LOCUS       NM_001037712            4438 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily H
            (eag-related), member 6 (Kcnh6), mRNA.
ACCESSION   NM_001037712 XM_112511 XM_895228 XM_903107 XM_903108 XM_912143
            XM_922264 XM_922267
VERSION     NM_001037712.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4438)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4438)
  AUTHORS   Xiong,F.R., Lu,J., Zhu,J.J., Zhao,R.X., Zhang,Y.C. and Yang,J.K.
  TITLE     KCNH6 is essential for insulin secretion by regulating
            intracellular ER Ca2+ store
  JOURNAL   FASEB J 38 (4), e23490 (2024)
   PUBMED   38363581
  REMARK    GeneRIF: KCNH6 is essential for insulin secretion by regulating
            intracellular ER Ca[2+] store.
REFERENCE   3  (bases 1 to 4438)
  AUTHORS   Wang,H., Li,Q., Yuan,Y.C., Han,X.C., Cao,Y.T. and Yang,J.K.
  TITLE     KCNH6 channel promotes insulin exocytosis via interaction with
            Munc18-1 independent of electrophysiological processes
  JOURNAL   Cell Mol Life Sci 81 (1), 86 (2024)
   PUBMED   38349432
  REMARK    GeneRIF: KCNH6 channel promotes insulin exocytosis via interaction
            with Munc18-1 independent of electrophysiological processes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4438)
  AUTHORS   Lu,J., Shi,T.T., Yuan,S.S., Xie,R.R., Zhao,R.X., Zhu,J.J. and
            Yang,J.K.
  TITLE     Cisapride induced hypoglycemia via the KCNH6 potassium channel
  JOURNAL   Front Endocrinol (Lausanne) 13, 1011238 (2022)
   PUBMED   36325440
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4438)
  AUTHORS   Zhang,Y.C., Xiong,F.R., Cheng,C., Shen,H., Zhao,R.X., Zhu,J.J.,
            Zhang,L., Lu,J. and Yang,J.K.
  TITLE     KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial
            Ca2+ Regulation and Oxidative Stress Inhibition
  JOURNAL   Oxid Med Cell Longev 2022, 3739556 (2022)
   PUBMED   36217412
  REMARK    GeneRIF: KCNH6 Enhanced Hepatic Glucose Metabolism through
            Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4438)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   7  (bases 1 to 4438)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 4438)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   9  (bases 1 to 4438)
  AUTHORS   Le,N., Nagarajan,R., Wang,J.Y., Araki,T., Schmidt,R.E. and
            Milbrandt,J.
  TITLE     Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies
            Sox2 as an inhibitor of Schwann cell differentiation and
            myelination
  JOURNAL   Proc Natl Acad Sci U S A 102 (7), 2596-2601 (2005)
   PUBMED   15695336
  REMARK    GeneRIF: One of the abnormally elevated genes in Egr2Lo/Lo Schwann
            cells, Sox2, encodes a transcription factor that is crucial for
            maintenance of neural stem cell pluripotency.
REFERENCE   10 (bases 1 to 4438)
  AUTHORS   Polvani,S., Masi,A., Pillozzi,S., Gragnani,L., Crociani,O.,
            Olivotto,M., Becchetti,A., Wanke,E. and Arcangeli,A.
  TITLE     Developmentally regulated expression of the mouse homologues of the
            potassium channel encoding genes m-erg1, m-erg2 and m-erg3
  JOURNAL   Gene Expr Patterns 3 (6), 767-776 (2003)
   PUBMED   14643686
  REMARK    GeneRIF: erg2 gene expression pattern in the developing embryo
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596331.15.
            
            On Feb 15, 2019 this sequence version replaced NM_001037712.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC109174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AL596331.15        16588-16718
            132-362             AL596331.15        17423-17653
            363-524             AL596331.15        22568-22729
            525-730             AL596331.15        22825-23030
            731-1156            AL596331.15        25675-26100
            1157-1556           AL596331.15        27192-27591
            1557-1756           AL596331.15        28562-28761
            1757-2009           AL596331.15        28931-29183
            2010-2203           AL596331.15        32165-32358
            2204-2288           AL596331.15        34234-34318
            2289-2445           AL596331.15        35156-35312
            2446-2626           AL596331.15        35997-36177
            2627-4438           AL596331.15        42223-44034
FEATURES             Location/Qualifiers
     source          1..4438
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.87 cM"
     gene            1..4438
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /note="potassium voltage-gated channel, subfamily H
                     (eag-related), member 6"
                     /db_xref="GeneID:192775"
                     /db_xref="MGI:MGI:2684139"
     exon            1..131
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            132..362
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            363..524
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            525..730
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1156
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1556
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1756
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..2009
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2203
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2288
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2445
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2626
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..4438
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3424..3429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
                     /note="hexamer: AATAAA"
     polyA_site      3444
                     /gene="Kcnh6"
                     /gene_synonym="m-erg2"
ORIGIN      
        1 ggagacgcca gaagccaggg caccggtcac tcccagcaag tggtgttaca gaaagatgcc
       61 agtccgcagg ggccacgttg ctccccaaaa cacttacttg gacaccatca tccgcaagtt
      121 tgagggccag agtcgtaagt tcctgattgc caatgcacag atggagaact gtgccatcat
      181 ctactgcaat gatggcttct gcgaactctt cggctactcc cgtgtggagg tgatgcagcg
      241 accctgtacc tgtgacttcc tcactggccc gaacactccg agcagtgctg tgtcccgcct
      301 ggcgcaggcc ctgcttgggg ctgaagagtg caaggtggac atcctctact atcgcaagga
      361 tgcctccagc ttccgctgcc tggtggatgt ggtccctgtg aagaacgagg atggggctgt
      421 catcatgttc atcctcaatt tcgaggacct ggcccagctc ctggccaaga gcagcagccg
      481 cagcctgacc caacgtttgt tgtcacacag cttcctgggc tctgagggct ctcacagcag
      541 gccaagcgga caggggcctg gtccaggcag gggcaagtat ggaactgtca gccagatccc
      601 gcagttcacg ctcagctttg tggagttcaa cctggagaag caccgctcag gctccaccac
      661 agagattgag atcatcgctc cccacaaggt ggtggagcgg acacagaatg tcactgaaaa
      721 ggtcacgcag gtcctgtccc tgggtgcaga tgtgctgcca gagtacaagc tgcaggcacc
      781 gcgcattcac cgaggtacca ttctgcacta cagccccttc aaggctgtat gggactggct
      841 catcttgctc ttagtcatct atacagcggt cttcacgccc tactctgctg cctttctgct
      901 tagcgaccag gacgactcac agcgtggtac ctgcggctat acctgcagcc cgctcaccgt
      961 ggtggacctc atcgtggata tcatgtttgt ggtggatatt gtcatcaact tccgaaccac
     1021 ctacgtcaac actaatgacg aggtggtcag ccacccccga cgaatcgccg tccactattt
     1081 caagggctgg ttcctcattg acatggtggc tgccatccct tttgacttgc ttatcttccg
     1141 cactggctca gatgagacca ccaccctgat cgggttactg aagacggcgc gcctcctacg
     1201 gctggtgcgc gtggcccgga agctggaccg ctattctgaa tacggggccg ccgtactctt
     1261 cctgctcatg tgtacttttg cgctcattgc gcactggctg gcctgtatct ggtacgccat
     1321 cggcaatgtg gagcgaccct acttggagcc caagattggt tggctggaca gcctgggcgc
     1381 gcagcttggc aagcactata acggcagcga cccagcctcg ggaccctctg tccaagacaa
     1441 gtatgtcacc gccctctact tcaccttcag cagcctcact agtgtgggct tcggcaatgt
     1501 gtcacccaac accaactctg agaaggtctt ctctatctgc gtcatgctca ttggctcact
     1561 tatgtacgcc agcatctttg gcaacgtgtc ggccatcatc cagcgcctgt actcaggcac
     1621 ggctcgctac cacactcaga tgctgcgggt caaggagttc atccgcttcc accagatccc
     1681 caacccactg aggcagcgcc tggaagagta tttccagcac gcctggtcct acaccaatgg
     1741 catcgacatg aacgcggtgc tgaaaggctt ccctgagtgc ctgcaggcgg acatctgcct
     1801 gcacctgcac cgcgctctgt tgcagcactg ccccgccttc cgcggcgcca gcaaggggtg
     1861 cctgcgcgcg ctcgccgtca agttcaagac cacgcacgcg ccgcctgggg acacgctggt
     1921 gcacctgggc gacgtgcttt ccactctcta cttcatctcc cgcggctcca tcgagatcct
     1981 gcgcgatgac gtggtcgtgg ccattctagg gaagaatgac atctttgggg agcctgccag
     2041 tctccatgcc agaccaggca aatcaagcgc cgatgtgcgt gccctgacct actgcgacct
     2101 gcacaagatc catcgagcag acctgctgga ggtgctggac atgtaccccg cctttgcaga
     2161 taccttctgg aataagctag aggtcacctt caacctgcgg gacgcagatg ggggtctcca
     2221 ctcaacaccc cgacaggccc caggcaacca agacccccaa ggcttcttcc tcaatgacag
     2281 ccaatcaggt gctgcccctt ccctgagcat ttcagacaca tctgggcttt ggcctgaatt
     2341 gctacagcaa atgcccccaa gtcccccaaa cccacgagag aagctggatt gctggcctcg
     2401 ggagctaggc tttaagttag aacagctcca agcccagatg aacagactgg agtcccgcgt
     2461 gtcgtcagac ctcagccgca tcctacagct acttcagcat ccacagggcc accccggcta
     2521 catcttgggg gcccctgcct ccagtgacct ggccttgttt cctgaaactt cagtgactca
     2581 gagttcagag tcgatgcttc tggtgggaca tctgccctct gcacagaccc taagctatgg
     2641 tgatttggac aaacatatcc ggatgcccag gaatttctcc cccaggatac ctcacgtggc
     2701 cgcggcaatg gacaaatctc tggtgccgtc ctcagaacaa gagcagccca aggggctcct
     2761 gtcacctctg gcctcacctc tgtgtcccct ggaagtacag ggactgggtg gtccccactt
     2821 ttcctccctc cctgaacacc tcagctccgt tcccaagcag ctggaattcc agagacacgg
     2881 ttcagatcct ggattcacaa ggagttaggc cctttagacc ccgggataaa agctaccatg
     2941 agggaattta aatacagcga ggtgagagtt aagccccctt ccatggaggg ccagacagct
     3001 ctcccataaa actctgaaaa ccattttctc tgaaaaactg cagactgctg aaccaggtga
     3061 ccaggatggc ctgagcagag aggcctggga cttggcccag cctccctggg agtccctata
     3121 gtcagcaagc caggcagagg gctgctcagg ggtagctcac aggatgtaag agtcagtgga
     3181 gaagagagat gcttcgggtc ttcgggagag tcttgcttgg ggccgcacat gatcagaacc
     3241 accctctgcc tccaaagctc agacccaagg ccagggttga ccagatcttt accaaaagcc
     3301 tctaatatgg ctggaattag aggtttcctc tgtggtggac ataaaagaaa gagctgcagc
     3361 cctcagcccc tcagcccccg agagtcccat aacgatatct gggacatgca gtaccacata
     3421 actaataaag ccttgaacat ttcatgttgg gctaggtgtg taacccaccc gaacatcctc
     3481 aggtccgtgc ctatgctggg accttctcca aacccttccc gcacccaacc tgttggagac
     3541 ctgaaggtgt ctcagctagg agcaggggct ccacagcctg aagctgtctc cagctgaagg
     3601 gaaacagact cagcctccta agtgtccaca gagaatcatg gccagagacg gtgtttgtcc
     3661 agccctccac catcctctcc tgcacatggt tgtccttcta acccgtagaa tagccttagg
     3721 aagttggttt tactatcctc atatgaaagg tcttgggtca gtagcagaga gactatggca
     3781 cttaccagag tgtgagcagg ccttctgggc acgtcagtat ttgctttctg ctctggtgat
     3841 gtgttccggt tagaaaaaca tgtgtgctcc catatgtaaa tgacatttca ataaaaagtt
     3901 aaactcaaca cactagaaaa aggagaacac ggtttcaacc cacactgcct cgcttgagag
     3961 acctgttaaa acatcgttgc ttgtcagata attctaatct gtcctcctca gcccattttt
     4021 ccttcctttt gcaatttcta tttgatgccc cagagtctgt tagtgagttt atgagcacac
     4081 attcgcaagt gtttatacaa gctaaaacgt taaagttaac ttttctgttg ggcgtggtgg
     4141 cgcatgcctt taatcccagc actcaggagg cagagacagg cggatttctg agttcaaggc
     4201 cagcctggtc tacaaagtga gttccaggac agccagggct atacagagaa accctgtctc
     4261 gaaaaaacaa aacaaaacaa aaaagacctg ttccgtaaaa tagatagata gacctccgct
     4321 aagattgtac tacaagacca ttattaaccc actgaaaaat cagaaatgat gtaaccaata
     4381 gaaaactatg gaccaaattt cctgatatgc acagaaataa aacgtttcaa taaaatac
//
