LOCUS       NM_010602               3671 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus potassium inwardly rectifying channel, subfamily J,
            member 11 (Kcnj11), transcript variant 1, mRNA.
ACCESSION   NM_010602
VERSION     NM_010602.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3671)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3671)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3671)
  AUTHORS   Grizzanti,J., Moritz,W.R., Pait,M.C., Stanley,M., Kaye,S.D.,
            Carroll,C.M., Constantino,N.J., Deitelzweig,L.J., Snipes,J.A.,
            Kellar,D., Caesar,E.E., Pettit-Mee,R.J., Day,S.M., Sens,J.P.,
            Nicol,N.I., Dhillon,J., Remedi,M.S., Kiraly,D.D., Karch,C.M.,
            Nichols,C.G., Holtzman,D.M. and Macauley,S.L.
  TITLE     KATP channels are necessary for glucose-dependent increases in
            amyloid-beta and Alzheimer's disease-related pathology
  JOURNAL   JCI Insight 8 (10), e162454 (2023)
   PUBMED   37129980
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3671)
  AUTHORS   Gong,Y., Laheji,F., Berenson,A., Qian,A., Park,S.O., Kok,R.,
            Selig,M., Hahn,R., Sadjadi,R., Kemp,S. and Eichler,F.
  TITLE     Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical
            Allodynia
  JOURNAL   Cells 11 (11), 1842 (2022)
   PUBMED   35681537
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3671)
  AUTHORS   Arrell,D.K., Park,S., Yamada,S., Alekseev,A.E., Garmany,A.,
            Jeon,R., Vuckovic,I., Lindor,J.Z. and Terzic,A.
  TITLE     KATP channel dependent heart multiome atlas
  JOURNAL   Sci Rep 12 (1), 7314 (2022)
   PUBMED   35513538
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3671)
  AUTHORS   Suzuki,M., Fujikura,K., Inagaki,N., Seino,S. and Takata,K.
  TITLE     Localization of the ATP-sensitive K+ channel subunit Kir6.2 in
            mouse pancreas
  JOURNAL   Diabetes 46 (9), 1440-1444 (1997)
   PUBMED   9287044
REFERENCE   7  (bases 1 to 3671)
  AUTHORS   Yamada,M., Isomoto,S., Matsumoto,S., Kondo,C., Shindo,T., Horio,Y.
            and Kurachi,Y.
  TITLE     Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive
            but ATP-insensitive K+ channel
  JOURNAL   J Physiol 499 (Pt 3) (Pt 3), 715-720 (1997)
   PUBMED   9130167
REFERENCE   8  (bases 1 to 3671)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P., Wang,C.Z., Aguilar-Bryan,L.,
            Bryan,J. and Seino,S.
  TITLE     A family of sulfonylurea receptors determines the pharmacological
            properties of ATP-sensitive K+ channels
  JOURNAL   Neuron 16 (5), 1011-1017 (1996)
   PUBMED   8630239
REFERENCE   9  (bases 1 to 3671)
  AUTHORS   Sakura,H., Ammala,C., Smith,P.A., Gribble,F.M. and Ashcroft,F.M.
  TITLE     Cloning and functional expression of the cDNA encoding a novel
            ATP-sensitive potassium channel subunit expressed in pancreatic
            beta-cells, brain, heart and skeletal muscle
  JOURNAL   FEBS Lett 377 (3), 338-344 (1995)
   PUBMED   8549751
REFERENCE   10 (bases 1 to 3671)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P. 4th, Namba,N., Inazawa,J.,
            Gonzalez,G., Aguilar-Bryan,L., Seino,S. and Bryan,J.
  TITLE     Reconstitution of IKATP: an inward rectifier subunit plus the
            sulfonylurea receptor
  JOURNAL   Science 270 (5239), 1166-1170 (1995)
   PUBMED   7502040
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115036.10.
            
            On Oct 12, 2022 this sequence version replaced NM_010602.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC057006.1, AK032689.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3671              AC115036.10        9040-12710
FEATURES             Location/Qualifiers
     source          1..3671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.66 cM"
     gene            1..3671
                     /gene="Kcnj11"
                     /gene_synonym="Kir6.2; mBIR"
                     /note="potassium inwardly rectifying channel, subfamily J,
                     member 11"
                     /db_xref="GeneID:16514"
                     /db_xref="MGI:MGI:107501"
     exon            1..3671
                     /gene="Kcnj11"
                     /gene_synonym="Kir6.2; mBIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             895..2067
                     /gene="Kcnj11"
                     /gene_synonym="Kir6.2; mBIR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-sensitive inward rectifier potassium channel 11;
                     inward rectifier K(+) channel Kir6.2"
                     /codon_start=1
                     /product="ATP-sensitive inward rectifier potassium channel
                     11 isoform 1"
                     /protein_id="NP_034732.1"
                     /db_xref="CCDS:CCDS21274.1"
                     /db_xref="GeneID:16514"
                     /db_xref="MGI:MGI:107501"
                     /translation="MLSRKGIIPEEYVLTRLAEDPAEPRYRTRERRARFVSKKGNCNV
                     AHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMVWWLIAFAHGDLAP
                     GEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMIN
                     AIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQ
                     VVRKTTSPEGEVVPLHQVDIPMENGVGGNGIFLVAPLIIYHVIDSNSPLYDLAPSDLH
                     HHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFG
                     NTIKVPTPLCTARQLDEDRSLLDALTLASSRGPLRKRSVAVAKAKPKFSISPDSLS"
     regulatory      3610..3615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj11"
                     /gene_synonym="Kir6.2; mBIR"
                     /note="hexamer: AATAAA"
     polyA_site      3630
                     /gene="Kcnj11"
                     /gene_synonym="Kir6.2; mBIR"
                     /note="major polyA site"
     polyA_site      3671
                     /gene="Kcnj11"
                     /gene_synonym="Kir6.2; mBIR"
ORIGIN      
        1 actcgctctc gggagccccc cgcccgcagc ctcccacccc caccgcgcac gggtcggtgc
       61 ctgaggacgg gctcacagac acacgccagg gaagccggcc gggagtgagc aacccggagt
      121 gggagggggc agggaggtgg ccgctgcttg agcagcacga gcaggtgcgg cggcgacagg
      181 cggggtggga acggagcggc ggcgggggct gcgggcgggc ggcagggcag cagggaggcc
      241 gcgacgcgga gccactgggg tctgggcggc ggggggcgag gggatccaga gcgtagacgg
      301 ttgcggggtg actcgaaggg caccggatcc caaggagact agaggacaag ggctagagaa
      361 ggaacgggag agcggcgagg gagccagggg aggggtggga tgggaaatcc ggggcacacc
      421 tggagaggag actgggtcaa gaagtaaggc tggtccttgg aggggaccgg ggacagaagt
      481 gggtgaggtc agagaagagc gcgggggggg gggtgctgag gggggggtcg agtgagggct
      541 ggtaagttgg gagacccgga ggtgacaagt tctgaggtgg tttgagaaga aaggctgggc
      601 cagggaaagg gagttagagg ggggtcctgg ggcggtggag gagagctgag cgggtagagc
      661 acaagctggg ttgggggctc agtaagcaat gagcaggtgg agccggcatc tgaggctagt
      721 agtataaaga gaagcagaac ccagctgagg ggcataccag cctagaggtt ggtacaagct
      781 tagggtaacc tgaggagagg gctcagagag ggggacccca caaagaggcc ctaggccaag
      841 ccagtgtagt gcctcccccc atgggggaaa ccccttcccg gggccaacgg agccatgctg
      901 tcccgaaagg gcattatccc tgaggaatat gtgctgaccc ggctggcaga ggaccctgca
      961 gagcccaggt accgtactcg agagaggagg gcccgcttcg tgtccaagaa aggcaactgc
     1021 aacgtcgccc acaagaacat tcgagagcag ggccgcttcc tgcaggatgt gttcaccacg
     1081 ctggtggacc tcaaatggcc acacactctg ctcattttca ccatgtcctt cctgtgcagc
     1141 tggctgctct ttgccatggt ctggtggctc atcgccttcg cccacggtga cctggccccc
     1201 ggagagggca ccaatgtgcc ctgcgtcaca agcatccact ccttttcatc tgccttcctt
     1261 ttctccatcg aggtccaggt gaccattggt ttcggcgggc gcatggtgac agaggaatgt
     1321 cccctggcca tcctcattct cattgtgcag aatatcgtcg ggctgatgat caacgccatc
     1381 atgctgggct gcatcttcat gaaaacggcc caggcccatc ggcgggcaga aaccctcatc
     1441 ttcagcaagc atgctgtgat caccctgcgc catggccgcc tgtgcttcat gctgcgcgta
     1501 ggggacctcc gaaagagcat gatcattagc gccaccatcc acatgcaggt ggtgcgcaag
     1561 accaccagcc ccgagggcga agttgtgcct ctccaccagg tagacatccc catggagaat
     1621 ggcgtgggtg gtaacggcat cttcctggtg gccccactca tcatctacca cgtcatcgac
     1681 tccaacagcc cgctctacga cctggctcct agtgacctgc accaccacca ggacctggag
     1741 atcattgtca tcttggaagg cgtggtagaa accacgggca tcaccaccca ggcccgcacc
     1801 tcctacctag ctgacgagat tctatggggg cagcgctttg tccccattgt ggccgaggag
     1861 gacggccgct attctgtgga ctactccaaa tttggtaaca ccattaaagt gcccacacca
     1921 ctctgcacag cccgccagct tgatgaggac cgcagtctgc tggatgccct gaccctcgcc
     1981 tcgtcgcggg ggcccctgcg caagcgcagt gtggctgtgg cgaaggccaa gcccaagttt
     2041 agcatctctc cagattcctt gtcctgagtt gcagttcctc aggcccccac tcacttgtgt
     2101 gggcacgtgg aaagtgaagt atggtatgta gagtggtggg gtgcgagcct cttggccaga
     2161 cgagggtctg gtgtgggaca agaccctgct cggctcagcc tccccgctgc tgtgtgtctg
     2221 gggtgttaca agatacttgt cactatgcta tttctggccc cagcaggagc ctgtaccggg
     2281 ttatttttgt tcctgctcct cccaggctca gctcgggact ggtttacccc tgtgtccctg
     2341 cccaacggtg gggagaccac agaaggttca gggcctctaa agctaaggtc tcaaagcccg
     2401 tcttggccct ccatgattca tcttgccaca agcagacagg taattgggca aaagcaaccc
     2461 cccaagttgg cagcctattg ttgtttctgt agccactaag aaatacctgg ccaggcccca
     2521 gccctgttcg tgccatgctg aagtatcctg ccagccaggg aggaaggtgg gtgtcagagc
     2581 atgggagctg aggagcccac acagacacgg cgggataagt ctacctaggc tcacctccat
     2641 aaggcaggct tgtgtgaggc agggggacaa gaagggggca aatgattgga gacctttcta
     2701 gtcctgtgca gacatgtgtc cctgtcctct agccttgact cagccttctg ctgacagtca
     2761 ggagtgctgc ctcattttgt cgtcgttccc cccccccccc agaggctggg gagtggagtg
     2821 ttgggcaaac actgatatac ctggatgaga ggccaaaagg ggtcctgtgc ttgccataca
     2881 agatgcactt caggcaaaac tctgctttca gctcccatgg gcagctgtga gtcactttgt
     2941 ctgggggacg ctggtggggt agcggtgcct tgtctgggtt actagaaaaa gaaatattgg
     3001 gaagttcagc ctggtgaggg aaaaggaagt ccccaaggcc cttgggcatg acctgagcct
     3061 ggactctcag agcagtgtgg tgtccttgcc cagaactcca ctgccccatt gtcataaagc
     3121 ctcccacctg tgacctgaac tctgggcgtt tcttgctggg gaggcagtgg gcatgccact
     3181 ggaaaaaaat aaagggcact gccagagtct gccacccaac atggccctga caggcaagag
     3241 gccaggaaag ctacttagac cagctctgtt tccctcatct ctggaagcca ccatccttcc
     3301 acctcaggtc cccccacccc cacccattct ctgtctgtct ggccaacttg gccatttgac
     3361 atccaccaga catcgtagtc aagggcctgg cctccctccc gagactctgc tggaaggctg
     3421 aggtagccat ggggagggaa gagagacgtt gtaagcttta gggcactgat tggttcaaat
     3481 cctggctccg gccgaacagc tctgtgactc agttgtctca ttcatgttaa tagtcccacc
     3541 tcattaagct gagcaggtga aagcacatgt atccatgctt cagaagtgcc tggtctataa
     3601 caagtactca ataaatgtta actgtcgtga tcgctgctgg gctagccgcg tgatgggaaa
     3661 actgaaccta a
//
