LOCUS       NM_001362456            3032 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus potassium voltage-gated channel, Isk-related
            subfamily, member 1 (Kcne1), transcript variant 2, mRNA.
ACCESSION   NM_001362456 XM_006522941
VERSION     NM_001362456.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3032)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3032)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3032)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3032)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3032)
  AUTHORS   Talbi,K., Ousingsawat,J., Centeio,R., Schreiber,R. and
            Kunzelmann,K.
  TITLE     KCNE1 does not shift TMEM16A from a Ca2+ dependent to a voltage
            dependent Cl- channel and is not expressed in renal proximal tubule
  JOURNAL   Pflugers Arch 475 (8), 995-1007 (2023)
   PUBMED   37442855
  REMARK    GeneRIF: KCNE1 does not shift TMEM16A from a Ca[2+] dependent to a
            voltage dependent Cl[-] channel and is not expressed in renal
            proximal tubule.
REFERENCE   6  (bases 1 to 3032)
  AUTHORS   Barhanin,J., Lesage,F., Guillemare,E., Fink,M., Lazdunski,M. and
            Romey,G.
  TITLE     K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks)
            cardiac potassium current
  JOURNAL   Nature 384 (6604), 78-80 (1996)
   PUBMED   8900282
REFERENCE   7  (bases 1 to 3032)
  AUTHORS   Felipe,A., Knittle,T.J., Doyle,K.L., Snyders,D.J. and Tamkun,M.M.
  TITLE     Differential expression of Isk mRNAs in mouse tissue during
            development and pregnancy
  JOURNAL   Am J Physiol 267 (3 Pt 1), C700-C705 (1994)
   PUBMED   7943198
REFERENCE   8  (bases 1 to 3032)
  AUTHORS   Lesage,F., Attali,B., Lazdunski,M. and Barhanin,J.
  TITLE     Developmental expression of voltage-sensitive K+ channels in mouse
            skeletal muscle and C2C12 cells
  JOURNAL   FEBS Lett 310 (2), 162-166 (1992)
   PUBMED   1383027
REFERENCE   9  (bases 1 to 3032)
  AUTHORS   Lesage,F., Attali,B., Lazdunski,M. and Barhanin,J.
  TITLE     ISK, a slowly activating voltage-sensitive K+ channel.
            Characterization of multiple cDNAs and gene organization in the
            mouse
  JOURNAL   FEBS Lett 301 (2), 168-172 (1992)
   PUBMED   1568475
REFERENCE   10 (bases 1 to 3032)
  AUTHORS   Honore,E., Attali,B., Romey,G., Heurteaux,C., Ricard,P., Lesage,F.,
            Lazdunski,M. and Barhanin,J.
  TITLE     Cloning, expression, pharmacology and regulation of a delayed
            rectifier K+ channel in mouse heart
  JOURNAL   EMBO J 10 (10), 2805-2811 (1991)
   PUBMED   1655403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162305.5.
            
            On Apr 18, 2018 this sequence version replaced XM_006522941.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X60457.1, SRR7345562.4571975.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC162305.5         61393-61432
            41-3032             AC162305.5         71275-74266
FEATURES             Location/Qualifiers
     source          1..3032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 53.57 cM"
     gene            1..3032
                     /gene="Kcne1"
                     /gene_synonym="Isk; MinK; nmf190"
                     /note="potassium voltage-gated channel, Isk-related
                     subfamily, member 1"
                     /db_xref="GeneID:16509"
                     /db_xref="MGI:MGI:96673"
     exon            1..40
                     /gene="Kcne1"
                     /gene_synonym="Isk; MinK; nmf190"
                     /inference="alignment:Splign:2.1.0"
     exon            41..3032
                     /gene="Kcne1"
                     /gene_synonym="Isk; MinK; nmf190"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..468
                     /gene="Kcne1"
                     /gene_synonym="Isk; MinK; nmf190"
                     /note="minimal potassium channel; delayed rectifier
                     potassium channel subunit IsK; IKs producing slow
                     voltage-gated potassium channel subunit beta Mink"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily E
                     member 1"
                     /protein_id="NP_001349385.1"
                     /db_xref="CCDS:CCDS28336.1"
                     /db_xref="GeneID:16509"
                     /db_xref="MGI:MGI:96673"
                     /translation="MSLPNSTTVLPFLARLWQETAEQGGNVSGLARKSQLRDDSKLEA
                     LYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKAVFQARVLES
                     FRACYVIENQAAVEQPATHLPELKPLS"
     polyA_site      602
                     /gene="Kcne1"
                     /gene_synonym="Isk; MinK; nmf190"
                     /note="major polyA site"
     polyA_site      636
                     /gene="Kcne1"
                     /gene_synonym="Isk; MinK; nmf190"
                     /note="major polyA site"
     polyA_site      699
                     /gene="Kcne1"
                     /gene_synonym="Isk; MinK; nmf190"
                     /note="major polyA site"
     polyA_site      715
                     /gene="Kcne1"
                     /gene_synonym="Isk; MinK; nmf190"
                     /note="major polyA site"
     regulatory      2979..2984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcne1"
                     /gene_synonym="Isk; MinK; nmf190"
                     /note="hexamer: AATAAA"
     polyA_site      3002
                     /gene="Kcne1"
                     /gene_synonym="Isk; MinK; nmf190"
ORIGIN      
        1 cccgctgcac acaccaggtt cccttggctt ctagacccag gagttttgct ctgcatcagg
       61 ggaaccttga cgcccaggat gagcctgccc aattccacga ctgttctgcc ctttctggcc
      121 aggctgtggc aggagacagc tgaacagggc ggcaacgtgt ccggcctggc tcgtaagtct
      181 cagctccgag atgacagcaa gctagaggcg ctctacatcc tcatggtgct gggcttcttc
      241 ggcttcttca ccctgggcat catgctgagt tacatccgat ccaagaagct ggagcactcc
      301 cacgaccctt tcaacgtgta catcgagtca gatgcctggc aggagaaagg caaggccgtc
      361 ttccaggccc gtgtcctgga gagcttcaga gcttgctatg tcattgaaaa ccaggcggcc
      421 gtagagcagc ctgccacaca ccttcctgaa ctgaagccat tgtcgtgaac cccacaccct
      481 acaggtgaca agcggatctt tctagtcgca tgcctgccat agtctttatt gtaggggcac
      541 cactgagttt ttgtgaaaga ctgtgagggg tgaattaatg acaccagttt tctgaaattg
      601 cattctttct atagtagaca atcgatttat tctgcagcgc ctgtccttgt ctttgtaaat
      661 ctagcagggt cccagacaac atggcttctg agaacacaag ctgagtttcc ccaaatctct
      721 ccacattagc tgtgtcacgt gactaagttc tgatgggaga catgggcatg atgagtccag
      781 tttgtaagca ggttttgaaa tgggaagtgt gtgctcttca tcctccctgt cctgggaagg
      841 ttgtgctctc catcctccct gtcctggaaa gattgtgctc tctgtcctct ctgtcatggg
      901 aaggttgtac tctctgtcct ccctatcctg ggaagagtat gttccctgtc ctccctatcc
      961 tgggaagagt gtgctctctg tcttccctgt cctgggaagg ttgtgctctc catcctccct
     1021 gtcctggaaa gattgtgctc tctgtcctct ctgtcatggg aaggttgtac tctccgtcct
     1081 ccctatcctg ggaagagtgt gctctctgtc ctccctgtcc tgggagggtt gtgctctcca
     1141 tcctccctat cctgggaaga gtgtgctctc tgtcctccct gtcctgggaa ggttgtgctc
     1201 tctgtcctcc ctatcctggg aaggttgtgc tctctgtcct ccctgtcctg ggagggttgt
     1261 gctctccatc ctccctatcc tgggaaggtt gtgctctcca tcctccctgt cctggaaaga
     1321 ttgtgctctc tgtcctctct gtcatgggaa ggttgtactc tccgtcctcc ctgtcctggg
     1381 agggttgtgc tctccatcct ccctatcctg ggaaggttgt gctctccata ctccctgtcc
     1441 tgggaagagt gtgctccctg tcctccctgt cctgggaagg ttgtgctctc catactccct
     1501 atcctggaaa gggtgtgctc tccatcctcc ctgtcctggg aagggtgtgc tctctgtgct
     1561 ccctgtccca cttaacagca ctgacagact tgaggcagct ttgatggagg cagtgactca
     1621 ctctcagtgg tactgaggag gcaggatcct catcttcctg tactgcccac ctgaccggtt
     1681 cataagaaag agcctatcac cacagtccct gcagccactg cttattttgg tctctgctaa
     1741 agccatggaa tcaatatcta aacagtgtca cctctgtcct tgttgtggtc acagccggga
     1801 ttctgccctc tgtcctcctg actcccactc ctccgttatt acacaccttt tctgcattcc
     1861 ttttccaaac actcctgacc cccacgtata ctctcccccc tccactcttc ccaccctcat
     1921 gtatactccc tcctgatgcc ccttacagtt caacctggac agaaattgct tcttgtaggg
     1981 ctgagacaga ggaggaaaaa aaaatgactc ctccagaata gagaccatga acaaggtgtg
     2041 cagttatcat cagagggaaa gtggctaccc gcccacccca aagggcccag aagaggtatg
     2101 ggtgtgggca ctgggaacac atggggcagg ggtggcacct tcctcgaggt gtcgggcctg
     2161 gtttgtcaga tgaattatgt ccctaaagac acactgaggc tccaagcccc cgtcctagtg
     2221 aatgtcgcct tgtttggaaa ccaggtttca gtgaccaact gaagtgggtc ctactctatg
     2281 tagtaggact cgtgactttc taagagggac acacacggag agcaccgtga gatgccagga
     2341 cagagactgg agtgacaagg acaaaagcca aggagagtgg aggacagatg gccactggac
     2401 tcaaaaaagg aacaattgtt cctgtgaccg tccaaggaca tgaggccctc ccaagccctt
     2461 gtttccaact ccagctttga gaacatggga caatgcccgc ctgttgcttg ggagactttg
     2521 ataaagcagt ctagacagcc aatgcagtat ctgctgcccc tcccccactc cccccagcca
     2581 gaaggaacca tgggagtgga gcggagaggg ggcaccagag ctgcagttgg cagcaaaggc
     2641 tcctcaggct acgttcccta ggagcatggg gaatcactgt cctgtggatc agccttctcc
     2701 ggctgcctcc tgaagacaca aggatccttc gcaccatggt actttgaaag ctcacctgcc
     2761 aggcactcct ggagagtatg gaacactcac tgagacacaa gttttggaaa gctgaacacc
     2821 gggcttagca agatggcctg gcacagagag gtgactgcag tttgatcccc agaacccatg
     2881 gtgggtggaa ggagaagaca gacttcagag aattgtcctc cgttctccac atgatataca
     2941 gtgtgtacac gcacacatac catacactat aaaacaataa taaagaagat ttaaatacac
     3001 aatacaatct aattaaaagc aacccccaca gc
//
