LOCUS       NM_021342               2524 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus potassium voltage-gated channel, Isk-related
            subfamily, gene 4 (Kcne4), mRNA.
ACCESSION   NM_021342
VERSION     NM_021342.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Mano,R., Tanaka,T., Hashiguchi,S., Takahashi,H., Sakata,N.,
            Kondo,S. and Kodama,S.
  TITLE     Induction of potassium channel regulator KCNE4 in a submandibular
            lymph node metastasis model
  JOURNAL   Sci Rep 12 (1), 13208 (2022)
   PUBMED   35915077
  REMARK    GeneRIF: Induction of potassium channel regulator KCNE4 in a
            submandibular lymph node metastasis model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Vallejo-Gracia,A., Sastre,D., Colomer-Molera,M., Sole,L.,
            Navarro-Perez,M., Capera,J., Roig,S.R., Pedros-Gamez,O.,
            Estadella,I., Szilagyi,O., Panyi,G., Hajdu,P. and Felipe,A.
  TITLE     KCNE4-dependent functional consequences of Kv1.3-related leukocyte
            physiology
  JOURNAL   Sci Rep 11 (1), 14632 (2021)
   PUBMED   34272451
  REMARK    GeneRIF: KCNE4-dependent functional consequences of Kv1.3-related
            leukocyte physiology.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Sole,L., Sastre,D., Colomer-Molera,M., Vallejo-Gracia,A.,
            Roig,S.R., Perez-Verdaguer,M., Lillo,P., Tamkun,M.M. and Felipe,A.
  TITLE     Functional Consequences of the Variable Stoichiometry of the
            Kv1.3-KCNE4 Complex
  JOURNAL   Cells 9 (5), 1128 (2020)
   PUBMED   32370164
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Estrada,S.M., Thagard,A.S., Dehart,M.J., Damicis,J.R.,
            Dornisch,E.M., Ippolito,D.L., Burd,I., Napolitano,P.G. and
            Ieronimakis,N.
  TITLE     The orphan nuclear receptor Nr4a1 mediates perinatal
            neuroinflammation in a murine model of preterm labor
  JOURNAL   Cell Death Dis 11 (1), 11 (2020)
   PUBMED   31907354
  REMARK    Erratum:[Cell Death Dis. 2020 Jun 30;11(6):495. doi:
            10.1038/s41419-020-2682-y.. PMID: 32606386]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2524)
  AUTHORS   Sole,L., Roig,S.R., Sastre,D., Vallejo-Gracia,A.,
            Serrano-Albarras,A., Ferrer-Montiel,A., Fernandez-Ballester,G.,
            Tamkun,M.M. and Felipe,A.
  TITLE     The calmodulin-binding tetraleucine motif of KCNE4 is responsible
            for association with Kv1.3
  JOURNAL   FASEB J 33 (7), 8263-8279 (2019)
   PUBMED   30969795
  REMARK    GeneRIF: experimental data and the in silico structure suggest that
            the KCNE4 interaction hides a forward-trafficking motif within
            Kv1.3 in addition to adding a strong endoplasmic reticulum
            retention signature to the Kv1.3-KCNE4 complex.
REFERENCE   6  (bases 1 to 2524)
  AUTHORS   Grunnet,M., Olesen,S.P., Klaerke,D.A. and Jespersen,T.
  TITLE     hKCNE4 inhibits the hKCNQ1 potassium current without affecting the
            activation kinetics
  JOURNAL   Biochem Biophys Res Commun 328 (4), 1146-1153 (2005)
   PUBMED   15707997
  REMARK    GeneRIF: Based upon previous studies and the present results, it is
            concluded that both hKCNE4 and mKCNE4 have a drastic inhibitory
            impact on both hKCNQ1 and mKCNQ1 currents.
REFERENCE   7  (bases 1 to 2524)
  AUTHORS   Grunnet,M., Rasmussen,H.B., Hay-Schmidt,A., Rosenstierne,M.,
            Klaerke,D.A., Olesen,S.P. and Jespersen,T.
  TITLE     KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium
            channels
  JOURNAL   Biophys J 85 (3), 1525-1537 (2003)
   PUBMED   12944270
  REMARK    GeneRIF: KCNE4 beta-subunit has a drastic inhibitory effect on
            currents generated by Kv1.1 and Kv1.3 potassium channels
REFERENCE   8  (bases 1 to 2524)
  AUTHORS   Boettger-Tong,H.L., Rohozinski,J., Agoulnik,A.I., Dohmae,K.,
            Nishimune,Y., Levy,N. and Bishop,C.E.
  TITLE     Identification and sequencing the juvenile spermatogonial depletion
            critical interval on mouse chromosome 1 reveals the presence of
            eight candidate genes
  JOURNAL   Biochem Biophys Res Commun 288 (5), 1129-1135 (2001)
   PUBMED   11700028
REFERENCE   9  (bases 1 to 2524)
  AUTHORS   Abbott,G.W., Sesti,F., Splawski,I., Buck,M.E., Lehmann,M.H.,
            Timothy,K.W., Keating,M.T. and Goldstein,S.A.
  TITLE     MiRP1 forms IKr potassium channels with HERG and is associated with
            cardiac arrhythmia
  JOURNAL   Cell 97 (2), 175-187 (1999)
   PUBMED   10219239
REFERENCE   10 (bases 1 to 2524)
  AUTHORS   Vullhorst,D., Klocke,R., Bartsch,J.W. and Jockusch,H.
  TITLE     Expression of the potassium channel KV3.4 in mouse skeletal muscle
            parallels fiber type maturation and depends on excitation pattern
  JOURNAL   FEBS Lett 421 (3), 259-262 (1998)
   PUBMED   9468318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133469.1 and BE948375.1.
            
            On Feb 17, 2018 this sequence version replaced NM_021342.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY328498.1, BC032920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               AK133469.1         2-328
            328-2500            AK133469.1         330-2502
            2501-2524           BE948375.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 40.89 cM"
     gene            1..2524
                     /gene="Kcne4"
                     /gene_synonym="MiRP3"
                     /note="potassium voltage-gated channel, Isk-related
                     subfamily, gene 4"
                     /db_xref="GeneID:57814"
                     /db_xref="MGI:MGI:1891125"
     exon            1..86
                     /gene="Kcne4"
                     /gene_synonym="MiRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            87..2508
                     /gene="Kcne4"
                     /gene_synonym="MiRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..625
                     /gene="Kcne4"
                     /gene_synonym="MiRP3"
                     /note="minK-related peptide 3; potassium channel subunit
                     beta MiRP3; minimum potassium ion channel-related peptide
                     3"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily E
                     member 4"
                     /protein_id="NP_067317.1"
                     /db_xref="CCDS:CCDS15088.1"
                     /db_xref="GeneID:57814"
                     /db_xref="MGI:MGI:1891125"
                     /translation="MLRMEPLNSTYPSAAASSSPLESHVPSNSSGNGNEYFYILVVMS
                     FYGVFLIGIMLGYMKSKRREKKSSLLLLYKDEERLWGEAMKPLPMMSGLRSGQVPMML
                     NMLQESVAPALSCTLCSMEGDSVSSESSSPDVHLPIQEEGADDELEETSETPLNDSSE
                     GSSENIHQNS"
     regulatory      2480..2485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcne4"
                     /gene_synonym="MiRP3"
                     /note="hexamer: AATAAA"
     polyA_site      2508
                     /gene="Kcne4"
                     /gene_synonym="MiRP3"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcaga gcctgacaga gaagagaaac atcctcagat ttggccgttt aagagttcca
       61 cacttgggac aaactgtcag cttttgatcc cggctgtgtg agcggcaatt caatgctgag
      121 gatggagcct ctgaacagca cataccccag cgctgcagcc tccagcagcc ccctcgagtc
      181 ccatgtgcct agtaacagca gtggtaatgg caatgaatac ttctatattt tggtcgttat
      241 gtccttctat ggcgttttcc tgatcggaat catgctgggc tacatgaaat ccaagaggcg
      301 ggagaagaag tccagccttc tgctgttgta caaagacgag gagaggctgt ggggggaggc
      361 tatgaagccg ctacctatga tgtccggctt gaggtcaggg caggtgccca tgatgctgaa
      421 tatgctgcag gagagtgtgg cgccggcact gtcctgcact ctttgctcga tggaagggga
      481 cagtgtgagc tccgagtcct cctctcctga tgtgcacctt cccatccagg aggagggggc
      541 tgatgacgag ctggaggaga cctccgagac gcctctcaac gacagcagtg aaggctcttc
      601 cgagaacatc caccagaatt cctagcaccc accaggtgct aggaggtagc tccgtaagct
      661 acacttgaca gagggaagac acttgccaag tgccgggttt cgcttttgct ctgcggctgc
      721 cacattgaac agactgaggg caagctccaa aatggggcag ggagagacaa ggctcagctg
      781 cagtccttga ggttcctgtg ggactcatct ctgaaaaagt cccagagaca tacagcatga
      841 ccattgactc tggggcctgg gtggtggtgg gtctgtggtc agcatctggc tggataatgt
      901 ggtgtttttt cactggaggc cctgggtaac ttctgcagca tctgtctgtg cccagggctg
      961 acaactgccc agggcaggct gaaggactcg tttcgatttg ctaattttcc tagagctttg
     1021 ttcttctaga tctgatgggc tgtaagtatc tttaatgtgt gcctgtggca ttcgattaga
     1081 gacagttata tatttcactt ggaggtggga gaaagctgaa gagagaaccc agattgtttg
     1141 cacaatgcaa agggagaagg taattcgtac acatgtctga attagctggg agtataagct
     1201 atgacctcat ctgagctttt gtctcacctg tgagcttgaa ctctacagca ttgcaggtga
     1261 gcatggcttt ctttgccagt cagcttcctc ataaccaagc ctgcattcgg gatggctgtt
     1321 catggtggtc ctcctgacct tcacagattg ggtaatggtg gggttataca aggccaaatc
     1381 attgacagct ctgctgcagc tctttttccc agcctagttt tctgaggcca gaaaggacac
     1441 atgtgggcct cataatatgg ggttttgtca cgtagctgga ccctggaagg gcatacttag
     1501 gcgagatcga gcagagctgg ggttcaagca atgtgcttcc tggtctgagc cctgacactc
     1561 attcactgtg aggttctggg catgtcatca caagattctg cctacatgag gctcctgagg
     1621 ctgtgcagcc ccagggggct gggaggacat ctttagactt tgtactgtgt gataaatcct
     1681 ccacagcctg gtgtgaggaa gtttggagca agtatttccc ctttggccgc ttagtctgga
     1741 gaaagatgtg ttgacttaaa gacacagttg gagactttgg atatgtgtag ctggggaatt
     1801 cgaggctgga tcatcggcct tccttactgt ggctttccca ggatgcgact gaagaagctg
     1861 gcagcatagt ttcctctgca gagtcgtgtg gatgggagga tgttaacaca cccaaccgag
     1921 ggaaagagaa atttaaaggg agctactcaa gagctttgca gcaggctctt gtgcccttag
     1981 aagaccagaa ggaagcagaa aactccccaa aggtcaagtt tgcctctagt gcaaaacctt
     2041 cttaattttt atttatctga actctccctg gattggagac agagcagtca ctaatgtccc
     2101 catgaggggt taacactata aggagctgtt tttttcaatc agttttgaca cagagataga
     2161 aaggtaattt atgttagagg cggaaagggg ccctctgttc actttaagat tcagagtgtg
     2221 gatcaactcc aaagggggcc gtttaagttg aaagaagcca agttaagttt ggcctcgtgc
     2281 ctggaatcac ttgaattctg aaactttact gcgacagaca tgtgcgttgt cacattttcc
     2341 attgcttaat cctggtttgg tgcaagtctg tctgcgcctg ttacaaagtg atgtatatac
     2401 ttccttccag tatgctgagt tgtagacaat tgtctggtgt atttaatggt ttgtaatttt
     2461 cacgatattt tttaatttaa ataaacacat tttcgatatg agaagccaaa aaaaaaaaaa
     2521 aaaa
//
