LOCUS       NM_008425               5468 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus potassium inwardly-rectifying channel, subfamily J,
            member 2 (Kcnj2), mRNA.
ACCESSION   NM_008425
VERSION     NM_008425.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5468)
  AUTHORS   Follmer,M.L., Isner,T.J., Ozekin,Y.H., Levitt,C.H., Burek,C.L.,
            Benninger,R.K.P. and Bates,E.A.
  TITLE     Depolarization induces calcium-dependent BMP4 release from mouse
            embryonic palate mesenchymal cells
  JOURNAL   Nat Commun 15 (1), 9806 (2024)
   PUBMED   39532850
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5468)
  AUTHORS   Rokka,S., Sadeghinejad,M., Hudgins,E.C., Johnson,E.J., Nguyen,T.
            and Fancher,I.S.
  TITLE     Visceral adipose of obese mice inhibits endothelial inwardly
            rectifying K+ channels in a CD36-dependent fashion
  JOURNAL   Am J Physiol Cell Physiol 326 (5), C1543-C1555 (2024)
   PUBMED   38586877
  REMARK    GeneRIF: Visceral adipose of obese mice inhibits endothelial
            inwardly rectifying K[+] channels in a CD36-dependent fashion.
REFERENCE   3  (bases 1 to 5468)
  AUTHORS   Moreno-Manuel,A.I., Macias,A., Cruz,F.M., Gutierrez,L.K.,
            Martinez,F., Gonzalez-Guerra,A., Martinez Carrascoso,I.,
            Bermudez-Jimenez,F.J., Sanchez-Perez,P., Vera-Pedrosa,M.L.,
            Ruiz-Robles,J.M., Bernal,J.A. and Jalife,J.
  TITLE     The Kir2.1E299V mutation increases atrial fibrillation
            vulnerability while protecting the ventricles against arrhythmias
            in a mouse model of short QT syndrome type 3
  JOURNAL   Cardiovasc Res 120 (5), 490-505 (2024)
   PUBMED   38261726
  REMARK    GeneRIF: The Kir2.1E299V mutation increases atrial fibrillation
            vulnerability while protecting the ventricles against arrhythmias
            in a mouse model of short QT syndrome type 3.
REFERENCE   4  (bases 1 to 5468)
  AUTHORS   Guo,H., Xin,Y., Wang,S., Zhang,X., Ren,Y., Qiao,B., Li,H., Wu,J.,
            Hao,X., Xu,L., Yan,Y. and Zhang,H.
  TITLE     Hypothalamic POMC neuron-specific knockout of MC4R affects insulin
            sensitivity by regulating Kir2.1
  JOURNAL   Mol Med 30 (1), 34 (2024)
   PUBMED   38448811
  REMARK    GeneRIF: Hypothalamic POMC neuron-specific knockout of MC4R affects
            insulin sensitivity by regulating Kir2.1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5468)
  AUTHORS   Huang,X., Henck,J., Qiu,C., Sreenivasan,V.K.A., Balachandran,S.,
            Amarie,O.V., Hrabe de Angelis,M., Behncke,R.Y., Chan,W.L.,
            Despang,A., Dickel,D.E., Duran,M., Feuchtinger,A., Fuchs,H.,
            Gailus-Durner,V., Haag,N., Hagerling,R., Hansmeier,N., Hennig,F.,
            Marshall,C., Rajderkar,S., Ringel,A., Robson,M., Saunders,L.M., da
            Silva-Buttkus,P., Spielmann,N., Srivatsan,S.R., Ulferts,S.,
            Wittler,L., Zhu,Y., Kalscheuer,V.M., Ibrahim,D.M., Kurth,I.,
            Kornak,U., Visel,A., Pennacchio,L.A., Beier,D.R., Trapnell,C.,
            Cao,J., Shendure,J. and Spielmann,M.
  TITLE     Single-cell, whole-embryo phenotyping of mammalian developmental
            disorders
  JOURNAL   Nature 623 (7988), 772-781 (2023)
   PUBMED   37968388
REFERENCE   6  (bases 1 to 5468)
  AUTHORS   Doupnik,C.A., Davidson,N. and Lester,H.A.
  TITLE     The inward rectifier potassium channel family
  JOURNAL   Curr Opin Neurobiol 5 (3), 268-277 (1995)
   PUBMED   7580148
  REMARK    Review article
REFERENCE   7  (bases 1 to 5468)
  AUTHORS   Raab-Graham,K.F., Radeke,C.M. and Vandenberg,C.A.
  TITLE     Molecular cloning and expression of a human heart inward rectifier
            potassium channel
  JOURNAL   Neuroreport 5 (18), 2501-2505 (1994)
   PUBMED   7696590
REFERENCE   8  (bases 1 to 5468)
  AUTHORS   Ishihara,K. and Hiraoka,M.
  TITLE     Gating mechanism of the cloned inward rectifier potassium channel
            from mouse heart
  JOURNAL   J Membr Biol 142 (1), 55-64 (1994)
   PUBMED   7707353
REFERENCE   9  (bases 1 to 5468)
  AUTHORS   Kubo,Y., Baldwin,T.J., Jan,Y.N. and Jan,L.Y.
  TITLE     Primary structure and functional expression of a mouse inward
            rectifier potassium channel
  JOURNAL   Nature 362 (6416), 127-133 (1993)
   PUBMED   7680768
REFERENCE   10 (bases 1 to 5468)
  AUTHORS   Pravtcheva,D.D., Adra,C.N. and Ruddle,F.H.
  TITLE     Timing of paternal Pgk-1 expression in embryos of transgenic mice
  JOURNAL   Development 111 (4), 1109-1120 (1991)
   PUBMED   1879353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB642909.1, AK044915.1, AL662912.14 and BP762467.1.
            
            On Apr 16, 2009 this sequence version replaced NM_008425.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044915.1, SRR10223971.12388.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BB642909.1         2-55
            55-2015             AK044915.1         56-2016
            2016-5220           AL662912.14        7675-10879
            5221-5468           BP762467.1         28-275              c
FEATURES             Location/Qualifiers
     source          1..5468
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 75.23 cM"
     gene            1..5468
                     /gene="Kcnj2"
                     /gene_synonym="IRK1; Kcnf1; Kir2.1"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 2"
                     /db_xref="GeneID:16518"
                     /db_xref="MGI:MGI:104744"
     exon            1..171
                     /gene="Kcnj2"
                     /gene_synonym="IRK1; Kcnf1; Kir2.1"
                     /inference="alignment:Splign:2.1.0"
     exon            172..5448
                     /gene="Kcnj2"
                     /gene_synonym="IRK1; Kcnf1; Kir2.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..1693
                     /gene="Kcnj2"
                     /gene_synonym="IRK1; Kcnf1; Kir2.1"
                     /note="IRK-1; inward rectifier K(+) channel Kir2.1;
                     potassium channel, inwardly rectifying subfamily J member
                     2"
                     /codon_start=1
                     /product="inward rectifier potassium channel 2"
                     /protein_id="NP_032451.1"
                     /db_xref="CCDS:CCDS25594.1"
                     /db_xref="GeneID:16518"
                     /db_xref="MGI:MGI:104744"
                     /translation="MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCR
                     SRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCV
                     FWLIALLHGDLDTSKVSKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFM
                     VVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLR
                     KSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDED
                     SPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEK
                     HYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEEDSE
                     NGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI"
     regulatory      5426..5431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj2"
                     /gene_synonym="IRK1; Kcnf1; Kir2.1"
                     /note="hexamer: AATAAA"
     polyA_site      5444
                     /gene="Kcnj2"
                     /gene_synonym="IRK1; Kcnf1; Kir2.1"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcact ggagccctgg ccagcgcgca gccttcccag caccggcaag cagtgtcttg
       61 ggaattctca cttgcttcgg ctcattctct ttcacaaaaa ccactggatc ttacatgctt
      121 ctgtaatccc cacttccact ccatgtcccc atgatcctgt accagcaaca ggacaagttc
      181 tctggatgtc agctgagtta ctaaggtaac tttgctggtc aaaagaaccc caaggttctc
      241 ggaagcatcc atctctcctc attaataaat atatatatta attatatata tatataattt
      301 tttttggtgt gtcttcaccg aacattcaaa actgtttctt ctaagggttt tgcaaaaact
      361 cagactgttt tctaaagcag aaacactggc gtccccagcg gaagcaatgg gcagtgtgag
      421 aaccaaccgc tacagcatcg tctcttcgga ggaagatggc atgaagctgg ccactatggc
      481 agttgccaat ggctttggga atggcaagag taaagtccat acccgacaac agtgcaggag
      541 ccgctttgtg aagaaagatg gtcattgcaa tgttcagttt atcaacgtgg gtgagaaggg
      601 acagaggtac ctggcagaca tctttactac ctgtgtcgac atccgctgga ggtggatgct
      661 ggttatcttc tgtcttgcct tcgtgctctc ctggctgttc tttggctgtg tgttttggtt
      721 gatagccctg ctccatgggg atctagatac ttctaaagtg agcaaagcat gcgtgtcaga
      781 ggtcaacagc ttcacggctg ccttcctctt ctccatcgag acccagacaa ccattggcta
      841 tggtttcagg tgtgtgacag acgagtgccc aattgctgtc ttcatggtgg tattccagtc
      901 aatcgtaggc tgcatcattg acgccttcat cattggtgca gtcatggcga agatggcaaa
      961 gccaaagaag agaaatgaga ctcttgtctt cagtcacaat gctgtgattg ccatgaggga
     1021 tggcaaactc tgcttgatgt ggagagtggg taaccttcga aagagccacc ttgtggaagc
     1081 tcatgtccgg gcacagcttc tcaaatctag gatcacttca gaaggggagt atatcccttt
     1141 ggaccagata gacatcaatg ttggttttga tagtggaatt gaccgcatat ttctagtgtc
     1201 ccccatcact atcgttcacg aaatagatga agacagccct ttatatgact tgagtaagca
     1261 ggacattgac aatgcagact ttgaaattgt tgtcatactg gaaggcatgg tggaggcgac
     1321 tgccatgaca actcaatgcc ggagttcgta tctggccaat gaaattctct ggggtcaccg
     1381 ctatgagcca gtgctctttg aagagaaaca ctactataaa gtagactatt caagattcca
     1441 taagacttat gaagtaccta acacccccct ttgtagtgcc agagacttag cagagaagaa
     1501 atacatcctt tcaaatgcaa attcattttg ctatgaaaat gaagttgccc taacaagcaa
     1561 agaggaagag gaggatagtg agaacggagt cccagagagc acaagcacag actcacctcc
     1621 tggcatagat ctccacaacc aggcaagcgt acctctagag cccaggccct taaggcgaga
     1681 atcggagata tgactggctg attccgtctt tggaatactt actttgctac acagcctgac
     1741 gttggtcaga ggtccgagac agttatacag accatggtac tggtcgagag gtgggtgaaa
     1801 gcaagcagcc acaagagact aaggctagca caaaggtttc aaggaaagac taagctggat
     1861 gactgatgta aagtgctttg caggcctcca agagacatga tggcacatat ctgttgtagt
     1921 ataagttatg gggtttttaa tgtattgttt tgtgttttta caaaacttga atatgcaggc
     1981 aagcctcagt ttgggtacat gacttacctg gaatgcttct ctttagggga acaagagtga
     2041 ttttaatggc ataacacagg caagactctg ccttaatttt ttgaaaagct gctaactaca
     2101 tgaacacgaa ctgtattttt gttgcagtgt agtttatctt ttacataacg ttaagacgtc
     2161 agtgttgagc attgttgaaa gcgcacagtg tgctttaaag catcaagtat ttggctatta
     2221 actgccaaaa atgaaagcct gattttctga ggccagtaat ttgtttgcta aaaattgatc
     2281 tctctgtcta cctgtcagtc tctgtctctg tctctctctc gttatctctc tctctctctc
     2341 tctctctctc tctctcatta cataatagca ttatataaca ctagccaaat ggtagcctct
     2401 gggttttata cttttctttt ccacaatgct aataggttat ctcaaacttt cagttagacg
     2461 accttaaatg aataccaaag ataatgcaca ttgttttgtt tttgtttttg tttttttctt
     2521 tttctttttt tttctttcct tttttttttc tttttttgca catggaggtt atattttttt
     2581 aaaaagaaac aaagctcctg cacagattgt cttggaaatc cagagacacc atctttgaac
     2641 ttcagcaggg tgtgaagcag tccgttcatt tttgcactat agtctgaaaa gaacaccaaa
     2701 gtctgatcaa tgtagtgtgt tttcgagtct gttcttttgt gcttctttct tatttggagg
     2761 ggaggaggga agcataggtc acagttacat atgcactata atcaatattt tttctttccc
     2821 tttttctgag cttttctctc ttagcacatt ccaaagttgg ttccataaga tcagatcttg
     2881 gttgaacttt gttggtaacc tggcaccttc caaactgtca cccagcaggg aagatgaaca
     2941 gatttcaaat tttgcagctg actcatagcc ttgactgcca gggcatttct agctcagtgt
     3001 cacattaaga aagatgtctg gcctctagtc ttgtccttct aaggtctctg cagagataga
     3061 gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga ctttcaatgc
     3121 agcaatccac tttacaggtg agagggaagt ttcctttttc atgacagagg gtaagaggga
     3181 ctgtttcagt attttaggtc ttagtgagcc atataaacac aacataatta caagctaagg
     3241 agttaagagt ctaaagggtt atttctctct ctgtaaacat tcatgattaa tgccagtggg
     3301 tcattgtctc ttggaaagtc tcagagcacg ttgccaagga ctcattattt tctagaagcc
     3361 tcttttacct attcaccttc ctttataaaa acctccctcc ctttcccaaa cactagctca
     3421 atcattcaat tctccctccc tttgtttctc ttggttttaa tgttctctac ttgtaaaccc
     3481 tggggctgct gagttccttt ttagttggcg tctcaaaatc aagcctctaa tggtattaca
     3541 ccctaatatg ccattaaaaa tcagcttgtt ctagaaccat gtattttatt taggttgatg
     3601 tttgtgccgg tctgtggctt gtgagcctct gtatctggat acagtgcctg taagaaacgt
     3661 tgacaatttc tgctgttttc aactttctaa gtcaatggat ttgaaaactg ttggtgttat
     3721 ggaaatcaag agagaagcgt cgagaaagtg tacatctggg ttttaaggca gggttgcaag
     3781 ttgcttaaag agtttgctgg gttggggaca gggagaagtc acaggagaga acacagactg
     3841 gcttctgaca gtgtgaggct atggaaggct tcagatgctg ctattaaggt gatttgcaaa
     3901 gtaaagtaat caaaccaaag agtattcagt ggaatgtcaa tcaaatgaag atgcagtaaa
     3961 gagtgggggt gacaacatgg actgacccca aacacaaaaa gacttgagtt atttgaaaag
     4021 agggaggggg tgggtacaga gacaagaaaa gtgggagggg aaatctttca atttttttta
     4081 tctttatttg cttaaaaaga agaaaccatc taaaatttct ggtgcataga tttgtttttc
     4141 gtttgtttgt ttgttcgttt tttttctttt tgtttttcaa ggaaaatttt gcagaagcga
     4201 catttttaaa gtgtacattt tataaagttt atcagatatt ttcatattta aagccaaatg
     4261 taaatagaaa tctgtaaagg aaaaaaaaat accctaagag gtataactac cgcagtgagt
     4321 tctgagagct agcacctata tgctaccggt tagcatggtt ttagcggata ttaccagcct
     4381 tttgaggttc gatttactat gttcttctgt tatttatttc agcatggact gttccttcga
     4441 gagctttttg tagttattag catctttata gttacaagct ttaaatggct ttttgttttg
     4501 ttctgccaag agccaagaca taggtaatgc atggcatctc ttcctgcatt tttaccttca
     4561 gaatacctgt ctttattgac tgggcctccg gaactagtgc acacacctgc cactagtatg
     4621 cagatggagg gactcacctc gaacatctgg ggctcctccc cagatgccag ttgcttctgt
     4681 gttgcaagca aatccctcta ggatgtattc ccttttaaag aatgtttgcc catatctaaa
     4741 tgggcattat attttttttg gaggggggag gcatagattc ctggttattc tatttttaaa
     4801 taaaaggtag acaaactgaa ttctattttg attattgaga aaggaatagt tttctatccc
     4861 tctaagagta tacttgaatc agacattttt agaatgtcat agagcactgt agtcatttct
     4921 aaatccctag agaagtttgt ttgactctgt tcctgttctg ttaatgcatt tttcctttgc
     4981 tttcactccc tctctcccta tatatcccct tcctaaatct tgatgtgtct ctgatgacct
     5041 tggttcccca atgatgttcc ccttgcagat aacaaacgtc agcttttaac ttataaccag
     5101 ccaccccata aaagcgaaaa gctcatctcg aggggtgggt taagctcctt atcaccctgt
     5161 tcaatgatgt taaggtggaa agtataaaag tgttgcatta ttgcatcccc tcccacaacc
     5221 ttcagcaaac tagagtttct ttcctagaaa tgttaggttt cagctctggg ctctggcgag
     5281 ttgaatgatc ctagcctttg acaatcatga tagttattat tttcccattt gccatctgtt
     5341 ttgtatctaa agtcttccta ttgtactgca caaaccatgg gttgtatata ttttttatat
     5401 attatgtctt attttattat ttctaaataa aaattgaaaa taaatgacaa aaaaaaaaaa
     5461 aaaaaaaa
//
