LOCUS       NM_013569               4221 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily H
            (eag-related), member 2 (Kcnh2), transcript variant 1, mRNA.
ACCESSION   NM_013569 XM_906142 XM_919669 XM_919680
VERSION     NM_013569.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4221)
  AUTHORS   Schwarz,J.R., Freitag,S., Pechmann,Y., Hermans-Borgmeyer,I.,
            Wagner,W., Hornig,S. and Kneussel,M.
  TITLE     Purkinje cell hyperexcitability and depressive-like behavior in
            mice lacking erg3 (ether-a-go-go-related gene) K+ channel subunits
  JOURNAL   Sci Adv 10 (40), eadn6836 (2024)
   PUBMED   39365861
REFERENCE   2  (bases 1 to 4221)
  AUTHORS   Sinha,T., Lammerts van Bueren,K., Dickel,D.E., Zlatanova,I.,
            Thomas,R., Lizama,C.O., Xu,S.M., Zovein,A.C., Ikegami,K.,
            Moskowitz,I.P., Pollard,K.S., Pennacchio,L.A. and Black,B.L.
  TITLE     Differential Etv2 threshold requirement for endothelial and
            erythropoietic development
  JOURNAL   Cell Rep 39 (9), 110881 (2022)
   PUBMED   35649376
REFERENCE   3  (bases 1 to 4221)
  AUTHORS   Anderson,L.B., Ravara,B., Hameed,S., Latour,C.D., Latour,S.M.,
            Graham,V.M., Hashmi,M.N., Cobb,B., Dethrow,N., Urazaev,A.K.,
            Davie,J.K., Albertin,G., Carraro,U., Zampieri,S. and Pond,A.L.
  TITLE     MERG1A Protein Abundance Increases in the Atrophied Skeletal Muscle
            of Denervated Mice, But Does Not Affect NFkappaB Activity
  JOURNAL   J Neuropathol Exp Neurol 80 (8), 776-788 (2021)
   PUBMED   34363662
  REMARK    GeneRIF: MERG1A Protein Abundance Increases in the Atrophied
            Skeletal Muscle of Denervated Mice, But Does Not Affect NFkappaB
            Activity.
REFERENCE   4  (bases 1 to 4221)
  AUTHORS   Dierich,M., Altoe,A., Koppelmann,J., Evers,S., Renigunta,V.,
            Schafer,M.K., Naumann,R., Verhulst,S., Oliver,D. and Leitner,M.G.
  TITLE     Optimized Tuning of Auditory Inner Hair Cells to Encode Complex
            Sound through Synergistic Activity of Six Independent K+ Current
            Entities
  JOURNAL   Cell Rep 32 (1), 107869 (2020)
   PUBMED   32640234
REFERENCE   5  (bases 1 to 4221)
  AUTHORS   van den Boogaard,M., van Weerd,J.H., Bawazeer,A.C., Hooijkaas,I.B.,
            van de Werken,H.J.G., Tessadori,F., de Laat,W., Barnett,P.,
            Bakkers,J. and Christoffels,V.M.
  TITLE     Identification and Characterization of a Transcribed Distal
            Enhancer Involved in Cardiac Kcnh2 Regulation
  JOURNAL   Cell Rep 28 (10), 2704-2714 (2019)
   PUBMED   31484079
  REMARK    GeneRIF: Identification and Characterization of a Transcribed
            Distal Enhancer Involved in Cardiac Kcnh2 Regulation.
REFERENCE   6  (bases 1 to 4221)
  AUTHORS   Trudeau,M.C., Titus,S.A., Branchaw,J.L., Ganetzky,B. and
            Robertson,G.A.
  TITLE     Functional analysis of a mouse brain Elk-type K+ channel
  JOURNAL   J Neurosci 19 (8), 2906-2918 (1999)
   PUBMED   10191308
REFERENCE   7  (bases 1 to 4221)
  AUTHORS   London,B., Trudeau,M.C., Newton,K.P., Beyer,A.K., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Satler,C.A. and Robertson,G.A.
  TITLE     Two isoforms of the mouse ether-a-go-go-related gene coassemble to
            form channels with properties similar to the rapidly activating
            component of the cardiac delayed rectifier K+ current
  JOURNAL   Circ Res 81 (5), 870-878 (1997)
   PUBMED   9351462
REFERENCE   8  (bases 1 to 4221)
  AUTHORS   Lees-Miller,J.P., Kondo,C., Wang,L. and Duff,H.J.
  TITLE     Electrophysiological characterization of an alternatively processed
            ERG K+ channel in mouse and human hearts
  JOURNAL   Circ Res 81 (5), 719-726 (1997)
   PUBMED   9351446
REFERENCE   9  (bases 1 to 4221)
  AUTHORS   Curran,M.E., Splawski,I., Timothy,K.W., Vincent,G.M., Green,E.D.
            and Keating,M.T.
  TITLE     A molecular basis for cardiac arrhythmia: HERG mutations cause long
            QT syndrome
  JOURNAL   Cell 80 (5), 795-803 (1995)
   PUBMED   7889573
REFERENCE   10 (bases 1 to 4221)
  AUTHORS   Warmke,J.W. and Ganetzky,B.
  TITLE     A family of potassium channel genes related to eag in Drosophila
            and mammals
  JOURNAL   Proc Natl Acad Sci U S A 91 (8), 3438-3442 (1994)
   PUBMED   8159766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113055.9.
            
            On Sep 7, 2007 this sequence version replaced NM_013569.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1, also known as
            Merg1a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF012868.1, BC051016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               AC113055.9         74448-74844
            398-628             AC113055.9         77511-77741
            629-793             AC113055.9         92996-93160
            794-1243            AC113055.9         93940-94389
            1244-1455           AC113055.9         94930-95141
            1456-1884           AC113055.9         99275-99703
            1885-2272           AC113055.9         100171-100558
            2273-2472           AC113055.9         100897-101096
            2473-2725           AC113055.9         101467-101719
            2726-2919           AC113055.9         102788-102981
            2920-3019           AC113055.9         103298-103397
            3020-3295           AC113055.9         103831-104106
            3296-3482           AC113055.9         104230-104416
            3483-3660           AC113055.9         104630-104807
            3661-4221           AC113055.9         105903-106463
FEATURES             Location/Qualifiers
     source          1..4221
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 10.94 cM"
     gene            1..4221
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /note="potassium voltage-gated channel, subfamily H
                     (eag-related), member 2"
                     /db_xref="GeneID:16511"
                     /db_xref="MGI:MGI:1341722"
     exon            1..397
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..3810
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium voltage-gated channel subfamily H member 2;
                     eag-related protein 1; ether-a-go-go-related protein 1;
                     ether-a-go-go-related gene potassium channel 1;
                     voltage-gated potassium channel subunit Kv11.1;
                     voltage-gated inwardly rectifying potassium channel KCNH2"
                     /codon_start=1
                     /product="voltage-gated inwardly rectifying potassium
                     channel KCNH2 isoform 1"
                     /protein_id="NP_038597.2"
                     /db_xref="CCDS:CCDS19116.1"
                     /db_xref="GeneID:16511"
                     /db_xref="MGI:MGI:1341722"
                     /translation="MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYC
                     NDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKD
                     GSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPSTSWLASGRA
                     KTFRLKLPALLALTARESSVRTGSMRSAGAPGAVVVDVDLTPAAPSSESLALDEVSAM
                     DNHVAGLGPAEERRALVGPGSASPVASIRGPHPSPRAQSLNPDASGSSCSLARTRSRE
                     SCASVRRASSADDIEAMRAGALPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISK
                     IPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKL
                     QAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYA
                     CQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAI
                     PFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL
                     ACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSL
                     TSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV
                     REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQ
                     HCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV
                     AILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWS
                     SLEITFNLRDTNMIPGSPGSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGP
                     ARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGDPP
                     GGEPLTEDGEKSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIPL
                     SSPGRRSRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPG
                     PGPTSASPLLPVGPVPTLTLDSLSQVSQFVAFEELPAGAPELPQDGPTRRLSLPGQLG
                     ALTSQPLHRHGSDPGS"
     exon            398..628
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            629..793
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1243
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1455
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1884
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2272
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2472
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2725
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2919
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3019
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3295
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3482
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3483..3660
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3661..4221
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4176..4181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /note="hexamer: AATAAA"
     polyA_site      4198
                     /gene="Kcnh2"
                     /gene_synonym="ERG1; LQT; Lqt2; M-erg; Merg1; merg1a;
                     merg1b"
                     /note="major polyA site"
ORIGIN      
        1 ccgggagccc ggcgctggag cgggcggagc gcggcgcggg gacgaggtgc agccgggccc
       61 gtggcaccac cagcccgggt cgacagacag gtgtgccggc gccgcagctc cagcagcttc
      121 aggcccggcc cagggtccgg agccggcagc cactaagcag agcgggaatc ccgcgccctc
      181 ggtccagttc cggccccgcc cgcactcagc ttggccgcgg ggtgcggaga ccacggcccg
      241 gccaggccac ccgaagccta gtgctgggcc gggccgggcc agggtgggtg ggggcccgcc
      301 cggcccgccc atgggctcag gatgccggtg cggaggggcc acgtcgcgcc gcagaacacc
      361 ttcctcgaca ccatcatccg caagtttgag ggccagagcc gcaagttcat catcgctaac
      421 gcgcgcgtag agaactgcgc tgtcatctac tgcaacgacg gcttctgcga actgtgtggc
      481 tactcgcggg ccgaggtgat gcagcggccc tgcacctgcg atttcctgca tgggccgcgc
      541 acgcagcgcc gtgccgccgc gcagatcgcg caggccctgc tgggcgcaga ggagcgcaaa
      601 gtggagatcg ccttctaccg gaaagatggg agctgcttcc tgtgtctggt ggatgtggta
      661 cccgtgaaga atgaagatgg ggctgtgatc atgttcatcc tcaactttga agtagtgatg
      721 gagaaggaca tggtagggtc cccggctcat gacaccaacc acaggggccc ctctaccagc
      781 tggctagctt ctggccgggc caagactttc cgcctgaagc tgcctgcctt gttggcactg
      841 acggccaggg aatcatctgt gcggacagga agcatgcgca gtgctggagc ccctggggcg
      901 gtggtggtgg atgtggacct gacgccggca gcacccagca gtgagtccct ggccttggat
      961 gaggtttctg ccatggacaa ccatgtggca gggcttgggc ctgcagaaga gaggcgagca
     1021 ctggtgggcc cggggtctgc ttcaccagta gccagcatcc gaggccctca cccatcgcca
     1081 cgagctcaga gccttaaccc tgatgcctca ggttccagct gcagcctggc ccggacacgc
     1141 tcccgtgaga gctgcgctag cgtgcgccgc gcatcatccg cggatgacat tgaggcaatg
     1201 cgggctggag cgctgccccc tccgccccgc catgcaagca caggggccat gcaccccctg
     1261 cgcagtggcc tgcttaactc cacctcagac tctgaccttg tacgctaccg aaccattagc
     1321 aagatacccc aaatcactct caactttgtg gacctcaaag gcgacccttt cctggcttca
     1381 cccaccagtg accgggagat tatagcaccc aagataaaag agcggaccca caatgtcacc
     1441 gagaaggtca cccaggtcct gtccttggga gcagatgtgc tgcctgagta taagctgcag
     1501 gccccaagaa tccaccgctg gaccatcctc cactacagcc ccttcaaggc ggtgtgggac
     1561 tggctcatcc tgctgctggt catctacacg gcagtcttca caccgtactc ggccgccttc
     1621 ctgctgaagg agactgaaga tgggtcccaa gcccctgact gtggctacgc ctgccagccc
     1681 ctggctgtag tggacctcat cgtggacatc atgttcattg tggacatcct tatcaatttc
     1741 cgtaccacct atgttaatgc caacgaggag gtggttagcc atcctggccg cattgctgtg
     1801 cactacttca agggctggtt tctcattgac atggtggctg ccatcccctt cgacctgctc
     1861 atctttggct ctggctccga ggagctgatc gggctgctga aaactgcgag gctgctgcgg
     1921 ctggtgcgcg tggctcggaa gctggaccgc tactcggagt acggggcagc agtgctcttc
     1981 ctgctcatgt gcaccttcgc cctcattgcg cactggttgg cctgcatctg gtacgcgatc
     2041 ggcaacatgg aacagcctca catggactca cacatcggct ggctgcacaa cttgggcgac
     2101 cagatcggca agccctacaa cagcagcggc ctgggaggcc cctccatcaa ggacaagtat
     2161 gtcacagcgc tctacttcac cttcagcagc ctcaccagcg tgggctttgg caatgtctct
     2221 cccaacacca actcagagaa gatcttctcc atctgtgtca tgctcattgg ctccctcatg
     2281 tatgccagca tcttcggcaa cgtgtccgcc atcatccagc ggctgtactc gggcacggcc
     2341 cgctaccaca cacagatgct ccgggtgcgg gagtttatcc gctttcacca gattcccaac
     2401 ccattacgcc agcgcctcga ggagtacttc cagcatgctt ggtcctacac caatggcatc
     2461 gacatgaacg cggtgctgaa gggcttccct gagtgcctcc aggctgacat ctgcctacac
     2521 ctgaaccgct cgctgctgca gcattgcaag ccattccgag gggccactaa aggctgcctg
     2581 agggcgctgg ctatgaagtt caagaccaca catgcaccac caggggacac actagtgcac
     2641 gccggggacc tgcttactgc cctctacttc atctccaggg gctccatcga gatcctgcgg
     2701 ggtgatgtcg tggtggccat cttggggaag aacgacatct ttggagagcc tctgaaccta
     2761 tatgcccgtc ctggaaagtc caatggggat gtgcgggccc tcacgtactg tgacctgcac
     2821 aagatccatc gtgatgactt gctggaggtg ttggacatgt atcccgagtt ctcagatcac
     2881 ttttggtcta gcctggagat caccttcaac cttcgagata ccaacatgat tcctggctcc
     2941 ccaggcagtg cagaactaga gagcggcttt aacaggcaac gcaagcgcaa actgtcattc
     3001 cgcaggcgta cagacaagga cacagagcag ccaggggagg tgtcagccct ggggcaaggc
     3061 cctgcccgag ttgggccagg gccgagttgc cggggacagc cgggagggcc atggggggag
     3121 agcccatcca gcggcccttc cagcccagag agcagtgaag atgagggccc tggtcgcagc
     3181 tccagtcccc tccgcctggt gcccttctcc agccccaggc ctccgggaga ccccccaggt
     3241 ggggagcctt tgacagagga tggggagaaa agtgacacct gtaatccctt gtcaggtgcc
     3301 ttctctgggg tgtccaatat tttcagcttc tggggggaca gtcgggggcg ccagtaccag
     3361 gagttgcctc gatgccctgc ccctgccccc agcctcctca acatcccctt gtctagccct
     3421 ggtcggcgat cccggggtga tgtggagagc aggctggacg cactccagag acagctgaac
     3481 aggctggaaa cccggctaag tgcagacatg gccactgtcc tacagctgct acagaggcaa
     3541 atgaccctgg tccctcctgc ctacagtgct gtgaccaccc ctgggcccgg ccccacttcc
     3601 gcatcccctt tgttgcctgt cggccctgtc cccactctca ccctggactc gctttctcag
     3661 gtttcccagt tcgtggcgtt tgaggagctt cctgcaggag ccccagagct cccccaagat
     3721 ggccccactc gacgcctctc cctgcccggc cagctggggg cccttacctc ccagcccctg
     3781 cacagacatg gctcagatcc aggcagttag tgatgctgcc cactgtggac atgtggctca
     3841 ccctgggttc agggcattac ctgaccgctc tccttggaga ccctggtttg gaggggagac
     3901 ctgtgcagaa gcacctccat ccccaccctt gggaccagca tctcctcctg caataccctg
     3961 ggccccactg ggaggggcag gacagagctg ggcagtggat gggggtctgt ggtcccccca
     4021 ctgccctggg ggcattagct ggtctaactg cccggaggca ccggccctgg gccttaggca
     4081 cctcaaggac ttttctgcta tttactgctc ttattgttaa ggataataat taaggatcat
     4141 atgaataatt aatgaagatg ctgatgacta tgaataataa ataattatcc tgaggagact
     4201 ccagggtgct ggttagcttc a
//
