LOCUS       NM_025734               3822 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily G, member 4
            (Kcng4), transcript variant 1, mRNA.
ACCESSION   NM_025734
VERSION     NM_025734.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3822)
  AUTHORS   Wang,Q., So,C. and Pan,F.
  TITLE     Cell firing between ON alpha retinal ganglion cells and coupled
            amacrine cells in the mouse retina
  JOURNAL   Am J Physiol Cell Physiol 327 (3), C716-C727 (2024)
   PUBMED   39010839
REFERENCE   2  (bases 1 to 3822)
  AUTHORS   Toma,K., Zhao,M., Zhang,S., Wang,F., Graham,H.K., Zou,J.,
            Modgil,S., Shang,W.H., Tsai,N.Y., Cai,Z., Liu,L., Hong,G.,
            Kriegstein,A.R., Hu,Y., Korbelin,J., Zhang,R., Liao,Y.J., Kim,T.N.,
            Ye,X. and Duan,X.
  TITLE     Perivascular neurons instruct 3D vascular lattice formation via
            neurovascular contact
  JOURNAL   Cell 187 (11), 2767-2784 (2024)
   PUBMED   38733989
REFERENCE   3  (bases 1 to 3822)
  AUTHORS   So,C., Zhang,T., Wang,Q., Qiu,C., Elie,L.A. and Pan,F.
  TITLE     The response of retinal ganglion cells to optical defocused visual
            stimuli in mouse retinas
  JOURNAL   Exp Eye Res 241, 109834 (2024)
   PUBMED   38382575
REFERENCE   4  (bases 1 to 3822)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3822)
  AUTHORS   McCracken,S., Fitzpatrick,M.J., Hall,A.L., Wang,Z.,
            Kerschensteiner,D., Morgan,J.L. and Williams,P.R.
  TITLE     Diversity in homeostatic calcium set points predicts retinal
            ganglion cell survival following optic nerve injury in vivo
  JOURNAL   Cell Rep 42 (10), 113165 (2023)
   PUBMED   37751356
REFERENCE   6  (bases 1 to 3822)
  AUTHORS   Regnier,G., Bocksteins,E., Marei,W.F., Pintelon,I.,
            Timmermans,J.P., Leroy,J.L.M.R. and Snyders,D.J.
  TITLE     Targeted deletion of the Kv6.4 subunit causes male sterility due to
            disturbed spermiogenesis
  JOURNAL   Reprod Fertil Dev 29 (8), 1567-1575 (2017)
   PUBMED   27677211
  REMARK    GeneRIF: targeted deletion of Kv6.4 in a transgenic mouse model
            causes male sterility as offspring from homozygous females were
            only obtained after mating with wild-type or heterozygous males.
            sterility of the homozygous males was caused by a severe reduction
            in total sperm-cell count and the absence of motile spermatozoa in
            the semen. spermatozoa of homozygous mice showed an abnormal
            morphology, with smaller head and shorter tail
REFERENCE   7  (bases 1 to 3822)
  AUTHORS   Shekhar,K., Lapan,S.W., Whitney,I.E., Tran,N.M., Macosko,E.Z.,
            Kowalczyk,M., Adiconis,X., Levin,J.Z., Nemesh,J., Goldman,M.,
            McCarroll,S.A., Cepko,C.L., Regev,A. and Sanes,J.R.
  TITLE     Comprehensive Classification of Retinal Bipolar Neurons by
            Single-Cell Transcriptomics
  JOURNAL   Cell 166 (5), 1308-1323 (2016)
   PUBMED   27565351
REFERENCE   8  (bases 1 to 3822)
  AUTHORS   Duan,X., Qiao,M., Bei,F., Kim,I.J., He,Z. and Sanes,J.R.
  TITLE     Subtype-specific regeneration of retinal ganglion cells following
            axotomy: effects of osteopontin and mTOR signaling
  JOURNAL   Neuron 85 (6), 1244-1256 (2015)
   PUBMED   25754821
REFERENCE   9  (bases 1 to 3822)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   10 (bases 1 to 3822)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC043936.1.
            
            On Jan 29, 2003 this sequence version replaced NM_025734.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043936.1, SRR1660825.23291.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3822
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 68.07 cM"
     gene            1..3822
                     /gene="Kcng4"
                     /gene_synonym="4921535I01Rik; KV6.3; KV6.4"
                     /note="potassium voltage-gated channel, subfamily G,
                     member 4"
                     /db_xref="GeneID:66733"
                     /db_xref="MGI:MGI:1913983"
     exon            1..449
                     /gene="Kcng4"
                     /gene_synonym="4921535I01Rik; KV6.3; KV6.4"
                     /inference="alignment:Splign:2.1.0"
     exon            450..1240
                     /gene="Kcng4"
                     /gene_synonym="4921535I01Rik; KV6.3; KV6.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..2011
                     /gene="Kcng4"
                     /gene_synonym="4921535I01Rik; KV6.3; KV6.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     voltage-gated potassium channel subunit Kv6.3;
                     voltage-gated potassium channel subunit Kv6.4;
                     voltage-gated potassium channel regulatory subunit KCNG4"
                     /codon_start=1
                     /product="voltage-gated potassium channel regulatory
                     subunit KCNG4 isoform 1"
                     /protein_id="NP_080010.2"
                     /db_xref="CCDS:CCDS22710.1"
                     /db_xref="GeneID:66733"
                     /db_xref="MGI:MGI:1913983"
                     /translation="MPMSSRDRDLHPGHHHFGSCSPLSQLWPGPEPKSVKGLYYSRAR
                     KVGNQDASPEANLKEILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDD
                     YDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCALSFREELSYWGIEETNLERCC
                     LRKLLKKLEEAAELRREEAAQRQQQRQACHSEVQASRWARSMNQLREMVEDPQSGLPG
                     KVFACLSVLFVATTAVSLCVSTMPDFRAEEGKGECTRKCYYIFVVESICVAWFSLEFC
                     LRFVQAPNKCQFFRGPLNVIDILAISPYYVSLAVSDESPEAGERPSSSSYLEKVGLVL
                     RVLRALRILYVMRLARHSLGLQTLGLTVRRCAREFGLLMLFLAVAVTLFSPLVYVAEN
                     ESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATS
                     IFHTFSHSYLELKREQEQVQARLRRLQNTNSASERELLSDVDDLVPEGLTSPGRYM"
     exon            1241..3806
                     /gene="Kcng4"
                     /gene_synonym="4921535I01Rik; KV6.3; KV6.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2980..2985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcng4"
                     /gene_synonym="4921535I01Rik; KV6.3; KV6.4"
                     /note="hexamer: AATAAA"
     polyA_site      2999
                     /gene="Kcng4"
                     /gene_synonym="4921535I01Rik; KV6.3; KV6.4"
                     /note="major polyA site"
     regulatory      3782..3787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcng4"
                     /gene_synonym="4921535I01Rik; KV6.3; KV6.4"
                     /note="hexamer: ATTAAA"
     polyA_site      3801
                     /gene="Kcng4"
                     /gene_synonym="4921535I01Rik; KV6.3; KV6.4"
                     /note="major polyA site"
ORIGIN      
        1 ctaagccctt cctggcagca cccccacccc catctcaggc aggaccatgc tggctgtccc
       61 cgtgggactt ggagcaccaa gtccaatgct gaggcaggac agctggccca gctccctgca
      121 gcatccggac cttcggcttc caggaggagg gaggacttca gagcccttct agagagccac
      181 cttgcgcctc tgctcttctg cggagtcaga ctgaataaac ttctgctctg tagaggaagt
      241 gggagaagaa ttggatgctg accctctgcc aggactgcta tgttgagagc tggttttgat
      301 ttgtgttttg ttttgttttt tggggggcgg gggttcttct catttccccc tacctctctg
      361 tcacaaccct gtcttttcct ggtcagtgag acatgggctc cccatgcccg gcagagaacc
      421 agctgggaac acacttccta aaacaagcga caggtgagcc cagtgatccc tggcctgaca
      481 gtctgaggca atgcccatgt cttccagaga cagggacttg catcctggac accatcactt
      541 tggctcctgc agccccttga gccagctctg gccgggcccc gagcctaagt cagtcaaggg
      601 cctttactac agcagggccc ggaaggtggg caaccaggac gcctctccgg aggccaactt
      661 gaaggagatc ctagtgaatg tgggtggcca gcggtacctg ctgccctgga gcaccctgga
      721 tgccttcccg ctgagccgcc tgagcaggct ccggctgtgc cgcagccatg aggagatcac
      781 gcagctctgc gatgactacg atgaggacag ccaggagttc ttcttcgaca ggaaccccag
      841 cgccttcggg gtgatcgtga gcttcctggc cgcgggaaag ctggtgcttc tgcgagagat
      901 gtgcgccctg tccttccggg aggagctgag ctactggggc atcgaggaaa ccaacctgga
      961 gcgctgctgc ctgcgcaagc tgctgaagaa gctggaggag gcggccgagc tgcgccggga
     1021 ggaggctgcc cagcgccagc agcagcgcca ggcctgccac tccgaggtgc aggcttcacg
     1081 atgggcccgc agcatgaacc agctgcgtga aatggtggag gacccacagt cggggctgcc
     1141 cgggaaggtc ttcgcctgcc tctccgtgct cttcgtggca accacggctg tcagcctgtg
     1201 tgtgagcacc atgcccgact tcagggctga ggagggcaag ggagaatgca ctagaaagtg
     1261 ctattacatc ttcgtggtgg aatccatctg tgtggcctgg ttctcgctgg agttttgcct
     1321 gcgctttgtc caggccccga acaaatgtca gttcttccgc gggcccctga atgtcatcga
     1381 cattctagcc atctccccat actatgtgtc gctcgcagtg tctgacgaat ccccggaggc
     1441 aggcgagagg ccgagcagca gctcctacct ggagaaagtg gggttagtgc tgcgtgttct
     1501 gcgggcacta cgcatcctct acgtaatgcg cctggctcgc cactccctgg ggctgcagac
     1561 gctgggcctc actgtgcgcc gctgcgcccg agagtttggt ctcctgatgc tcttcctggc
     1621 tgtggcggtt accctcttct caccgttggt ctatgtagct gagaatgagt ccggaagggt
     1681 cctggagttc actagcatcc ccgcatccta ttggtgggcc atcatctcca tgacgaccgt
     1741 gggctatggg gacatggtcc ctcgcagcgt cccgggacag atggtggctc tgagcagcat
     1801 ccttagcggg atccttatca tggctttccc agccacatcc atcttccaca cgttctctca
     1861 ctcctacctg gagctgaagc gggagcagga gcaggtccag gcccgcctcc ggcgtcttca
     1921 gaacaccaat tcggccagcg aacgggagct cctgagtgac gtagatgatc tggtccctga
     1981 gggtctgacc tccccaggcc gctacatgta actcccacca ccttaagtat gtgccatagc
     2041 ttcaacccat cccatggctg agacgggctc ctgcatctct ccaatggacc acctgggcat
     2101 gtgagctcag aatactgact tacttccaaa gcaggaaagg tgccaggtca tgacatcatt
     2161 ggcgcaatcc tgggcccatc cctattcctt ccccagctcc ctgccagtca ctgggcactg
     2221 cccatcttgc catactggat cagtgctcct gggatctttt cccttctttg caaactctat
     2281 gctattccac cctgggctct ggatgctcac agaactgact tccactaaga gccaaatacg
     2341 gagtctgcag atttccacct tctccctcag accccctgtc ctgggccaca ccactcctga
     2401 gactcagaga gctccgacac tgagaccggc tcagagctcc gcgcagcctg agaggcttcc
     2461 gggcagatct tgtgttcttt tactgccttc caccaccaac catattgcca aatgccatgg
     2521 aagcacgtac tgttctagaa gctcttagcc aagaaggcag ccctggccac ttcagcaaat
     2581 cctgtcaggt tctcatggct gcaagcctac tgtcacctac aacacgcctg gggacctacc
     2641 tgggcaggag ggccacctgc aagtacccag ttggccagct ggactctggg tggacattcc
     2701 tagttatcca gctcttagcc ttgacaaggg gactctgaga actgcgtaat gttcctccag
     2761 gaggaacctc agtcagctaa actggctgac agctcagcag gacagcctta ggcattcccc
     2821 agttttagct agctccctgc ttgctcgtga cccacactga tggaggacag gcatccctgc
     2881 tgtctctgtg tccacatatc catgggctca tctgtgcata gactcagccc tgggatccac
     2941 agagaggcag atcgctatgc cttacagaga cgaacctgaa ataaagtgac ttctgagcag
     3001 ccggtgcccc agagtttccc aagacaatgg gggctaatgc tggagagtcc cttgcggggt
     3061 tggggtgcag agcagtaggg caggctagga tcgggagctg gtggacctca gagcacggtg
     3121 gctgtactag gggtgaggac gaggttgaca gtccaagggg ccgtgagacc gagcagaagt
     3181 aggggtgaca accatccagg agtgacctgt gggttcaact cctctataac actaccagtc
     3241 tggcccagca cacctgtgag agatctctgt gccatttctc aggagttaca cagttctgct
     3301 gtcatttggt attggctgtg aggccactgg agaaagtaca aggggtgaca gggagataga
     3361 caggaccctg tgaatctgac atggttcatg tgtggataca gtcagtactg cgccctgcta
     3421 acacattggt ctttccacta gtattaagct gagccctgct tcatgccacg cccctacttt
     3481 cctgactgtc accacatggc caagggctct gcccagagat gccccagcat ctactctaaa
     3541 gtgcatcttg accatgtgga aattctcaca tcctctgact ccccaaacag atgcacacac
     3601 atgctcctat ccctctagac atcaaggtgt ggggagcacc ctcagccctc tcaagctcac
     3661 aggtctcaag caggcccttt atgtcacact aggagagctg aggcccctgg catgatgctt
     3721 tgctccagga ataggctagc acagtcctgg tgggggggac ctggatgtat tctgagaaca
     3781 tattaaaaat agctatgtta acctttaaaa aaaaaaaaaa aa
//
