LOCUS       NM_001363115            2027 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus Kv channel-interacting protein 1 (Kcnip1), transcript
            variant E, mRNA.
ACCESSION   NM_001363115 XM_006514803
VERSION     NM_001363115.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2027)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2027)
  AUTHORS   Russell,N.X., Burra,K., Shah,R.M., Bottasso-Arias,N.,
            Mohanakrishnan,M., Snowball,J., Ediga,H.H., Madala,S.K. and
            Sinner,D.
  TITLE     Wnt signaling regulates ion channel expression to promote smooth
            muscle and cartilage formation in developing mouse trachea
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (6), L788-L802 (2023)
   PUBMED   37873566
REFERENCE   3  (bases 1 to 2027)
  AUTHORS   Leca,I., Phillips,A.W., Hofer,I., Landler,L., Ushakova,L.,
            Cushion,T.D., Durnberger,G., Stejskal,K., Mechtler,K. and
            Keays,D.A.
  TITLE     A proteomic survey of microtubule-associated proteins in a R402H
            TUBA1A mutant mouse
  JOURNAL   PLoS Genet 16 (11), e1009104 (2020)
   PUBMED   33137126
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2027)
  AUTHORS   Niewiadomska-Cimicka,A., Krzyzosiak,A., Ye,T.,
            Podlesny-Drabiniok,A., Dembele,D., Dolle,P. and Krezel,W.
  TITLE     Genome-wide Analysis of RARbeta Transcriptional Targets in Mouse
            Striatum Links Retinoic Acid Signaling with Huntington's Disease
            and Other Neurodegenerative Disorders
  JOURNAL   Mol Neurobiol 54 (5), 3859-3878 (2017)
   PUBMED   27405468
REFERENCE   5  (bases 1 to 2027)
  AUTHORS   Klein,A.D., Ferreira,N.S., Ben-Dor,S., Duan,J., Hardy,J., Cox,T.M.,
            Merrill,A.H. Jr. and Futerman,A.H.
  TITLE     Identification of Modifier Genes in a Mouse Model of Gaucher
            Disease
  JOURNAL   Cell Rep 16 (10), 2546-2553 (2016)
   PUBMED   27568557
REFERENCE   6  (bases 1 to 2027)
  AUTHORS   Van Hoorick,D., Raes,A. and Snyders,D.J.
  TITLE     The aromatic cluster in KCHIP1b affects Kv4 inactivation gating
  JOURNAL   J Physiol 583 (Pt 3), 959-969 (2007)
   PUBMED   17640927
  REMARK    GeneRIF: aromatic cluster in exon1b modulates the transitions
            towards and from the closed inactivated states and the steady state
            distribution over the respective states
REFERENCE   7  (bases 1 to 2027)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   8  (bases 1 to 2027)
  AUTHORS   Pruunsild,P. and Timmusk,T.
  TITLE     Structure, alternative splicing, and expression of the human and
            mouse KCNIP gene family
  JOURNAL   Genomics 86 (5), 581-593 (2005)
   PUBMED   16112838
REFERENCE   9  (bases 1 to 2027)
  AUTHORS   Xiong,H., Kovacs,I. and Zhang,Z.
  TITLE     Differential distribution of KChIPs mRNAs in adult mouse brain
  JOURNAL   Brain Res Mol Brain Res 128 (2), 103-111 (2004)
   PUBMED   15363885
  REMARK    GeneRIF: KChIP1 was expressed in a subpopulation of neurons widely
            distributed in brain and enriched in Purkinje cells of the
            cerebellum and in the reticular thalamic and medial habenular
            nuclei.
REFERENCE   10 (bases 1 to 2027)
  AUTHORS   Van Hoorick,D., Raes,A., Keysers,W., Mayeur,E. and Snyders,D.J.
  TITLE     Differential modulation of Kv4 kinetics by KCHIP1 splice variants
  JOURNAL   Mol Cell Neurosci 24 (2), 357-366 (2003)
   PUBMED   14572458
  REMARK    GeneRIF: Differential expression of KCh1P1 splice variants can
            shape the function of Kv4.2 channels involved in protection against
            back propagating action potentials in dendritic spines.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662902.14 and AL669814.16.
            
            On Nov 15, 2022 this sequence version replaced NM_001363115.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.675996.1,
                                           SRR7345562.520904.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AL662902.14        5673-5897           c
            226-350             AL669814.16        167033-167157       c
            351-420             AL669814.16        166029-166098       c
            421-491             AL669814.16        164826-164896       c
            492-599             AL669814.16        163961-164068       c
            600-704             AL669814.16        156109-156213       c
            705-767             AL669814.16        154678-154740       c
            768-2027            AL669814.16        150869-152128       c
FEATURES             Location/Qualifiers
     source          1..2027
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 19.21 cM"
     gene            1..2027
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /note="Kv channel-interacting protein 1"
                     /db_xref="GeneID:70357"
                     /db_xref="MGI:MGI:1917607"
     exon            1..225
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..815
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /note="isoform E is encoded by transcript variant E;
                     A-type potassium channel modulatory protein 1.2; potassium
                     channel-interacting protein 1; A-type potassium channel
                     modulatory protein KCNIP1"
                     /codon_start=1
                     /product="A-type potassium channel modulatory protein
                     KCNIP1 isoform E"
                     /protein_id="NP_001350044.1"
                     /db_xref="GeneID:70357"
                     /db_xref="MGI:MGI:1917607"
                     /translation="MPARVLLAYPRTEMLTQGESEGLQTLGIVVVLCSSLKLLHYLGL
                     IDLSDDKIEDELEMTMVCHRPEGLEQLEAQTNFTKRELQVLYRGFKNECPSGVVNEET
                     FKQIYAQFFPHGDASTYAHYLFNAFDTTQTGSVKFEDFVTALSILLRGTVHEKLRWTF
                     NLYDINKDGYINKEEMMDIVKAIYDMMGKYTYPVLKEDTPRQHVDVFFQKMDKNKDGI
                     VTLDEFLESCQEDDNIMRSLQLFQNVM"
     exon            226..350
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            351..420
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..491
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            492..599
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            600..704
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            705..767
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            768..2027
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1557..1562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /note="hexamer: AATAAA"
     polyA_site      1586
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /note="major polyA site"
     regulatory      2008..2013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
                     /note="hexamer: AACAAG"
     polyA_site      2027
                     /gene="Kcnip1"
                     /gene_synonym="KCHIP1; Kchip1.2"
ORIGIN      
        1 agtgagagga agctaggctg gtggaaataa ccctgcattt ggaacagcgg caaagaagcg
       61 cgattttcta gctttaaatg cctgcccgcg tcctgcttgc ctacccgaga acggagatgt
      121 tgacacaggg cgagtccgaa gggctccaga ccttgggaat tgtagtggtc ctgtgctcct
      181 ccctgaaact attgcactac ctcgggctga ttgacttgtc ggacgacaag attgaggatg
      241 agctagagat gaccatggtt tgccaccggc ctgagggact ggagcagctt gaggcacaga
      301 cgaacttcac caagagagaa ctgcaagtct tgtaccgggg attcaaaaac gagtgcccta
      361 gcggtgtggt caatgaagaa acattcaagc agatctacgc tcagtttttc cctcacggag
      421 atgccagcac atatgcacat tacctcttca atgccttcga caccacccag acaggctctg
      481 taaagttcga ggactttgtg actgctctgt cgattttact gagagggaca gtccatgaaa
      541 aactaaggtg gacgtttaat ttgtatgaca tcaataaaga cggctacata aacaaagagg
      601 agatgatgga catagtcaaa gccatctatg acatgatggg gaaatacacc tatcctgtgc
      661 tcaaagagga cactcccagg cagcatgtgg atgtcttctt ccagaaaatg gataaaaata
      721 aagatggcat tgtaacgtta gatgaatttc ttgaatcatg tcaggaggat gacaacatca
      781 tgagatctct acagctgttc caaaatgtca tgtaactgag gacactggcc attctgctct
      841 cagagacact gacaaacacc ttaatgccct gatctgccct tgttccaatt ttacacacca
      901 actcttggga cagaaatacc ttttacactt tggaagaatt ctctgctgaa gactttctac
      961 aaaacctggc accacgtggc tctgtctctg agggacgagc ggagatccga ctttgttttg
     1021 gaagcatgcc catctcttca tgctgctgcc ctgtggaagg cccctctgct tgagcttaat
     1081 caatagtgca cagttttatg cttacacata tccccaactc actgcctcca agtcaggcag
     1141 actctgatga atctgagcca aatgtgcacc atcctccgat ggcctcccaa gccaatgtgc
     1201 ctgcttctct tcctctggtg ggaagaaaga gtgttctacg gaacaattag agcttaccat
     1261 gaaaatattg ggagaggcag cacctaacac atgtagaata ggactgaatt attaagcatg
     1321 gtgatatcag atgatgcaaa ttgcccatgt catttttttc aaaggtaggg acaaatgatt
     1381 ctcccacact agcacctgtg gtcatagagc aagtctctta acatgcccag aaggggaacc
     1441 actgtccagt ggtctatccc tcctctccat cccctgctca aacccagcac tgcatgtccc
     1501 tccaagaagg tccagaatgc ctgcgaaacg ctgtactttt ataccctgtt ctaatcaata
     1561 aacagaacta tttcgtacac tctcaattac ttcttctatg actctatggc tcaggagagg
     1621 caagttgtga caaagggtgg ttagtccacc catttggcct ctggttacta gtactttctt
     1681 ggggccacat gctttcaccc ttaaaccatc ttcattagca tgcaattcaa atactgtgat
     1741 catgtgcaaa tggtacttcc agacagcacc tcttttctaa taggattgct cctcccaaga
     1801 ctccaatata aaaaaatacc agagcctcat atggcacaac tagagctgaa aaggaccagt
     1861 cctctctgat gatgatgtag agtccaaaga ctgatcaagt agttccatct tataaccata
     1921 aaatgattac gtgggtccaa tgtcatgtat cttagttttc cgtgtgttat cacattaaat
     1981 atttccttac acattaaaaa atgctctaac aagagcttcc ttgaaaa
//
