LOCUS       NM_001081194            3784 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily H
            (eag-related), member 4 (Kcnh4), mRNA.
ACCESSION   NM_001081194 XM_354643
VERSION     NM_001081194.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3784)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3784)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 3784)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3784)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   5  (bases 1 to 3784)
  AUTHORS   Tuck,E., Estabel,J., Oellrich,A., Maguire,A.K., Adissu,H.A.,
            Souter,L., Siragher,E., Lillistone,C., Green,A.L., Wardle-Jones,H.,
            Carragher,D.M., Karp,N.A., Smedley,D., Adams,N.C., Bussell,J.N.,
            Adams,D.J., Ramirez-Solis,R., Steel,K.P., Galli,A. and White,J.K.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   6  (bases 1 to 3784)
  AUTHORS   Cui,Y., Li,M., Walton,K.D., Sun,K., Hanover,J.A., Furth,P.A. and
            Hennighausen,L.
  TITLE     The Stat3/5 locus encodes novel endoplasmic reticulum and
            helicase-like proteins that are preferentially expressed in normal
            and neoplastic mammary tissue
  JOURNAL   Genomics 78 (3), 129-134 (2001)
   PUBMED   11735219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC150990.1 and AL591469.9.
            
            On Jun 25, 2009 this sequence version replaced NM_001081194.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC150990.1, SRR7345562.1684267.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3508              BC150990.1         9-3516
            3509-3540           AL591469.9         152208-152239       c
            3541-3784           AL591469.9         151293-151536       c
FEATURES             Location/Qualifiers
     source          1..3784
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.57 cM"
     gene            1..3784
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /note="potassium voltage-gated channel, subfamily H
                     (eag-related), member 4"
                     /db_xref="GeneID:380728"
                     /db_xref="MGI:MGI:2156184"
     exon            1..249
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..3230
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily H
                     member 4"
                     /protein_id="NP_001074663.1"
                     /db_xref="CCDS:CCDS36334.1"
                     /db_xref="GeneID:380728"
                     /db_xref="MGI:MGI:2156184"
                     /translation="MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGPRGFPIVY
                     CSDGFCELTGYGRTEVMQKTCSCRFLYGPETSEPALQRLQKALEGHQEHRTEICFYRK
                     DGSAFWCLLDMMPIKNEMGEVVLFLFSFKDISQSGGPGLGSPGIHGDNNHENSLGRRG
                     TSSRLRSTKRQNRTVLHRLTGHFGRRGQSSVKANSNLFEPKPSVPEYKVASVGGSRCL
                     LLHYSIPKAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEMLFIL
                     DIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFVDLIAALPFDLLYVFNITVTSLVH
                     LLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACVWYVIGRREMEAND
                     PLLWDIGWLHELGKRLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTD
                     AEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPL
                     KQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLR
                     ALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIP
                     ELGQEPGSGAGPSCVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYAAAFRAGLPR
                     DLTFNLRQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLPSITETEGGTEPGAGSKP
                     RRPHLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPTPSPALAGRGQSPSPHGP
                     PRGSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSSNTAEAPTFRFSKRPEPTRTRS
                     QAPPSGPRLSRELATEAAEEVKEKVCRLNQEISRLNQEVSQLSRELRQVMGLLQARLG
                     PPSHTAGPAWLPDLPCPHQRLPCISPHMSGPPPGLQNTTLAVVHCPASVGTVEIGATP
                     SELRPSTIPPYPSEPDPLGPSPAPEAPPLTPSLLKHSFQSGSDTFH"
     exon            250..483
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..630
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..758
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1002
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1160
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1368
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1563
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1763
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2013
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2258
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2297
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2650
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2757
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2834
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..3540
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3784
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3752..3757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /note="hexamer: GATAAA"
     regulatory      3763..3768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /note="hexamer: AATAAA"
     polyA_site      3768
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /note="major polyA site"
     polyA_site      3784
                     /gene="Kcnh4"
                     /gene_synonym="BEC2"
                     /note="major polyA site"
ORIGIN      
        1 tgcggagcag agcttagaac taacaggttc agagcacaca ggcagcggcg gcgagaggag
       61 gggaggaggc aggccggcgc atggggcgcc ccggccccgc cggtagcgcg ccccctccgg
      121 ccaggccgcg ctgaacgcag cccgcgcaac gcctcgaatc cgtacccggg gccatgccgg
      181 tcatgaaggg gttgctggcc ccgcaaaaca cctttctgga caccatcgcc acccgctttg
      241 acggcacgca cagcaacttc cttctggcca atgcacaggg cccacggggt tttcccatcg
      301 tctactgctc tgacggcttc tgtgagctca caggctacgg ccgcaccgag gtcatgcaga
      361 aaacctgtag ctgtcggttc ctctatggcc cagagaccag tgaaccagcc ctgcaacggt
      421 tgcaaaaagc cctggagggc caccaagaac accgaactga aatctgcttt taccgaaagg
      481 atggctcagc cttctggtgt cttctggaca tgatgcccat caagaatgag atgggggagg
      541 ttgtgctttt cctattttcc ttcaaggaca tctctcagag tggaggccca ggacttggct
      601 caccaggaat ccatggggac aataatcacg aaaactctct tgggaggaga ggaactagct
      661 caagacttag gtccacgaag aggcagaacc ggactgtcct acaccggttg actggccact
      721 ttggtcgccg gggccagagc agtgtgaagg ccaacagtaa cctgtttgag ccaaaaccat
      781 cagtgcccga gtacaaggtg gcctctgtgg ggggctcccg ctgcctcctc ctccactaca
      841 gcatccccaa ggctgtctgg gatggtctca tcctcctcgc cacattctac gtcgcggtca
      901 ctgtccccta caacgtctgc ttcgcgggtg atgacgacac ccccatcact tcccgacaca
      961 cccttgtcag tgacatcgct gtggaaatgc tcttcatcct ggacatcatc ttgaacttcc
     1021 gcaccaccta cgtgtcccag tctggccagg tgatttcggc tcctcggtcc attggcctcc
     1081 actatctggc cacctggttc tttgtagacc tcattgctgc tttgcccttt gatctgctgt
     1141 atgtcttcaa catcactgtg acctcactgg tacatctgct gaaaaccgtg cggctcctgc
     1201 ggctgctgcg gctgctgcag aagttagagc ggtactcaca gtgcagtgca gtggtgctca
     1261 cgctgctcat gtccgtcttt gccctccttg ctcattggat ggcctgcgtc tggtatgtca
     1321 tcgggcgccg ggagatggag gccaatgatc cactgctctg ggacattggt tggttgcatg
     1381 agctgggcaa gcggttggag gagccttatg tcaatggctc ggcaggtgga ccatctcggc
     1441 gcagtgccta catcgctgcg ctgtacttca cgctgagcag cctcaccagt gtaggcttcg
     1501 gcaacgtgtg tgccaacaca gacgctgaga agatcttctc catctgcacg atgctcatag
     1561 gcgcgctgat gcacgcagtg gtgtttggga atgtcacagc catcatccag cgcatgtact
     1621 cccgacgctc gctctaccac agccgcatga aggatctcaa ggacttcatc cgagtgcatc
     1681 gcctgccccg cccactcaag cagcgcatgc tcgagtactt ccagacgacg tgggcagtca
     1741 acagcggcat cgatgccaac gagttactgc gtgacttccc ggatgagctg cgtgctgaca
     1801 ttgctatgca cctgaacagg gagatcctgc agctgcctct gtttggagcg gctagcaggg
     1861 gctgcctgcg ggccctctcc ttgcacatca agacctcctt ctgtgctcct ggggagtacc
     1921 tgttacgccg tggggatgcc ctccaggcac actactacgt ctgctctggc tcgcttgagg
     1981 tgctccggga caacatggtg ctggccatcc tggggaaggg ggacttgatt ggggcagaca
     2041 tccctgagtt gggacaggag cctgggtcag gggcaggccc cagctgtgtg ctgaagacca
     2101 gcgccgatgt gaaagctctg acttactgtg gcctgcagca gctgagcagc cgagggctgg
     2161 cggaggtcct gcggctgtat ccggaatatg cagctgcctt ccgggctggc ctaccccggg
     2221 acctaacctt caacctgcgc caaggttctg aaaacaatgg cctcggccgc ttctcacggt
     2281 ctcctcgtct ctcccaggca cgctccgaca ctcttggttc ctcctcagac aagactctgc
     2341 catccatcac agaaaccgag ggtggcacgg agcctggggc tggttccaag ccccgtcggc
     2401 cccacctgct gcccaacctc agtccagcac gacctcgggg gtccctggtc agccttttgg
     2461 gcgaggagct gcccccattc tcagcccttg tctcctctcc ttccctgtcc ccaactcctt
     2521 cccctgccct ggctggccgg ggtcagagtc cctccccgca cggccccccc aggggctctg
     2581 ctgcctggaa gcccccccag ctcctcattc ccccactggg aacatttgga cctccggacc
     2641 tcagtccccg gatcgtggat ggcattgaag actccagtaa cacagctgag gctcctacat
     2701 tccgcttcag caagaggcca gagcccacca gaactcgctc acaggctccc ccttcaggcc
     2761 ccaggctcag ccgggaactg gccacagagg cagcagagga ggtgaaggaa aaggtctgca
     2821 ggctgaacca agagatctcc cgtctcaatc aggaagtgtc tcagctgagc cgggagctgc
     2881 ggcaagtgat gggtctctta caggccaggc tgggaccccc aagtcacaca gctggtccag
     2941 cttggctccc agaccttcct tgcccccacc agagactacc atgcatctct cctcatatgt
     3001 ctggaccacc acctggtctc cagaatacta cactcgctgt agtccactgt ccagccagtg
     3061 ttgggacagt ggagataggg gccaccccct cagagctgag accttccacg ataccaccct
     3121 atccctcgga acctgatcct ctgggaccct ctccagcgcc agaggctcct cccctgaccc
     3181 caagcctcct gaagcacagc ttccagtctg ggtcagacac attccactga ccctggcctt
     3241 gggcctaggc ctgtctgggg taggctttac cacctgccat ccagggaggc gctgggctcc
     3301 ttggcctctt gccttggggt cagcagctgc cagctggact ggttggctct ggattctctg
     3361 gactttttaa acaacgaatg gccacatcta accccgttcc attttctaaa ccatccccca
     3421 tcctcctctt ctgggagggg agtcacttga agccatggaa tccagcaggc atgaaatgga
     3481 ccatggcgcc ctgttgggct acgcagagga gatgtcttac tttctcccga agacttggag
     3541 gctgtcatgc aaggtggttc cttctgctgt cagcagctca aagcattcta gcattaccct
     3601 tctgcaggtc ccacctccca acatcagcca aacctgcatc ccctccctcc caacatggtc
     3661 tcaacctcag ggagggtctg ggcaactccc aagccctctc tggtttccag ccctcctttc
     3721 tcactcaatg ccccacccag gcgcactttt ggataaaaaa aaaataaatc catatatttt
     3781 tgta
//
