LOCUS       NM_001199242            2362 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Kv channel interacting protein 4 (Kcnip4), transcript
            variant 1, mRNA.
ACCESSION   NM_001199242
VERSION     NM_001199242.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2362)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2362)
  AUTHORS   Wang,W., Cho,H., Lee,J.W. and Lee,S.K.
  TITLE     The histone demethylase Kdm6b regulates subtype diversification of
            mouse spinal motor neurons during development
  JOURNAL   Nat Commun 13 (1), 958 (2022)
   PUBMED   35177643
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2362)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2362)
  AUTHORS   Himes,B.E., Sheppard,K., Berndt,A., Leme,A.S., Myers,R.A.,
            Gignoux,C.R., Levin,A.M., Gauderman,W.J., Yang,J.J., Mathias,R.A.,
            Romieu,I., Torgerson,D.G., Roth,L.A., Huntsman,S., Eng,C.,
            Klanderman,B., Ziniti,J., Senter-Sylvia,J., Szefler,S.J.,
            Lemanske,R.F. Jr., Zeiger,R.S., Strunk,R.C., Martinez,F.D.,
            Boushey,H., Chinchilli,V.M., Israel,E., Mauger,D., Koppelman,G.H.,
            Postma,D.S., Nieuwenhuis,M.A., Vonk,J.M., Lima,J.J., Irvin,C.G.,
            Peters,S.P., Kubo,M., Tamari,M., Nakamura,Y., Litonjua,A.A.,
            Tantisira,K.G., Raby,B.A., Bleecker,E.R., Meyers,D.A., London,S.J.,
            Barnes,K.C., Gilliland,F.D., Williams,L.K., Burchard,E.G.,
            Nicolae,D.L., Ober,C., DeMeo,D.L., Silverman,E.K., Paigen,B.,
            Churchill,G., Shapiro,S.D. and Weiss,S.T.
  TITLE     Integration of mouse and human genome-wide association data
            identifies KCNIP4 as an asthma gene
  JOURNAL   PLoS One 8 (2), e56179 (2013)
   PUBMED   23457522
  REMARK    GeneRIF: Genome-wide association study identifies KCNIP4 as an
            asthma gene in human and in mouse.
REFERENCE   5  (bases 1 to 2362)
  AUTHORS   Norris,A.J., Foeger,N.C. and Nerbonne,J.M.
  TITLE     Interdependent roles for accessory KChIP2, KChIP3, and KChIP4
            subunits in the generation of Kv4-encoded IA channels in cortical
            pyramidal neurons
  JOURNAL   J Neurosci 30 (41), 13644-13655 (2010)
   PUBMED   20943905
REFERENCE   6  (bases 1 to 2362)
  AUTHORS   Pruunsild,P. and Timmusk,T.
  TITLE     Structure, alternative splicing, and expression of the human and
            mouse KCNIP gene family
  JOURNAL   Genomics 86 (5), 581-593 (2005)
   PUBMED   16112838
REFERENCE   7  (bases 1 to 2362)
  AUTHORS   Xiong,H., Kovacs,I. and Zhang,Z.
  TITLE     Differential distribution of KChIPs mRNAs in adult mouse brain
  JOURNAL   Brain Res Mol Brain Res 128 (2), 103-111 (2004)
   PUBMED   15363885
  REMARK    GeneRIF: KChIP4 was highly expressed by neurons in layers II-IV of
            cortex and in hippocampus, thalamus and the Purkinje cell layer of
            the cerebellum.
REFERENCE   8  (bases 1 to 2362)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2362)
  AUTHORS   Morohashi,Y., Hatano,N., Ohya,S., Takikawa,R., Watabiki,T.,
            Takasugi,N., Imaizumi,Y., Tomita,T. and Iwatsubo,T.
  TITLE     Molecular cloning and characterization of CALP/KChIP4, a novel
            EF-hand protein interacting with presenilin 2 and voltage-gated
            potassium channel subunit Kv4
  JOURNAL   J Biol Chem 277 (17), 14965-14975 (2002)
   PUBMED   11847232
REFERENCE   10 (bases 1 to 2362)
  AUTHORS   Holmqvist,M.H., Cao,J., Hernandez-Pineda,R., Jacobson,M.D.,
            Carroll,K.I., Sung,M.A., Betty,M., Ge,P., Gilbride,K.J.,
            Brown,M.E., Jurman,M.E., Lawson,D., Silos-Santiago,I., Xie,Y.,
            Covarrubias,M., Rhodes,K.J., Distefano,P.S. and An,W.F.
  TITLE     Elimination of fast inactivation in Kv4 A-type potassium channels
            by an auxiliary subunit domain
  JOURNAL   Proc Natl Acad Sci U S A 99 (2), 1035-1040 (2002)
   PUBMED   11805342
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051130.1 and AK148685.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ148501.1, BC051130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1188              BC051130.1         1-1188
            1189-2362           AK148685.1         1232-2405
FEATURES             Location/Qualifiers
     source          1..2362
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 26.26 cM"
     gene            1..2362
                     /gene="Kcnip4"
                     /gene_synonym="Calp; Calp250; KChIP4; KChIP4a"
                     /note="Kv channel interacting protein 4"
                     /db_xref="GeneID:80334"
                     /db_xref="MGI:MGI:1933131"
     exon            1..264
                     /gene="Kcnip4"
                     /gene_synonym="Calp; Calp250; KChIP4; KChIP4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..956
                     /gene="Kcnip4"
                     /gene_synonym="Calp; Calp250; KChIP4; KChIP4a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calsenilin-like protein; kv channel-interacting protein 4;
                     potassium channel interacting protein 4; A-type potassium
                     channel modulatory protein 4"
                     /codon_start=1
                     /product="Kv channel-interacting protein 4 isoform 1"
                     /protein_id="NP_001186171.1"
                     /db_xref="CCDS:CCDS57342.1"
                     /db_xref="GeneID:80334"
                     /db_xref="MGI:MGI:1933131"
                     /translation="MNVRRVESISAQLEEASSTGGFLYAQNNTKRSIKERLMKLLPCS
                     AAKTSSPAIQNSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGV
                     VNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEK
                     LNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDK
                     NKDGVVTIDEFIESCQKDENIMRSMQLFENVI"
     exon            265..366
                     /gene="Kcnip4"
                     /gene_synonym="Calp; Calp250; KChIP4; KChIP4a"
                     /inference="alignment:Splign:2.1.0"
     exon            367..491
                     /gene="Kcnip4"
                     /gene_synonym="Calp; Calp250; KChIP4; KChIP4a"
                     /inference="alignment:Splign:2.1.0"
     exon            492..561
                     /gene="Kcnip4"
                     /gene_synonym="Calp; Calp250; KChIP4; KChIP4a"
                     /inference="alignment:Splign:2.1.0"
     exon            562..632
                     /gene="Kcnip4"
                     /gene_synonym="Calp; Calp250; KChIP4; KChIP4a"
                     /inference="alignment:Splign:2.1.0"
     exon            633..740
                     /gene="Kcnip4"
                     /gene_synonym="Calp; Calp250; KChIP4; KChIP4a"
                     /inference="alignment:Splign:2.1.0"
     exon            741..845
                     /gene="Kcnip4"
                     /gene_synonym="Calp; Calp250; KChIP4; KChIP4a"
                     /inference="alignment:Splign:2.1.0"
     exon            846..908
                     /gene="Kcnip4"
                     /gene_synonym="Calp; Calp250; KChIP4; KChIP4a"
                     /inference="alignment:Splign:2.1.0"
     exon            909..2362
                     /gene="Kcnip4"
                     /gene_synonym="Calp; Calp250; KChIP4; KChIP4a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2338
                     /gene="Kcnip4"
                     /gene_synonym="Calp; Calp250; KChIP4; KChIP4a"
                     /note="major polyA site"
ORIGIN      
        1 gccccccgcc ggcctccgcc tgcacctgca aggcttcgcg cgccctgcct gccgccgccg
       61 ccgccgctgc cgctgcctcc agctcccagc gtcttggtcg cccaggacag agtggctgtg
      121 cgctcccgta gcggacccat cgccagacgc ccctgggtca gtggactcta agagtgtcgc
      181 tccggcatcc agtgtcctta aagatgaacg tgagaagggt ggaaagcatc tcggctcagc
      241 tggaggaggc gagctccaca ggcggtttcc tctacgcgca gaacaacacc aagcgcagca
      301 ttaaagagcg gctcatgaag ctcttgccct gctcagctgc caaaacgtcg tctcctgcta
      361 ttcaaaacag cgtggaagat gagctggaga tggctactgt caggcatcgg cctgaagccc
      421 tggagctgct ggaggcccag agcaaattca ccaagaaaga gcttcagatt ctttacagag
      481 gatttaagaa tgaatgcccc agtggtgttg ttaatgaaga aactttcaag gagatttact
      541 cacagttctt tccacaggga gactccacca catatgcaca ttttctcttc aatgcattcg
      601 acacggacca caatggagct gtgagctttg aggatttcat caaaggtctt tccattttgc
      661 ttcgagggac agtacaagaa aaactcaact gggcatttaa tttgtatgac ataaacaaag
      721 atggctacat cactaaagaa gaaatgctgg acataatgaa agcaatctac gacatgatgg
      781 ggaaatgcac atacccggtc ctcaaggaag atgctccccg acagcatgtg gagacgttct
      841 tccagaagat ggacaaaaat aaagatggtg tcgttaccat agatgagttc attgaaagtt
      901 gccaaaaaga tgaaaacata atgcgctcca tgcagctctt tgaaaatgtg atctagaatg
      961 tcagcacctc ctcgaccgaa gaggcaaatg tgaacgacta cacacaagtt gaagccccca
     1021 cttgtagcat agatagctca gctttacact gaggcagatt atgcaaacag ctttgtttta
     1081 ataaaaagca acccaccacc accaccaaaa ttaagttttc cagttacaaa tctgcatcca
     1141 tgtcaccggg gtcatgaaat gtgctaactt atttcatact caaaaggcac agaatctgga
     1201 atagctttga tccttagcca cgttattatt gaggttttta cagttcagtg attttaaaac
     1261 accagtgggt tttcctactt gtttgtatgt attcagccct gggttttaaa tggttttcta
     1321 aaatacttac atctgcattt aacttccaga aagtcaatga actttcatta aattcgactc
     1381 atgtaacact gaaaaatgaa acaaagatta ctacaattta aatagaccaa aaacacagtc
     1441 ccaatttcta tggcttctcc acctgctgtt aaagatatta atgtatttgg cattttttta
     1501 aaaggacact taaaaaatta gtttattatc agatgttagc atatacctaa taaaattatt
     1561 ttagtatttg ttaattttcc atactcaagc caaggctcta tataatccat gaaactttgg
     1621 acctgttcaa tcttacatgt agactgtttt gtattgtgtt atgaagtaga aattcaaagt
     1681 gtcaaacaaa ccaaggatgt ttacagactt gccaagggtc cggatgtctg tcctgcaatg
     1741 cctagtgacg cttattaaca agtaacccta acagcagtaa agggcagttc ttgccaccct
     1801 ccaagcccct taatgttttc acagcatgtt tatcatacat aagccattca ggaacagaga
     1861 atccttgacg ccccaaagcc tactaggaat aatgatcaag taacatactc tttgagaaca
     1921 cccgtgattc tatagtattg gaaattatac acaagaatgt atagaaaatg actgcaaaca
     1981 ctgacggttc atctgaaatg cattatgatt tagcacatca tatagctcaa aggattcata
     2041 gtcctttcag tggtcttaag ccaaaactgt agagttgcca caacagtact atagagatac
     2101 acatcttccc tgttgcgcag aaatacaaga accaagagga tacaggagga gaaaatttac
     2161 gactgtctgc aacaataaat caggtatcta ttctggtgta gagataggat gttgaaagct
     2221 gccctgctat caccagtgta ggaattaaga gtagtacagt acatgtacag aaatctgcca
     2281 tcgcgtgttt gtgtaaactc aatgtgcaca ttttgtatct caaaacggaa aaataaaagc
     2341 aaaataaagt gtttattact ct
//
