LOCUS       NM_010606               3086 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus potassium inwardly-rectifying channel, subfamily J,
            member 6 (Kcnj6), transcript variant Girk2A-1, mRNA.
ACCESSION   NM_010606 XM_358884 XM_489694
VERSION     NM_010606.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3086)
  AUTHORS   Luo,H., Marron Fernandez de Velasco,E., Gansemer,B., Frederick,M.,
            Aguado,C., Lujan,R., Thayer,S.A. and Wickman,K.
  TITLE     Amyloid-beta oligomers trigger sex-dependent inhibition of GIRK
            channel activity in hippocampal neurons in mice
  JOURNAL   Sci Signal 17 (856), eado4132 (2024)
   PUBMED   39353038
REFERENCE   2  (bases 1 to 3086)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3086)
  AUTHORS   Lana-Elola,E., Aoidi,R., Llorian,M., Gibbins,D.,
            Buechsenschuetz,C., Bussi,C., Flynn,H., Gilmore,T.,
            Watson-Scales,S., Haugsten Hansen,M., Hayward,D., Song,O.R.,
            Brault,V., Herault,Y., Deau,E., Meijer,L., Snijders,A.P.,
            Gutierrez,M.G., Fisher,E.M.C. and Tybulewicz,V.L.J.
  TITLE     Increased dosage of DYRK1A leads to congenital heart defects in a
            mouse model of Down syndrome
  JOURNAL   Sci Transl Med 16 (731), eadd6883 (2024)
   PUBMED   38266108
REFERENCE   4  (bases 1 to 3086)
  AUTHORS   Oh,Y., Yoo,E.S., Ju,S.H., Kim,E., Lee,S., Kim,S., Wickman,K. and
            Sohn,J.W.
  TITLE     GIRK2 potassium channels expressed by the AgRP neurons decrease
            adiposity and body weight in mice
  JOURNAL   PLoS Biol 21 (8), e3002252 (2023)
   PUBMED   37594983
  REMARK    GeneRIF: GIRK2 potassium channels expressed by the AgRP neurons
            decrease adiposity and body weight in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3086)
  AUTHORS   Van Heesbeen,H.J., Von Oerthel,L., De Vries,P.M., Wagemans,C.M.R.J.
            and Smidt,M.P.
  TITLE     Neuronal Dot1l Activity Acts as a Mitochondrial Gene-Repressor
            Associated with Human Brain Aging via H3K79 Hypermethylation
  JOURNAL   Int J Mol Sci 24 (2), 1387 (2023)
   PUBMED   36674903
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3086)
  AUTHORS   Takeda,H., Yoshiki,A., Nishikawa,S., Nishikawa,S., Kunisada,T.,
            Sakakura,T., Amanuma,H. and Kusakabe,M.
  TITLE     Expression of c-kit, a proto-oncogene of the murine W locus, in
            cerebella of normal and neurological mutant mice:
            immunohistochemical and in situ hybridization analysis
  JOURNAL   Differentiation 51 (2), 121-127 (1992)
   PUBMED   1282111
REFERENCE   7  (bases 1 to 3086)
  AUTHORS   Crepel,F. and Mariani,J.
  TITLE     Multiple innervation of Purkinje cells by climbing fibers in the
            cerebellum of the Weaver Mutant Mouse
  JOURNAL   J Neurobiol 7 (6), 579-582 (1976)
   PUBMED   1003203
REFERENCE   8  (bases 1 to 3086)
  AUTHORS   Mallet,J., Huchet,M., Pougeois,R. and Changeux,J.P.
  TITLE     Anatomical, physiological and biochemical studies on the cerebellum
            from mutant mice. III. Protein differences associated with the
            weaver, staggerer and nervous mutations
  JOURNAL   Brain Res 103 (2), 291-312 (1976)
   PUBMED   1252920
REFERENCE   9  (bases 1 to 3086)
  AUTHORS   Sotelo,C.
  TITLE     Anatomical, physiological and biochemical studies of the cerebellum
            from mutant mice. II. Morphological study of cerebellar cortical
            neurons and circuits in the weaver mouse
  JOURNAL   Brain Res 94 (1), 19-44 (1975)
   PUBMED   1148865
REFERENCE   10 (bases 1 to 3086)
  AUTHORS   Murad,S. and Kishimoto,Y.
  TITLE     Alpha hydroxylation of lignoceric acid to cerebronic acid during
            brain development. Diminished hydroxylase activity in
            myelin-deficient mouse mutants
  JOURNAL   J Biol Chem 250 (15), 5841-5846 (1975)
   PUBMED   1150661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB591362.2, AK044218.1, AB029502.1 and AC165271.2.
            
            On Jul 21, 2005 this sequence version replaced NM_010606.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51124.1, BC120794.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               BB591362.2         7-565
            560-1480            AK044218.1         675-1595
            1481-2514           AB029502.1         1243-2276
            2515-3086           AC165271.2         32540-33111
FEATURES             Location/Qualifiers
     source          1..3086
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 55.44 cM"
     gene            1..3086
                     /gene="Kcnj6"
                     /gene_synonym="BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
                     wv"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 6"
                     /db_xref="GeneID:16522"
                     /db_xref="MGI:MGI:104781"
     exon            1..510
                     /gene="Kcnj6"
                     /gene_synonym="BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
                     wv"
                     /inference="alignment:Splign:2.1.0"
     exon            511..559
                     /gene="Kcnj6"
                     /gene_synonym="BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
                     wv"
                     /inference="alignment:Splign:2.1.0"
     CDS             529..1806
                     /gene="Kcnj6"
                     /gene_synonym="BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
                     wv"
                     /note="isoform Girk2A-1 is encoded by transcript variant
                     Girk2A-1; potassium inwardly-rectifying channel J6; g
                     protein-activated inward rectifier potassium channel 2;
                     GIRK-2; G-protein-coupled inward rectifier K+ channel 2-B;
                     inward rectifier K(+) channel Kir3.2; potassium channel,
                     inwardly rectifying subfamily J member 6;
                     G-protein-coupled inward rectifier K+ channel 2-1;
                     G-protein-coupled inward rectifier K+ channel 2-A;
                     G-protein-coupled inward rectifier K+ channel 2-C"
                     /codon_start=1
                     /product="G protein-activated inward rectifier potassium
                     channel 2 isoform Girk2A-1"
                     /protein_id="NP_034736.2"
                     /db_xref="CCDS:CCDS37409.1"
                     /db_xref="GeneID:16522"
                     /db_xref="MGI:MGI:104781"
                     /translation="MTMAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPR
                     HISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVY
                     TVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYR
                     VITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDG
                     KLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLV
                     SPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILW
                     GYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELANRAELPLSWSVSSKLN
                     QHAELETEEEEKNPEELTERNGDVANLENESKV"
     exon            560..1480
                     /gene="Kcnj6"
                     /gene_synonym="BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
                     wv"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..3086
                     /gene="Kcnj6"
                     /gene_synonym="BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
                     wv"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2884..2889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj6"
                     /gene_synonym="BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
                     wv"
                     /note="hexamer: AATATA"
     polyA_site      2902
                     /gene="Kcnj6"
                     /gene_synonym="BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
                     wv"
                     /note="major polyA site"
ORIGIN      
        1 tggaaccgag tagcattcgt tgaatctgcg gctttcatga cgtctccctg caaggtctat
       61 cactttgctc ctaaacgagg atttattccc tctgccactc aaggctgtcc cccagtttcc
      121 tcgcaaccgg gcttcctcct cagtccctgc ccacacgcgc actcctctgc cccgcggtgg
      181 ccccagcgcc cagccctcca gccagaggga gccagtcacc agacggcagc acctggctgg
      241 agaggttggg cgggccgagg gtggggatcc gcgggaaccg gcgagtcgga gctggagcag
      301 gagctggacc caaccgctag cagcagaatg gagtctcctg aaagcctgcc ggggctgatg
      361 tgaaattgga ccatctgctt ccagttggtc tgtttcctcc ttttcttgta ttttcttccc
      421 tcgccattca ccgtggagtg aattattgaa tcttgctccg ttccgagaga ggcgatcagg
      481 atggagtgaa cctaccctgt ccactacaag gaaaagcaca aagaagaaat gacaatggcc
      541 aagttaactg aatccatgac taacgtcttg gaaggcgatt ccatggacca ggatgtggaa
      601 agcccagtgg ccattcacca gccaaagttg cctaagcagg ccagggacga cctgccgaga
      661 cacatcagcc gagacaggac caaaaggaaa atccagaggt acgtgaggaa ggatgggaag
      721 tgcaacgttc accacggcaa tgtgcgggag acgtaccgat acctgacgga catcttcacc
      781 accctggtgg acctgaagtg gagattcaac ctgttgatct ttgtcatggt ctacacagtg
      841 acgtggcttt tctttgggat gatctggtgg ctgattgcgt acatccgggg agatatggac
      901 cacatagagg acccctcgtg gactccttgt gtcaccaacc tcaacgggtt tgtctctgct
      961 tttttattct ccatagagac agaaaccacc atcggttatg gctaccgggt catcacggac
     1021 aagtgccctg aggggattat tctcctctta atccagtccg tgttggggtc cattgtcaac
     1081 gccttcatgg taggatgtat gtttgtgaaa atatcccaac ccaagaagag ggcagagacc
     1141 ctggtctttt ccacccacgc ggtgatctcc atgcgggatg ggaaactgtg cttgatgttc
     1201 cgggtggggg acttgaggaa ttctcacatt gtggaggcat ccatcagagc caagttgatc
     1261 aagtccaaac agacttcaga gggggagttt attcccctca accagactga tatcaacgtg
     1321 gggtactaca caggggacga ccggctcttt ctggtgtcac cattgattat tagccatgaa
     1381 attaaccaac agagtccctt ctgggagatc tccaaagcgc agctgcctaa agaggaactg
     1441 gagattgtgg tcatcctgga gggaatggtg gaagccacag gaatgacgtg ccaagcccga
     1501 agctcctaca tcaccagtga gatcttgtgg ggttaccggt tcacacctgt cctaacgctg
     1561 gaagacgggt tctacgaagt tgactacaac agcttccatg agacctatga gaccagcacc
     1621 ccgtccctta gtgccaaaga gctagcggag ctggctaacc gggcagagct gcctctgagt
     1681 tggtctgtgt ccagcaaact gaaccaacat gcagaattgg agacagaaga ggaagagaag
     1741 aacccggaag aactgacgga gaggaatggt gacgtggcaa acctagagaa tgaatccaaa
     1801 gtataggccc agctgggtca gcctccccca tcagacatga cccctcctta taggctcagc
     1861 tgggtcagcc tcccccctca gatgacccct ccttgtagac tcagctgggt cagcctcccc
     1921 tctcagacat gacttctcct tgtctcccat ttccttcttt tctgtctctc ttactttgat
     1981 cttgattcat ttgtatttaa ttttggcatt tccagaacac aaaccttcaa ggtgtaaaat
     2041 acctacctgc ccctctcaga tgttcagatg ggacaagcag acagatattt ggtgaaggta
     2101 caatgtacct tcattgtgcc caagcctagt ctccactcac agaagagact acttaatcct
     2161 ctttactatc caatacgaat cattcaaaag agctgtcaga gttttaccca gtgtcacaaa
     2221 gaacatgacc tgtttaccat gccctcgggt catgcagaga agccccttgg ttttacagag
     2281 cccagtccat cttacctagc acagggcagg tacttgacca cacagacact gacagtacag
     2341 gacccagatg agccaaggat agaccactgt acatagatct gccctatgga attattttct
     2401 ctcggcgagt agagacaaac ccagcatgca caaaagtact atggagcaga aatcctaata
     2461 attaatgtac atagacatat cattcatgta gctttagatt tataacttta gaaataagaa
     2521 gaaaaaagac tcccaatgta cagtaggcgt ttctgttttg atatctgagt cttctaatta
     2581 tttttgatcc ccttgactgc tggccctcta aatgcatggc ctttgttcca ggtcccccag
     2641 actgacagtt tttagggcac ctctctgttc ccttgtcatc cttaagttga atctaataag
     2701 ccataggtct ggggacagtc tggaggtgta aaaagatgtc caccatccaa aatgctgata
     2761 aaccatgaca catttacgaa acgggtgtca ttgtttatag ataatgtggg actctctgag
     2821 cacccttgag aggctctacc aggaacagga ctctagcaca gccccagatg acatttccag
     2881 tgaaatatag cagtttaaga aacctttctg tgaaagcatt gattgctttt ttatgtagtc
     2941 atgagagact gcagaatgtc catggagctg tctagtcgac agaagacttg tgggaaaggc
     3001 catggcattc aggaaggccc tgtgggtgaa atgacaggac tacattgcca gcttcctgct
     3061 ctctcacttc atctagcaag tctgcc
//
