LOCUS       NM_172805               4061 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily H
            (eag-related), member 5 (Kcnh5), mRNA.
ACCESSION   NM_172805
VERSION     NM_172805.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4061)
  AUTHORS   Huang,X., Dubuc,A.M., Hashizume,R., Berg,J., He,Y., Wang,J.,
            Chiang,C., Cooper,M.K., Northcott,P.A., Taylor,M.D., Barnes,M.J.,
            Tihan,T., Chen,J., Hackett,C.S., Weiss,W.A., James,C.D.,
            Rowitch,D.H., Shuman,M.A., Jan,Y.N. and Jan,L.Y.
  TITLE     Voltage-gated potassium channel EAG2 controls mitotic entry and
            tumor growth in medulloblastoma via regulating cell volume dynamics
  JOURNAL   Genes Dev 26 (16), 1780-1796 (2012)
   PUBMED   22855790
  REMARK    GeneRIF: Disruption of EAG2 expression results in G2 arrest and
            mitotic catastrophe associated with failure of premitotic
            cytoplasmic condensation
REFERENCE   2  (bases 1 to 4061)
  AUTHORS   Wende,H., Lechner,S.G., Cheret,C., Bourane,S., Kolanczyk,M.E.,
            Pattyn,A., Reuter,K., Munier,F.L., Carroll,P., Lewin,G.R. and
            Birchmeier,C.
  TITLE     The transcription factor c-Maf controls touch receptor development
            and function
  JOURNAL   Science 335 (6074), 1373-1376 (2012)
   PUBMED   22345400
REFERENCE   3  (bases 1 to 4061)
  AUTHORS   Zhang,X., Bursulaya,B., Lee,C.C., Chen,B., Pivaroff,K. and Jegla,T.
  TITLE     Divalent cations slow activation of EAG family K+ channels through
            direct binding to S4
  JOURNAL   Biophys J 97 (1), 110-120 (2009)
   PUBMED   19580749
  REMARK    GeneRIF: Our results suggest close conformational conservation
            between closed EAG (Kv12.1 and Kv10.2) and Shaker family channels,
            despite large differences in voltage sensitivity, activation rates,
            and activation threshold
REFERENCE   4  (bases 1 to 4061)
  AUTHORS   Mishina,M. and Sakimura,K.
  TITLE     Conditional gene targeting on the pure C57BL/6 genetic background
  JOURNAL   Neurosci Res 58 (2), 105-112 (2007)
   PUBMED   17298852
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110175.14, AK032438.1, CT010432.7 and AC131762.2.
            
            On Aug 6, 2009 this sequence version replaced NM_172805.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032438.1, BC066138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-564               AC110175.14        4115-4678
            565-2458            AK032438.1         566-2459
            2459-2459           CT010432.7         91966-91966         c
            2460-4058           AK032438.1         2461-4059
            4059-4061           AC131762.2         142672-142674       c
FEATURES             Location/Qualifiers
     source          1..4061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 32.62 cM"
     gene            1..4061
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /note="potassium voltage-gated channel, subfamily H
                     (eag-related), member 5"
                     /db_xref="GeneID:238271"
                     /db_xref="MGI:MGI:3584508"
     exon            1..877
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /inference="alignment:Splign:2.1.0"
     CDS             805..3771
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /note="potassium voltage-gated channel subfamily H member
                     5; ether-a-go-go potassium channel 2; voltage-gated
                     potassium channel subunit Kv10.2"
                     /codon_start=1
                     /product="voltage-gated delayed rectifier potassium
                     channel KCNH5"
                     /protein_id="NP_766393.2"
                     /db_xref="CCDS:CCDS25980.1"
                     /db_xref="GeneID:238271"
                     /db_xref="MGI:MGI:3584508"
                     /translation="MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSN
                     DGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNR
                     TPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSR
                     SVLQQLTPMNKTETVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWD
                     WVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGE
                     VISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV
                     ARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQL
                     ALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSV
                     AMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDY
                     IVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEF
                     QTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDEEVVAILGKGDVFGDIFWKETTLA
                     HACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDV
                     KKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRIQGSAQSDPERSQLQVESRP
                     LQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPNGGAEPKCLKVN
                     SPIRMKNGNGKGWLRLKNNMGAQEEKKEDWNNVTKAESMGLLSEDPKGSDSENSVTKN
                     PLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPSQADVKHSFYPIPEQALQTTLQEVK
                     HELKEDIQLLSCRMTALEKQVAEILKLLSEKSVPQTSSPKPQIPLQVPPQIPCQDIFS
                     VSRPESPESDKDEINF"
     exon            878..1001
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1108
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1237
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1353
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1746
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..2173
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2373
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2626
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2823
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..4061
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4033..4038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /note="hexamer: AATAAA"
     polyA_site      4060
                     /gene="Kcnh5"
                     /gene_synonym="Eag2; mEag2"
                     /note="major polyA site"
ORIGIN      
        1 agtctgggct agagcaggag ccctcttgca tctcagcccc aggacccgag tcctccggag
       61 ctgctggggt ttcggacagc ggcagcagga gaagctgaga tgtgacctgc tctccccaga
      121 gattgccatt tccctctctg gtgcctgcct cgcgaacaac agcccgcacc agccagcgag
      181 cacttgtctg gatcttcctg gagaaaggag cagccactag gcgctcgcaa agcctggaca
      241 gaactttggc tgccctgggt agctgtgaaa cagctgagtg agaagggtgg gctaggagac
      301 caagggagca gagagctaag gaatggggtc ttagcctggg ctaggggtgg ggagagggaa
      361 gtcgagttgc tcctcgctct ctcccagagc ccgggcgcgg ggcagaggga gaaatgctga
      421 gcccgcgtcc gggctcctgc ctccccggca gcatcttcag cagcagcctc agcatcagca
      481 ccggcgggac agcgacagcg ggggcggcgc aggcgcactg tgcccggcgg agcctgcagt
      541 tccccagccc cgtgtgcggc accgccacag tctgggcagc ggcggccggg ggagcgctac
      601 taccatgaac tgcttggtcc tccttcccag agctgctcat ccgggtcggg ctggagacac
      661 actcagggga ccccgccgcc gccgccgcgc ccccttttct ttcagcacca tctccactac
      721 cttttcctcc tcttcttcca ccttttcttc ctgcttcccc ccctcccccg ccgcggatcc
      781 tggccgctgc tttccagacc caggatgccg gggggcaaga gagggctggt ggctccgcag
      841 aacacatttt tggagaacat cgtcaggcgc tccagtgaat caagtttctt actgggaaat
      901 gcccaaattg tggactggcc tgtagtttat agtaatgacg gtttttgtaa actctctgga
      961 tatcatcgag ctgacgtcat gcagaaaagc agcacctgca gttttatgta tggagaactg
     1021 accgacaaga agaccattga gaaagtcagg cagacttttg acaactacga gtcaaactgt
     1081 tttgaagttc ttctgtacaa aaaaaaccgt acccctgttt ggttttacat gcaaatcgca
     1141 ccaataagaa atgaacacga gaaggtggtc ttgttcctgt gtacattcaa ggacattaca
     1201 ctgttcaaac agcctataga ggatgactca acgaaaggtt ggacgaagtt tgcccgattg
     1261 acacgggctt tgacaaatag ccgaagtgtt ttacagcagc ttacaccaat gaataaaaca
     1321 gagacagtcc acaagcattc aagactagct gaagtgcttc agctgggatc agacatcctt
     1381 cctcagtaca aacaagaagc gccaaagacg ccaccacata tcatcttaca ctattgtgct
     1441 tttaaaacta cttgggattg ggtgatttta attcttacct tctacaccgc catcatggtt
     1501 ccttacaatg tttctttcaa aacaaagcag aacaatatcg cctggctggt gctggacagt
     1561 gtggtggacg tgatttttct ggtggacatt gttttaaatt ttcacacgac ttttgtgggg
     1621 ccgggtggag aggtcatttc tgacccgaag cttataagga tgaactatct gaaaacttgg
     1681 tttgtgattg atctgctgtc ttgtttacct tatgacatca tcaatgcctt tgaaaatgtg
     1741 gatgagggaa tcagcagtct cttcagctct ttaaaggtgg tgcgcctttt acgcctgggc
     1801 cgtgttgcta ggaaactgga ccattacctg gaatatggag cagcggtcct tgtgctcctg
     1861 gtatgtgtgt ttggactggt ggctcactgg ctggcttgca tctggtacag cattggagac
     1921 tatgaggtca ttgatgaagt caccaacacc attcaaatag acagctggct ctaccagttg
     1981 gccttgagca ttgggacccc atatcgctac aatacgagtg cagggatctg ggaaggagga
     2041 cccagcaagg actccctgta tgtgtcctcc ctctacttca ccatgacgag ccttacaacc
     2101 ataggatttg gaaacatagc tccgaccaca gacgtggaga agatgttctc agtggccatg
     2161 atgatggtcg gctctcttct ttatgcaact atttttggaa atgttaccac aattttccag
     2221 caaatgtatg ccaacaccaa ccgttaccat gagatgctga ataatgttcg agatttcctg
     2281 aaattatatc aggtcccaaa aggccttagt gaacgagtga tggattatat tgtctcaaca
     2341 tggtcaatgt caaaaggcat cgacacagag aaggtcctct ccatctgtcc caaggacatg
     2401 agagctgaca tctgtgttca tctgaaccgg aaggttttta atgaacatcc tgcattccga
     2461 ttggccagcg atggatgtct gcgtgccttg gcagtggagt tccaaaccat tcactgtgct
     2521 cctggggacc tgatttacca tgctggagag agtgtggatg ccctctgctt tgtggtgtcc
     2581 gggtccttgg aagttatcca ggatgaggag gtggtggcca ttttagggaa aggtgacgtg
     2641 tttggagaca tcttctggaa ggaaaccacc cttgctcatg cgtgtgccaa tgtccgggcc
     2701 ctgacttact gtgatctgca catcatcaag cgagaagcct tgctcaaggt ccttgacttc
     2761 tatacagcat ttgcaaactc attttccagg aacctcactc tcacttgcaa tctaaggaag
     2821 cggatcatct tccgtaaaat tagtgatgtg aagaaggagg aggaggagcg gctgcggcag
     2881 aagaatgagg tgactctgag catccccgtg gaccacccag tgaggaagct cttccagaag
     2941 ttcaaacagc agaaagaact gaggatccag ggctctgcac agagtgatcc tgagaggagc
     3001 cagcttcagg tagagagccg ccctttgcag aacggagcct ccatcacagg taccagtgtg
     3061 gtcaccgtat cacagattac ccccatccag acgtctctgg cgtatgtgaa aaccagcgag
     3121 tctcttaagc agaacaaccg cgatgccatg gaactgaagc ccaatggtgg cgctgaaccc
     3181 aaatgtctca aggtcaacag ccccatcagg atgaaaaacg gaaatgggaa ggggtggctg
     3241 agactcaaga acaacatggg ggctcaggag gagaaaaagg aagactggaa taatgtcacc
     3301 aaagccgagt cgatggggct cttgtcggag gaccccaagg gcagtgactc agagaacagt
     3361 gtgaccaaga accccttaag gaaaacggat tcttgtgaca gtgggattac aaaaagtgac
     3421 cttcgtttgg ataaagccgg tgaggcccga agtcctctag aacacagccc cagccaggct
     3481 gatgtcaagc attctttcta ccccatcccc gagcaggcct tacaaaccac actgcaggaa
     3541 gtcaaacatg aactcaagga ggatatccag ctgctaagct gcagaatgac tgccctggaa
     3601 aagcaggtgg cagagatttt aaaactactc tcagagaaaa gcgtacccca gacatcttct
     3661 ccaaaacccc aaattccact ccaagtacct ccccaaatac catgtcagga tatttttagt
     3721 gtctcaaggc ctgagtcacc cgaatctgac aaagacgaaa tcaactttta atatatatat
     3781 acatatatat ttgttaatat atttaaaaca gtatatacat ctatatacat aagtgtgtat
     3841 atatagtata tacatatata ttttcacttg ctttcaatat gatgaacaca atatggattt
     3901 tgatatgtac atactgcatg tccagctgga ttctggcctg ccaaagacaa ttattcaaaa
     3961 catagatatt gcttgtacat tatgcagttg actgcatgca cactttacat ttatttataa
     4021 tctctattct gtaataaaaa aaaagtatga attttgttaa c
//
