LOCUS       NM_008428               2564 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus potassium inwardly-rectifying channel, subfamily J,
            member 8 (Kcnj8), transcript variant 1, mRNA.
ACCESSION   NM_008428
VERSION     NM_008428.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2564)
  AUTHORS   Samper,N., Hardardottir,L., Depierreux,D.M., Song,S.C.,
            Nakazawa,A., Gando,I., Nakamura,T.Y., Sharkey,A.M., Nowosad,C.R.,
            Feske,S., Colucci,F. and Coetzee,W.A.
  TITLE     Kir6.1, a component of an ATP-sensitive potassium channel,
            regulates natural killer cell development
  JOURNAL   Front Immunol 15, 1490250 (2024)
   PUBMED   39687626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2564)
  AUTHORS   Samper,N., Harethardottir,L., Depierreux,D.M., Song,S.C.,
            Nakazawa,A., Gando,I., Nakamura,T.Y., Sharkey,A.M., Nowosad,C.R.,
            Feske,S., Colucci,F. and Coetzee,W.A.
  TITLE     Kir6.1, a component of an ATP-sensitive potassium channel,
            regulates natural killer cell development
  JOURNAL   bioRxiv (2024)
   PUBMED   39211194
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2564)
  AUTHORS   Russell,N.X., Burra,K., Shah,R.M., Bottasso-Arias,N.,
            Mohanakrishnan,M., Snowball,J., Ediga,H.H., Madala,S.K. and
            Sinner,D.
  TITLE     Wnt signaling regulates ion channel expression to promote smooth
            muscle and cartilage formation in developing mouse trachea
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (6), L788-L802 (2023)
   PUBMED   37873566
REFERENCE   4  (bases 1 to 2564)
  AUTHORS   Davis,M.J., Castorena-Gonzalez,J.A., Kim,H.J., Li,M., Remedi,M. and
            Nichols,C.G.
  TITLE     Lymphatic contractile dysfunction in mouse models of Cantu Syndrome
            with KATP channel gain-of-function
  JOURNAL   Function (Oxf) 4 (3), zqad017 (2023)
   PUBMED   37214333
  REMARK    GeneRIF: Lymphatic contractile dysfunction in mouse models of Cantu
            Syndrome with KATP channel gain-of-function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2564)
  AUTHORS   Nichols,C.G., Singh,G.K. and Grange,D.K.
  TITLE     KATP channels and cardiovascular disease: suddenly a syndrome
  JOURNAL   Circ Res 112 (7), 1059-1072 (2013)
   PUBMED   23538276
  REMARK    Review article
REFERENCE   6  (bases 1 to 2564)
  AUTHORS   Hibino,H., Inanobe,A., Furutani,K., Murakami,S., Findlay,I. and
            Kurachi,Y.
  TITLE     Inwardly rectifying potassium channels: their structure, function,
            and physiological roles
  JOURNAL   Physiol Rev 90 (1), 291-366 (2010)
   PUBMED   20086079
  REMARK    Review article
REFERENCE   7  (bases 1 to 2564)
  AUTHORS   Miki,T., Suzuki,M., Shibasaki,T., Uemura,H., Sato,T., Yamaguchi,K.,
            Koseki,H., Iwanaga,T., Nakaya,H. and Seino,S.
  TITLE     Mouse model of Prinzmetal angina by disruption of the inward
            rectifier Kir6.1
  JOURNAL   Nat Med 8 (5), 466-472 (2002)
   PUBMED   11984590
  REMARK    GeneRIF: gene disruption causes prinzmetal angina in knockout mice
REFERENCE   8  (bases 1 to 2564)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 2564)
  AUTHORS   Isomoto,S., Horio,Y., Matsumoto,S., Kondo,C., Yamada,M.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Kurachi,Y.
  TITLE     Sur2 and Kcnj8 genes are tightly linked on the distal region of
            mouse chromosome 6
  JOURNAL   Mamm Genome 8 (10), 790-791 (1997)
   PUBMED   9321483
REFERENCE   10 (bases 1 to 2564)
  AUTHORS   Yamada,M., Isomoto,S., Matsumoto,S., Kondo,C., Shindo,T., Horio,Y.
            and Kurachi,Y.
  TITLE     Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive
            but ATP-insensitive K+ channel
  JOURNAL   J Physiol 499 (Pt 3) (Pt 3), 715-720 (1997)
   PUBMED   9130167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK389528.1, AC121611.3, AA672233.1 and CJ238449.1.
            
            On Aug 24, 2016 this sequence version replaced NM_008428.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1104043.1,
                                           SRR7345562.1103978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               CK389528.1         1-508
            509-732             AC121611.3         14894-15117         c
            733-759             AA672233.1         1-27
            760-797             AC121611.3         14829-14866         c
            798-1057            AA672233.1         64-323
            1058-1058           AC121611.3         11068-11068         c
            1059-1174           AA672233.1         325-440
            1175-1879           AC121611.3         10247-10951         c
            1880-2564           CJ238449.1         3-687
FEATURES             Location/Qualifiers
     source          1..2564
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 74.31 cM"
     gene            1..2564
                     /gene="Kcnj8"
                     /gene_synonym="gnite; Kir6.1; slmbr; sltr; uKATP-1"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 8"
                     /db_xref="GeneID:16523"
                     /db_xref="MGI:MGI:1100508"
     exon            1..431
                     /gene="Kcnj8"
                     /gene_synonym="gnite; Kir6.1; slmbr; sltr; uKATP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..879
                     /gene="Kcnj8"
                     /gene_synonym="gnite; Kir6.1; slmbr; sltr; uKATP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..1780
                     /gene="Kcnj8"
                     /gene_synonym="gnite; Kir6.1; slmbr; sltr; uKATP-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-sensitive inward rectifier potassium channel 8; inward
                     rectifier K(+) channel Kir6.1; inwardly rectifier K(+)
                     channel Kir6.1"
                     /codon_start=1
                     /product="ATP-sensitive inward rectifier potassium channel
                     8 isoform 1"
                     /protein_id="NP_032454.1"
                     /db_xref="CCDS:CCDS20685.1"
                     /db_xref="GeneID:16523"
                     /db_xref="MGI:MGI:1100508"
                     /translation="MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACN
                     LAHKNIREQGRFLQDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIY
                     AYMEKGTMEKSGLESAVCVTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLI
                     LQNIVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKS
                     MIISASVRIQVVKKTTTPEGEVVPIHQQDIPVDNPIESNNIFLVAPLIICHVIDKRSP
                     LYDISATDLANQDLEVIVILEGVVETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGV
                     YSVDYSKFGNTVRVAAPRCSARELDEKPSILIQTLQKSELSHQNSLRKRNSMRRNNSM
                     RRNNSIRRNNSSLMVPKVQFMTPEGNQCPSES"
     exon            880..2548
                     /gene="Kcnj8"
                     /gene_synonym="gnite; Kir6.1; slmbr; sltr; uKATP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1998..2003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj8"
                     /gene_synonym="gnite; Kir6.1; slmbr; sltr; uKATP-1"
                     /note="hexamer: AATAAA"
     polyA_site      2017
                     /gene="Kcnj8"
                     /gene_synonym="gnite; Kir6.1; slmbr; sltr; uKATP-1"
                     /note="major polyA site"
     regulatory      2529..2534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj8"
                     /gene_synonym="gnite; Kir6.1; slmbr; sltr; uKATP-1"
                     /note="hexamer: AATAAA"
     polyA_site      2548
                     /gene="Kcnj8"
                     /gene_synonym="gnite; Kir6.1; slmbr; sltr; uKATP-1"
ORIGIN      
        1 tgggaaccga gctggctcgg ctggtgcctc ctcccccggt ggtccctccc ttctggccgg
       61 ctccctgcct ccccggctcc cccgactggc ctccgcctcc actttccccg gctcgctcgg
      121 aggtctggcc ccagctaggc ggctgaggag ctggcggagc atggccacta gcacctctat
      181 ccccagctcc taccccgccc tccccgtggc ccggcagcag gaggggggaa gccaaaccca
      241 accctcatct tccagccctc ctccccgcgt gcactatgga tcgcaccttc tagagtctta
      301 actcagttct ggaggaccaa catcccccgg atctgcactt cgggaggtct ctgctcccgg
      361 gatgcgagag cctgggacca gcccgccctg tgcggagctc aagccgcagc cgggagcgca
      421 aacccgagtc ttctaggagg acgcgtgtgg aggaaaggag ccacaggttc aggcaggtgc
      481 ataggcgggc tatggtgaaa ggaagatgtt ggccaggaag agcatcatcc cggaggagta
      541 tgtgctggcg cgcatcgcag cggagaacct gcgcaaaccg cgcatccgcg accgtctccc
      601 caaagcccgc ttcatcgcca agagcggagc ctgcaacctg gcacacaaga acatccgaga
      661 gcaaggtcgc ttcctgcagg acatcttcac caccttggta gacctgaagt ggcgtcacac
      721 gctggtcatc ttcaccatgt ccttcctctg cagctggctg ctcttcgcta tcatgtggtg
      781 gctggtggcc ttcgcccacg gggacatcta tgcttacatg gagaaaggca ccatggagaa
      841 gagtggcctg gagtccgctg tctgtgtgac caatgtcagg tcattcacgt ctgcgtttct
      901 cttctccatt gaggttcaag tgaccattgg gtttggaggg agaatgatga ctgaggaatg
      961 ccctctggcc atcacggttt tgattctgca gaacatcgtg ggtctgatca tcaacgcagt
     1021 catgttgggc tgcatcttca tgaagacggc gcaggcccac agaagggcag agacgctgat
     1081 tttcagccgc catgctgtga ttgccgtccg caatggcaag ctgtgcttca tgttccgggt
     1141 gggtgacctg aggaagagca tgatcattag cgcctcggtg cgcatccagg tggtcaagaa
     1201 aaccacgacg ccagaagggg aggtggtgcc tattcatcag caggacattc ctgttgataa
     1261 tcccatcgag agcaataata tcttcctagt ggccccattg atcatctgcc acgtgattga
     1321 caagcgtagc cccctgtatg atatctcagc aactgacctt gccaatcaag acctggaggt
     1381 catagtgatt ctcgagggcg tggtagaaac cacaggcatc accacacaag cacggacctc
     1441 ctacattgcc gaggagatcc agtggggaca ccgcttcgtg tcaattgtga ctgaggagga
     1501 gggcgtgtac tctgtggact attccaaatt tggtaacacg gtgagagtgg ctgcgccaag
     1561 atgcagtgcc cgggagctgg atgagaagcc ttccatcctg attcagaccc tccaaaagag
     1621 cgaactgtcg caccagaatt ctctgcggaa gcgcaactcc atgaggagaa acaactccat
     1681 gaggagaaac aactccatca ggaggaataa ctcttccctc atggtgccca aggtgcagtt
     1741 catgactcca gaaggaaacc agtgtccatc agaatcatga gggcaggatg accggagaca
     1801 gttacttgtt gagtcctgat gactgatagc cctgaacagt cactgtgtcc tgatgactga
     1861 gagacaatcc ggagacagtt cattgagttc cgatgatcaa aatattgcac tcatcaccag
     1921 ttcagggctg gagcacagta ttcctatcct aatgcactga gaaatattaa tatttgagac
     1981 attaaacttc ctgtattaat aaacaataac acacaaacct gagctcttta ttctcctctc
     2041 atcttaaaat tctgttttct tcccagcagt ctctgtagtc aggtcagttg gcctgtgttt
     2101 ttgagcttct gtcacttagc agagatgaga tcttctaccc aagcccagtt tcgtcattct
     2161 taggtcctgc accctcaagt aagggcagag tagagagacg tcctgggtta acacggtgtg
     2221 tgatgtgggg ttaacccagt gtgtgatatg ggggtaacac gttgtgtgat gcggtaaaac
     2281 atggaagctg ggcagctggg tagcctttta ttcagagtct ggggcttgaa ttcatttctt
     2341 acatgagcca ttgaaccaca cgggtcatca tgaatatgtt caaatctaac cttcaaagac
     2401 tcaggttgct aaccaagcaa atagcacctg ctgggttaat tattcctaaa aaaaaaaaaa
     2461 aaaaatgtct gacttggaac tccagactca aagatcaaac aggtacctga agccctgctt
     2521 gcctgtttaa taaaatactc aaaacctaaa aaaaaaaaaa aaaa
//
