LOCUS       NM_008429               3884 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus potassium inwardly-rectifying channel, subfamily J,
            member 9 (Kcnj9), transcript variant 2, mRNA.
ACCESSION   NM_008429
VERSION     NM_008429.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3884)
  AUTHORS   Luo,H., Marron Fernandez de Velasco,E., Gansemer,B., Frederick,M.,
            Aguado,C., Lujan,R., Thayer,S.A. and Wickman,K.
  TITLE     Amyloid-beta oligomers trigger sex-dependent inhibition of GIRK
            channel activity in hippocampal neurons in mice
  JOURNAL   Sci Signal 17 (856), eado4132 (2024)
   PUBMED   39353038
REFERENCE   2  (bases 1 to 3884)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3884)
  AUTHORS   Taylor,E.L., Weaver,S.R., Lorang,I.M., Arnold,K.M., Bradley,E.W.,
            Marron Fernandez de Velasco,E., Wickman,K. and Westendorf,J.J.
  TITLE     GIRK3 deletion facilitates kappa opioid signaling in chondrocytes,
            delays vascularization and promotes bone lengthening in mice
  JOURNAL   Bone 159, 116391 (2022)
   PUBMED   35314385
REFERENCE   4  (bases 1 to 3884)
  AUTHORS   Rose,T.R., Marron Fernandez de Velasco,E., Vo,B.N., Tipps,M.E. and
            Wickman,K.
  TITLE     Impact of Acute and Persistent Excitation of Prelimbic Pyramidal
            Neurons on Motor Activity and Trace Fear Learning
  JOURNAL   J Neurosci 41 (5), 960-971 (2021)
   PUBMED   33402420
REFERENCE   5  (bases 1 to 3884)
  AUTHORS   Kozell,L.B., Denmark,D.L., Walter,N.A.R. and Buck,K.J.
  TITLE     Distinct Roles for Two Chromosome 1 Loci in Ethanol Withdrawal,
            Consumption, and Conditioned Place Preference
  JOURNAL   Front Genet 9, 323 (2018)
   PUBMED   30210527
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3884)
  AUTHORS   Lesage,F., Guillemare,E., Fink,M., Duprat,F., Heurteaux,C.,
            Fosset,M., Romey,G., Barhanin,J. and Lazdunski,M.
  TITLE     Molecular properties of neuronal G-protein-activated inwardly
            rectifying K+ channels
  JOURNAL   J Biol Chem 270 (48), 28660-28667 (1995)
   PUBMED   7499385
REFERENCE   7  (bases 1 to 3884)
  AUTHORS   Lesage,F., Fink,M., Barhanin,J., Lazdunski,M. and Mattei,M.G.
  TITLE     Assignment of human G-protein-coupled inward rectifier K+ channel
            homolog GIRK3 gene to chromosome 1q21-q23
  JOURNAL   Genomics 29 (3), 808-809 (1995)
   PUBMED   8575783
REFERENCE   8  (bases 1 to 3884)
  AUTHORS   Doupnik,C.A., Davidson,N. and Lester,H.A.
  TITLE     The inward rectifier potassium channel family
  JOURNAL   Curr Opin Neurobiol 5 (3), 268-277 (1995)
   PUBMED   7580148
  REMARK    Review article
REFERENCE   9  (bases 1 to 3884)
  AUTHORS   Kobayashi,T., Ikeda,K., Ichikawa,T., Abe,S., Togashi,S. and
            Kumanishi,T.
  TITLE     Molecular cloning of a mouse G-protein-activated K+ channel
            (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3)
            mRNAs in mouse brain
  JOURNAL   Biochem Biophys Res Commun 208 (3), 1166-1173 (1995)
   PUBMED   7702616
REFERENCE   10 (bases 1 to 3884)
  AUTHORS   Lesage,F., Duprat,F., Fink,M., Guillemare,E., Coppola,T.,
            Lazdunski,M. and Hugnot,J.P.
  TITLE     Cloning provides evidence for a family of inward rectifier and
            G-protein coupled K+ channels in the brain
  JOURNAL   FEBS Lett 353 (1), 37-42 (1994)
   PUBMED   7926018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY128973.1, AK033970.1 and BC038600.1.
            
            On Feb 14, 2018 this sequence version replaced NM_008429.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.46153.1,
                                           SRR1660817.231969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BY128973.1         2-60
            60-3329             AK033970.1         1-3270
            3330-3884           BC038600.1         1096-1650
FEATURES             Location/Qualifiers
     source          1..3884
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.66 cM"
     gene            1..3884
                     /gene="Kcnj9"
                     /gene_synonym="1700085N21Rik; Girk3; Kir3.3; mbGIRK3"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 9"
                     /db_xref="GeneID:16524"
                     /db_xref="MGI:MGI:108007"
     exon            1..188
                     /gene="Kcnj9"
                     /gene_synonym="1700085N21Rik; Girk3; Kir3.3; mbGIRK3"
                     /inference="alignment:Splign:2.1.0"
     exon            189..289
                     /gene="Kcnj9"
                     /gene_synonym="1700085N21Rik; Girk3; Kir3.3; mbGIRK3"
                     /inference="alignment:Splign:2.1.0"
     exon            290..1167
                     /gene="Kcnj9"
                     /gene_synonym="1700085N21Rik; Girk3; Kir3.3; mbGIRK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1499
                     /gene="Kcnj9"
                     /gene_synonym="1700085N21Rik; Girk3; Kir3.3; mbGIRK3"
                     /note="GIRK-3; inwardly rectifier K(+) channel Kir3.3;
                     potassium channel, inwardly rectifying subfamily J member
                     9; inward rectifier K(+) channel Kir3.3"
                     /codon_start=1
                     /product="G protein-activated inward rectifier potassium
                     channel 3"
                     /protein_id="NP_032455.2"
                     /db_xref="CCDS:CCDS35783.1"
                     /db_xref="GeneID:16524"
                     /db_xref="MGI:MGI:108007"
                     /translation="MAQENAAFSPGSEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRY
                     LTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVN
                     NLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVK
                     ISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEG
                     EFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVIL
                     EGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCS
                     ARELAEAAARLDAHLYWSIPSRLDEKVEEEGAGEGAGAGDGADKEHNGCLPPPESESK
                     V"
     exon            1168..3854
                     /gene="Kcnj9"
                     /gene_synonym="1700085N21Rik; Girk3; Kir3.3; mbGIRK3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacctgggaa gtggggatga cacagatacc aagtcctagt ctgagctgcc gttacattca
       61 ggagaaacag cagtgtcggc ggctcccaat ctcagaggga acctagggta ctgggggaga
      121 tggtgtcagg gacatggacg ccaaccccca agggtccctg ctgctggcta ctcttctctc
      181 caggctctgg gaccctgaaa gcctaggaac cgactctggc catccatctc tccgggaaga
      241 ttataaccca gagtgcttct caggggggaa gaatttgaag caaaaccaga ccccgcagga
      301 tccccgctgc ggccgccatg gcgcaggaga acgccgcttt ctctcccggg tcggaggagc
      361 cgccacgccg ccgcggtcgc cagcgctacg tggagaagga cggtcgctgt aacgtgcagc
      421 agggcaacgt ccgcgagacc taccgctacc tgaccgacct gttcaccacg ctggtggacc
      481 tgcagtggcg cctcagcctg ctcttcttcg tgctcgccta cgcgctcact tggctcttct
      541 tcggcgccat ctggtggctc atcgcctacg gccgcggcga cctggaacac ctggaggaca
      601 ccgcgtggac cccgtgcgtc aacaacctca acggcttcgt ggccgccttc ctcttctcca
      661 tcgagacgga gaccaccatc ggctatgggc accgggtcat caccgaccag tgtcccgagg
      721 gcatcgtgct gctgctgctg caggctatcc tgggctccat ggtgaacgct ttcatggtgg
      781 gctgcatgtt cgtcaagatc tcgcagccca acaagcgcgc cgccactctc gtcttctcct
      841 cgcacgccgt ggtgtctctg cgcgacgggc gcctctgtct catgtttcgc gtgggcgacc
      901 tgcgatcctc gcacatcgtc gaggcctcca tccgcgccaa gctcatccgc tcccgtcaga
      961 cgctcgaggg cgagttcatc cctttgcacc agaccgacct cagcgtgggc tttgacacgg
     1021 gggacgaccg cctctttctc gtctcacctc tcgtcatcag ccacgaaatc gatgccgcca
     1081 gccccttctg ggaggcatcg cgccgcgccc tcgagaggga cgacttcgag atcgtagtca
     1141 ttctcgaggg catggtggag gccacgggaa tgacgtgcca agctcgaagc tcgtacctgg
     1201 tggatgaagt gttgtggggc caccggttca catcggtgct caccctggag gatggtttct
     1261 atgaggtgga ctacgccagc ttccacgaaa cctttgaggt gcccacaccc tcgtgcagtg
     1321 ctcgggaact ggcagaagcc gcggcccgcc tcgatgccca tctctactgg tccatcccca
     1381 gcaggctgga tgagaaggtg gaggaagaag gggctgggga gggggcaggt gcgggagatg
     1441 gagctgacaa ggagcacaat ggctgcctgc cacccccaga gagtgagtcc aaggtgtgac
     1501 tggtttcctc ccaccccctg tggcagacca gggggccgga ctcaggtaca cagaagctgc
     1561 gagtggaggt ggaagaagag gaggcaggca gtgtcccgag gaacagctaa agttgggaga
     1621 ggcccgctga gtccaggatc gagtagggaa ggctgaggtc ctggtttgaa gagagagggt
     1681 tgcagggcgg ggtgagagaa cgtgtcagtc tgtctgtgtt tgaccttcac atcggttcat
     1741 gggtggatgg atggacagaa ggatgggctc atgggggttg atcgggaagg tggggcagat
     1801 agagacagcc aatggatagc tcaggtggta agtggcttga cagtcgatga ttgtcacctg
     1861 cagcacacct ttgtgagaaa tccatgggca tccttttctt ccagatatag gtagcctcaa
     1921 accagggagc gtggcttagg gagcaggctg tcaggtggac taccatcccc actcacctcc
     1981 cctcaactgg cctccctatg tgtgacacgc ctgcctaact agagaagaga gcactgggta
     2041 gaggtgggca caggtgtggg tgccctcccc agcatcactg tcccatggcg agaggtcaga
     2101 aaggcaaaca agcaatgggg gtagatgctg agcagggagg ggccctgaag caggacctgg
     2161 ggacagccaa ggacaactat tttgtgagag aggaatgaaa ccttgcaggt cctgccacag
     2221 aagcaagaag cagaggaaag gccatggaga gacttaataa agggttttac aagggtacct
     2281 ggatcccagg gggaagtagt ttatccttgg ggcacagtgg cagggctcat tcagaacggt
     2341 gagtaagtgt caggtgtgat attcaaagac ctggttccta acaccagagc acagcgaagg
     2401 tggaggtcag aaataactcc cagccactga aggaagtatg gcttcagtct ggagagctca
     2461 gaaaagactc gaccctagga gcccacacaa gcggttatag ccacaagtga gagggcatta
     2521 gcaacaggaa gctaaggatt gagtaaggca atggggaatg gtgggagcca gcagttacaa
     2581 cgctttactc acctggatgg gcttgttaaa acacagatta ccagccccac tccctgcatt
     2641 ctgactcagt aggtccggga cggaaaccaa aaaaaaaatc tgcacgtcta actagttccc
     2701 agacctaaca ggttcccaga tcacggtgac actgtctgtc tggggactgc acttgggtga
     2761 agcatctaag cggaagagaa gctggaggaa ctgaaaagcg ccccaggttc ctcgaggaac
     2821 agagaaacaa gaagggaaat gttggggaga ggggacccag gtccagactc gaagggctta
     2881 actctgggtc caagaaacgt cattggtaac tggccagtgg cacccgagag gccaacagag
     2941 ataggagaag gccatttggg gacccccaag gaggcagtgg ggggtctgta gctgaatcgg
     3001 ctttaccaca aaagaccaac tctcttaaga gactcacaag gcaagactga ctaggggaga
     3061 aaatggagcc tgtacctgca ggtgtctgct gtctgccacc tgtcctccca ggatagggca
     3121 ccctggagac attccacctc cactgcatcc ttgtcttgcc ccagtcatct tgggatggtt
     3181 gaggggacag caacagcatg gcaatggacc tgaggctggc ccccctggag ctaagtgtag
     3241 cccaagtgag cacgtaacct gataggactg gctcagactc tggccctggc tatacccatt
     3301 cctgccctcg aataaaagtc tgttgctctg tcccaggcta agaagccagc atccaatggg
     3361 gcatcgggcc tccctcccag tgcccagctc agagtgggtc cacgcagaga ggactcaagc
     3421 tgcctgttgc ctctcccctt ccgtctagca atggccacag gtttcgggac cagctgggtc
     3481 actctcaaag atgaggccca catgaacctg ctgggatccc acgaacacat attggacctg
     3541 agcacaggga gtgagcaggg tttgaattca gagaaaatcg aggtgtctag acaagagggg
     3601 tggggtgctt ggtatccgca cacgaagcaa tggaatggag acattgaagc tgttcctgga
     3661 ggtcactcag ggcaccgctg tccagggcac agccaggaga cctgtgttct agcaccaatg
     3721 ctgattgtca ctaattacct ctacgactct cagcaagacc tattacttct ctgggcctca
     3781 gcttccttat ctgttaaaaa aaaaatgata tgttggcaaa ctcaataatg ctcaataaac
     3841 tttcaactac tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
