LOCUS       NM_019789               2775 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Kv channel interacting protein 3, calsenilin (Kcnip3),
            transcript variant 1, mRNA.
ACCESSION   NM_019789
VERSION     NM_019789.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Ohayon,D., Aguirrebengoa,M., Escalas,N., Jungas,T. and Soula,C.
  TITLE     Transcriptome profiling of the Olig2-expressing astrocyte subtype
            reveals their unique molecular signature
  JOURNAL   iScience 24 (7), 102806 (2021)
   PUBMED   34296073
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2775)
  AUTHORS   Yamamoto,H., Kon,T., Omori,Y. and Furukawa,T.
  TITLE     Functional and Evolutionary Diversification of Otx2 and Crx in
            Vertebrate Retinal Photoreceptor and Bipolar Cell Development
  JOURNAL   Cell Rep 30 (3), 658-671 (2020)
   PUBMED   31968244
REFERENCE   5  (bases 1 to 2775)
  AUTHORS   Starski,P., Peyton,L., Oliveros,A., Heppelmann,C.J., Dasari,S. and
            Choi,D.S.
  TITLE     Proteomic Profile of a Chronic Binge Ethanol Exposure Model
  JOURNAL   J Proteome Res 18 (9), 3492-3502 (2019)
   PUBMED   31329447
  REMARK    GeneRIF: Proteomic Profile of a Chronic Binge Ethanol Exposure
            Model.
REFERENCE   6  (bases 1 to 2775)
  AUTHORS   Cheng,H.Y., Pitcher,G.M., Laviolette,S.R., Whishaw,I.Q., Tong,K.I.,
            Kockeritz,L.K., Wada,T., Joza,N.A., Crackower,M., Goncalves,J.,
            Sarosi,I., Woodgett,J.R., Oliveira-dos-Santos,A.J., Ikura,M., van
            der Kooy,D., Salter,M.W. and Penninger,J.M.
  TITLE     DREAM is a critical transcriptional repressor for pain modulation
  JOURNAL   Cell 108 (1), 31-43 (2002)
   PUBMED   11792319
REFERENCE   7  (bases 1 to 2775)
  AUTHORS   Osawa,M., Tong,K.I., Lilliehook,C., Wasco,W., Buxbaum,J.D.,
            Cheng,H.Y., Penninger,J.M., Ikura,M. and Ames,J.B.
  TITLE     Calcium-regulated DNA binding and oligomerization of the neuronal
            calcium-sensing protein, calsenilin/DREAM/KChIP3
  JOURNAL   J Biol Chem 276 (44), 41005-41013 (2001)
   PUBMED   11535596
REFERENCE   8  (bases 1 to 2775)
  AUTHORS   Liss,B., Franz,O., Sewing,S., Bruns,R., Neuhoff,H. and Roeper,J.
  TITLE     Tuning pacemaker frequency of individual dopaminergic neurons by
            Kv4.3L and KChip3.1 transcription
  JOURNAL   EMBO J 20 (20), 5715-5724 (2001)
   PUBMED   11598014
REFERENCE   9  (bases 1 to 2775)
  AUTHORS   Spreafico,F., Barski,J.J., Farina,C. and Meyer,M.
  TITLE     Mouse DREAM/calsenilin/KChIP3: gene structure, coding potential,
            and expression
  JOURNAL   Mol Cell Neurosci 17 (1), 1-16 (2001)
   PUBMED   11161465
REFERENCE   10 (bases 1 to 2775)
  AUTHORS   An,W.F., Bowlby,M.R., Betty,M., Cao,J., Ling,H.P., Mendoza,G.,
            Hinson,J.W., Mattsson,K.I., Strassle,B.W., Trimmer,J.S. and
            Rhodes,K.J.
  TITLE     Modulation of A-type potassium channels by a family of calcium
            sensors
  JOURNAL   Nature 403 (6769), 553-556 (2000)
   PUBMED   10676964
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ148267.1, AF287732.1 and BC057329.1.
            
            On Mar 21, 2014 this sequence version replaced NM_019789.3.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF287733.1, AF184624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CJ148267.1         2-23
            23-81               AF287732.1         1-59
            82-2775             BC057329.1         1-2694
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.02 cM"
     gene            1..2775
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /note="Kv channel interacting protein 3, calsenilin"
                     /db_xref="GeneID:56461"
                     /db_xref="MGI:MGI:1929258"
     exon            1..155
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..911
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /note="isoform a is encoded by transcript variant 1;
                     calsenilin, presenilin binding protein, EF hand
                     transcription factor; potassium channel interacting
                     protein 3; DRE-antagonist modulator; kv
                     channel-interacting protein 3; A-type potassium channel
                     modulatory protein 3; downstream regulatory element
                     antagonist T-; downstream regulatory element antagonist
                     T+; calsenilin/KChIP3 T+; calsenilin/KChIP3 T-"
                     /codon_start=1
                     /product="calsenilin isoform a"
                     /protein_id="NP_062763.2"
                     /db_xref="CCDS:CCDS16703.1"
                     /db_xref="GeneID:56461"
                     /db_xref="MGI:MGI:1929258"
                     /translation="MQRTKEAVKASDGNLLGDPGRIPLSKRESIKWQRPRFTRQALMR
                     CCLIKWILSSAAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKN
                     ECPTGLVDEDTFKLIYSQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLR
                     GTVHEKLKWAFNLYDINKDGCITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERF
                     FQKMDRNQDGVVTIDEFLETCQKDENIMNSMQLFENVI"
     exon            156..321
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            322..446
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            447..516
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            517..587
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..695
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            696..800
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            801..863
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            864..2754
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1004..1009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /note="hexamer: AATATA"
     polyA_site      1023
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /note="major polyA site"
     regulatory      2732..2737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /note="hexamer: AATAAA"
     polyA_site      2754
                     /gene="Kcnip3"
                     /gene_synonym="4933407H12Rik; Csen; DREAM; KChIP3"
                     /note="major polyA site"
ORIGIN      
        1 agggggcggg agagaaacct ccagtgacaa ttgcgtctgg gtccaagcaa acatgaggca
       61 gctgccagcc ggaccaagca gtctggcttg ctcgggctgc aaagcgggaa gattagtgac
      121 ggtccctttc agcagcagag atgcagagga ccaaggaagc cgtgaaggca tcagatggca
      181 acctcctggg agatcctggg cgcataccac tgagcaagag ggaaagcatc aagtggcaaa
      241 ggccacggtt cacccgccag gccctgatgc gttgctgctt aatcaagtgg atcctgtcca
      301 gtgctgcccc acaaggctca gacagcagtg acagtgaact ggagttatcc acggtgcgcc
      361 atcagccaga gggcttggac cagctacaag ctcagaccaa gttcaccaag aaggagctgc
      421 agtcccttta ccgaggcttc aagaatgagt gtcccacagg cctggtggat gaagacacct
      481 tcaaactcat ttattcccag ttcttccctc agggagatgc caccacctat gcacacttcc
      541 tcttcaatgc cttcgatgct gatgggaacg gggccatcca ctttgaggac tttgtggttg
      601 ggctctccat cctgcttcga gggacggtcc atgagaagct caagtgggcc ttcaatctct
      661 atgacattaa caaggatggt tgcatcacca aggaggagat gctggccatc atgaagtcca
      721 tctacgacat gatgggccgc cacacctacc ccatcctgcg ggaggatgca cccctggagc
      781 atgtggagag gttctttcag aaaatggaca ggaaccagga tggagtggtg accattgatg
      841 aatttctgga gacttgtcag aaggatgaga acatcatgaa ctccatgcag ctgtttgaga
      901 acgtcatcta ggacatgtgg gaggggaccc cggtggtcat tgcttctcaa cccagagaag
      961 cctcaatcct gacaggagaa gcctctatga gaaacatttt tctaatatat ttgcaaaaag
     1021 tgagcagttt acttccaaga cacagccacc atcacacaca gacacagaca cagacataca
     1081 gacacacaca cacacacaca cacacacaca cacacacaca cacacatggt tcctctggct
     1141 tggccaagga agtggcagcc agaaggcacc cccgcctatt cctaggtcaa taaaaaaggc
     1201 tgcctctggg atggccagcc ctggctagat gttacccaca aggaactcag agatcgagag
     1261 gaccaggtct acaaagctaa ggtccctgtg tcttttctac cactcgggag atcaaactac
     1321 tccctgccta tggacccatg ctcttaggaa gctcccagaa actccaaggg gacaaagagg
     1381 ggagaggtct ataggaagaa atggttttgg aagctgggct tgcagcctta tgctaatgat
     1441 cacctggggt cctggaacct gagtgccagg ctacctacta tgccgtgagc ttagatagtg
     1501 aggggccatt ggactaagac ctcctgtaag agtggggcag gattgaggtt tttggagaaa
     1561 ctgaggaaac aatttgtcca taccactggg tgaagactgc tggccagtgg gaatgtggct
     1621 ggtggagatt tcccaacttc cagcaccagg atggcctctc caaggtcctc tttgattccc
     1681 tggggagatc acctggctca tagactgaca accagggaac tgggctgaaa tgggaggtct
     1741 ggtagggggc atccccctcc ttttccctgg ccacttgcca cccagttcct taacacagtg
     1801 gatcggccac acctctgtgg ctgcccttga acagactcat cccgaccaag acaaaaaagc
     1861 acaaactcct agcagctcag gccaagccca caagggaagg cctgggtccc tgcagccctg
     1921 attcagtggc cgaggaagac gctcagacat ccatcctgta cctcggagcc ttgggggtct
     1981 cacagccctt tcccagccca gctcgccaac attctaaagc acaaacctgc ggattctgct
     2041 tgcttgggct gcgccctggg gattgaaggc cactgttaac cctaagctgg agctagccct
     2101 gagggctggg gacctgtgac caggcaacag gtcagcagac cctcaggagg agagagagct
     2161 gttcctgcct ccccaggcct cgcccagaag gaacagtgtc ccaagaagca tgtttcctgg
     2221 aggaacatcc ccacaaaagt acattccatc atctgaagcc cggtctctgc tcaggcctgc
     2281 ctctgaaagt ccacgtgtgt tccccagaag gccagcccca agataaggga ggtccttaga
     2341 ggaaggacag ggtgacaaca cccctataca caggtggacc ccccccccct ctgagggctg
     2401 tactgacccc atctccatcc tgaccggggc cttcctttac ccgatctaca gaccaccagt
     2461 tctccctggc tcagggaccc cctgtccccc agtctgactc ttcccatcga ggtccctgtc
     2521 ttgtgaaaag ccaaggccac gggaaaaggc caccactcta acctgctgca tcccttagcc
     2581 tctggctgca cgcccaacct ggaggggtct gtcccctttg cagggacaca gactggccgc
     2641 atgtccgcat ggcagaagcg tctcccttgg gtgcagcctg gaagggtggt tcctgtctca
     2701 gcgcccacca atattcagtc ctatatattt taataaaaga aacttgacaa aggaaaaaaa
     2761 aaaaaaaaaa aaaaa
//
