /db_xref="MGI:MGI:109322"
                     /translation="MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSV
                     ELPYEDLLRQELRKLKRRFLEEHECLSEPQLEQFLGRVLEASNYGVSVLSNASGNWNW
                     DFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRVTVHV
                     TRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYF
                     CFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKF
                     RKMFYVKKDKDEDLVHIMEHDQLSFSSVTEQVAGLKEEQKQSEPFVASQSPPYEDGSA
                     DH"
     exon            714..1109
                     /gene="Kcnk1"
                     /gene_synonym="TWIK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..2303
                     /gene="Kcnk1"
                     /gene_synonym="TWIK-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2281..2286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnk1"
                     /gene_synonym="TWIK-1"
                     /note="hexamer: AATAAA"
     polyA_site      2303
                     /gene="Kcnk1"
                     /gene_synonym="TWIK-1"
                     /note="major polyA site"
ORIGIN      
        1 gggggttacg gtggcgcgcg cgcgcgcgcg cacactctct ctctctctct ctctctctct
       61 ctctctctca gctcaggcct gctgactgca ctggggaagg gaagagggag ccaggcagcc
      121 tccgggtggc ctggccaggg tctggcgcca ccaaacctgc actttccggt ttcggaagcc
      181 aggtaggggg cgcgggcagc cagcagctcc cgccaagtgg gtgagagcgc tccgcccgac
      241 caactcccgc tacctgagcc ggccaccacg tcaccgccac atcatctggc ctcttgtatt
      301 tgcacgaaac caggaaaggg agcggcggcg ggaggcgcgg agcgcgggcg ccgggaagat
      361 gctgcagtcc ctggccggca gctcgtgcgt gcgcctggtg gagcggcacc gttcggcctg
      421 gtgcttcggc ttcctggtgc tgggctacct gctctacctg gtgttcggcg ccgtggtctt
      481 ctcgtccgtg gagctgcctt atgaggacct gctgcgccag gagctgcgca agctgaagcg
      541 gcgcttcctg gaggagcacg agtgcctgtc ggagccgcag ctggagcagt tcctgggccg
      601 cgtgctggag gccagcaatt atggagtgtc ggtgctcagc aacgcctcgg gaaattggaa
      661 ttgggacttc acctcggcgc tcttcttcgc cagcaccgtg ctctccacca caggctatgg
      721 ccacacggtg cccctgtcag atgggggcaa agccttctgc atcatctact ctgtcatcgg
      781 catcccgttc accctcctct tcctgacggc cgtggtccag cgtgtcaccg tgcatgtcac
      841 ccgcagacca gtcctctact tccacatacg ctggggcttc tccaagcagg tggtggccat
      901 tgtccatgcc gttctgctgg gatttgtcac cgtttcctgc ttcttcttca tcccagccgc
      961 cgtgttctct gtgctggagg atgactggaa cttcctcgag tctttttact tctgtttcat
     1021 ctccctgagc accatcggcc tgggggacta tgttccaggg gaaggctaca accagaagtt
     1081 ccgagagctg tacaagatcg gaatcacgtg ttacctgctc ctcggactca tcgccatgct
     1141 ggttgtcctg gagaccttct gtgaactcca cgagctgaag aagttcagga agatgttcta
     1201 cgtgaagaaa gacaaggacg aagacctggt tcacatcatg gagcacgacc agctgtcctt
     1261 ctcctccgtc actgagcagg tggctggcct gaaggaggag cagaagcaaa gtgagccttt
     1321 tgtggcctcc cagtccccac cctatgagga tggctctgca gaccactgag tgtgggcgga
     1381 caagaggcag agccttgact gcatccattt ttaaaagaaa gtcaaagcta agatgatgtt
     1441 attttaagaa atatctactg ttaacaacat tttaaaaaaa aaatggaact ttggattctt
     1501 ggggtgggtt ttaatccctg ggcaaatgag gtatgcacct gtaactcata ggagatgtga
     1561 tcacctggtg ccatacactg gggacgaata cttgaaacag tgtactgcag taggcggagg
     1621 cagattttat atgtaactgg ggactctggg tttgcattcc aatcattttg ccgacagcta
     1681 agcagcaaca tttatattta taaacgaaac aaaacaaaaa tctatagaga tgtattttat
     1741 aagtaggttt aagtgtcctg gcttgcatgt gcctatccaa aatgattatt tttgtagagt
     1801 ctaaattaac tctatttata atgaataggc caccatccac tgtgtacata aaacatataa
     1861 atatgtttat attctgtaca tatgtgtagg ctaacagata tccctgtact tcttaagcca
     1921 agataagaga tatttttttt ttcttcttga tttctcttta tactaaagaa cccagaattg
     1981 ctaccacaag ctgggaggcc taacaaactc aagagaaaat cggtacgata ttctgttcct
     2041 gtatacattt ctaccctctt gcaacggtgt aggaccagac aacaagtgag gaagagagtt
     2101 ggtgagaagg tgaatctatt tggactggaa ggcataccac cacttctacc cacttcacag
     2161 gtctggaggg cataccacca tttctaccca cctcacacta aagcacaatg gcagtccccc
     2221 tctcccctga acagattatg tcaggttaat ctgagaattc tacatttaga atctgaaatc
     2281 aataaaatca tggcagatgg caaaaa
//
