LOCUS       NM_019697               5325 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus potassium voltage-gated channel, Shal-related family,
            member 2 (Kcnd2), mRNA.
ACCESSION   NM_019697
VERSION     NM_019697.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5325)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5325)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5325)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5325)
  AUTHORS   Gong,Y., Laheji,F., Berenson,A., Qian,A., Park,S.O., Kok,R.,
            Selig,M., Hahn,R., Sadjadi,R., Kemp,S. and Eichler,F.
  TITLE     Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical
            Allodynia
  JOURNAL   Cells 11 (11), 1842 (2022)
   PUBMED   35681537
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5325)
  AUTHORS   Oule,M., Atucha,E., Wells,T.M., Macharadze,T., Sauvage,M.M.,
            Kreutz,M.R. and Lopez-Rojas,J.
  TITLE     Dendritic Kv4.2 potassium channels selectively mediate spatial
            pattern separation in the dentate gyrus
  JOURNAL   iScience 24 (8), 102876 (2021)
   PUBMED   34386734
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5325)
  AUTHORS   Kurschner,C. and Yuzaki,M.
  TITLE     Neuronal interleukin-16 (NIL-16): a dual function PDZ domain
            protein
  JOURNAL   J Neurosci 19 (18), 7770-7780 (1999)
   PUBMED   10479680
REFERENCE   7  (bases 1 to 5325)
  AUTHORS   Xu,H., Li,H. and Nerbonne,J.M.
  TITLE     Elimination of the transient outward current and action potential
            prolongation in mouse atrial myocytes expressing a dominant
            negative Kv4 alpha subunit
  JOURNAL   J Physiol 519 Pt 1 (Pt 1), 11-21 (1999)
   PUBMED   10432335
REFERENCE   8  (bases 1 to 5325)
  AUTHORS   Barry,D.M., Xu,H., Schuessler,R.B. and Nerbonne,J.M.
  TITLE     Functional knockout of the transient outward current, long-QT
            syndrome, and cardiac remodeling in mice expressing a
            dominant-negative Kv4 alpha subunit
  JOURNAL   Circ Res 83 (5), 560-567 (1998)
   PUBMED   9734479
REFERENCE   9  (bases 1 to 5325)
  AUTHORS   Voss,G.C. and Jockusch,H.
  TITLE     Genetic mapping of members of the polyubiquitin gene subfamily
            coding for UbB
  JOURNAL   Mamm Genome 7 (2), 169 (1996)
   PUBMED   8835546
REFERENCE   10 (bases 1 to 5325)
  AUTHORS   Klocke,R., Roberds,S.L., Tamkun,M.M., Gronemeier,M., Augustin,A.,
            Albrecht,B., Pongs,O. and Jockusch,H.
  TITLE     Chromosomal mapping in the mouse of eight K(+)-channel genes
            representing the four Shaker-like subfamilies Shaker, Shab, Shaw,
            and Shal
  JOURNAL   Genomics 18 (3), 568-574 (1993)
   PUBMED   7905852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY279027.1, CB520748.1 and BC079667.1.
            
            On May 29, 2018 this sequence version replaced NM_019697.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB045326.1, BC079667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               BY279027.1         9-296
            289-763             CB520748.1         1-475
            764-5325            BC079667.1         1-4562
FEATURES             Location/Qualifiers
     source          1..5325
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 8.49 cM"
     gene            1..5325
                     /gene="Kcnd2"
                     /gene_synonym="Gm52855; Kv4.2"
                     /note="potassium voltage-gated channel, Shal-related
                     family, member 2"
                     /db_xref="GeneID:16508"
                     /db_xref="MGI:MGI:102663"
     exon            1..2068
                     /gene="Kcnd2"
                     /gene_synonym="Gm52855; Kv4.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             954..2846
                     /gene="Kcnd2"
                     /gene_synonym="Gm52855; Kv4.2"
                     /note="potassium voltage-gated channel subfamily D member
                     2; voltage-gated potassium channel subunit Kv4.2"
                     /codon_start=1
                     /product="A-type voltage-gated potassium channel KCND2"
                     /protein_id="NP_062671.1"
                     /db_xref="CCDS:CCDS19934.1"
                     /db_xref="GeneID:16508"
                     /db_xref="MGI:MGI:102663"
                     /translation="MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIV
                     LNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTG
                     KLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDNTGES
                     ALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKE
                     LPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIG
                     LVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMA
                     IIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSL
                     SGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRN
                     GLLSNQLQSSEDEPAFISKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVAT
                     VNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHRGSVQELSTIQIRCVER
                     TPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGNI
                     VRVSAL"
     exon            2069..2231
                     /gene="Kcnd2"
                     /gene_synonym="Gm52855; Kv4.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2327
                     /gene="Kcnd2"
                     /gene_synonym="Gm52855; Kv4.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2420
                     /gene="Kcnd2"
                     /gene_synonym="Gm52855; Kv4.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2668
                     /gene="Kcnd2"
                     /gene_synonym="Gm52855; Kv4.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..5309
                     /gene="Kcnd2"
                     /gene_synonym="Gm52855; Kv4.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5282..5287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnd2"
                     /gene_synonym="Gm52855; Kv4.2"
                     /note="hexamer: AATAAA"
     polyA_site      5309
                     /gene="Kcnd2"
                     /gene_synonym="Gm52855; Kv4.2"
                     /note="major polyA site"
ORIGIN      
        1 ggctgctcgg gagccgctgg ctctgccttt ccctttccgg gtacaaggcg acagcaaagt
       61 ctctatgcaa ctcagccccg gtgcgcactt tgccaggtat gtaccgcggg cgaggcgcgt
      121 tctgcgcgga ggcagatgct gctgccgcca cggcggcggc ggctgccagc tcccaggctc
      181 tataactgtc acactgcacc tgagctgaac ttgaacagag agtgaaaggg cccatcgggc
      241 aaacgctctc ggctagcgca gagggtgtca gtcgtcgttg tgggggggag aaagagctct
      301 agaccgacgc cccccgccgc gagccctgca cttcacctcc atctctgcaa gcgcagcgtg
      361 agtacaggcg gccagcggac tccaagggac gcgggacagc ggctgtgacc gcatctccgg
      421 agctacaaca acaggtcgtc tttttgagac gcctttggcg ggaaggacca cttcagcaaa
      481 aggggaaggt gaaagggttc tttcttttaa gagactacca ctgactggtt gactttccct
      541 gtttcctctc tcctgctcta tataccgacc ccatatctac cagactgtat caggggagaa
      601 gcgaagacac ctgtttgaag ccaggctgtc tccgaagtca cctgtacgtt tacatgtgcc
      661 aggacctgcc ctggtccaac tgttggcaga gatttgttta ggctttatgg agagagattt
      721 ttaggtcact gtattttttt tttcttagta ttccaaatac ttctgtgagg gaaacctgac
      781 cttcttgagt actgtgactt gacctgcgcc accttggaat aatcgtgttc ctgtgagcag
      841 tgtcccccca gtgttttgcc tgaggtgaag aagtgggggg cactttctta ctttcattgt
      901 gttattttgg gtgacccccc tgctcactct cgtgacctcc acttccagac aacatggcag
      961 ccggtgttgc agcatggctg ccctttgcca gggcagccgc cattgggtgg atgcctgttg
     1021 cttcggggcc tatgcctgcg cccccaagac aggagagaaa aaggactcag gacgctctga
     1081 tagtgctgaa cgtgagtggc acccgtttcc agacatggca agacaccctg gaacgatacc
     1141 cagacactct gctgggtagt tctgagagag actttttcta ccacccagag acccaacaat
     1201 acttctttga ccgtgacccg gacatcttcc gccacatcct caacttctac cgcacgggga
     1261 agcttcacta tccccgccat gagtgcatct cggcttatga tgaagaactg gccttctttg
     1321 gcctcatccc agaaattatt ggcgactgct gttatgagga gtacaaggac cgcaggcggg
     1381 agaatgctga gcgcctccag gatgatgcag acactgacaa tacaggagag agtgcgctgc
     1441 ccaccatgac tgctaggcag agggtctggc gggcctttga gaatccccac accagcacca
     1501 tggccctggt gttctactat gtgactgggt tcttcattgc cgtctcagtc atcgcgaatg
     1561 tggtggaaac agttccatgt gggtctagcc caggccacat aaaagaactg ccttgtgggg
     1621 agaggtatgc ggtggccttc ttctgcttgg ataccgcctg tgtcatgatc ttcacagttg
     1681 agtacttgct tcgcctggcc gcagcaccta gtcgttaccg tttcgtgcgc agtgtcatga
     1741 gtatcatcga cgtggtggcc atcctaccct attacattgg gctggtgatg acagacaatg
     1801 aggatgtcag tggagccttt gtcacactcc gagtctttcg agtcttcagg atctttaagt
     1861 tttcccgcca ctctcaaggg ctgcgtatac tggggtacac cctgaagagc tgtgcatcag
     1921 aactgggctt cttgctcttt tctctcacaa tggctatcat cattttcgct accgttatgt
     1981 tctacgcaga gaagggctct tcagcaagca agttcaccag catcccggca gccttctggt
     2041 acaccatcgt caccatgaca acactggggt atggcgacat ggtaccaaaa accatagcag
     2101 ggaagatttt tgggtccatc tgctcactga gcggagtctt ggtcattgcg ctacccgtgc
     2161 ctgtgatcgt gtcgaacttc agtcggatct accaccaaaa ccaacgagca gacaaacgaa
     2221 gggcacagaa gaaagccagg ctggccagga tccgagcagc caaaagcggg agtgcaaatg
     2281 cctacatgca gagcaagcgg aatgggctac tgagcaacca gctgcagtcc tcggaggatg
     2341 aaccggcctt cataagcaaa tctggatcca gctttgagac acagcaccac cacctgcttc
     2401 actgcctgga gaaaaccacg aaccatgagt ttgtcgatga acaagtcttt gaagaaagct
     2461 gcatggaagt tgccaccgtc aatcgcccat caagtcacag tccctctctc tcctcacaac
     2521 aaggagtcac cagcacttgc tgctcacgga gacacaaaaa gactttccgc attcctaatg
     2581 ccaatgtgtc gggaagccat agaggcagtg tgcaagaact cagtacaatt cagatcagat
     2641 gtgtggagag aactccacta tccaacagcc gatccagctt aaatgccaaa atggaagagt
     2701 gtgttaaact aaactgtgaa caaccttacg tgaccacagc aataataagc atcccaacac
     2761 ctccagtaac caccccagaa ggcgacgaca ggcccgagtc tcctgagtat tcgggaggaa
     2821 atatcgtcag ggtgtctgcc ttgtaagaca attgccgcag gtctgagaga atttgagccc
     2881 tgactatgga aagaatctaa aggagaagaa agaagaaata ataacccctt tttgcatatt
     2941 tagacagcaa agcaagaagg ttggcgatga aacaaaaaaa tcaagatttc agagttgaag
     3001 atgtgaatca aaccaccaaa aggcatttct agacagcgtt caacctgtcc acagagggtg
     3061 actctgtggc cctttgactt tgtgaatgag cacaatgaaa tgccatttat tgatgcctct
     3121 tatgatcaga actctttttt aataaaacaa ataaaacaaa tctttggaca taatgttcca
     3181 gttgaatgca aaacaaaaaa aatatggaaa acattttgat aaaaattttt cctgttaaaa
     3241 accatgaaca ttggctctga tgaagattgc tattgatgaa aaattcatac gatccatttg
     3301 tgtggactga aggaaaccat cccaatgcat gctagaattc tttggagcag tgatctcagt
     3361 ttccttatgt tgtcttcaga ataggcatga caaactatac ctgtagaaag gggaaatttc
     3421 tgtgcactta caatgagctg attgtccatg ttctatggtg ggctgtgcaa ataaactcct
     3481 tttagcacca cagtgtttct catggggatg cacactagta tatctaaagt gttcggatag
     3541 ttcagtatta attattgttt aaccttgcac ctagtcattg ttataactgc aataattcat
     3601 tctatatctg ttgtatcggg aaccaggatt ttttttttgg actttccata tattcataga
     3661 tacagtgaga gccacattca tagaaaaact cctggtgtgg ccgggtttta gctgactttt
     3721 taatccaaaa ctactgtgtc ataaatgtat tttggtagta ttctttggtc cactgtattc
     3781 ctgtgaccca gtgcattatc tgtccctgga tctctttagt gtctttccac tgagcttacc
     3841 cactaatgac aggactagtg tctactgtag tagtaaaaca aacgttccct gcctttgtat
     3901 ttctcaacca gttattataa gaagactgtc accaatcccc ttgataacaa ctagagtaaa
     3961 ggagttgaca tgaaatatct ccagtgtttc actatttgta gaaaacccag accctgcaaa
     4021 cacccatatg tgttttatga gaggcgttaa atggtacttt taaaaaaatc ataggatgga
     4081 tgatttcaga atctaactca atgtattaat tattttgctt cagatcttca atacattttg
     4141 aggacaactg gaatgcagag gaaaactgaa gtgctttgta tagcaatatt tgatgagagc
     4201 atgctttaaa tgccatccaa gaaagcaaca atgtatctca aaagattcta gtgtatcaca
     4261 aggcacaaag ttctctgcaa aatcaggaag agggagtatg gtgatgtgaa gtcgaccact
     4321 gtgtacattt aagtgaaaag tcttgctacc ttttcaccct tgaatatccg cagatgtgtc
     4381 tgcacgtgac aatgtaaaaa taaaaaaaaa gttttatgtc aaatgaaaag ttttgttcat
     4441 tccaagccac cactgtaaga acgaaagctt agtttctata catgaaaaag aattaataat
     4501 tagtcctctg acatagagat tttgaaatgc ttttcacaat ttatcataag aaaatgaatt
     4561 aatccaaaca ttttcaggta aagccagaaa tggtcacttc ccatttatag aatagcttct
     4621 aggacagtgc taggcacaca gtagctcttc atcaaagctg agtgacaggg aaaagaactc
     4681 agctgaccct cgggaagacc tggctttact cctagtgtgt ctttgaaaca gttactaata
     4741 ttcctgagac gtgaatatta acaattctat taacacctgc ctgttgtcac tttatgcttc
     4801 tagagcaaat gtatagtgaa acttctttga tggcacttat taaaaactct tttaaagtaa
     4861 gtacaatcag gaacatttac catcttttga ttcccaataa gaaattctat tttcatgttc
     4921 ctaataggac ataaaacaac atagacttgg cttatttggg ttgatactta ttattcctgc
     4981 tttggtttgt cgtttatcac aaattattaa tttcttcaga ttttcagaag tgaaatttta
     5041 aaaataatct tttggatgtt ttaggtgatt taaaatatac tgtgttggtg gtgaatgact
     5101 tttgatgacg gtgttaagtg caactgtact gtaagtgaaa tgtaattatt tctgtgtatc
     5161 atatggagta actaaggtca ttgtttttga caattttgtt tgaaattcat atatcttatt
     5221 tcaaaggata gcataatatc tgcattatgc tggaaaaaaa tagacctttg gagaatactt
     5281 aaataaaaca tgtgcatgct tgaacaggaa aaaaaaaaaa aaaaa
//
