LOCUS       NM_001039484            5407 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus potassium inwardly-rectifying channel, subfamily J,
            member 10 (Kcnj10), mRNA.
ACCESSION   NM_001039484
VERSION     NM_001039484.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5407)
  AUTHORS   Feng,Y.H., Tang,R.J., Zhang,Y.Y., Lin,J., Liu,Y.J., Li,Y.K.,
            Li,C.J., Zhou,C., Liu,F. and Shen,J.F.
  TITLE     Contribution of inwardly rectifying potassium channel 4.1 in
            orofacial neuropathic pain: Regulation of pannexin 3 via the
            reactive oxygen species-activated P38 MAPK signal pathway
  JOURNAL   Eur J Neurosci 60 (4), 4569-4585 (2024)
   PUBMED   38992988
  REMARK    GeneRIF: Contribution of inwardly rectifying potassium channel 4.1
            in orofacial neuropathic pain: Regulation of pannexin 3 via the
            reactive oxygen species-activated P38 MAPK signal pathway.
REFERENCE   2  (bases 1 to 5407)
  AUTHORS   Peters,C., Aberle,T., Sock,E., Brunner,J., Kuspert,M.,
            Hillgartner,S., Wust,H.M. and Wegner,M.
  TITLE     Voltage-Gated Ion Channels Are Transcriptional Targets of Sox10
            during Oligodendrocyte Development
  JOURNAL   Cells 13 (13), 1159 (2024)
   PUBMED   38995010
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5407)
  AUTHORS   Tan,R.L., Sciandra,F., Hubner,W., Bozzi,M., Reimann,J., Schoch,S.,
            Brancaccio,A. and Blaess,S.
  TITLE     The missense mutation C667F in murine beta-dystroglycan causes
            embryonic lethality, myopathy and blood-brain barrier
            destabilization
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38616731
REFERENCE   4  (bases 1 to 5407)
  AUTHORS   Bataveljic,D., Pivonkova,H., de Concini,V., Hebert,B., Ezan,P.,
            Briault,S., Bemelmans,A.P., Pichon,J., Menuet,A. and Rouach,N.
  TITLE     Astroglial Kir4.1 potassium channel deficit drives neuronal
            hyperexcitability and behavioral defects in Fragile X syndrome
            mouse model
  JOURNAL   Nat Commun 15 (1), 3583 (2024)
   PUBMED   38678030
  REMARK    GeneRIF: Astroglial Kir4.1 potassium channel deficit drives
            neuronal hyperexcitability and behavioral defects in Fragile X
            syndrome mouse model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5407)
  AUTHORS   Cleary,C.M., Browning,J.L., Armbruster,M., Sobrinho,C.R.,
            Strain,M.L., Jahanbani,S., Soto-Perez,J., Hawkins,V.E., Dulla,C.G.,
            Olsen,M.L. and Mulkey,D.K.
  TITLE     Kir4.1 channels contribute to astrocyte CO2/H+-sensitivity and the
            drive to breathe
  JOURNAL   Commun Biol 7 (1), 373 (2024)
   PUBMED   38548965
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5407)
  AUTHORS   Kofuji,P., Ceelen,P., Zahs,K.R., Surbeck,L.W., Lester,H.A. and
            Newman,E.A.
  TITLE     Genetic inactivation of an inwardly rectifying potassium channel
            (Kir4.1 subunit) in mice: phenotypic impact in retina
  JOURNAL   J Neurosci 20 (15), 5733-5740 (2000)
   PUBMED   10908613
REFERENCE   7  (bases 1 to 5407)
  AUTHORS   Kurschner,C. and Yuzaki,M.
  TITLE     Neuronal interleukin-16 (NIL-16): a dual function PDZ domain
            protein
  JOURNAL   J Neurosci 19 (18), 7770-7780 (1999)
   PUBMED   10479680
REFERENCE   8  (bases 1 to 5407)
  AUTHORS   Mayeda,A.R. and Hofstetter,J.R.
  TITLE     A QTL for the genetic variance in free-running period and level of
            locomotor activity between inbred strains of mice
  JOURNAL   Behav Genet 29 (3), 171-176 (1999)
   PUBMED   10547923
REFERENCE   9  (bases 1 to 5407)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
REFERENCE   10 (bases 1 to 5407)
  AUTHORS   Tada,Y., Horio,Y., Takumi,T., Terayama,M., Tsuji,L., Copeland,N.G.,
            Jenkins,N.A. and Kurachi,Y.
  TITLE     Assignment of the glial inwardly rectifying potassium channel
            KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome
            1
  JOURNAL   Genomics 45 (3), 629-630 (1997)
   PUBMED   9367690
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048864.1, AK044640.1 and AC074311.28.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB651348.1, BC099932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-935               AK048864.1         4-938
            936-1887            AK044640.1         860-1811
            1888-2163           AK048864.1         1891-2166
            2164-5407           AC074311.28        134239-137482
FEATURES             Location/Qualifiers
     source          1..5407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.69 cM"
     gene            1..5407
                     /gene="Kcnj10"
                     /gene_synonym="BIR10; BIRK-1; Kir1.2; Kir4.1"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 10"
                     /db_xref="GeneID:16513"
                     /db_xref="MGI:MGI:1194504"
     exon            1..242
                     /gene="Kcnj10"
                     /gene_synonym="BIR10; BIRK-1; Kir1.2; Kir4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            243..5407
                     /gene="Kcnj10"
                     /gene_synonym="BIR10; BIRK-1; Kir1.2; Kir4.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1382
                     /gene="Kcnj10"
                     /gene_synonym="BIR10; BIRK-1; Kir1.2; Kir4.1"
                     /note="inward rectifier K(+) channel Kir4.1; potassium
                     channel, inwardly rectifying subfamily J member 10"
                     /codon_start=1
                     /product="ATP-sensitive inward rectifier potassium channel
                     10"
                     /protein_id="NP_001034573.1"
                     /db_xref="CCDS:CCDS15512.1"
                     /db_xref="GeneID:16513"
                     /db_xref="MGI:MGI:1194504"
                     /translation="MTSVAKVYYSQTTQTESRPLVAPGIRRRRVLTKDGRSNVRMEHI
                     ADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELGPP
                     ANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIF
                     ITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLL
                     QTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGD
                     FELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIADFSLFDQVV
                     KVASPSGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV"
     regulatory      5384..5389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnj10"
                     /gene_synonym="BIR10; BIRK-1; Kir1.2; Kir4.1"
                     /note="hexamer: AATAAA"
     polyA_site      5407
                     /gene="Kcnj10"
                     /gene_synonym="BIR10; BIRK-1; Kir1.2; Kir4.1"
                     /note="major polyA site"
ORIGIN      
        1 acaaagtttg gcttcggcac tgcagaggga gggggcggcc cggcccggcc caactctgcc
       61 cccggccggc ccgaccccgg ccccggcccc cggacaaacc cttatctgat tccagctccg
      121 ggtttaagag tcttggccct gcctgtcgca cagctccgct cgccgctcct gcccgccccg
      181 tctgttcatc tgtcccgctg ccccgcgatt tatcagagca gccacttcac cttcgagcca
      241 agatgacgtc ggtcgctaag gtctattaca gtcagacgac tcagacagag agccgccccc
      301 tagtggcccc aggaatacgc cggaggaggg tcctcacgaa agacggccgg agcaatgtga
      361 gaatggagca cattgctgac aaacgtttcc tctacctcaa ggatctatgg acgaccttca
      421 ttgacatgca atggcgctac aagcttctgc tcttctctgc aacctttgca ggcacgtggt
      481 tcctctttgg tgtggtgtgg tatctggtag ctgtggccca tggggacctg ttggagctgg
      541 gacctcctgc caaccacacg ccttgtgtgg tgcaggtgca cacgctcacc ggagccttcc
      601 tcttctccct ggaatcccag accaccatcg gctatggctt ccgctacatc agtgaggaat
      661 gcccactggc catcgtgctt cttattgcgc agctggtgct caccaccatt ctggaaatct
      721 tcatcacagg taccttcctt gcaaagattg cccggcctaa gaagagggcc gagacgatcc
      781 gcttcagcca gcatgccgtt gtggcttccc ataacgggaa gccttgcctt atgatccggg
      841 ttgccaatat gcggaagagt ctcctcattg gatgccaggt gacaggcaaa ctgcttcaaa
      901 cgcaccagac aaaggagggt gagaatattc ggctcaacca ggtcaacgtg actttccaag
      961 tagacacagc ctcagacagc ccctttctca tcctacccct gactttctac cacgtggtag
     1021 atgagaccag ccccttaaaa gatctcccgc tccgcagtgg ggagggggac tttgagctgg
     1081 tgctgatcct gagtgggaca gtggagtcca ccagtgccac ctgccaagtt cgcacttcct
     1141 acctaccgga ggagatcctc tggggttacg agttcacgcc tgcgatctca ctgtcagcca
     1201 gtggcaaata catagctgac ttcagccttt tcgaccaggt tgtgaaagtg gcatctccca
     1261 gtggtctccg cgatagcacc gtacgctatg gagaccccga gaagctcaag ttggaggagt
     1321 cattaagaga gcaagctgaa aaggaaggca gtgcccttag tgtgcgcatc agcaacgtct
     1381 gatatcctgt tctctcctcc ccagccctct ggccttttcc tcttccagtg ctctgggaaa
     1441 aggatacaat ctgggttcgc tggagagacc ctgaagcacc caccctcaac ttccccttag
     1501 cccggtggcc tgtgagcagt cggggcctgc tggagccctt ccttttcctc tcactgtccc
     1561 cttgtacctt cctctaccac tacaccaatg tatatgactc ttaagccagc ttgggggaaa
     1621 gagagggaag atgaggctga catggcttgg aaggccgcag ccatgcttgg agattcacat
     1681 tcagaggacc atgtgactgg atggatagac tcccccccaa acgcccacca ctagaaaatt
     1741 tgatggcttg agactggagc ttcctccttt tctcttccat ctagctaagt tccctgaggc
     1801 agaactctct cagagagtca ctctatgggc tctgccctca gaagtactgg gatctgaaat
     1861 cagttttccc tgggctatca aatcctgaag aaagaagcca gagtttgtca tggtgtttta
     1921 atttcagctg gtaactcctg acagagcctg gactcttggt caccacctaa ttttccctct
     1981 ccagttctca agtggatctt ctcagcaaag ccggttctct ctcagcttct gtttctgtag
     2041 aactggggtt gactcgagaa acacaagcag ccacctttcc tgcacccatc ctggattctg
     2101 agaaattcaa ttttggaaat actgtctaat actctggccc tgtcctttgg gcagctctgt
     2161 cctgaaaaga tatgttttag tgtttcctgg gaataggaag accttaacca atgctctctc
     2221 tctctctctc tctctctctc tctctctctc tctctctctc cctccctccc tccctccctc
     2281 cctccctccc tccctccctc cctctctctc tctctctctc tctctctctc tctctctctt
     2341 tcatgggctg tccttgaatt tactatgtag actaggctgg ccttgaactc acagatacct
     2401 agctgcctcc gtctcccata tactgggatt aaaggcatga accactatgc caagccccca
     2461 atgttctctt gaataagtcc attgcacata cctcacgaaa atatctaaaa ccatccagat
     2521 tacactgtac cagttccatt gcttcctttt ctcccacccc agaccttccc ttaactcaac
     2581 cttttgaagt aagagaggga aacatggtca tttgcctttc ttaacatcga tctattaaaa
     2641 ctagtcacag ggcacagatt ccccaggaaa gctgaaccca cttctcagat ttccagattg
     2701 ctgtacagag cctcggggaa tttgtgatgt tttgttatgg tttgggctga ggcagaactc
     2761 tggctgacag ccactatttt gttccatctc ctggtgccct tctgagaagt gccagctatt
     2821 ttatgaggca atgctgagag gagaggaact tacattctga tctctgccat tctgacacct
     2881 ggcataaaat gatgaaaacc agcgccatct ctcctctttt ctgcctacgg gccagttcca
     2941 ggcaaattac aaagacagct taagatcaca cccaagccat tcctagttct ctggtgaggg
     3001 ttgtggcagg ggtcatggaa gggcatttga agcaccaggt cctgtcctag tgagctttgg
     3061 ctccacttgg gtacccagga aacctcgcaa ggtagtttgg caggaatgac gtaagctgta
     3121 aggtggactt gacagatgac aagcgacaca tctatacaga atgcatgccc ggatctctgg
     3181 gcaaagcctt gcagagaaac tcagaagatc ccaagactga gtggatctca actgtgcaca
     3241 gtctttttac gttggtcttc ccttgaactc aattaactgt agcctgaaaa cgaagagcct
     3301 ttggtctctc cttactgtaa agctcaccgt tagcctccaa ctctcatcaa caaccagaac
     3361 cagaagaacc tgaatgtctg aaacaaagag cagaaggcaa gagccagctt atgtgctttc
     3421 aaatacattc aacgctgcgc ttacctgatg tgtccagtgt gcaaggacca tgtgtactgc
     3481 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtctt cttatcctgt
     3541 ggcaatttat cctctgtcct gtttcttctt cacattgctg cttcccttct gagggaatga
     3601 ccctcgtccc agagccttgc caaggcccaa ctctcctcag aatcttggat aacaatgtga
     3661 gagagcattt cctgccttaa ccccttttga acttcctcta caatcccagg ctttgctcta
     3721 agttgcactt taaaatcatt taaaaatcat taacatctgt cctgttaatt cagaattcag
     3781 aacggcacct ttctccaaca agccttatgt tctgcagaac aactcccact cacaacccta
     3841 agtggttctt tagatcccag cccgactctc tgacctgaaa tcctttctca ggatgcaggg
     3901 caagctttac taacagccac ggctgatgaa aaatgggttc cctgtctgta ccagctagag
     3961 acttggaatg tcaggagaat aacaggtgcg ccaattctaa gtgggatggg agatttcagg
     4021 tgagcaaaac gaccaatggg gaaggatctc cagagtgggg aaaaagtgaa cgacgaggct
     4081 aaggggccta gggagatgaa actcagagtc ttacttactt atgactgaca cacaggaggt
     4141 ggggggaaac ttgggagatt gagatatgat atatgtttat ctaaggagaa aaacagagat
     4201 aatatataca gagaaatgta catagatgta catataccca aatatacgga ctgtacagaa
     4261 ggaagtattc agactttaac aaagggacaa atattttgcc ttggtttggg ggagcaggat
     4321 agctggatct tctgtgttat ggtctgaaca acagtgacag tagctgatgg ttttaagttt
     4381 gcttgatgga aaagggaggg ctagaccctg cccttttcat aaataaagga gcatccgtcg
     4441 aggtttgatg aattgtgctg gcaggacaag aggaaaacta ggaggaaatg ggacacaggg
     4501 atgctccact catggagaag taggaaaatc taccactcac acaatccctg gccaacaacc
     4561 tgccgctgaa caagttctaa aacaagcaag caagggagca agtaagcgat cgagcaagcg
     4621 agcaaacaaa agcatccttc cattttcctc tcttcttcca ccaagatggg agctgtaggt
     4681 ctaggcccca tcattaaaaa ttgagaagct gaaattttag tacggggggg tgtgtcaaat
     4741 gcaaacacta gaatgcaagc cctaggactg atgagctgtt gagctcaaga tactctcaag
     4801 gcagaggccc aagcctatat agagaaatcc taaagagggt acttcatctg tcatcgtctc
     4861 agccccggcg tggaggcagg tgaatgcgat ggctacaagg cttcttgatg gaaatgcaga
     4921 attctgcttt cctcttcccc agaggctgat gcagttctat gcaaagcttc tgaaatccct
     4981 aacctgggct tcacttcatt ctggctgctc cctactgttc ctcccactct ctgaaaccca
     5041 caccagctag cactatgcag ggatttccct gaggtcagca gaaaaagaaa agcagtcgta
     5101 atgtggctat tagccaggga cattgcacat tctccaaggc ttgctaccac aaacctttac
     5161 ccatgctagc taacctagtt tctttgcaaa ataacacatt acctatgctg tgcatagctg
     5221 ggcttgcagg cccagtattg gccagtgcta ctgaaacaga agaatctagg gatgatttct
     5281 ctacacgctg cattaaagac taaaccaggt caaatgtatt tagaaaaaaa aagatgtgtg
     5341 aggcattttt ggtttatttt tgtctgttca gaacaaacta ctaaataaac tggatgcatc
     5401 tcttgtt
//
