LOCUS       NM_145703               2414 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus Kv channel-interacting protein 2 (Kcnip2), transcript
            variant a, mRNA.
ACCESSION   NM_145703
VERSION     NM_145703.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2414)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   2  (bases 1 to 2414)
  AUTHORS   Albisetti,G.W., Ganley,R.P., Pietrafesa,F., Werynska,K., Magalhaes
            de Sousa,M., Sipione,R., Scheurer,L., Bosl,M.R., Pelczar,P.,
            Wildner,H. and Zeilhofer,H.U.
  TITLE     Inhibitory Kcnip2 neurons of the spinal dorsal horn control
            behavioral sensitivity to environmental cold
  JOURNAL   Neuron 111 (1), 92-105 (2023)
   PUBMED   36323322
  REMARK    GeneRIF: Inhibitory Kcnip2 neurons of the spinal dorsal horn
            control behavioral sensitivity to environmental cold.
REFERENCE   3  (bases 1 to 2414)
  AUTHORS   Wu,Q., Li,E. and Zhang,Y.
  TITLE     A synaptic filtering mechanism in visual threat identification in
            mouse
  JOURNAL   Proc Natl Acad Sci U S A 120 (1), e2212786120 (2023)
   PUBMED   36574675
REFERENCE   4  (bases 1 to 2414)
  AUTHORS   Wang,F., Li,E., De,L., Wu,Q. and Zhang,Y.
  TITLE     OFF-transient alpha RGCs mediate looming triggered innate defensive
            response
  JOURNAL   Curr Biol 31 (11), 2263-2273 (2021)
   PUBMED   33798432
REFERENCE   5  (bases 1 to 2414)
  AUTHORS   Zhang,X., Liao,C., Sun,K., Liu,L. and Xu,D.
  TITLE     A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2
            by Downregulating MicroRNA-29 in a Mouse Model of Myocardial
            Infarction
  JOURNAL   Heart Surg Forum 23 (5), E579-E585 (2020)
   PUBMED   32990585
  REMARK    GeneRIF: A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12
            and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of
            Myocardial Infarction.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2414)
  AUTHORS   Li,H., Guo,W., Mellor,R.L. and Nerbonne,J.M.
  TITLE     KChIP2 modulates the cell surface expression of Kv 1.5-encoded K(+)
            channels
  JOURNAL   J Mol Cell Cardiol 39 (1), 121-132 (2005)
   PUBMED   15878168
  REMARK    GeneRIF: KChIP2 contributes to the formation of functional mouse
            ventricular Kv1.5 channels
            Erratum:[J Mol Cell Cardiol. 2005 Oct;39(4):723]
REFERENCE   7  (bases 1 to 2414)
  AUTHORS   Xiong,H., Kovacs,I. and Zhang,Z.
  TITLE     Differential distribution of KChIPs mRNAs in adult mouse brain
  JOURNAL   Brain Res Mol Brain Res 128 (2), 103-111 (2004)
   PUBMED   15363885
  REMARK    GeneRIF: KChIP2 transcripts were highly expressed in layer IV of
            the cerebral cortex and in striatum and hippocampus, but expressed
            at low levels in cerebellum.
REFERENCE   8  (bases 1 to 2414)
  AUTHORS   Guo,W., Li,H., Aimond,F., Johns,D.C., Rhodes,K.J., Trimmer,J.S. and
            Nerbonne,J.M.
  TITLE     Role of heteromultimers in the generation of myocardial transient
            outward K+ currents
  JOURNAL   Circ Res 90 (5), 586-593 (2002)
   PUBMED   11909823
REFERENCE   9  (bases 1 to 2414)
  AUTHORS   Kuo,H.C., Cheng,C.F., Clark,R.B., Lin,J.J., Lin,J.L., Hoshijima,M.,
            Nguyen-Tran,V.T., Gu,Y., Ikeda,Y., Chu,P.H., Ross,J., Giles,W.R.
            and Chien,K.R.
  TITLE     A defect in the Kv channel-interacting protein 2 (KChIP2) gene
            leads to a complete loss of I(to) and confers susceptibility to
            ventricular tachycardia
  JOURNAL   Cell 107 (6), 801-813 (2001)
   PUBMED   11747815
REFERENCE   10 (bases 1 to 2414)
  AUTHORS   Ohya,S., Morohashi,Y., Muraki,K., Tomita,T., Watanabe,M.,
            Iwatsubo,T. and Imaizumi,Y.
  TITLE     Molecular cloning and expression of the novel splice variants of
            K(+) channel-interacting protein 2
  JOURNAL   Biochem Biophys Res Commun 282 (1), 96-102 (2001)
   PUBMED   11263977
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CX122626.1, BC056434.1 and
            DQ148496.1.
            
            On Feb 2, 2013 this sequence version replaced NM_145703.1.
            
            Summary: This gene encodes a member of the voltage-gated potassium
            channel-interacting protein (KCNIP) family. KCNIP family members
            are small calcium binding proteins that commonly exhibit unique
            variation at their N-termini, and which modulate A-type potassium
            channels. This gene is predominantly expressed in the adult heart,
            and to a lesser extent in the brain. Disruption of this gene is
            associated with susceptibility to cardiac arrhythmias and lack of
            transient outward potassium current in ventricular myocytes, and
            downregulated expression is associated with cardiac hypertrophy.
            The encoded protein has also been implicated as a repressor of
            immune response. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (a) represents the longest
            transcript and encodes the longest isoform (a, also known as
            KCHIP2L).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.30582.1, DQ148496.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                CX122626.1         1-41
            42-260              BC056434.1         1-219
            261-1073            DQ148496.1         1-813
            1074-2414           BC056434.1         1791-3131
FEATURES             Location/Qualifiers
     source          1..2414
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     gene            1..2414
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /note="Kv channel-interacting protein 2"
                     /db_xref="GeneID:80906"
                     /db_xref="MGI:MGI:2135916"
     exon            1..333
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1073
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /note="isoform a is encoded by transcript variant a;
                     potassium channel-interacting protein 2; A-type potassium
                     channel modulatory protein 2; A-type potassium channel
                     modulatory protein KCNIP2"
                     /codon_start=1
                     /product="A-type potassium channel modulatory protein
                     KCNIP2 isoform a"
                     /protein_id="NP_663749.1"
                     /db_xref="CCDS:CCDS38004.1"
                     /db_xref="GeneID:80906"
                     /db_xref="MGI:MGI:2135916"
                     /translation="MRGQGRKESLSESRDLDGSYDQLTGHPPGPSKKALKQRFLKLLP
                     CCGPQALPSVSETLAAPASLRPHRPRPLDPDSVEDEFELSTVCHRPEGLEQLQEQTKF
                     TRRELQVLYRGFKNECPSGIVNEENFKQIYSQFFPQGDSSNYATFLFNAFDTNHDGSV
                     SFEDFVAGLSVILRGTIDDRLNWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYP
                     ALREEAPREHVESFFQKMDRNKDGVVTIEEFIESCQQDENIMRSMQLFDNVI"
     exon            334..429
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            430..483
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..608
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..678
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            679..749
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..857
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..962
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1025
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..2397
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2372..2377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /note="hexamer: AATAAA"
     polyA_site      2394
                     /gene="Kcnip2"
                     /gene_synonym="KChIP2"
                     /note="major polyA site"
ORIGIN      
        1 ctgggctcag gctcggctct cagctccacg ctgccttctg ctccgctctc acttgctgcc
       61 caaggatcct gctcctgccc cgggactctg aggtgggccc taaaatccag cgctccccag
      121 agaaaagcct tgccagcccc tactcccggc ccccagcccc agcaggtcgc tgcgccgcca
      181 gggggcactg tgtgagcgcc ctatcctggc cacccggcgc cccctcccac ggcccaggcg
      241 ggagcggggc gccgggggcc atgcggggcc aaggccgaaa ggagagtttg tccgaatccc
      301 gagatttgga cggctcctat gaccagctta cgggccaccc tccagggccc agtaaaaaag
      361 ccctgaagca gcgtttcctc aagctgctgc cgtgctgcgg gccccaagcc ctgccctcag
      421 tcagtgaaac attagctgcc ccagcctccc tccgccccca cagaccccgc ccgctggacc
      481 cagacagcgt ggaggatgag tttgaactat ccacggtgtg ccaccggcct gagggtctgg
      541 aacaactcca ggaacaaacc aagttcacac gcagagagtt gcaggtcctg tacagaggct
      601 tcaagaacga atgtcccagc ggaattgtca acgaggagaa cttcaagcaa atttattctc
      661 agttctttcc ccaaggagac tccagcaact acgctacttt tctcttcaat gcctttgaca
      721 ccaaccatga tggctctgtc agttttgagg actttgtggc tggtttgtca gtgattcttc
      781 ggggaaccat agatgataga ctgaactggg ctttcaactt atatgacctc aacaaggatg
      841 gctgtatcac gaaggaggaa atgctcgaca tcatgaagtc catctatgac atgatgggca
      901 agtacaccta ccctgccctc cgggaggagg ccccgaggga acacgtggag agcttcttcc
      961 agaagatgga cagaaacaag gacggcgtgg tgaccattga ggaattcatt gagtcttgtc
     1021 aacaggacga gaacatcatg aggtccatgc aactctttga taatgtcatc tagctcccca
     1081 gggagagggg ttagtgtgtc ccagggtaac catgctgtag ccctagtcca ggcaaaccta
     1141 accctcctct ccccgggtct gtcctcatcc tacctgtacc ctgggggctg tagggattca
     1201 acatcctggc gcttcagtag tccagatccc tgagctaagt ggcgagagta ggcaagctaa
     1261 gtctttggag ggtgggtggg ggcgcgcaga ttcccaaccc ccgacgactc tcaccccttt
     1321 ctcgactgat acccagtgct gaggctaccc ctggtgtcgg gaacgaccaa gtggttctct
     1381 gcctcccagc ccactctaga gaccacacta gacggaatat ctcctgctat ggtgctttcc
     1441 ccatccctga ccgcagattt tcctctaaga ctcccttctc agagaatatg ctttgtccct
     1501 gtccctggct ggcttttcag cctagccttt gaggaccctg tgggagggga gaataagaaa
     1561 gcagacaaat cttggccctg agccagtggt taggtcctag gaatcaggct ggagtggaga
     1621 ccagaaagcc tgggcaggct atgagagccc aggttggctg tcaccgccag gttccacagg
     1681 gctgctgctc tgggtcagca gagtatgagt ttccagactt tccagaaggc cttatgtcct
     1741 tagcaatgtc ccagaaattc accatacact tctcagtgtc ttaggatcca gatgtccggt
     1801 ccatccctga aacctctccc tcctccttgc tcctatggtg ggagtggtgg ccaggggacg
     1861 atgagtgagc ggtgtcctgg atgatgcctg tcaaggtccc acctaccctc cggctgtcag
     1921 ccgttctggt gaccctgttt gattctccat gacccctgtc tagatgtaga ggtgtggagt
     1981 gagtctagtg gcagccttag gggaatggga agaacgagag gggcactcca tctgaaccca
     2041 gtgtgggggc atccattcga atctttgcct ggctccccac aatgccctag gatcctctag
     2101 ggtccccacc cccactcttt agtctaccca gagatgctcc agagctcacc tagagggcag
     2161 ggaccatagg atccaggtcc aacctgtcat cagcatccgg ccatgctgct gctgcttatt
     2221 aataaacctg cttgtcgttc agcgcccctt cccagtcagc cagggtctga ggggaaggcc
     2281 cccactttcc cgcctcctgt cagacattgt tgactgcttt gcattttggg ctcttctacc
     2341 tattttgtat aataagaaag acaccagatc caataaaaca catggctatg cacagccaaa
     2401 aaaaaaaaaa aaaa
//
