LOCUS       NM_001110227            3056 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus potassium inwardly-rectifying channel, subfamily J,
            member 13 (Kcnj13), mRNA.
ACCESSION   NM_001110227 XM_001475110
VERSION     NM_001110227.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3056)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3056)
  AUTHORS   Jiao,X., Ma,Z., Lei,J., Liu,P., Cai,X., Shahi,P.K., Chan,C.C.,
            Fariss,R., Pattnaik,B.R., Dong,L. and Hejtmancik,J.F.
  TITLE     Retinal Development and Pathophysiology in Kcnj13 Knockout Mice
  JOURNAL   Front Cell Dev Biol 9, 810020 (2022)
   PUBMED   35096838
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3056)
  AUTHORS   Papanikolaou,M., Butt,A.M. and Lewis,A.
  TITLE     A critical role for the inward rectifying potassium channel Kir7.1
            in oligodendrocytes of the mouse optic nerve
  JOURNAL   Brain Struct Funct 225 (3), 925-934 (2020)
   PUBMED   32086565
  REMARK    GeneRIF: A critical role for the inward rectifying potassium
            channel Kir7.1 in oligodendrocytes of the mouse optic nerve.
REFERENCE   4  (bases 1 to 3056)
  AUTHORS   Papanikolaou,M., Lewis,A. and Butt,A.M.
  TITLE     Glial and neuronal expression of the Inward Rectifying Potassium
            Channel Kir7.1 in the adult mouse brain
  JOURNAL   J Anat 235 (5), 984-996 (2019)
   PUBMED   31309576
  REMARK    GeneRIF: Glial and neuronal expression of the Inward Rectifying
            Potassium Channel Kir7.1 in the adult mouse brain.
REFERENCE   5  (bases 1 to 3056)
  AUTHORS   Vera,E., Cornejo,I., Burgos,J., Niemeyer,M.I., Sepulveda,F.V. and
            Cid,L.P.
  TITLE     A novel Kir7.1 splice variant expressed in various mouse tissues
            shares organisational and functional properties with human Leber
            amaurosis-causing mutations of this K+ channel
  JOURNAL   Biochem Biophys Res Commun 514 (3), 574-579 (2019)
   PUBMED   31056263
  REMARK    GeneRIF: the presence of a novel splice variant of Kir7.1 in mouse
            tissues including kidney, lung, choroid plexus and retinal pigment
            epithelium, is reported.
REFERENCE   6  (bases 1 to 3056)
  AUTHORS   Ghamari-Langroudi,M., Digby,G.J., Sebag,J.A., Millhauser,G.L.,
            Palomino,R., Matthews,R., Gillyard,T., Panaro,B.L., Tough,I.R.,
            Cox,H.M., Denton,J.S. and Cone,R.D.
  TITLE     G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic
            neurons
  JOURNAL   Nature 520 (7545), 94-98 (2015)
   PUBMED   25600267
  REMARK    GeneRIF: Coupling of MC4R to Kir7.1 may explain unusual aspects of
            the control of energy homeostasis by melanocortin signalling,
            including the gene dosage effect of MC4R and the sustained effects
            of AgRP on food intake.
REFERENCE   7  (bases 1 to 3056)
  AUTHORS   McCloskey,C., Rada,C., Bailey,E., McCavera,S., van den Berg,H.A.,
            Atia,J., Rand,D.A., Shmygol,A., Chan,Y.W., Quenby,S., Brosens,J.J.,
            Vatish,M., Zhang,J., Denton,J.S., Taggart,M.J., Kettleborough,C.,
            Tickle,D., Jerman,J., Wright,P., Dale,T., Kanumilli,S.,
            Trezise,D.J., Thornton,S., Brown,P., Catalano,R., Lin,N.,
            England,S.K. and Blanks,A.M.
  TITLE     The inwardly rectifying K+ channel KIR7.1 controls uterine
            excitability throughout pregnancy
  JOURNAL   EMBO Mol Med 6 (9), 1161-1174 (2014)
   PUBMED   25056913
  REMARK    GeneRIF: Kir7.1 regulates the transition from quiescence to
            contractions in the pregnant uterus.
REFERENCE   8  (bases 1 to 3056)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 3056)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   10 (bases 1 to 3056)
  AUTHORS   Roepke,T.K., Kanda,V.A., Purtell,K., King,E.C., Lerner,D.J. and
            Abbott,G.W.
  TITLE     KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid
            plexus epithelium
  JOURNAL   FASEB J 25 (12), 4264-4273 (2011)
   PUBMED   21859894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ131832.1, CK623705.1 and AC157811.3.
            
            On Sep 1, 2015 this sequence version replaced NM_001110227.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189670.75084.1, CJ132004.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                CJ131832.1         5-22
            19-643              CK623705.1         1-625
            644-3056            AC157811.3         31328-33740         c
FEATURES             Location/Qualifiers
     source          1..3056
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.3 cM"
     gene            1..3056
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 13"
                     /db_xref="GeneID:100040591"
                     /db_xref="MGI:MGI:3781032"
     exon            1..118
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            119..594
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1217
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /note="inward rectifier K(+) channel Kir7.1"
                     /codon_start=1
                     /product="inward rectifier potassium channel 13"
                     /protein_id="NP_001103697.1"
                     /db_xref="CCDS:CCDS35653.1"
                     /db_xref="GeneID:100040591"
                     /db_xref="MGI:MGI:3781032"
                     /translation="MDSSNCKVNAPLLSQRHRRMVTKDGHSTLQMDGAQRGLVYLRDA
                     WGILMDMRWRWMMLVFSASFVVHWLVFAVLWYAVAEMNGDLEIDHDVPPENHTICVKH
                     ITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKI
                     ARPKNRAFSIRFTDLAVVAHKDGKPNLIFQVANTRPSPLTNVRVSAVLYQERENGELY
                     QTSVDFHLDGISSEECPFFIFPLTYYHTISPSSPLATLLQHETPPHFELVVFLSAMQE
                     GTGEICQRRTSYLPSEIMLHHRFAALMTRGSKGEYQVKMENFDKTVPEHPTPVVSKSP
                     HRTDLDIHINGQSIDNFQIAETGLTE"
     exon            595..3056
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1249..1254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /note="hexamer: ATTAAA"
     regulatory      1253..1258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /note="hexamer: AATATA"
     polyA_site      1270
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /note="major polyA site"
     polyA_site      1293
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /note="major polyA site"
     regulatory      2880..2885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /note="hexamer: AATAAA"
     polyA_site      2897
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /note="major polyA site"
     regulatory      2980..2985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /note="hexamer: AATACA"
     polyA_site      3006
                     /gene="Kcnj13"
                     /gene_synonym="100040591; Kir7.1"
                     /note="major polyA site"
ORIGIN      
        1 cagtccaaga ggagaaccta caaacgacac tacaggttaa aaccaccggg tcaaaaagac
       61 aagaggctgc tagcttcctt aagaccttct ttggtaggct ggccccacaa aggaaccgag
      121 aaacacagcc tgcgatggac agcagtaatt gtaaagtgaa tgctcctctc ctgagtcaaa
      181 gacaccggag gatggtcaca aaagacggcc acagcacact tcagatggat ggtgctcaaa
      241 ggggccttgt gtatctccga gatgcatggg gaatcctaat ggacatgcgc tggcgctgga
      301 tgatgctggt cttttctgct tcttttgttg tccactggct tgtctttgca gtcctctggt
      361 atgctgtagc tgagatgaat ggtgatctgg aaatagacca cgacgtccca cctgaaaacc
      421 acactatctg tgtgaagcac atcaccagct tcacagctgc attctccttc tctctggaga
      481 cacaacttac aattggttat ggtaccatgt ttcccagtgg tgactgtcca agtgcaatcg
      541 ccttacttgc catacaaatg ctcctaggcc tcatgctaga ggcttttatc acaggtgcct
      601 ttgtggcgaa gattgcacgg ccaaaaaata gagctttctc aattcgattc actgacttag
      661 cagttgtagc tcacaaagat ggcaaaccta atcttatctt ccaagtggcc aacacccggc
      721 ccagccctct gaccaacgtt cgtgtctctg ctgtactcta tcaggaaaga gaaaatggtg
      781 aactttacca gaccagtgtg gacttccacc ttgatggcat cagttctgag gaatgtccat
      841 tcttcatctt cccgctaacc tattaccata ctatctcacc atcaagtcct ctagctaccc
      901 tgctccaaca tgagactcct ccacactttg aattagttgt gttcctctca gcaatgcaag
      961 aaggcactgg ggaaatctgc caaaggagga catcctacct gccctctgag atcatgttac
     1021 atcaccgatt tgcagctcta atgactcgag gttccaaagg tgagtatcaa gtcaagatgg
     1081 agaattttga caagactgtt cctgaacatc caacacctgt ggtctctaag agtccacaca
     1141 ggactgacct agatattcat atcaatggac aaagcattga caatttccag attgctgaaa
     1201 cagggctgac agaataagac tcatctacac cgtcctactt cttaatgtat taaatatatg
     1261 cagccagcta tgcagctatt ttccttcact gtatctcatg tttccttgtt ctcagtgctg
     1321 attatatcat agtaatgatg tctatgccca caaaaaaaaa aagaaaaaag aaaaaaaggc
     1381 taactataca catccctcaa aacaaaaccg cctagttacc tattcatatc agtggtaatc
     1441 tgctcttatc aaggcaactc aatctgatag gtatccatgc tagcaaatct gcaaagatgt
     1501 aggcatggta tcagaaacaa tgataaaatg gacagttatg gcgcacacag ttgaactctt
     1561 aagaaaatca cctctcattt acatctgtaa actgaaacaa caaactagtt tcaaacctag
     1621 ctccctgggt agaaagctga tttcacagta tttggtgaac atccttgtac aacttttatt
     1681 tttcaacata gcaaacatca ttcctttaat tctttaaact acaaaactgg gataagcatc
     1741 tcaatttcta acagctagaa acaaaagtac aaaagaaaag taacaatatg gatttataga
     1801 gaatcccaaa agcatttgaa tacaacaccc aaatacatgt atgtatattc atgtatttgt
     1861 ggtagaaaat tcagaacaaa taagaaaagc tctgcccaga cagagcttac agggtggcat
     1921 ttctggcaaa gagatgcaaa actttgttct aactattttt aaatcttact tgcataacat
     1981 taagtagtaa tctaaaagtt aatcacctca ggacttgagc tgcttctaac gcaagtaaaa
     2041 gattatcttc gtacttatga cccattcaat gacataaaag agtcctacaa actttctaaa
     2101 tacaaatatg tatttaagtt tttataaaac aaggccttag ttaaatatat aactcaacca
     2161 ggaaaaaaat ctccaatcga taaagcaaaa aattaggtaa caaagtattt tcaaacccaa
     2221 attcctgttt ccaacatcaa atagtttttt ctataaacag aaaatgagtg tttattcacc
     2281 agtaggaggc tggactagat gatccctatt atttcattcc aagtctaata ttccatgaaa
     2341 attatgcttt ctctgcctgt ttttatttca tatatactaa gatgaacccc tttttatata
     2401 tccagcttaa aatatttctt taaacaattt tcatttcaat taaaaactga gctgagctgt
     2461 tctttaccaa acaaaaacaa aaacaaagtt atactatcaa gtttcaaaga gatctgcatg
     2521 gcttctcttc cttcccttat tcggaattaa atgggaaaag taacagatta agtttcactg
     2581 cagtggacga gccagcacaa tcatcttgaa atatagacta tgtaacagta aatgttacag
     2641 acagcagcag gtcacatttt tctactcttt gacagaaaga taagaaaaac aacaacaaca
     2701 acaaattgga gtgccctaag aatggtaata gcagaagact attaagaaca gagaacttat
     2761 ttattataaa gtttgactat aaaaatggag gcatatacgc ttccatggct tgcagaccaa
     2821 cctaaggctg ctgataaaga gcagaaattc ctattaacaa gattatcctg acctgtgaaa
     2881 ataaactgta tgtaagactc ctctgaatgt tccttcctaa agaacactta cacagatttc
     2941 aaatttatca agctgtctaa ggagactgta aatactgtga atacattaag agacttgaaa
     3001 cccaaatctc tctagaggct tcatgttgtc caattaaatc ggataaatat gtttct
//
