LOCUS       NM_145963               2659 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus potassium inwardly-rectifying channel, subfamily J,
            member 14 (Kcnj14), mRNA.
ACCESSION   NM_145963
VERSION     NM_145963.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2659)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2659)
  AUTHORS   Patel,T., Hammelman,J., Aziz,S., Jang,S., Closser,M.,
            Michaels,T.L., Blum,J.A., Gifford,D.K. and Wichterle,H.
  TITLE     Transcriptional dynamics of murine motor neuron maturation in vivo
            and in vitro
  JOURNAL   Nat Commun 13 (1), 5427 (2022)
   PUBMED   36109497
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2659)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 2659)
  AUTHORS   Kim,G.E., Ross,J.L., Xie,C., Su,K.N., Zaha,V.G., Wu,X., Palmeri,M.,
            Ashraf,M., Akar,J.G., Russell,K.S., Akar,F.G. and Young,L.H.
  TITLE     LKB1 deletion causes early changes in atrial channel expression and
            electrophysiology prior to atrial fibrillation
  JOURNAL   Cardiovasc Res 108 (1), 197-208 (2015)
   PUBMED   26378152
REFERENCE   5  (bases 1 to 2659)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2659)
  AUTHORS   Sulaiman,P., Xu,Y., Fina,M.E., Tummala,S.R., Ramakrishnan,H.,
            Dhingra,A. and Vardi,N.
  TITLE     Kir2.4 surface expression and basal current are affected by
            heterotrimeric G-proteins
  JOURNAL   J Biol Chem 288 (10), 7420-7429 (2013)
   PUBMED   23339194
  REMARK    GeneRIF: Data indicate that rectifying potassium channel Kir2.4
            interacts with G-protein subunit Galphao.
REFERENCE   7  (bases 1 to 2659)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   8  (bases 1 to 2659)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149053.3.
            
            On Mar 29, 2023 this sequence version replaced NM_145963.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030711.1, BC031753.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC149053.3         136950-137089
            141-902             AC149053.3         141573-142334
            903-2659            AC149053.3         143494-145250
FEATURES             Location/Qualifiers
     source          1..2659
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.53 cM"
     gene            1..2659
                     /gene="Kcnj14"
                     /gene_synonym="A930026G01Rik; IRK4; Kir2.4"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 14"
                     /db_xref="GeneID:211480"
                     /db_xref="MGI:MGI:2384820"
     exon            1..140
                     /gene="Kcnj14"
                     /gene_synonym="A930026G01Rik; IRK4; Kir2.4"
                     /inference="alignment:Splign:2.1.0"
     exon            141..902
                     /gene="Kcnj14"
                     /gene_synonym="A930026G01Rik; IRK4; Kir2.4"
                     /inference="alignment:Splign:2.1.0"
     exon            903..2659
                     /gene="Kcnj14"
                     /gene_synonym="A930026G01Rik; IRK4; Kir2.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2635..2640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj14"
                     /gene_synonym="A930026G01Rik; IRK4; Kir2.4"
                     /note="hexamer: AATACA"
     polyA_site      2659
                     /gene="Kcnj14"
                     /gene_synonym="A930026G01Rik; IRK4; Kir2.4"
                     /note="major polyA site"
ORIGIN      
        1 agaggttggg tgccccggct caggctcagg ccccaggggc cgaggacaga cctgaacaca
       61 ttagcaccca cagaggcccc tctccagcct gagcagagga acccccagtg cagggaatgg
      121 gggtgggcgg ccccccccag gtttggggcg cctgcccccc gctaggacag atctagaggg
      181 ggtctcccca cccaatgggc ctggctaggg ccctgcgccg cctgagcggc gcgctggagc
      241 caggaaacag tcgagctggg gatgaggaag aggcgggggc cggactgtgc cgcaatgggt
      301 gggctcctgg accggtagct gggagccggc gccgcgggcg cttcgtcaaa aaagatgggc
      361 actgcaatgt gcgcttcgtg aatctgggcg gccagggcgc gcgctaccta agtgacctgt
      421 tcaccacatg tgtggacgtg cgctggcgct ggatgtgcct gctcttctcc tgttccttcc
      481 tcgcctcctg gttgctcttc ggcctgacct tctggctcat cgcctcgctg cacggcgacc
      541 tagctgcccc accgccaccg gctccctgtt tctcgcaagt ggccagcttc ctggctgcct
      601 tcctctttgc actggagaca cagacgtcca taggctatgg tgtgcgcagc gtcaccgagg
      661 agtgtccagc tgctgtggcc gctgtggtgc tgcagtgcat cgcaggctgt gtgctcgacg
      721 ccttcgtcgt gggtgcagtt atggccaaga tggccaagcc caagaaacgc aacgagacac
      781 tagtcttcag tgagaacgca gtggtggctc tgcgagacca ccgtctctgc ctcatgtggc
      841 gggtgggcaa cctgcgacgc agtcacctgg tggaagctca cgtgcgggcc cagctgctgc
      901 agccccgtgt gacccccgag ggtgagtaca tcccactgga ccaccaggat gtagatgttg
      961 gttttgatgg aggcactgat cgcatcttcc tcgtctcccc cattaccatt gtgcatgaga
     1021 ttgactctgc cagtccactg tatgagctgg ggcgggccga gctggcccgg gctgactttg
     1081 agctggtggt cattcttgaa ggtatggttg aggccacagc catgactaca cagtgccgct
     1141 catcttacct cccaggtgag ctgctctggg gacatcgctt cgagccggtc ctcttccagc
     1201 gtggctccca gtatgaggtt gactatcgcc acttccatcg aacatatgag gtcccaggga
     1261 caccagtctg cagtgccaag gagctggatg aacgggcaga gcaggcttcc cacagcccta
     1321 agtcaagttt ccctggctcc ctcactgcat tttgttatga gaatgaactt gctctgagct
     1381 gctgccagga ggaagatgag gaggaggaca ctaaggaggg gacttcagca gagaccccag
     1441 agagggctgc cagcccccaa gctcttacac caaccctggc tctgaccctg cctccatgac
     1501 acagctgagg cccacttccc catgtgacac cccttcccaa agatgacagc ttccttccag
     1561 cctctgatgg gagtgggaca ggggtttctc aggcccagtg gcctgctgag gtgaccatta
     1621 accacgagga tgtctaccac agatagacca cacctttatt tctctgctcc attctcactc
     1681 ccgagacccc tttatgagct ggattcctga ggcttaccag agccgaagga tcagatttct
     1741 ggaccataca agagacaagg cgtggaggct gggttttggt tgaacatcag tgagatacac
     1801 agcgtcatgg aggaaaatgt caatttacac agatcaagaa acaaggattc aggatcatta
     1861 taattgacca aagacagaac agtgactgga ccgtgtgtgg agaaaaggcc cagtggctcc
     1921 agaaagccca agagttgaga ttctcttgag tctaagttga cactggggat tctaaaacag
     1981 gttggctaga ggagagtgga gctgctccag aaactacaaa gctatgtttc tagaatacac
     2041 aaaacattgg taggtttctg agtgtggaag gactaagctg acacacgaag gttccagatc
     2101 ccggaggact ctggaggact ggctgtgtag ggtccggcta gagggggtag gtaggtctgg
     2161 cttctccatg atccacaggg tgaattttgt ttttgtttga agtgccattc ttagagcatc
     2221 caaaggaatc aggttctgtg gttcagggct gatcagagtc cgggtgggat cctagctgtc
     2281 tgtgatttgc tggctccgct ctgcctagca gggctgggga cctccatgac cttggctggc
     2341 ttgctatggt tctgtaatgc caaaaggaat caaaactcca gagaccagcg ctgtcctgtc
     2401 ccaaagccta gaagtcctag tcaccttcag atggacagcc tgacagctct aggaggtaga
     2461 cactgctctg ggtggagctt gcaagcaaga gcctggacga tcacagagct aacgaatgga
     2521 aaagggaagg aagaggctga ggccggcaag cctaaaatat cctggattac tatacctagt
     2581 gatgtgtgtc tctttctcac agatattata cagatgtgta ttatatatga tataaataca
     2641 gatctctatc ttttctgtt
//
