LOCUS       NM_001271691            5118 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus potassium inwardly-rectifying channel, subfamily J,
            member 15 (Kcnj15), transcript variant 7, mRNA.
ACCESSION   NM_001271691
VERSION     NM_001271691.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5118)
  AUTHORS   Zhang,Y., Bock,F., Ferdaus,M., Arroyo,J.P., L Rose,K., Patel,P.,
            Denton,J.S., Delpire,E., Weinstein,A.M., Zhang,M.Z., Harris,R.C.
            and Terker,A.S.
  TITLE     Low potassium activation of proximal mTOR/AKT signaling is mediated
            by Kir4.2
  JOURNAL   Nat Commun 15 (1), 5144 (2024)
   PUBMED   38886379
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5118)
  AUTHORS   Duan,X.P., Xiao,Y., Su,X.T., Zheng,J.Y., Gurley,S., Emathinger,J.,
            Yang,C.L., McCormick,J., Ellison,D.H., Lin,D.H. and Wang,W.H.
  TITLE     Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in
            Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2),
            Kir4.1, and Epithelial Na+ Channel (ENaC)
  JOURNAL   Hypertension 81 (1), 126-137 (2024)
   PUBMED   37909221
  REMARK    GeneRIF: Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal
            Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2
            (Kir4.2), Kir4.1, and Epithelial Na[+] Channel (ENaC).
REFERENCE   3  (bases 1 to 5118)
  AUTHORS   Terker,A.S., Zhang,Y., Arroyo,J.P., Cao,S., Wang,S., Fan,X.,
            Denton,J.S., Zhang,M.Z. and Harris,R.C.
  TITLE     Kir4.2 mediates proximal potassium effects on glutaminase activity
            and kidney injury
  JOURNAL   Cell Rep 41 (12), 111840 (2022)
   PUBMED   36543132
REFERENCE   4  (bases 1 to 5118)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   5  (bases 1 to 5118)
  AUTHORS   Poli,G., Hasan,S., Belia,S., Cenciarini,M., Tucker,S.J.,
            Imbrici,P., Shehab,S., Pessia,M., Brancorsini,S. and D'Adamo,M.C.
  TITLE     Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and Increases the
            Prevalence of Morphologically Abnormal Spermatozoa
  JOURNAL   Int J Mol Sci 22 (11), 5972 (2021)
   PUBMED   34205849
  REMARK    GeneRIF: Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and
            Increases the Prevalence of Morphologically Abnormal Spermatozoa.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5118)
  AUTHORS   Kurschner,C. and Yuzaki,M.
  TITLE     Neuronal interleukin-16 (NIL-16): a dual function PDZ domain
            protein
  JOURNAL   J Neurosci 19 (18), 7770-7780 (1999)
   PUBMED   10479680
REFERENCE   7  (bases 1 to 5118)
  AUTHORS   Pearson,W.L., Dourado,M., Schreiber,M., Salkoff,L. and Nichols,C.G.
  TITLE     Expression of a functional Kir4 family inward rectifier K+ channel
            from a gene cloned from mouse liver
  JOURNAL   J Physiol 514 (Pt 3) (Pt 3), 639-653 (1999)
   PUBMED   9882736
REFERENCE   8  (bases 1 to 5118)
  AUTHORS   Cabin,D.E., McKee-Johnson,J.W., Matesic,L.E., Wiltshire,T.,
            Rue,E.E., Mjaatvedt,A.E., Huo,Y.K., Korenberg,J.R. and Reeves,R.H.
  TITLE     Physical and comparative mapping of distal mouse chromosome 16. 5
            p5
  JOURNAL   Genome Res 8 (9), 940-950 (1998)
   PUBMED   9750193
REFERENCE   9  (bases 1 to 5118)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
REFERENCE   10 (bases 1 to 5118)
  AUTHORS   Gosset,P., Ghezala,G.A., Korn,B., Yaspo,M.L., Poutska,A.,
            Lehrach,H., Sinet,P.M. and Creau,N.
  TITLE     A new inward rectifier potassium channel gene (KCNJ15) localized on
            chromosome 21 in the Down syndrome chromosome region 1 (DCR1)
  JOURNAL   Genomics 44 (2), 237-241 (1997)
   PUBMED   9299242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165436.1, AW012236.1 and AC154691.3.
            
            Transcript Variant: This variant (7) differs in the 5' UTR and 5'
            coding region and uses a downstream start codon, compared to
            variant 1. The encoded isoform (b) has a shorter N-terminus,
            compared to isoform a. Variants 2, 3, 5, 7, 9 and 11 encode the
            same isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF782321.1, AW012236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AK165436.1         2-171
            171-514             AW012236.1         37-380
            515-5118            AC154691.3         80013-84616         c
FEATURES             Location/Qualifiers
     source          1..5118
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 55.86 cM"
     gene            1..5118
                     /gene="Kcnj15"
                     /gene_synonym="4930414N08Rik; IRKK; Kir4.2"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 15"
                     /db_xref="GeneID:16516"
                     /db_xref="MGI:MGI:1310000"
     exon            1..177
                     /gene="Kcnj15"
                     /gene_synonym="4930414N08Rik; IRKK; Kir4.2"
                     /inference="alignment:Splign:2.1.0"
     exon            178..350
                     /gene="Kcnj15"
                     /gene_synonym="4930414N08Rik; IRKK; Kir4.2"
                     /inference="alignment:Splign:2.1.0"
     exon            351..448
                     /gene="Kcnj15"
                     /gene_synonym="4930414N08Rik; IRKK; Kir4.2"
                     /inference="alignment:Splign:2.1.0"
     exon            449..5118
                     /gene="Kcnj15"
                     /gene_synonym="4930414N08Rik; IRKK; Kir4.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..1587
                     /gene="Kcnj15"
                     /gene_synonym="4930414N08Rik; IRKK; Kir4.2"
                     /note="isoform b is encoded by transcript variant 7;
                     inward rectifier K+ channel Kir4.2; ATP-sensitive inward
                     rectifier potassium channel 15; potassium channel,
                     inwardly rectifying subfamily J member 15"
                     /codon_start=1
                     /product="ATP-sensitive inward rectifier potassium channel
                     15 isoform b"
                     /protein_id="NP_001258620.1"
                     /db_xref="CCDS:CCDS37410.1"
                     /db_xref="GeneID:16516"
                     /db_xref="MGI:MGI:1310000"
                     /translation="MDAIHLGMSSAPLVKHTNGVGLKAHRPRVMSKSGHSNVRIDKVD
                     GIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVVYYAIAFIHGDLQLGESNS
                     NHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFI
                     TGTFLAKIARPKKRAETIKFSHCAVISKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQ
                     THVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKE
                     FELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIR
                     KSPDCTFYCADSEKQKLEEQYRQEDQRERELRSLLLQQSNV"
     regulatory      5048..5053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj15"
                     /gene_synonym="4930414N08Rik; IRKK; Kir4.2"
                     /note="hexamer: ATTAAA"
     polyA_site      5071
                     /gene="Kcnj15"
                     /gene_synonym="4930414N08Rik; IRKK; Kir4.2"
                     /note="major polyA site"
ORIGIN      
        1 atctgtttgt ttatagttta cttaagcaaa gggaccttta aaaaacggac tttgataaga
       61 ggggacaaag tttcttcaga aatgaaccgg agttccttag taagaacttc agtttctttt
      121 atacacaggt gcccggagaa ctggggagtc cttgccattc caagccgccc tgtgccggta
      181 attcctctca gaaacttgta cgaacttgtt tttgactgac agtgaacagt aagactggtt
      241 cttcactttg aagaaccctc agcacctacc tttgcaaggc accctggatc acttccttgc
      301 ctggtcttaa tttcccaccc acccaggagc ctgcactggg cactcggcag gccatagcag
      361 agccccatgg tagccaggtg ggagaagggg agcgaggacg cgccacttac cctgcagaag
      421 attcctgacc tacagagtga gtgaccaggt ggtccaaaga tggatgccat tcaccttggc
      481 atgtccagtg ccccactggt gaagcatacc aacggggttg gactcaaggc ccacagaccc
      541 cgagtcatgt caaagagtgg gcacagtaat gtgagaatcg ataaggtaga cggaatctat
      601 ttactctacc tccaggactt gtggacaacc gtcatcgaca tgaagtggcg atacaagctc
      661 accctatttg ctgccacctt tgtgatgacc tggtttctgt ttggagtggt ctactatgcc
      721 atagccttta ttcatggtga cttacaactt ggggaatcta attccaacca cacaccctgc
      781 attatgaaag tggactctct cacaggagca ttcctctttt ccttggaatc tcagacaacc
      841 attggctacg gggtccgttc catcacagag gagtgtcccc atgctatctt cctcttagtc
      901 gcccaactgg tcatcaccac attgattgag atcttcatta cggggacctt tctggctaaa
      961 attgcaagac ccaaaaagcg agccgagacc attaagttca gccactgtgc tgtcatcagc
     1021 aagcagaatg gaaagctatg cctggtcatc caggtggcca acatgaggaa gagtctcctg
     1081 attcagtgcc agctctctgg aaaactcctg cagacacacg tcaccaaaga gggagaacgc
     1141 attctcctca accaggccac tgtcaaattc cacgtggact cctcttccga gagtcccttc
     1201 ctcatcctgc ccatgacctt ctaccacgtg ttggatgaga caagccccct gcgggacctc
     1261 acaccccaaa acctaaagga gaaggagttt gagctggtgg tacttctcaa cgccacggtg
     1321 gagtctacca gcgccgtctg ccagagccga acgtcttaca tcccggagga gatctactgg
     1381 ggctttgagt ttgtgcctgt ggtttctctc tccaaaaatg gaaagtatgt ggctgatttc
     1441 agtcaatttg agcagatcag gaagagcccg gattgtacct tctactgtgc cgattctgag
     1501 aagcagaagc ttgaagaaca gtacaggcaa gaggaccaga gggagcggga gctgaggagc
     1561 ctcctgctac agcagagcaa tgtctgactc caccggcctc tgggcgtctc ctaaccaggg
     1621 ctcctttcaa aagcaatggc tgccatgaac gtgggatggg tggccccact accaaatcac
     1681 acagacgttc gtggccatct tcccctttgt tctgatggct gaacaagcat ttctgaatat
     1741 aaaaagatgt cttcagagtg cctggtcaga ggtgagcact caaattcaga tttcccccca
     1801 cccctaaaat ggagctatac attgaagaac tgagtgtagg aagatggaga gaattcccgc
     1861 tggagggcag acccagcagt gctgacagtg gatggcatgt atgcctactc aagaacatct
     1921 gctcataatg caaaatattt atttacccac ctaacaaggg cattggtggc tgaggtctga
     1981 ggcgtaattt gctatttgct catagcactg cttaagaact cactccttct catgttcaag
     2041 tgcatacgtt tttatttgca atgacggtta tctggagatg acaaaaaaaa aaaaagttgg
     2101 gaaagcaggg tcttaaagct tgcagaataa tacagccgtt ttatttttac attcttccat
     2161 agactttaat tgtgtggagc gaacatcatc aaatcaggaa tcaagagttc agaaaatatg
     2221 tccatctctt gattctgtgg tccccatcac ttctggagga agcgtgtact agcctctttt
     2281 tcctttaaaa tgtccttcac agacaaacca aatagcacca tttagggaca tattggcaac
     2341 acgcacagcc gggtttcagc caggcttcca gaaacctcaa tgttgcaggc tctgagtaat
     2401 gtttgcaatg tcatctgtct agatccacgt tggaaaaaag agcgtgtgcg ttccgagtcc
     2461 atgtgccctc caggtctgcc ctctgtcagc gttatcagtc gacacatcca tctctcagct
     2521 atctcagctt ttccctggga acatacctta gccacaaaga aattgtacag agttactagt
     2581 gtcttaagaa ttagacagtt ccctgagagc tgtgactgtc accattgtgt taattcatgg
     2641 actgaagacg gcagtcacca caaaagaaaa ctgaaactgt gtcacaaata ggaagtctgc
     2701 attagatgct gcagtttgca gctcatgaca cagagaagag gagccaaggg ggaaaggtgt
     2761 ctgtgagcaa gaagagccct tgtgcaagag cctagacaaa tacgtagtac aactcagtgt
     2821 tacaggggta acattttacc tctgagaaat ataggagtat aacgcctgca tttccttggg
     2881 aaagagaatt aagcaggcta ggattgactg aatagataag cgctgtgtgc tcattttatc
     2941 tggacaaact agaaatttac tcaagtgcca tgtaaccatg aatgtacagg caatactctc
     3001 tctctctctc tctctctctc tctctcacac acacacacac acacacacac acacacacac
     3061 acacacacac acacacacat gttcctcata caatatgcca gggtgtgctc tggctctgca
     3121 aacacaatac caggcatgtg ggatcagagg tcacactaag aaagtctacc aagttatcct
     3181 catgcttatc tgattcttta agaaaaatga acatttggac ccagagaaac tggggagact
     3241 ttagctggat ctagctgtta gtgtgaacaa ctgcaccccc agtcataacc ttgagagacc
     3301 actttcacac tgtctttcct tcaaacaaca acaaaatgtg gaaataaaat ctttgggttg
     3361 gaaccaagct aatgcagtga gagtctgaga cccatggagg aaaagtttgc agaacgattt
     3421 ctattaagga ggatttaggg ctggagaaat ggctcggtag gtaagggcta cagctcaaat
     3481 gctcaacacc cttgtaaaat gccagggagg ggttcacaag cctagaactg caagatcatg
     3541 gggagctgag acagggggat cactgggact tactgggcac cagagagctc caggctcagt
     3601 aagacaccct gtctcagaag aataaggcag ataaaggaaa gtgacctact cctctggcct
     3661 ctaggcacat gcatgctctc cccactccac ataccaatct gtctgtctgt ctctgtctct
     3721 ctccctgtct ctttctgtct ctgtctctct ccctgtcaat ctctctccct ctctcccttt
     3781 gtctctccct ccctgtctct gtctctccct gcctctccct gtttctctct ctctctctct
     3841 ctctctctct ctcacacaca cacacacaca cacacagaga gaggttaaat cattcaagaa
     3901 aatgttttcc actccttcct gacttcatgg cagcctgtgt tagtttcccc ctttttcaaa
     3961 ctgttagatg tttgcccgct cagacattag tccctttcac tattaatctt gtgtatttgt
     4021 gtcacatatt acagtagaat caataggaaa aatcgtgcca cgagggcgtt tgtggtggct
     4081 tttctattgt tttatgaaat tcctcaccca aaatccactt tggtggccat ctgaatctga
     4141 ttaatcccag taactcagct tgcttctgtt gtatacggta caaatggtaa cacgccagtc
     4201 tcaaaatcgt ctttgtataa tcactgagca tattatattc atccagattt ggaatatctg
     4261 atcatttgaa agttttttgt aatacacacc aatatattcg gtgccttcaa aaccactgta
     4321 tgggccaggt gtgctggtac atgcctgtga tcctagcaca tgggaggtgg aggtaccagg
     4381 attaggaatt caaggccagc ctcgatgaca taatgcctcc acgacatgag cccctctaac
     4441 aaaatatgta atgtttaggt caataaatca tattgtaaca taatatctag taattcattc
     4501 tatagttgac tggtttgaaa cttaacattt ttcagaatcc cttagatatt attttgaacc
     4561 acatattctc atgttaatgt actagtagaa gaattaaatg ataagcttac tggatgtcat
     4621 ctagacagct ttctgatggc aacagattca gaagagtcat caaaacaata gagtgtttaa
     4681 cctgaagaaa gctttgtgtt tcttcagaaa ctcaatgcat tcactttctc tatgattctg
     4741 aaattgttct tcatttggga gaccacaggg cagcagatca atgtatacca caagccatgt
     4801 cttctgcctt gctgcctgtg accgcagaca aaggagagac gcacctctga cccatacagt
     4861 gagccacttt gggtcgaggg tgggagttaa accttggttc tctgttttct ttttcatggg
     4921 gaaattaaca gtgacgtttt ttaatatcta aaaacaaatg catagtggga agaaaaaata
     4981 atattcatta gagtggatca aatatttaga taaatgtaaa cacccatttt gtttgatctt
     5041 taattgaatt aaatttctac tttgaactgg ctgtggtttt gatatcaatg aagtgtaaaa
     5101 ttatatacat atttaaaa
//
