LOCUS       NM_001031811            4305 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily H
            (eag-related), member 8 (Kcnh8), mRNA.
ACCESSION   NM_001031811 XM_140016
VERSION     NM_001031811.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4305)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4305)
  AUTHORS   Hermanstyne,T.O., Yang,N.D., Granados-Fuentes,D., Li,X.,
            Mellor,R.L., Jegla,T., Herzog,E.D. and Nerbonne,J.M.
  TITLE     Kv12-encoded K+ channels drive the day-night switch in the
            repetitive firing rates of SCN neurons
  JOURNAL   J Gen Physiol 155 (9) (2023)
   PUBMED   37516908
  REMARK    GeneRIF: Kv12-encoded K+ channels drive the day-night switch in the
            repetitive firing rates of SCN neurons.
REFERENCE   3  (bases 1 to 4305)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   4  (bases 1 to 4305)
  AUTHORS   Zhang,X., Bursulaya,B., Lee,C.C., Chen,B., Pivaroff,K. and Jegla,T.
  TITLE     Divalent cations slow activation of EAG family K+ channels through
            direct binding to S4
  JOURNAL   Biophys J 97 (1), 110-120 (2009)
   PUBMED   19580749
  REMARK    GeneRIF: Our results suggest close conformational conservation
            between closed EAG (Kv12.1 and Kv10.2) and Shaker family channels,
            despite large differences in voltage sensitivity, activation rates,
            and activation threshold
REFERENCE   5  (bases 1 to 4305)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ165858.1, AK048629.1, AC125051.4, AC131674.3 and BC029690.1.
            
            On Jun 13, 2012 this sequence version replaced NM_001031811.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048629.1, SRR1660811.69112.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               CJ165858.1         1-111
            112-706             AK048629.1         1-595
            707-707             AC125051.4         66998-66998         c
            708-1221            AK048629.1         597-1110
            1222-1222           AC125051.4         31160-31160         c
            1223-1722           AK048629.1         1112-1611
            1723-1723           AC131674.3         158066-158066       c
            1724-4126           AK048629.1         1613-4015
            4127-4305           BC029690.1         3354-3532
FEATURES             Location/Qualifiers
     source          1..4305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 27.37 cM"
     gene            1..4305
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /note="potassium voltage-gated channel, subfamily H
                     (eag-related), member 8"
                     /db_xref="GeneID:211468"
                     /db_xref="MGI:MGI:2445160"
     exon            1..172
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            173..406
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..538
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..666
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..907
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1065
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1273
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1471
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1671
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1921
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2136
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2175
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2531
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2638
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2715
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..4287
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4255..4260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /note="hexamer: AATAAA"
     polyA_site      4279
                     /gene="Kcnh8"
                     /gene_synonym="C130090D05Rik; ELK; ELK1; ELK3; Kv12.1"
                     /note="major polyA site"
ORIGIN      
        1 atcacgctcc tggtggcttc ttccagcttg gcactttcct acagagccat ccttgtggac
       61 aaactttgat ggggaatttc acacagcgct ggaaaaatgc cggttatgaa aggattactg
      121 gcgccacaga acaccttcct ggacactatt gccacccgtt tcgacggaac acatagcaac
      181 ttcatcctgg ccaatgccca agtggcaaag ggtttcccca tagtctactg ttcagatggc
      241 ttctgtgagc tggccgggtt tgcacgaact gaagtcatgc agaagagctg cagctgcaag
      301 tttttgtttg gggtggagac caacgagcag ctgatgcttc agatagaaaa gtccctggag
      361 gagaaagtag aattcaaagg agaaattatg ttctacaaga agaatggggc tccattttgg
      421 tgcctgctgg atatcgttcc tataaagaat gagaaaggag atgtagtcct tttcctggcc
      481 tcattcaaag acataacaga cacgaaagtg aagattacat cagaagataa aaaagaagac
      541 agaaccaaag gaagatcaag agcagggagc cactttgact cagcccggag acggagccga
      601 gccgtccttt atcacatctc aggacacctt caaagaagag aaaagaacaa attgaaaata
      661 aataataacg tgtttgtaga taaaccagcg tttccagagt ataaggtttc tgatgcaaaa
      721 aagtccaagt tcatcctgct gcatttcagc actttcaaag ctggctggga ctggctcatt
      781 ttgctggcaa cgttttatgt tgctgtgaca gtcccttaca atgtgtgttt cattggcaat
      841 gaggacctgt ccaccactcg gagcacaacg gtcagtgaca ttgcagtgga gatactgttc
      901 attatagata ttattctaaa tttccgaaca acttatgtca gcaagtctgg ccaagttatc
      961 tttgaagcga gatccatttg cattcactac gtcaccacct ggttcatcat tgatctgatt
     1021 gctgccttgc cctttgacct cctgtatgct ttcaatgtca cagtggtgtc cctcgttcat
     1081 ctcctgaaga ctgttcggct gctgcgtctt ttgcgcctcc tccagaagct ggaccgttat
     1141 tctcagcaca gtaccatcgt cctcaccctg ctcatgtcca tgtttgctct ccttgcacac
     1201 tggatggcat gtatctggta tgtcattgga aaaatggaga gggaggacaa cagccttctc
     1261 aagtgggaag tcggttggct tcatgagctg gggaagagac tggaatctcc atattatggc
     1321 aacaacacgc tggggggccc atccatccga agtgcctata ttgcggccct gtacttcact
     1381 ctcagcagcc tcacaagcgt tgggtttggg aatgtgtctg ctaacacaga tgcagagaag
     1441 atcttctcca tctgcaccat gctgattgga gccctgatgc atgccttagt atttgggaac
     1501 gtgactgcca tcatacagag aatgtactct agatggagcc tgtaccacac tagaaccaag
     1561 gacctaaaag acttcatccg tgtgcaccac ctgccccagc aactcaagca gaggatgctc
     1621 gagtactttc agacaacttg gtcagtcaac aatgggatag attcaaatga gcttttaaaa
     1681 gactttccag atgagctgcg ctctgacatc acaatgcatc tgaacaagga gatcttacag
     1741 ctgtccctgt tcgaatgtgc cagccggggc tgcctcaggt ctctgtctct ccatattaaa
     1801 acctcctttt gtgctccagg agagtatctg ctgcgccagg gggatgcttt gcaggccatc
     1861 tacttcgtgt gctcaggctc tatggaagtt cttaaagaca gcatggtgtt ggctattcta
     1921 gggaagggag atttaattgg agcaaattta tcaattaaag accaagtgat caagaccaac
     1981 gctgatgtga aggcgctgac ctactgtgat ctacagtgca tcatcctgaa aggtctcttt
     2041 gaggtgctgg gcctttaccc agagtatgca cacaaattcg tagaagacat ccagcacgac
     2101 ctcacataca accttcgaga aggtcatgag agtgatgtaa tatcaagatt atcgaacaaa
     2161 tctacagtct cacaggcaga gcccaagggg aatggaagca tcaacaagag actcccatcc
     2221 attgtggaag atgaggagga agaagaggtt gaggaagagg agacgacctc cctttctcct
     2281 atctacacaa ggggatcctc tgtctcacat agcaaaaaga ctggaagcaa taagacctat
     2341 ctaggcttga gcttaaagca actggcctca ggaacggtac cattccactc acctatcaga
     2401 gtctccagtg ccaactcccc taaaaccaag caggaagctg acccacctaa ccatggtaga
     2461 aagaaagaga agaacctgaa agtgcagctt tccagcctgg gtagtgctgg aaccccagag
     2521 cttagtccaa ggattgttga tggaattgaa gatggtaaca gcaatgagga aactcagact
     2581 tttgactttg gctctgaaca gatcaggcca gagcccagga tttcccctcc ccttgcagaa
     2641 tccgagatcg gagctgcgtt tctgttcatc aaggctgaag aaaccaagca gcagattaac
     2701 aagctcaaca gtgaggtcac aacattaact caggaggttt cccagctagg gagagatatg
     2761 agaagcatca tgcaacttct ggaaaacatc ttgtcacctc agcagccatc ccagttttgt
     2821 tctctacatc ccaccccaat gtgtccttcc agagaaagtt tacagactag ggtgagttgg
     2881 agtgctcacc agccttgcct acatttgcag gcaggtggag cacatcttta ccatggtaat
     2941 gtcgcctctg gtatctggag tgttgatcca tccttggtgg gcagcagccc tcaacgaact
     3001 gaagctcacg agcaaaaccc agcagacagt gaacttcatc attctccaaa cctggattat
     3061 tctccatccc actgccaggt tatccaagaa ggccacttgc agttcctgag gtgcatctcc
     3121 ccccattcag ataccacact gacacctttg cagtccatct ctgccactct ctcatcttct
     3181 gtgtgctcct catcagaaac atccttgcac ctggttctcc caagtaggtc agaggagggc
     3241 agcatcactc acggaccggt gagttctttc agtttggaaa acttaccagg ctcttgggac
     3301 cgagaacaaa tgatgtcagc ctcttcagaa cgcttggaga actttccagt agaagttgtc
     3361 acaagcacag cggatgtaaa ggacagcaaa gccataaacg tataatatca gcacacaagg
     3421 gccgttttcg atgccaaacc cactgctgca tgacagctct agtttgcctt tgtggctttt
     3481 agcaggtgtg gagcctgagc aaagttagga attctgcagg aaagagggca aggggccaga
     3541 aaaaggcaga gccacctcta tactgtagca aacaatttct agattgtaga agcatcaaac
     3601 cttttctgta taggtattaa catactggtc tgattgacag actttggtaa ccatccaagg
     3661 acccagaggg tctgagcaga tagaaacccc agacaaagag tttggggatt agttttgtca
     3721 tagcagtttt tgtgaagtgc agcaaaggtt tttcctgagt gcctgattgt cattcctgaa
     3781 caatatccat agcactgttg gcctcgggag tgcatggctc ccgctgatct attttccttt
     3841 ttgtgaaggc agaggaacaa ttatcactgc atgtcatctc ctagacaatc agtcaaatag
     3901 agctggtggc cagtggttag ctatccgcac gttatttgcc atgtaaatga aaatgtcttt
     3961 atttatcaaa aaaagaagct atttttatat ccttggtatg aattatgtat ttaaactatt
     4021 tataaagaaa tgaacgtttt cttttcattt tggttaaaaa aagcttgctg ttttaacaaa
     4081 aaatacatta ctgttatgta tagtaaatca aaaattattt atcatcaaga ggttgtagtt
     4141 ttgaaaggaa tcccctttta tctgcatgca gtttgcaaaa caggaaaaaa aatgtacatg
     4201 taccctcaca cttctgggat acaaaaggac agtggggtta tattttatca atgaaataaa
     4261 aacatggact cagtgcaaac tccatgaaaa aaaaaaaaaa aaaaa
//
