LOCUS       NM_001360467            1082 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus potassium voltage-gated channel, Isk-related
            subfamily, gene 3 (Kcne3), transcript variant 7, mRNA.
ACCESSION   NM_001360467 XM_006508058
VERSION     NM_001360467.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1082)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1082)
  AUTHORS   Phansalkar,R., Krieger,J., Zhao,M., Kolluru,S.S., Jones,R.C.,
            Quake,S.R., Weissman,I., Bernstein,D., Winn,V.D., D'Amato,G. and
            Red-Horse,K.
  TITLE     Coronary blood vessels from distinct origins converge to equivalent
            states during mouse and human development
  JOURNAL   Elife 10, e70246 (2021)
   PUBMED   34910626
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1082)
  AUTHORS   Deckelbaum,R.A., Lobov,I.B., Cheung,E., Halasz,G., Rajamani,S.,
            Lerner,J., Tong,C., Li,Z., Boland,P., Dominguez,M., Hughes,V.,
            Yancopoulos,G.D., Murphy,A.J., Thurston,G., Cao,J., Romano,C. and
            Gale,N.W.
  TITLE     The potassium channel Kcne3 is a VEGFA-inducible gene selectively
            expressed by vascular endothelial tip cells
  JOURNAL   Angiogenesis 23 (2), 179-192 (2020)
   PUBMED   31754927
  REMARK    GeneRIF: The potassium channel Kcne3 is a VEGFA-inducible gene
            selectively expressed by vascular endothelial tip cells.
REFERENCE   4  (bases 1 to 1082)
  AUTHORS   Julio-Kalajzic,F., Villanueva,S., Burgos,J., Ojeda,M., Cid,L.P.,
            Jentsch,T.J. and Sepulveda,F.V.
  TITLE     K2P TASK-2 and KCNQ1-KCNE3 K+ channels are major players
            contributing to intestinal anion and fluid secretion
  JOURNAL   J Physiol 596 (3), 393-407 (2018)
   PUBMED   29143340
REFERENCE   5  (bases 1 to 1082)
  AUTHORS   King,E.C., Patel,V., Anand,M., Zhao,X., Crump,S.M., Hu,Z.,
            Weisleder,N. and Abbott,G.W.
  TITLE     Targeted deletion of Kcne3 impairs skeletal muscle function in mice
  JOURNAL   FASEB J 31 (7), 2937-2947 (2017)
   PUBMED   28356343
  REMARK    GeneRIF: This study showed that Kcne3 deletion impairs muscle
            strength and flexibility in mice.
REFERENCE   6  (bases 1 to 1082)
  AUTHORS   Teng,S., Ma,L., Zhen,Y., Lin,C., Bahring,R., Vardanyan,V., Pongs,O.
            and Hui,R.
  TITLE     Novel gene hKCNE4 slows the activation of the KCNQ1 channel
  JOURNAL   Biochem Biophys Res Commun 303 (3), 808-813 (2003)
   PUBMED   12670483
REFERENCE   7  (bases 1 to 1082)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   8  (bases 1 to 1082)
  AUTHORS   Grahammer,F., Warth,R., Barhanin,J., Bleich,M. and Hug,M.J.
  TITLE     The small conductance K+ channel, KCNQ1: expression, function, and
            subunit composition in murine trachea
  JOURNAL   J Biol Chem 276 (45), 42268-42275 (2001)
   PUBMED   11527966
REFERENCE   9  (bases 1 to 1082)
  AUTHORS   Franco,D., Demolombe,S., Kupershmidt,S., Dumaine,R.,
            Dominguez,J.N., Roden,D., Antzelevitch,C., Escande,D. and
            Moorman,A.F.
  TITLE     Divergent expression of delayed rectifier K(+) channel subunits
            during mouse heart development
  JOURNAL   Cardiovasc Res 52 (1), 65-75 (2001)
   PUBMED   11557234
REFERENCE   10 (bases 1 to 1082)
  AUTHORS   Abbott,G.W., Sesti,F., Splawski,I., Buck,M.E., Lehmann,M.H.,
            Timothy,K.W., Keating,M.T. and Goldstein,S.A.
  TITLE     MiRP1 forms IKr potassium channels with HERG and is associated with
            cardiac arrhythmia
  JOURNAL   Cell 97 (2), 175-187 (1999)
   PUBMED   10219239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121815.4 and BM936467.1.
            
            On Feb 3, 2018 this sequence version replaced XM_006508058.2.
            
            Transcript Variant: This variant (7) differs in the 5' UTR compared
            to variant 6. All seven variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004629.1, BM936467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC121815.4         93801-93832         c
            33-65               BM936467.1         1-33
            66-630              BM936467.1         35-599
            631-1082            AC121815.4         87646-88097         c
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.33 cM"
     gene            1..1082
                     /gene="Kcne3"
                     /gene_synonym="2210017H05Rik; MiRP2"
                     /note="potassium voltage-gated channel, Isk-related
                     subfamily, gene 3"
                     /db_xref="GeneID:57442"
                     /db_xref="MGI:MGI:1891124"
     exon            1..84
                     /gene="Kcne3"
                     /gene_synonym="2210017H05Rik; MiRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            85..208
                     /gene="Kcne3"
                     /gene_synonym="2210017H05Rik; MiRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..350
                     /gene="Kcne3"
                     /gene_synonym="2210017H05Rik; MiRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            351..1082
                     /gene="Kcne3"
                     /gene_synonym="2210017H05Rik; MiRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..702
                     /gene="Kcne3"
                     /gene_synonym="2210017H05Rik; MiRP2"
                     /note="minK-related peptide 2; potassium channel subunit
                     beta MiRP2; minimum potassium ion channel-related peptide
                     2"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily E
                     member 3"
                     /protein_id="NP_001347396.1"
                     /db_xref="CCDS:CCDS21495.1"
                     /db_xref="GeneID:57442"
                     /db_xref="MGI:MGI:1891124"
                     /translation="METSNGTETWYMSLHAVLKALNTTLHSHLLCRPGPGPGPDNQTE
                     DRRASLPGRNDNSYMYILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHVYIKNRVSM
                     I"
     regulatory      1060..1065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcne3"
                     /gene_synonym="2210017H05Rik; MiRP2"
                     /note="hexamer: GATAAA"
     polyA_site      1078
                     /gene="Kcne3"
                     /gene_synonym="2210017H05Rik; MiRP2"
                     /note="major polyA site"
ORIGIN      
        1 gccagtaggc gtgcagagat ctgagagcac tgagcgcatc tgggcattat tgcagtgttc
       61 accggagaca gatcgtagag gcggggctct gccacgtcca tcctggaaac ttgataatca
      121 atgactctct aggagttgga aatccgggga ctcaaggaag agaaacaaaa caccagtgtt
      181 tctgtctgtg cccatttgga accaagagtt tctagctctg ggcctttcct gttaacacca
      241 cgactctggc tgcttccaga tgcaccttgc aaggaactga ggggttgtgg gacatccacg
      301 aagagatcct caaagatgtc tcagagccag cagagtctct gaactgtttg atcacattcc
      361 agctcttccc atacctcaat atctgttgct atggagactt ccaacgggac tgagacctgg
      421 tacatgagcc tccatgctgt gctgaaggct ctgaacacaa cccttcacag tcacttgctc
      481 tgccggcctg ggccaggacc agggccagac aatcaaactg aggatcgtcg ggctagcctt
      541 cctggtcgta atgacaactc ctacatgtat attctctttg tcatgttcct atttgccgtc
      601 actgtgggca gtctcatcct gggatatacc cgttcacgca aagtggacaa acgtagtgac
      661 ccctatcatg tgtacatcaa gaaccgtgtg tctatgatct gatgtgagga acctgaagac
      721 aatggaagat tacaatgtct gaggattgtc ttctggtgcc tccggaactc aactcaacca
      781 tatcaagcca cagtgtatct atgtaagatc aacaggaaac tggtaagagg attaggtcat
      841 tattaggacc agagaagagg gactgatagg cccagtcttg tggatgagac atttttcgag
      901 acacagatgc gcattataaa ctcagagccc atgaacacat atatataaag tatggacaac
      961 cagcaagtag aagaggaagc tgtggcgaag ggaaatgggg cagaaagatg ctctggatat
     1021 ataatctttt aatgtatgat cttcaacatg agaaaccttg ataaaactga gaatgctact
     1081 ta
//
