LOCUS       NM_134110               1707 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus potassium voltage-gated channel, Isk-related
            subfamily, gene 2 (Kcne2), transcript variant 1, mRNA.
ACCESSION   NM_134110
VERSION     NM_134110.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1707)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1707)
  AUTHORS   Ng,L., Liu,H., Liu,Y. and Forrest,D.
  TITLE     Biphasic expression of thyroid hormone receptor TRbeta1 in
            mammalian retina and anterior ocular tissues
  JOURNAL   Front Endocrinol (Lausanne) 14, 1174600 (2023)
   PUBMED   37033230
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1707)
  AUTHORS   Jones,M.R., Lingampally,A., Ahmadvand,N., Chong,L., Wu,J.,
            Wilhem,J., Vazquez-Armendariz,A.I., Ansari,M., Herold,S.,
            Ornitz,D.M., Schiller,H.B., Chao,C.M., Zhang,J.S., Carraro,G. and
            Bellusci,S.
  TITLE     FGFR2b signalling restricts lineage-flexible alveolar progenitors
            during mouse lung development and converges in mature alveolar type
            2 cells
  JOURNAL   Cell Mol Life Sci 79 (12), 609 (2022)
   PUBMED   36445537
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1707)
  AUTHORS   Lisewski,U., Kohncke,C., Schleussner,L., Purfurst,B., Lee,S.M., De
            Silva,A., Manville,R.W., Abbott,G.W. and Roepke,T.K.
  TITLE     Hypochlorhydria reduces mortality in heart failure caused by Kcne2
            gene deletion
  JOURNAL   FASEB J 34 (8), 10699-10719 (2020)
   PUBMED   32584506
  REMARK    GeneRIF: Hypochlorhydria reduces mortality in heart failure caused
            by Kcne2 gene deletion.
REFERENCE   5  (bases 1 to 1707)
  AUTHORS   Lindner,M., Gilhooley,M.J., Palumaa,T., Morton,A.J., Hughes,S. and
            Hankins,M.W.
  TITLE     Expression and Localization of Kcne2 in the Vertebrate Retina
  JOURNAL   Invest Ophthalmol Vis Sci 61 (3), 33 (2020)
   PUBMED   32191288
  REMARK    GeneRIF: The data we present here suggest an important and specific
            role for Kcne2 in the highly specialized photoreceptor-bipolar cell
            synapse.
REFERENCE   6  (bases 1 to 1707)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   7  (bases 1 to 1707)
  AUTHORS   Roepke,T.K., Anantharam,A., Kirchhoff,P., Busque,S.M., Young,J.B.,
            Geibel,J.P., Lerner,D.J. and Abbott,G.W.
  TITLE     The KCNE2 potassium channel ancillary subunit is essential for
            gastric acid secretion
  JOURNAL   J Biol Chem 281 (33), 23740-23747 (2006)
   PUBMED   16754665
  REMARK    GeneRIF: KCNE2 is essential for gastric acid secretion, the first
            genetic evidence that a member of the KCNE gene family is required
            for normal gastrointestinal function.
REFERENCE   8  (bases 1 to 1707)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   9  (bases 1 to 1707)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 1707)
  AUTHORS   Franco,D., Demolombe,S., Kupershmidt,S., Dumaine,R.,
            Dominguez,J.N., Roden,D., Antzelevitch,C., Escande,D. and
            Moorman,A.F.
  TITLE     Divergent expression of delayed rectifier K(+) channel subunits
            during mouse heart development
  JOURNAL   Cardiovasc Res 52 (1), 65-75 (2001)
   PUBMED   11557234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008619.1 and AW048273.1.
            
            On Jul 7, 2010 this sequence version replaced NM_134110.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008619.1, BB564873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1690              AK008619.1         2-1691
            1691-1707           AW048273.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1707
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 53.55 cM"
     gene            1..1707
                     /gene="Kcne2"
                     /gene_synonym="2200002I16Rik; MiRP1"
                     /note="potassium voltage-gated channel, Isk-related
                     subfamily, gene 2"
                     /db_xref="GeneID:246133"
                     /db_xref="MGI:MGI:1891123"
     exon            1..135
                     /gene="Kcne2"
                     /gene_synonym="2200002I16Rik; MiRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            136..1694
                     /gene="Kcne2"
                     /gene_synonym="2200002I16Rik; MiRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1672..1677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcne2"
                     /gene_synonym="2200002I16Rik; MiRP1"
                     /note="hexamer: AATAAA"
     polyA_site      1691
                     /gene="Kcne2"
                     /gene_synonym="2200002I16Rik; MiRP1"
                     /note="major polyA site"
ORIGIN      
        1 attgcagact ccaggcagca gggcttacag gtctcaagct gaaagtgccc agcctgctga
       61 gatttacatc cagtcctgaa gaggggcaga gcctggcttt ctgaaggtct cctgcattgc
      121 tcacatacca cacagcaagg gggaagcatg gccacattag ccaatttgac ccagacactg
      181 gaggatgcct tcaaaaagat ttttattact tatatggaca gctggaggag gaacacgaca
      241 gccgaggagc aggcactcca ggccagagtg gatgccgaga acttctacta cgtcatcctg
      301 tacctcatgg tgatgatcgg catgttctcg ttcatcgtgg tggccatcct ggtgagcacg
      361 gtgaagtcga agcggcgaga gcactcccag gacccgtacc accagtacat cgtggaagat
      421 tggcaggaaa agtacaaaag tcagatcctg catctggaag actccaaggc caccatccat
      481 gagaacatgg gggcgacggg gttcacagtg tcaccctgat tgataaggaa tgggggcccg
      541 tctggctcag acagggtgct tctgctgcct cgagagcccc acttgtgctt gctcagaaga
      601 cagctagttc ctctgtgcag cctggctggc agttgacaca gtgacatttc tatctcagtg
      661 gtttaggtga gcctgttggg gtgatacttt atgctaagga tctctttttt cacatgttat
      721 gcaatgtaac tgttatttta aacaatttca atcatgagaa cagaggcaaa catgaagcaa
      781 ggggacgggg caggagcagt gggaataaat aggaaataga aagcagagat ttacaaagtt
      841 ttcaaccttc cttctcatga aatattagtt tggatgtagc agattcagtt tatgagtaag
      901 tcgcacgtgt tcagaagctg gggtttaaat ctctctcggg cttgctgaac tgacaggaga
      961 gcatttactt accgctttat gtatgggcag cgagcccgag gtggtcaatg gagcgaagtg
     1021 cgggttattt tgcattcata gctttcctgg tatttaactg agttggacat ctggacagaa
     1081 caaacactga aaggacaaat aacccgcacc agaagcagca aatattcaag agcccccagt
     1141 gcaaccaaac gcacttctaa ctttttatag aaacttaaac tctaaaagct ctctggcttg
     1201 aaaaagtatg gcattttttc ctaaacatca tattctttat ttaattttag atccgcttta
     1261 tagcttattt tcacacatat ttgacaagat ggaagctaca gaacacccca ctagatgttt
     1321 gatgcaagct agacagtgac tacttaatcc tttgcaccac agtcagggtg ctggagagat
     1381 gttggtcaaa ggctacaaat tttaatgggg ctggggatgt acacccataa tccaaccctc
     1441 aggggactga ggtgggacag gctagctgag gttccaagcc attctagacc cattgcactg
     1501 caaggtcagt aacatgcctt ttggtcttaa aaactgatac ctgagaggat agtaagtatc
     1561 cttaccacaa aacagtagct atgtgagatg atacattagt cattccacaa tgtgtatatg
     1621 cttcaaaaca ccatgttgtg tgtgtaatac aatgtaacct gtccttaaga aaataaaatg
     1681 aatattttgc acaaaaaaaa aaaaaaa
//
