LOCUS       NM_008427               2152 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus potassium inwardly-rectifying channel, subfamily J,
            member 4 (Kcnj4), mRNA.
ACCESSION   NM_008427 XM_128262
VERSION     NM_008427.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2152)
  AUTHORS   Ragancokova,D., Rocca,E., Oonk,A.M., Schulz,H., Rohde,E.,
            Bednarsch,J., Feenstra,I., Pennings,R.J., Wende,H. and Garratt,A.N.
  TITLE     TSHZ1-dependent gene regulation is essential for olfactory bulb
            development and olfaction
  JOURNAL   J Clin Invest 124 (3), 1214-1227 (2014)
   PUBMED   24487590
  REMARK    Erratum:[J Clin Invest. 2022 Aug 15;132(16):e163087. doi:
            10.1172/JCI163087.. PMID: 35968788]
REFERENCE   2  (bases 1 to 2152)
  AUTHORS   Chinchilla,A., Daimi,H., Lozano-Velasco,E., Dominguez,J.N.,
            Caballero,R., Delpon,E., Tamargo,J., Cinca,J., Hove-Madsen,L.,
            Aranega,A.E. and Franco,D.
  TITLE     PITX2 insufficiency leads to atrial electrical and structural
            remodeling linked to arrhythmogenesis
  JOURNAL   Circ Cardiovasc Genet 4 (3), 269-279 (2011)
   PUBMED   21511879
REFERENCE   3  (bases 1 to 2152)
  AUTHORS   Liu,A., Tang,M., Xi,J., Gao,L., Zheng,Y., Luo,H., Hu,X., Zhao,F.,
            Reppel,M., Hescheler,J. and Liang,H.
  TITLE     Functional characterization of inward rectifier potassium ion
            channel in murine fetal ventricular cardiomyocytes
  JOURNAL   Cell Physiol Biochem 26 (3), 413-420 (2010)
   PUBMED   20798526
REFERENCE   4  (bases 1 to 2152)
  AUTHORS   Dyachenko,V., Husse,B., Rueckschloss,U. and Isenberg,G.
  TITLE     Mechanical deformation of ventricular myocytes modulates both TRPC6
            and Kir2.3 channels
  JOURNAL   Cell Calcium 45 (1), 38-54 (2009)
   PUBMED   18635261
  REMARK    GeneRIF: modulated by mechanical deformation of ventricular
            myocytes
REFERENCE   5  (bases 1 to 2152)
  AUTHORS   Wang,C., Mirshahi,U.L., Liu,B., Jia,Z., Mirshahi,T. and Zhang,H.
  TITLE     Arachidonic acid activates Kir2.3 channels by enhancing
            channel-phosphatidyl-inositol 4,5-bisphosphate interactions
  JOURNAL   Mol Pharmacol 73 (4), 1185-1194 (2008)
   PUBMED   18202303
  REMARK    GeneRIF: Enhanced interaction with PIP(2) is the molecular
            mechanism for Kir2.3 channel activation by arachidonic acid.
REFERENCE   6  (bases 1 to 2152)
  AUTHORS   Coulter,K.L., Perier,F., Radeke,C.M. and Vandenberg,C.A.
  TITLE     Identification and molecular localization of a pH-sensing domain
            for the inward rectifier potassium channel HIR
  JOURNAL   Neuron 15 (5), 1157-1168 (1995)
   PUBMED   7576658
REFERENCE   7  (bases 1 to 2152)
  AUTHORS   Doupnik,C.A., Davidson,N. and Lester,H.A.
  TITLE     The inward rectifier potassium channel family
  JOURNAL   Curr Opin Neurobiol 5 (3), 268-277 (1995)
   PUBMED   7580148
  REMARK    Review article
REFERENCE   8  (bases 1 to 2152)
  AUTHORS   Lesage,F., Duprat,F., Fink,M., Guillemare,E., Coppola,T.,
            Lazdunski,M. and Hugnot,J.P.
  TITLE     Cloning provides evidence for a family of inward rectifier and
            G-protein coupled K+ channels in the brain
  JOURNAL   FEBS Lett 353 (1), 37-42 (1994)
   PUBMED   7926018
REFERENCE   9  (bases 1 to 2152)
  AUTHORS   Takahashi,N., Morishige,K., Jahangir,A., Yamada,M., Findlay,I.,
            Koyama,H. and Kurachi,Y.
  TITLE     Molecular cloning and functional expression of cDNA encoding a
            second class of inward rectifier potassium channels in the mouse
            brain
  JOURNAL   J Biol Chem 269 (37), 23274-23279 (1994)
   PUBMED   8083233
REFERENCE   10 (bases 1 to 2152)
  AUTHORS   Morishige,K., Takahashi,N., Jahangir,A., Yamada,M., Koyama,H.,
            Zanelli,J.S. and Kurachi,Y.
  TITLE     Molecular cloning and functional expression of a novel
            brain-specific inward rectifier potassium channel
  JOURNAL   FEBS Lett 346 (2-3), 251-256 (1994)
   PUBMED   8013643
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165278.4.
            
            On Aug 15, 2018 this sequence version replaced NM_008427.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137594.1, U11075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC165278.4         178352-178397       c
            47-2152             AC165278.4         156870-158975       c
FEATURES             Location/Qualifiers
     source          1..2152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.74 cM"
     gene            1..2152
                     /gene="Kcnj4"
                     /gene_synonym="IRK3; Kcnf2; MB-IRK3"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 4"
                     /db_xref="GeneID:16520"
                     /db_xref="MGI:MGI:104743"
     exon            1..46
                     /gene="Kcnj4"
                     /gene_synonym="IRK3; Kcnf2; MB-IRK3"
                     /inference="alignment:Splign:2.1.0"
     exon            47..2152
                     /gene="Kcnj4"
                     /gene_synonym="IRK3; Kcnf2; MB-IRK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1426
                     /gene="Kcnj4"
                     /gene_synonym="IRK3; Kcnf2; MB-IRK3"
                     /note="IRK-3; inward rectifier K(+) channel Kir2.3;
                     potassium channel, inwardly rectifying subfamily J member
                     4; Kir 2.3"
                     /codon_start=1
                     /product="inward rectifier potassium channel 4"
                     /protein_id="NP_032453.3"
                     /db_xref="CCDS:CCDS27641.1"
                     /db_xref="GeneID:16520"
                     /db_xref="MGI:MGI:104743"
                     /translation="MHGHNRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMA
                     DIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPSVPAAGGPGGN
                     GGASPNAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGC
                     VIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHV
                     RAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKE
                     ELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSR
                     FHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAA
                     AAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQAATLPLDNISYRRESAI"
     regulatory      2129..2134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj4"
                     /gene_synonym="IRK3; Kcnf2; MB-IRK3"
                     /note="hexamer: AATAAA"
     polyA_site      2149
                     /gene="Kcnj4"
                     /gene_synonym="IRK3; Kcnf2; MB-IRK3"
                     /note="major polyA site"
ORIGIN      
        1 agcggacact cgccgcccag accctcctcg gaccttacgc cccggggccc tgcatctccc
       61 caggtgacca cgacgacgtc ctcaggtcat gcacggacac aaccgaaacg ggcaggccca
      121 cgtgcccagg cggaaacgcc gcaaccgctt tgtcaagaag aacggccagt gtaacgtcta
      181 cttcgccaac ctgagcaaca agtcccagcg ctacatggca gacatcttca ccacctgcgt
      241 ggacacgcgc tggcgctata tgctcatgat cttctccgcg gccttcctcg tttcctggct
      301 cttcttcggc ctcctcttct ggtgcattgc cttcttccat ggtgacctgg aggccagtcc
      361 ctctgtgccc gcggcaggag gcccgggggg caatggcggg gcaagcccga atgcccccaa
      421 accctgtatc atgcacgtaa acggcttttt gggggccttc ctcttctcag tggagaccca
      481 gacgaccatt ggctacgggt tccggtgtgt gacagaggag tgcccgttgg cggtcattgc
      541 ggtggttgtc cagtccattg tgggctgtgt cattgactcc ttcatgattg gcacgatcat
      601 ggccaagatg gcacggccca agaagcgggc acagaccctg ctgttcagcc accatgctgt
      661 catctccgtt cgagacggca agctctgcct gatgtggcgc gtgggtaacc tgcgcaagag
      721 tcacattgtg gaggcccacg tccgggccca gctcatcaaa ccctacatga cacaggaggg
      781 tgagtacctg ccactggacc agcgggacct caacgtgggc tatgacatcg gcctggaccg
      841 catcttcttg gtgtcaccca tcatcatagt gcatgaaatc gacgaggaca gcccactcta
      901 cggcatgggc aaggaggagc tggagtcaga ggactttgag attgtggtca tcctggaggg
      961 tatggtggag gccacggcta tgaccactca ggcccgcagc tcctatctgg ccagtgagat
     1021 cctgtggggt caccggtttg agcctgtggt cttcgaggaa aagagtcact acaaggtgga
     1081 ctactcacga ttccacaaga cctatgaggt ggctggcacg ccttgctgct ccgcccgtga
     1141 gctgcaggag agcaagatca cggtgctgcc cgccccaccg ccccctccca gtgccttctg
     1201 ctatgagaat gagctggccc ttatgagcca ggaggaagag gagatggaag aggaggctgc
     1261 ggccgcagca gccgtggctg caggcctggg cctggaggca ggttccaaag aggaggcagg
     1321 cattatccgg atgcttgagt ttggcagcca cctggatctg gagcgcatgc aagccgccac
     1381 ccttccactg gacaatattt cctatcgcag ggaatctgcc atctgacctc caggccctgc
     1441 cctcctctat tcccgcaaga gcctctgcca ggggtgggac gccaggacaa gccttccact
     1501 cttaggacag agttgaacgt ggctctgtgg acctagagga aggtgggggc ttcaaagact
     1561 gggagatccc ttcctgttga ctacagggcc caggactgga aaggacccag gtactccgcc
     1621 ctgatggccc agggccccct ggcatctccc cacggtggct ctgggccccc agatcttcca
     1681 cccttttccc actgaccctt caaggatgta ccccttctgc tctcaggacc tcggggaagg
     1741 cggctggact gctggggggc gggcatcatg gggttctggg tgggcagggt gggtctgggg
     1801 gagggggaag ggtgtgtttc ttttgcatga ctgtggtctg tgctcttgat tctcttttgt
     1861 aaatatctat aaatggaaga gatggagaca caagtccacc tctgcccatt tctacctgtg
     1921 agacagagag aggctgccaa cccctctctg tgcactcccc cgtccagcct cagcccgacc
     1981 cagctggctg gtcccttgag acctttgaag ccggctctgt atggtgttgg gtttgggtac
     2041 agaggggact cagaggtagg atgagtaccc ctccctcctt gcagtccctc cagtttccag
     2101 attgatgacg gcgtttgtaa ctatttttaa taaagcatat ggtccactag aa
//
