LOCUS       NM_010600               7269 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily H
            (eag-related), member 1 (Kcnh1), transcript variant 1, mRNA.
ACCESSION   NM_010600
VERSION     NM_010600.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7269)
  AUTHORS   Shawer H, Aiyelaagbe E, Clowes C, Lean SC, Lu Y, Kadler KE, Kerby
            A, Dilworth MR, Hentges KE and Heazell AEP.
  TITLE     A missense mutation of ErbB2 produces a novel mouse model of
            stillbirth associated with a cardiac abnormality but lacking
            abnormalities of placental structure
  JOURNAL   PLoS One 15 (6), e0233007 (2020)
   PUBMED   32492036
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7269)
  AUTHORS   Fernandes AS, Morais-Cabral JH and Harley CA.
  TITLE     Screening for Non-Pore-Binding Modulators of EAG K+ Channels
  JOURNAL   J Biomol Screen 21 (7), 758-765 (2016)
   PUBMED   26975997
  REMARK    GeneRIF: n this report, we present two independent screening
            campaigns in which we wanted to identify small molecules that bind
            to either the intracellular cytoplasmic amino terminal Per-Arnt-Sim
            (PAS) domain from the human EAG-related gene (ERG) channel or the
            amino or carboxy terminal globular domains from the mouse EAG1
            channel, affecting their interaction.
REFERENCE   3  (bases 1 to 7269)
  AUTHORS   Sanchez A, Urrego D and Pardo LA.
  TITLE     Cyclic expression of the voltage-gated potassium channel KV10.1
            promotes disassembly of the primary cilium
  JOURNAL   EMBO Rep 17 (5), 708-723 (2016)
   PUBMED   27113750
  REMARK    GeneRIF: KV10.1 localizes to the centrosome and the primary cilium
            and promotes ciliary disassembly. Interference with KV10.1 ciliary
            localization abolishes not only the effects on ciliary disassembly,
            but also KV10.1-induced tumor progression in vivo Conversely.
REFERENCE   4  (bases 1 to 7269)
  AUTHORS   Urrego D, Movsisyan N, Ufartes R and Pardo LA.
  TITLE     Periodic expression of Kv10.1 driven by pRb/E2F1 contributes to
            G2/M progression of cancer and non-transformed cells
  JOURNAL   Cell Cycle 15 (6), 799-811 (2016)
   PUBMED   27029528
  REMARK    GeneRIF: Expression of Kv10.1 driven by phosphorylated Rb/E2F1
            contributes to G2/M progression of cancer and non-transformed
            cells.
REFERENCE   5  (bases 1 to 7269)
  AUTHORS   Mortensen LS, Schmidt H, Farsi Z, Barrantes-Freer A, Rubio ME,
            Ufartes R, Eilers J, Sakaba T, Stuhmer W and Pardo LA.
  TITLE     KV 10.1 opposes activity-dependent increase in Ca(2) influx into
            the presynaptic terminal of the parallel fibre-Purkinje cell
            synapse
  JOURNAL   J Physiol 593 (1), 181-196 (2015)
   PUBMED   25556795
  REMARK    GeneRIF: KV 10.1 opposes activity-dependent increase in calcium
            influx into the presynaptic terminal of the parallel fibre-Purkinje
            cell synapse
REFERENCE   6  (bases 1 to 7269)
  AUTHORS   Ohya S, Horowitz B and Greenwood IA.
  TITLE     Functional and molecular identification of ERG channels in murine
            portal vein myocytes
  JOURNAL   Am J Physiol Cell Physiol 283 (3), C866-C877 (2002)
   PUBMED   12176743
REFERENCE   7  (bases 1 to 7269)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 7269)
  AUTHORS   Pond AL, Scheve BK, Benedict AT, Petrecca K, Van Wagoner DR, Shrier
            A and Nerbonne JM.
  TITLE     Expression of distinct ERG proteins in rat, mouse, and human heart.
            Relation to functional I(Kr) channels
  JOURNAL   J Biol Chem 275 (8), 5997-6006 (2000)
   PUBMED   10681594
REFERENCE   9  (bases 1 to 7269)
  AUTHORS   Weinshenker D, Wei A, Salkoff L and Thomas JH.
  TITLE     Block of an ether-a-go-go-like K(+) channel by imipramine rescues
            egl-2 excitation defects in Caenorhabditis elegans
  JOURNAL   J Neurosci 19 (22), 9831-9840 (1999)
   PUBMED   10559392
  REMARK    GeneRIF: Both M-eag and its C. elegans homolog egl-2 are inhibited
            by the tricyclic antidepressant imipramine.
REFERENCE   10 (bases 1 to 7269)
  AUTHORS   Warmke JW and Ganetzky B.
  TITLE     A family of potassium channel genes related to eag in Drosophila
            and mammals
  JOURNAL   Proc Natl Acad Sci U S A 91 (8), 3438-3442 (1994)
   PUBMED   8159766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ104826.1, AK140193.1, AC109240.30, AK147461.1 and CJ256689.1.
            
            [WARNING] On Apr 28, 2023 this sequence was replaced by
            NM_010600.4.
            
            On Jun 26, 2014 this sequence version replaced NM_010600.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U04294.1, BC109013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                CJ104826.1         4-98
            96-399              AK140193.1         2-305
            400-400             AC109240.30        153135-153135       c
            401-3220            AK140193.1         307-3126
            3221-6929           AK147461.1         3134-6842
            6930-7269           CJ256689.1         173-512
FEATURES             Location/Qualifiers
     source          1..7269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..7269
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /note="potassium voltage-gated channel, subfamily H
                     (eag-related), member 1"
                     /db_xref="GeneID:16510"
                     /db_xref="MGI:MGI:1341721"
     exon            1..310
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..3201
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium voltage-gated channel subfamily H member 1; EAG
                     channel 1; ether-a-go-go potassium channel 1;
                     voltage-gated potassium channel subunit Kv10.1; ether a
                     go-go"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily H
                     member 1 isoform 1"
                     /protein_id="NP_034730.1"
                     /db_xref="CCDS:CCDS15627.1"
                     /db_xref="GeneID:16510"
                     /db_xref="MGI:MGI:1341721"
                     /translation="MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVY
                     SNDGFCKLSGYHRAEVMQKSSACSFMYGELTDKDTVEKVRQTFENYEMNSFEILMYKK
                     NRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTS
                     SRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKT
                     TWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGP
                     AGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQI
                     PPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHW
                     MACIWYSIGDYEIFDEDTKTIRNNSWLYQLALDIGTPYQFNGSGSGKWEGGPSKNSVY
                     ISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYAN
                     TNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRAD
                     ICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSG
                     SLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLE
                     FYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRL
                     FQRFRQQKEARLAAERGGRDLDDLDVEKGNALTDHTSANHSLVKASVVTVRESPATPV
                     SFQAATTSTMSDHAKLHAPGSECLGPKAVSCDPAKRKGWARFKDACGKGEDWNKVSKA
                     ESMETLPERTKAPGEATLKKTDSCDSGITKSDLRLDNVGETRSPQDRSPILAEVKHSF
                     YPIPEQTLQATVLEVKYELKEDIKALNAKMTSIEKQLSEILRILMSRGSAQSPQETGE
                     ISRPQSPESDRDIFGAS"
     exon            311..434
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /inference="alignment:Splign:2.1.0"
     exon            435..541
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /inference="alignment:Splign:2.1.0"
     exon            542..670
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /inference="alignment:Splign:2.1.0"
     exon            671..789
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1263
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1693
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1893
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2146
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2343
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..7239
                     /gene="Kcnh1"
                     /gene_synonym="EAG1; Kv10.1; M-eag"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcggc gcaccgagcc cggggcactc gagcgcacac ccgggcgggc cgcagcgggg
       61 aggtgcggag cgcagcgagg gcggcagcgg gagccagccg ccgcccctgc gctccggggc
      121 tgcggagcgc atggggcgcg tggagccagg aacgcttgcg ggctgcgcac ccggccgcct
      181 gctgcggtga gacacggcgc cggacgcccc cagagtccgg cagtcgggag gatgaccatg
      241 gctggcggcc ggcggggact agtggccccg cagaacacgt ttctggagaa catcgtgcgg
      301 cggtccaacg acactaattt tgtgttgggg aatgcccaga tagtcgactg gcccatcgtg
      361 tacagcaatg atggattctg caagctgtct ggctaccacc gggcagaagt gatgcagaaa
      421 agcagcgcct gcagttttat gtatggagag ctgactgaca aggacacagt tgaaaaggtt
      481 cgccagacct ttgagaacta cgagatgaat tccttcgaaa ttctgatgta caagaagaac
      541 aggacacctg tgtggttttt tgtgaagatc gctccgatca ggaacgaaca ggataaagtg
      601 gtcctgttcc tttgcacttt cagcgacata actgcattca agcagcccat cgaggacgac
      661 tcctgcaaag gttgggggaa gtttgcccga ctgaccagag ctctgacaag cagcagggga
      721 gtcctgcagc agctggcccc cagtgtacag aagggtgaga atgttcacaa gcactcgcgc
      781 ctggcagagg tcctgcagct gggttcagac atccttcccc agtacaagca agaggcgcca
      841 aagacacccc ctcacatcat cctacactac tgtgtcttta agaccacgtg ggattggatc
      901 atcttgatcc tgaccttcta cacagccatc ttggtccctt acaacgtctc ctttaaaacc
      961 aggcagaata atgtggcctg gctggtggtg gacagcatcg tggatgtcat ctttttggtg
     1021 gacattgttt tgaattttca caccaccttt gtcgggccag cgggggaagt gatatctgac
     1081 cccaaactta tccgcatgaa ctacctgaag acgtggtttg tgatcgacct tctgtcctgt
     1141 ttgccgtatg acgtcatcaa cgcttttgag aacgtggatg aggttagtgc ctttatgggt
     1201 gatccaggga agattggttt tgctgatcag atcccaccac cactggaggg gagagagagt
     1261 cagggcatca gcagcctgtt cagttctctg aaagttgtgc ggctgctccg tctcgggcga
     1321 gtggcccgca aactggatca ttacatcgag tatggagccg cggtactggt cctgttggtg
     1381 tgcgtgtttg ggcttgctgc ccactggatg gcctgcatct ggtacagcat tggggactat
     1441 gagatctttg atgaagacac caagaccatc cgcaacaaca gctggctcta ccaactggca
     1501 ttggacatcg gcactccata ccagtttaat gggtctggtt cagggaagtg ggaaggtggg
     1561 ccaagcaaga actctgtcta catctcctcg ctgtacttca ccatgacaag tctcaccagt
     1621 gtgggctttg gtaacattgc cccatccaca gacatcgaga agatcttcgc agtggccatc
     1681 atgatgattg gctctcttct gtatgccacc atctttggga acgtgacaac cattttccag
     1741 cagatgtacg ccaacaccaa caggtaccac gagatgctca acagtgtccg ggatttcctg
     1801 aagctctacc aggtgcccaa agggctgagt gagcgggtca tggactacat tgtgtccacc
     1861 tggtccatgt cccgaggcat cgacacagag aaggtcctgc agatctgccc caaggacatg
     1921 cgagccgaca tttgcgtgca cctgaaccgc aaagtgttca aagaacaccc tgcctttcga
     1981 ttggccagcg atggctgcct gcgggccttg gccatggagt tccagacagt gcactgtgcc
     2041 ccaggggacc tcatctatca tgctggagag agtgtggaca gcctctgctt cgtggtctca
     2101 ggctccctgg aggtgatcca ggatgacgag gtggtggcca tcctagggaa aggagacgtg
     2161 tttggggatg ttttctggaa ggaagctacc cttgcacagt cctgtgctaa tgtccgggcc
     2221 ttgacctact gtgacctgca cgtgatcaag agggacgccc ttcagaaagt gctagaattc
     2281 tacacagcct tctcccactc cttctcccgg aacctgattc tcacctacaa cctgaggaag
     2341 aggattgtgt tccggaagat cagcgacgtg aaacgagaag aggaggagag gatgaaacgg
     2401 aagaacgagg ccccccttat cctgcctcct gaccaccccg tcagaagact cttccaaagg
     2461 ttccgccagc agaaagaagc caggctggca gccgagagag ggggccggga cctggatgac
     2521 ctggatgtag aaaagggcaa tgccctcacg gaccatacct cagccaacca cagcctggtg
     2581 aaggccagtg tggtcacggt gcgtgagagc cccgccacgc ctgtgtcctt ccaggcggcc
     2641 accacctcca ccatgtcaga ccacgccaag ctgcatgccc ccggatctga gtgcctaggt
     2701 cccaaggcag tcagctgtga ccctgccaag cgcaaaggct gggcccgttt caaagatgcc
     2761 tgtggaaagg gtgaggattg gaacaaggtg tccaaggcag agtccatgga gacgctgccc
     2821 gagaggacaa aggcaccggg tgaggccacg ctgaagaaga cagactcctg tgacagcgga
     2881 atcaccaaga gcgacctgcg cttggacaat gtgggtgaga ccaggagtcc tcaggaccgg
     2941 agccccatct tggctgaggt caagcattct ttctacccca tccctgagca gacgctgcag
     3001 gccacagtgc tggaggtgaa atatgagctg aaggaggata tcaaggcctt gaatgccaaa
     3061 atgacctcca ttgagaagca gctgtctgag atactcagga tactaatgtc cagagggtcc
     3121 gcccaatctc ctcaggagac gggtgagatc tccaggcccc agtccccaga gtcagacaga
     3181 gacatttttg gagcaagctg agaggatcat ttcaaaacac acaaacaaac aaacaaacaa
     3241 atcaaagaca aaagcctgcc tcctcaccct gcccctgaca ctacccacaa caccaaacac
     3301 atgaccaaca actttcatac tgggcttttt ctgacaggaa gtcaaaatca gaccaagtgg
     3361 cttgggtgtg cctgcatggt ctctggaaaa cataagaggg aacatggcca ggcaccccac
     3421 cctgcaagat ggcagctgtg ttggaacagc cactgacagt tgttgaagaa ggggcacgct
     3481 ctccatctaa agagcatttc ctctaacatg ttttacggat gtgatatttg cagggcagcg
     3541 gccatgtaga gactggtggg agagccctga gaacctctca gaaatagacc acaccaggct
     3601 tctttaccaa gacccctgaa gaccaccaca ggcacaggga cttctgggta ttcaccaccc
     3661 ccagctgtgt ctgacatcac cacctgtttt tctactttca tcatttgtaa caaactcgtg
     3721 ataaggggag cttgacggac tggagagact ttctgctctg acagtagagg tggagcatca
     3781 ggtgctgtgc catggacaca tgggctgggc ccctcaggtt tccttgccca gaagaggtga
     3841 ggcaagagta ggggctggag caggcccttg gcttcgagtg ggatcttgtt gaatggtcca
     3901 cagcctgctc ttgtggacag ttgacgtgga agctccagac cccaggggac cctctggagc
     3961 tgcaccatct tataggcctc atgacatatg agcttctctc cgtctccctc gactgacctt
     4021 tttccaggct tgtctatggc tttcctcagg gtgtagggca ccgacaggaa ggggcaggca
     4081 ctcagcattg ttttcctaac aaagcagata cacatacaac ctcaaaaaaa aaaaatgatt
     4141 gtagcaagta ctaggtttct cctttgagtc tcatggggat ttctgtccag tgcatggggt
     4201 cattagagga cacatgggag ccacacttag ccttatttga aagccaacct atttcctaca
     4261 ctaaaaataa tggcaggacc atgaagcact ggttttcaaa atatctcagt aacaagctgg
     4321 ggtgggggga ggtgacggtg gaactgtagt cttggggaag gtgggggctc agagccatgg
     4381 tcccagggcc atctctgtgt cattcaaatt cccacatcgt ggtgctcagg gacactcgct
     4441 gccttgatca cttgaggaca tgctgtttgg tgttgtttca acggcatcag acaggacagg
     4501 ggagctggct caggtgcaca cctggagaga tgtcaggggc gtaactctgc cagtaagcct
     4561 ggaaactcgg ctctgcagtc aggacagcaa gtgacacggg cacctctgct tagcattgct
     4621 tggctgttgt gattcagaat ctcagcctct ctcaggagcc tgacattgga aacctgccct
     4681 accaaagaca ttgttctgat tggtgaccat ggcacttgct gggacttgat gcatggctgt
     4741 ctgtacaggc tggaaagccc tggaaagtca agggtgtaca cacatgaagc tttctggaac
     4801 tcgctgggat ttaaggaccc tcagagcaga ggccccattg ctccttgact gaactctgtc
     4861 tgaggtggcg gtgcagccaa gctcatcctt gtgacaggag acagataaag cttcaggcta
     4921 ctctctgggg tcgatgcaca ggctgaagtc ccattagatg gaggtccaca ccctgtctct
     4981 gctcaccttg gggtcctagg cgtctagggc ttcagttcct gcagatgata gtgaagaaca
     5041 cctgacagtg gcttttagct ttccccattt ctacagtggt tttgctagga ttgccttatc
     5101 tgaaacaaat tttcaatgag ccaacccatg tctctttact gtcatggcat gcactgggct
     5161 ggaggcaagt tctgagcaag gaccacaggg aacagatacc cacagcctga accttcctgc
     5221 tttagcagtt atctggtggc tagggagaga ctgggaaaca aaatttgcca tgtgcagact
     5281 gaacactgaa atttcagaca aaagattctt ttggggggcg ggggggtgtg gcaaacacac
     5341 gatgtggtgc gctactgtct agtaagtgct ggccacttgg tctctctaaa cgagctactg
     5401 tgaatgccag ccatagtgaa gtacaatttc ccagtggcta tcctgacaag agacttggat
     5461 ggattgctct cttcctgaag gtgtgcagta gtgtgggtat cagaaccaaa atggcagtag
     5521 atgttctggc tttggtgagt atgcctcgtc agccatgtca tcccagggca atggcaaggc
     5581 tccaacatgg ggcatgtggc ggcttttgca ttgctatgat ctcggcatgg ccaaccccac
     5641 ttctctgctt actgctggag cggggctcaa gtgttttgac tctcatgcct gttgtagcag
     5701 cttcccgcca cgcttggctt tgtttttggt gctggaggtc aaagttaggc cctggcttat
     5761 gctagggaag agctctgcca ttgaatggta cctctggctc cccagcaagc tctggattca
     5821 catttctcga tttgatttct tgctatctgg ttccaaggcc ctgttttagc ctccacctca
     5881 aggagtccct gctgcttcaa cagcaaggat ggtcggacat ggggtagaaa cagtaccacc
     5941 ccaccacctg ctggcgtcag tctctgaatc cttcagtgga aggagagaat gttaagccaa
     6001 atgctaggtg tgtccaagtt ggaacagggc ctgagtgaac acttcagaaa taccagtcag
     6061 aggcagacag accttcatct ctgtgtgaca ctgacatctc acaggtacac tccggggcct
     6121 ctcgggaacc ctggtgaagg tacaaatcat agatgtgcac gcaactaatt gtattttatt
     6181 ttgccataaa gctgtttagc cttaagaccc ttgagtggaa gtctaactgc cattgaggtg
     6241 ttggtacccc tttttacccc atcttgtgtg gcttagaaaa gaggcctgcc taggtttgct
     6301 ctggccctca gatgccctct cctccctaaa tgtccctgtc tttgttgctg cttcatgtac
     6361 tgccttctta ctcgcttcaa taaaaactat cttcaccagc tccggtgccc tccacctgga
     6421 agagtcctca gagtccttga agcaccgacc ctaagcttcc aaaagagaac cattttacat
     6481 ccaaggtgtt ggtgtggaga catgttgcca cctctcacac agttcaaagg aatcaatgtg
     6541 aacttacctg aagcttaagt gagtctcaag taaaacgtca gtcttcacac tagtgtatca
     6601 gaacctttaa aggaggtctt gaattcctgc aggtgccaga cctggtgggg gcatctccac
     6661 ctgccacttg accttcctta gagctactga ctctttatac ctgtgacttc tgagtcatcc
     6721 catcgaccta ttagtccttg agaagttcac agctcaactt tcagaagtca gactgcttct
     6781 tggtaagaat gcagcaccca ccacccccac cccaatgaat gtagcctctt aatattcaga
     6841 cactgtattt cagcatcagt tggagactgt ccaccatcca agttgcaagg acatttatac
     6901 tcatgagcag ttcgtcatcc tgaggcttct catacaaaca ttctccatca aatcctgcca
     6961 aatcctttat tggggttttt gttgttgttg ttgttgtttc tttttcctct gtccgaatga
     7021 gcatgaataa acaggtgcaa atgagctgag gctatttttg tggtcagctg aggatgctgc
     7081 caagagctcc cctgtgtggc tgtacggatg tggagaacat gtgggcactc catggatgat
     7141 accccctttc ttgacatttt taaacaagca caaatgatat ttgtaaaaaa aaaaaagttt
     7201 aattttattt attatggtaa taaactattt tatatgtgaa aaaaaaaaaa aaaaaaaaaa
     7261 aaaaaaaaa
//
