LOCUS       NM_001411836            4792 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus potassium inwardly-rectifying channel, subfamily J,
            member 5 (Kcnj5), transcript variant 6, mRNA.
ACCESSION   NM_001411836 XM_017313153
VERSION     NM_001411836.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4792)
  AUTHORS   Delgado-Betancourt,V., Chinda,K., Mesirca,P., Barrere,C.,
            Covinhes,A., Gallot,L., Vincent,A., Bidaud,I., Kumphune,S.,
            Nargeot,J., Piot,C., Wickman,K., Mangoni,M.E. and
            Barrere-Lemaire,S.
  TITLE     Heart rate reduction after genetic ablation of L-type Cav1.3
            channels induces cardioprotection against ischemia-reperfusion
            injury
  JOURNAL   Front Cardiovasc Med 10, 1134503 (2023)
   PUBMED   37593151
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4792)
  AUTHORS   Bidaud,I., D'Souza,A., Forte,G., Torre,E., Greuet,D., Thirard,S.,
            Anderson,C., Chung You Chong,A., Torrente,A.G., Roussel,J.,
            Wickman,K., Boyett,M.R., Mangoni,M.E. and Mesirca,P.
  TITLE     Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels
            Prevents Training-Induced Sinus Bradycardia
  JOURNAL   Front Physiol 11, 519382 (2021)
   PUBMED   33551824
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4792)
  AUTHORS   Anderson,A., Masuho,I., Marron Fernandez de Velasco,E., Nakano,A.,
            Birnbaumer,L., Martemyanov,K.A. and Wickman,K.
  TITLE     GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6
            in mouse sinoatrial nodal cells
  JOURNAL   Proc Natl Acad Sci U S A 117 (25), 14522-14531 (2020)
   PUBMED   32513692
REFERENCE   4  (bases 1 to 4792)
  AUTHORS   Lee,S.W., Anderson,A., Guzman,P.A., Nakano,A., Tolkacheva,E.G. and
            Wickman,K.
  TITLE     Atrial GIRK Channels Mediate the Effects of Vagus Nerve Stimulation
            on Heart Rate Dynamics and Arrhythmogenesis
  JOURNAL   Front Physiol 9, 943 (2018)
   PUBMED   30072916
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4792)
  AUTHORS   Kulkarni,K., Xie,X., Marron Fernandez de Velasco,E., Anderson,A.,
            Martemyanov,K.A., Wickman,K. and Tolkacheva,E.G.
  TITLE     The influences of the M2R-GIRK4-RGS6 dependent parasympathetic
            pathway on electrophysiological properties of the mouse heart
  JOURNAL   PLoS One 13 (4), e0193798 (2018)
   PUBMED   29668674
  REMARK    Erratum:[PLoS One. 2018 Jul 6;13(7):e0200553. doi:
            10.1371/journal.pone.0200553. PMID: 29979785]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4792)
  AUTHORS   Pecker,I., Avraham,K.B., Gilbert,D.J., Savitsky,K., Rotman,G.,
            Harnik,R., Fukao,T., Schrock,E., Hirotsune,S., Tagle,D.A.,
            Collins,F.S., Wynshaw-Boris,A., Ried,T., Copeland,N.G.,
            Jenkins,N.A., Shiloh,Y. and Ziv,Y.
  TITLE     Identification and chromosomal localization of Atm, the mouse
            homolog of the ataxia-telangiectasia gene
  JOURNAL   Genomics 35 (1), 39-45 (1996)
   PUBMED   8661102
REFERENCE   7  (bases 1 to 4792)
  AUTHORS   Kofuji,P., Hofer,M., Millen,K.J., Millonig,J.H., Davidson,N.,
            Lester,H.A. and Hatten,M.E.
  TITLE     Functional analysis of the weaver mutant GIRK2 K+ channel and
            rescue of weaver granule cells
  JOURNAL   Neuron 16 (5), 941-952 (1996)
   PUBMED   8630252
REFERENCE   8  (bases 1 to 4792)
  AUTHORS   Lesage,F., Guillemare,E., Fink,M., Duprat,F., Heurteaux,C.,
            Fosset,M., Romey,G., Barhanin,J. and Lazdunski,M.
  TITLE     Molecular properties of neuronal G-protein-activated inwardly
            rectifying K+ channels
  JOURNAL   J Biol Chem 270 (48), 28660-28667 (1995)
   PUBMED   7499385
REFERENCE   9  (bases 1 to 4792)
  AUTHORS   Szpirer,C., Molne,M., Antonacci,R., Jenkins,N.A., Finelli,P.,
            Szpirer,J., Riviere,M., Rocchi,M., Gilbert,D.J., Copeland,N.G. et
            al.
  TITLE     The genes encoding the glutamate receptor subunits KA1 and KA2
            (GRIK4 and GRIK5) are located on separate chromosomes in human,
            mouse, and rat
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 11849-11853 (1994)
   PUBMED   7527545
REFERENCE   10 (bases 1 to 4792)
  AUTHORS   Lesage,F., Duprat,F., Fink,M., Guillemare,E., Coppola,T.,
            Lazdunski,M. and Hugnot,J.P.
  TITLE     Cloning provides evidence for a family of inward rectifier and
            G-protein coupled K+ channels in the brain
  JOURNAL   FEBS Lett 353 (1), 37-42 (1994)
   PUBMED   7926018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132114.4.
            
            On Sep 7, 2022 this sequence version replaced XM_017313153.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219383.4122.1,
                                           SRR17784650.996200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AC132114.4         115823-116063       c
            242-544             AC132114.4         113941-114243       c
            545-656             AC132114.4         96896-97007         c
            657-1595            AC132114.4         93800-94738         c
            1596-4792           AC132114.4         86425-89621         c
FEATURES             Location/Qualifiers
     source          1..4792
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 17.65 cM"
     gene            1..4792
                     /gene="Kcnj5"
                     /gene_synonym="CIR; GIRK4; KATP-1; Kir3.4"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 5"
                     /db_xref="GeneID:16521"
                     /db_xref="MGI:MGI:104755"
     exon            1..241
                     /gene="Kcnj5"
                     /gene_synonym="CIR; GIRK4; KATP-1; Kir3.4"
                     /inference="alignment:Splign:2.1.0"
     exon            242..544
                     /gene="Kcnj5"
                     /gene_synonym="CIR; GIRK4; KATP-1; Kir3.4"
                     /inference="alignment:Splign:2.1.0"
     exon            545..656
                     /gene="Kcnj5"
                     /gene_synonym="CIR; GIRK4; KATP-1; Kir3.4"
                     /inference="alignment:Splign:2.1.0"
     exon            657..1595
                     /gene="Kcnj5"
                     /gene_synonym="CIR; GIRK4; KATP-1; Kir3.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..4792
                     /gene="Kcnj5"
                     /gene_synonym="CIR; GIRK4; KATP-1; Kir3.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4713..4718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj5"
                     /gene_synonym="CIR; GIRK4; KATP-1; Kir3.4"
                     /note="hexamer: ACTAAA"
     polyA_site      4737
                     /gene="Kcnj5"
                     /gene_synonym="CIR; GIRK4; KATP-1; Kir3.4"
                     /note="major polyA site"
     regulatory      4761..4766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj5"
                     /gene_synonym="CIR; GIRK4; KATP-1; Kir3.4"
                     /note="hexamer: AATAAA"
     polyA_site      4792
                     /gene="Kcnj5"
                     /gene_synonym="CIR; GIRK4; KATP-1; Kir3.4"
                     /note="major polyA site"
ORIGIN      
        1 agagagcctc ccgctgttct ctctagatag aagggcgagg cagaccggtg aaggggcggg
       61 aggtttagac gcctctgcta gctggacctg cgacaccaga gtggctcggg gcgtctgccc
      121 gtccgtaggc aatgcctgag gctagggaat cccctggaga gccctgagag ccacctgcac
      181 cgccttggaa ggatctccag aagttagccc caagggttcg gagaagctct ctgcgctaca
      241 agggaaggct cagcttccag tgggagccct agggaacagg gtgtacttgg gagcatggca
      301 gcatcagatc accactgaaa gaggtgccat cccagagata acttcatcct ccaacagcac
      361 ccagccatct tccccacgct gaccacctag ctgcccaaca gcaaaagcac ccaccactct
      421 gccaccgcct ctccaagatg gctacctact gctggccggg cactctgaaa cagcacttct
      481 tgcttaagag cacatctgct ttaagcataa aatgagtgtg ttctatgctc catctagcaa
      541 gcaggcactg acagagcctc tcaggagaca actatatcag actcctgtca ggaagaactt
      601 gttggcatct acatcagtgc ctgcgtttga tgattgtaaa tgggatggat ccccagctat
      661 ggccggtgat tctaggaatg ctatgaatca agacatggag ataggagtca cttcccagga
      721 ccacaagaag attcccaaac aggctcggga ttacatcccc attgccacag accgcacccg
      781 cctgctgaca gaaggcaaga agccacgcca gcgctacatg gagaagactg gcaagtgcaa
      841 tgtacaccac ggcaatgttc aggaaaccta ccgctaccta agtgacctct tcaccaccct
      901 ggtggacctc aaatggcgct tcaaccttct ggtcttcacc atggtctaca ccatcacctg
      961 gctgttcttt ggcttcattt ggtggctcat tgcttatgtc cgaggtgatc tggatcacgt
     1021 gggtgaccaa gagtggatcc cttgtgttga aaaccttagc ggctttgtat ctgctttcct
     1081 gttctccatc gagacagaaa caaccattgg gtatggcttc agagtcatta cagagaagtg
     1141 tccagaaggg atcatactcc ttctggtgca ggccattctg ggctcgattg ttaatgcctt
     1201 catggtgggg tgcatgtttg taaagatcag ccagccaaag aagagagcag agaccctaat
     1261 gttttccaac aatgccgtca tctccatgcg ggatgagaag ctgtgcctca tgttccgggt
     1321 aggggacctc cgaaactccc acatcgtgga ggcctccatc cgtgccaagc ttatcaagtc
     1381 ccggcagacc aaagaaggag aattcatccc cttgaaccag accgacatta atgtgggctt
     1441 tgacactggt gacgaccgcc tcttcctggt ctccccactc atcatctccc acgagatcaa
     1501 cgagaagagc cctttttggg agatgtctcg tgctcaactg gaacaggaag agttcgaagt
     1561 tgtggtcata ctagaaggaa tggtagaagc aacaggcatg acttgccaag cacggagctc
     1621 ttacatggat acagaggtgc tctggggtca ccgattcaca ccagttctca ccttggaaaa
     1681 gggcttctat gaggtggact acaacacttt ccatgacacc tatgagacca acacacccag
     1741 ttgctgtgcc aaggagctgg cggagatgaa gcggagcggt cggctcctcc agtaccttcc
     1801 cagtcctccc ttgcttgggg gctgtgctga ggctgggaac gaagctgagg ccgagaagga
     1861 tgaagagggt gagcccaatg gactgagtgt gtcccaggcc accaggggct caatgtgaag
     1921 tctgtgtgct acccagagcc tcttcttgcc agacaccgag gagcctggga ggccagagag
     1981 gccaattagt tgagcaagct ttgtggggcc ccaggagtat ggaagctcta cagagaggaa
     2041 tagtgtgtca aggcctcaca tctcctcctt ggggcctcag agaaagtagc cttgcctagg
     2101 cctcctgaca agtgctttct aggcctctgt gagagcatta gttgcctcca gagtggggct
     2161 cccaatgaga gttctagggt gccatctatc ctctgtctga ttactggagc ctgttcactt
     2221 tcctccccaa ttcctggtct cctcagcaca acacctgaga ccttcggatc aagggaggta
     2281 attttatcca tggatactca ggcctccagc tggggaggcg ttcacagagg ccttccaggg
     2341 gcaatgcctt ttagtctgag gccaaaaccc actaattaat agcttcttag caaggccact
     2401 tgttcacctc tgatactact tagcgtgtgt tttcctcatc tgtgtcgagt agacactaac
     2461 actatggctt acagggtaat tgatttcatt agagtggcct taggacacca agtacctagg
     2521 agcatacacc atgtcgttct cactactgcc tgacaccctt agtcatactg tgctctgtgc
     2581 ttcaaaggag agccccccag cagttgtacc ttttgtaaga ctatttggcc caagaacttc
     2641 aaagaacctg tggagtggtc ctggggaaca tatgaatttc aaagagccag atgagccctt
     2701 tggtactaac acagggatgg cagacaggag agagacacaa ggataatttt aaaataagat
     2761 gatctggagc ctgtaatcct agcgtttggc aggctgaggc agaatttcga atctgaagcc
     2821 aggccagtct acacagaccg ctctcaaaaa agcaagagac aaataacaac caagaaaaca
     2881 tctgccgcag ttgttgcacg ggggctcctt ggagaaaagt aggctatgaa acacaagtga
     2941 caagtgccca taaaggcatc ttcaagctga gcagccttag gctgctactg agatgcctct
     3001 gggcctccct tctgtggaac agctccaaca tggtggtggg acctagaggg cgggccctga
     3061 ggacaggatg agagttcgtg ggtgactagg gggagaagaa tcaaagagtg gagaagagct
     3121 ttggggtcca cagcctcaca gatttttctc ttccagtcta ggtctgaggg tcaggtcagt
     3181 gaagcattag gttgaaaaca ataagctgtc ctggtcttgg gaattggctt acatgtttcc
     3241 tgacacctct accccagtgt ttatggctct caaccagcct ttgaaaatag aagcaccttc
     3301 ttgccaggcc ctggagaact ttctctggca tctataggga ggcaagaagc taaggcagcc
     3361 tagagaatgg cttcccaacc tcaggccttg tgcccctcag actgggtgcc cgggtccctg
     3421 agctcgtaag gagatggggt ctgtgatgga ttgttacact gtggatccct gcacttggca
     3481 tctgcacgag tctaggccag tgggtctcaa ccttcctaat gctgtgaccc tttaatccag
     3541 ttcctcgtgt tgtgatgacc tcacaacatt ataataatca tagcattatt tttgttgcta
     3601 cttcatagtt ttaatttttc tactgttatg aattgtaatg tagatatcca aatttgaagg
     3661 atatctgata tgcaatccct gtgaaagggt tatccaactc ccaaaacggt ctcaacccac
     3721 agacctacag gttaagactg gtctaggcag aggtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3781 gtgtgttgtg catgtctgtg agtgtggtat atgtgtggat gtacggggtg gtgtgtatat
     3841 gtatgttcgt gtgtgtatat atggtgtgag ggttggtaag taggtgtggg attgggtgga
     3901 gatggtgtgt atacttaagt gtgtgtgtgt gtgttatatg atgaatatgg tgtttgtgta
     3961 catgcgtgtg gcatgtatga tgtagcatgt gtatgctgtg gtgtgtatgt ctttgtgtgt
     4021 gatgggaaag ggagtccaca gtgatgaggt agggggttat acatcttcta tgtggtgaaa
     4081 caggtctagt ggagaatgga aaatgagcag ccatccctac tcaggaaaga aaatcaccga
     4141 gcgggtccac aacacccaat aggtaagctg caggagtcta aggatggagt ctgctgatga
     4201 gactagaggt ctagggtaac aggagatgca gtcattgtca caagagacag acactcagcc
     4261 tggctttcta gaccccaggc ttaggcaggc aggatcagtt ctactccttg gtaggcctgt
     4321 cttgatcaga actagctagt gcctacaggt taagaccctc agtgagtcaa gttggtaaag
     4381 ataagaaata gcagggaatg atgctcttat ggccggacag tggtctggct cctgtttcac
     4441 aattgcctta tttgtatttc tgaaacatcc cccacttggc caagagagaa cagtggtctg
     4501 tgtgagtcag ggccactggt gtgtcaatga gaagctgtgg aggctatcaa agaagtggat
     4561 gcactcctga agatacccga atgccaacgc tgatatgtac tggagttagt aagataacag
     4621 acccaatcag gtttctatcg tggtgaccta agtgtgaggg gactgccctt cccatcccaa
     4681 ggacatctcc atatcaatga acagttgatg tcactaaagt tttaaaaact cttcaaataa
     4741 ttttctgaaa gttcttgacc aataaattta aaatataggt ttataagtct ga
//
