LOCUS       NM_201531               4451 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily F, member 1
            (Kcnf1), mRNA.
ACCESSION   NM_201531 XM_356576
VERSION     NM_201531.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4451)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4451)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   3  (bases 1 to 4451)
  AUTHORS   Slaats,G.G., Wheway,G., Foletto,V., Szymanska,K., van Balkom,B.W.,
            Logister,I., Den Ouden,K., Keijzer-Veen,M.G., Lilien,M.R.,
            Knoers,N.V., Johnson,C.A. and Giles,R.H.
  TITLE     Screen-based identification and validation of four new ion channels
            as regulators of renal ciliogenesis
  JOURNAL   J Cell Sci 128 (24), 4550-4559 (2015)
   PUBMED   26546361
REFERENCE   4  (bases 1 to 4451)
  AUTHORS   Hirst,C.S., Foong,J.P., Stamp,L.A., Fegan,E., Dent,S., Cooper,E.C.,
            Lomax,A.E., Anderson,C.R., Bornstein,J.C., Young,H.M. and
            McKeown,S.J.
  TITLE     Ion channel expression in the developing enteric nervous system
  JOURNAL   PLoS One 10 (3), e0123436 (2015)
   PUBMED   25798587
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4451)
  AUTHORS   Johnson,H.L., Hanson,L.M., Chen,Y., Bieber,A.J., Buono,R.J.,
            Ferraro,T.N., Pirko,I. and Johnson,A.J.
  TITLE     Quantitative trait loci analysis reveals candidate genes implicated
            in regulating functional deficit and CNS vascular permeability in
            CD8 T cell-initiated blood-brain barrier disruption
  JOURNAL   BMC Genomics 14, 678 (2013)
   PUBMED   24090483
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4451)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159312.2.
            
            On Dec 21, 2021 this sequence version replaced NM_201531.4.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus. The use of an alternative upstream start codon, which
            appears to be rodent-specific, would result in a protein that is 12
            aa longer at the N-terminal.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC053089.1, AK137367.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4451              AC159312.2         2171-6621
FEATURES             Location/Qualifiers
     source          1..4451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.04 cM"
     gene            1..4451
                     /gene="Kcnf1"
                     /gene_synonym="Gm1182; Kv5.1"
                     /note="potassium voltage-gated channel, subfamily F,
                     member 1"
                     /db_xref="GeneID:382571"
                     /db_xref="MGI:MGI:2687399"
     exon            1..4451
                     /gene="Kcnf1"
                     /gene_synonym="Gm1182; Kv5.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..1850
                     /gene="Kcnf1"
                     /gene_synonym="Gm1182; Kv5.1"
                     /note="voltage-gated potassium channel subunit Kv5.1"
                     /codon_start=1
                     /product="voltage-gated potassium channel regulatory
                     subunit KCNF1"
                     /protein_id="NP_963289.3"
                     /db_xref="CCDS:CCDS25825.2"
                     /db_xref="GeneID:382571"
                     /db_xref="MGI:MGI:2687399"
                     /translation="MDASAEQSLPEPGSQDSVAGEDIEIVVNVGGVRQVLYGDLLSQY
                     PETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKK
                     GICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGR
                     WRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMGTIPELQVVDSEGNRVE
                     HPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLG
                     ARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVG
                     IFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFL
                     CGVIAIALPIHPIINNFVRYYNKQRVLETAAKHELELMELNSSSAEGKPGGSRSDLDT
                     LPPEPAAREGPSWGSRLKLSHSDTFIPLLTEEKHHRTRLQSCK"
     regulatory      4430..4435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnf1"
                     /gene_synonym="Gm1182; Kv5.1"
                     /note="hexamer: AATAAA"
     polyA_site      4451
                     /gene="Kcnf1"
                     /gene_synonym="Gm1182; Kv5.1"
                     /note="major polyA site"
ORIGIN      
        1 actccaagtt agctctctat acagcccgga tcgcgcagct ctcgggctga cccacctctg
       61 ccgctcaacc ggggaaggag gacgctgcct acgagaagaa ccaagtcctg tcccggaccg
      121 agctgaagga gcccgtgggt gagtgtcacc ggaggccacc ggccgcagag tcccccgcca
      181 gcgctcctgg atgcccgcgt gcagccccgc cactgggtgc atggctccct tgcggcgcgc
      241 cccagcctgc ctccgcccgc tgtgagtgcc ttttccggca ggtggttgtt gtcccctagg
      301 gcctcgcatt ggcagcggct gcggcagggc tcatggaacc ggggcttgca agcgaacccg
      361 cggggagcat ggacgcatct gctgagcaaa gcctcccgga gccaggcagc caggactccg
      421 tggcaggcga agacattgag atcgtggtaa atgtgggggg cgtgcggcag gtgctctacg
      481 gagacctgct cagccagtac cctgagaccc ggttggcaga gctcatcaac tgtttggcgg
      541 ggggctacga caccatcttc tctctgtgcg acgattacga tccgggcaag cgcgaattct
      601 actttgaccg ggacccagac gcgttcaagt gtgtcattga ggtatactat ttcggggagg
      661 tccacatgaa gaagggcatt tgccccatct gcttcaagaa cgagatggac ttctggaagg
      721 tggacctcaa attcctggat gactgttgca agagccatct gagcgagaag cgcgaggagc
      781 tggaggagat cgcgcgcagg gtgcagctca tcttggacga cctgggtgtt gacgctgctg
      841 agggccgctg gcgccgctgc cagaagtgtg tctggaagtt cctagagaag ccggagtctt
      901 catgccctgc gcgggtggtg gcggttctat ccttcctgct catccttgtc tcctccgtgg
      961 tcatgtgcat gggtaccata cccgagctgc aagtggtgga ctccgaaggc aaccgcgtgg
     1021 agcacccaac gctggagaac gtagagacgg cttgcatcgg ctggttcact ctggagtacc
     1081 tgctgcgcct cttctcatcg cccaacaagc ttcactttgc cctgtccttc atgaacatcg
     1141 tggatgtgct ggccattctc cccttctatg tgagcctcac actcacgcac ctgggcgcaa
     1201 gaatgatgga gctgaccaac gtacagcagg cagtgcaggc cctgaggatc atgcgcatcg
     1261 cacgcatctt caaactggcc cgccactcct ccggcctgca gaccctcacc tacgccctca
     1321 agcgcagttt caaggaactg gggctattgc ttatgtatct ggccgtgggc atcttcgtct
     1381 tttccgcact gggctacacc atggagcaga gccatcctga aactctgttc aagagcatcc
     1441 cccagtcctt ctggtgggct atcatcacca tgaccacagt gggctatggt gacatctacc
     1501 ccaagaccac tctgggcaag ctcaacgcag ccatcagctt cttgtgtggg gtaattgcca
     1561 ttgccctgcc cattcacccc atcattaaca actttgtcag gtactacaac aaacaacgtg
     1621 tcctggagac ggcagccaag catgagctgg agctgatgga gctcaactcc agcagtgcag
     1681 aaggcaagcc cgggggttct cgcagcgacc tggacaccct gcccccagag cctgctgcca
     1741 gggaggggcc aagctggggt agccggctga agctctcaca cagcgatacc ttcattcccc
     1801 tgctgacaga ggagaagcat cataggaccc gcctacagag ttgcaagtga gagctggact
     1861 ccctggcagg gacggactgg gctgtggatg gacaaaccat tgggtagaca tgtcagtagg
     1921 cacgtctgtg gtttcagagg agctgcttgt gtcttccagc cctcccctga gcagaccttt
     1981 gccaagactg ggtaagactc cttgggtgcc agctgtccag gtacagggga cctggggagt
     2041 gcaggagcca cagggccact ttgggctatc agatggcctg gcatgagctc acatctgctt
     2101 ttgtgtcccc ctcaataaaa cctcctgttc agcataccct ccgtgctgtg ggttgtctca
     2161 ggctggttac cccaagagtg actactgcac accctagtgc caggccagga aggaggtgtg
     2221 cagctccaga gggagtgggg ggtagctatt tttagttgag agctaattaa agaagggctg
     2281 caaggcaagg ttcagctcca aggcgccttg ccacattcca ggagacactc tcctgcttcc
     2341 ttctgtggga aagctggctc cctgaggttt ggggaggaag gagaggtgac agagcccatt
     2401 ggtggggcag ctaactcaca gttatcatct gtggagtagc cctttccaca cccccttttt
     2461 cctttccagc tactctgata gactggcacc cccattttac aggtaaaaaa actgaggctc
     2521 agggtcacaa cagaggagaa attcaactct ggttttgatt gttcccatgt ggtctctcca
     2581 acaacaggct gtattggggc agaggccttt tgggagtctt acaagggagg gtccaaattc
     2641 ctcagatatt tgtgtatcag ggggacctca gagaatcaca gttcttagtt cagctcctgg
     2701 cattaggatg gctcagtcat ttattgaagg ggaagcagtg agttgcacac ctgcccactg
     2761 gggtctctgc tggtctgggc tggctgggca caagggcagt taaaggacgg gcacgacact
     2821 atagtgctgc tcttggccaa aggctaagct gggccagtgg gcctaaccct ttatggtttt
     2881 ctaccttcta ggagccgtag agccttgttc ttcaccccag caccctaccc cagctgtggg
     2941 ggcaccaagg aaggaacact gtggtggagt aggaggtaga gggtaaaaag ggagggatag
     3001 aggtatcttc catctgcttc tattctggtt ggctcttttc tcttccctga gcacagattt
     3061 tcccagaagt atgaggaggg cttatttttc agggcacctt ctaagtctgc ctctccagaa
     3121 tttccaaggt ttgagcttct gattcttatg gcagtgtttc tatgaggaag gaggttgtca
     3181 ttcggaggga gaagtcttaa gagtcgaggt tctatcttca gggtgcaggc ttacttcatg
     3241 gcttcattgt taagatactc agacctgggg tagatggccc atgtagcagc aacatcaatg
     3301 gccatcctag gggacacagg gattgcccca tgtctgccca gccctctcac ttaggaacct
     3361 gaaggtcttt agcacttcta gctggctaag gcactggttc ctccaaacgt atgcctcctc
     3421 ttcacatttc tccaggctga caccaggtcc tggagatatt aaaggcagag gaagaagttg
     3481 gggtctgagg aagtagagac tctagataag ggaggacagg gactaccagg gtattgtttg
     3541 ttcttggagc tcaggagatt tgccgaaagg ttggcttgtc tttgtttgtc ccctctatgc
     3601 agaatccttg ggaagctaga atatggggta ccatcctcat agccccagag agtgggagaa
     3661 gcccaagatt tacagagagc tgagtgacct tgggacagaa ggctatcttc ctgttccctg
     3721 acttctgggg tagtggtact ggagatcgag gtggggaatt acagggaaga atactcagag
     3781 atccaaagta tctttttgct gctcgttcag gaatagaaga ccaagcccag agaagtgagc
     3841 catctgtgag atctccatag tctaggatcc actggtccca gggggactga gtgactgata
     3901 gtgatcctta cacagtgata tgctttgtca cagaggagtg gtccagatgt tctgagagcc
     3961 aggacagtcc ctaggaaata tctgggtttc aagtacttga aaacttgtac cttagaacca
     4021 acaggggttg ggtgtggagt tttgaaagct tggtgtccag gctacacccc attgctgtga
     4081 aattagaatg tctgagatga cccttcagtg tcagtatttt tataacttaa agtacacatg
     4141 agtcatggtg attgggttaa atccagggtt tgcatctgta gagctgaaaa aaggtgttct
     4201 ttctcaacaa gcttccaggt acagctggag cctggggctg ctaatccaca aaatggcttt
     4261 gaactatcag aataaccata gccagacctg gtggaccatc tgtttttgca caacccatga
     4321 ctttagaata ggttttatat ttttaaatgg ttgatgaaaa aaaaaactca aaggaataac
     4381 attttgtgaa tcgtgaatag tactttacat tcaaaatttg ttgtccataa ataaagtgtt
     4441 attggaacta a
//
