LOCUS       NM_008423               3815 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus potassium voltage-gated channel, Shal-related family,
            member 1 (Kcnd1), mRNA.
ACCESSION   NM_008423 XM_973323
VERSION     NM_008423.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3815)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3815)
  AUTHORS   Kim,K.R., Jeong,H.J., Kim,Y., Lee,S.Y., Kim,Y., Kim,H.J., Lee,S.H.,
            Cho,H., Kang,J.S. and Ho,W.K.
  TITLE     Calbindin regulates Kv4.1 trafficking and excitability in dentate
            granule cells via CaMKII-dependent phosphorylation
  JOURNAL   Exp Mol Med 53 (7), 1134-1147 (2021)
   PUBMED   34234278
  REMARK    GeneRIF: Calbindin regulates Kv4.1 trafficking and excitability in
            dentate granule cells via CaMKII-dependent phosphorylation.
REFERENCE   3  (bases 1 to 3815)
  AUTHORS   Kim,K.R., Kim,Y., Jeong,H.J., Kang,J.S., Lee,S.H., Kim,Y., Lee,S.H.
            and Ho,W.K.
  TITLE     Impaired pattern separation in Tg2576 mice is associated with
            hyperexcitable dentate gyrus caused by Kv4.1 downregulation
  JOURNAL   Mol Brain 14 (1), 62 (2021)
   PUBMED   33785038
  REMARK    GeneRIF: Impaired pattern separation in Tg2576 mice is associated
            with hyperexcitable dentate gyrus caused by Kv4.1 downregulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3815)
  AUTHORS   Kim,K.R., Lee,S.Y., Yoon,S.H., Kim,Y., Jeong,H.J., Lee,S.,
            Suh,Y.H., Kang,J.S., Cho,H., Lee,S.H., Kim,M.H. and Ho,W.K.
  TITLE     Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate
            Granule Cells, Is Crucial for Pattern Separation
  JOURNAL   J Neurosci 40 (11), 2200-2214 (2020)
   PUBMED   32047055
  REMARK    GeneRIF: Kv4.1, a Key Ion Channel For Low Frequency Firing of
            Dentate Granule Cells, Is Crucial for Pattern Separation.
REFERENCE   5  (bases 1 to 3815)
  AUTHORS   Hermanstyne,T.O., Granados-Fuentes,D., Mellor,R.L., Herzog,E.D. and
            Nerbonne,J.M.
  TITLE     Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and
            Clock Gene Expression in the Suprachiasmatic Nucleus and Daily
            Rhythms in Locomotor Behavior
  JOURNAL   eNeuro 4 (3) (2017)
   PUBMED   28560311
  REMARK    GeneRIF: Expression of the Kv4.1-targeted shRNA significantly
            decreased interspike intervals and increased repetitive firing
            rates in suprachiasmatic nucleus (SCN) neurons during the day and
            at night. results presented here also revealed that the acute
            knockdown of Kv4.1 had differential effects on the daytime and
            nighttime input resistance and repetitive firing rates in SCN
            neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3815)
  AUTHORS   Duprat,F., Guillemare,E., Romey,G., Fink,M., Lesage,F.,
            Lazdunski,M. and Honore,E.
  TITLE     Susceptibility of cloned K+ channels to reactive oxygen species
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11796-11800 (1995)
   PUBMED   8524851
REFERENCE   7  (bases 1 to 3815)
  AUTHORS   Lock,L.F., Gilbert,D.J., Street,V.A., Migeon,M.B., Jenkins,N.A.,
            Copeland,N.G. and Tempel,B.L.
  TITLE     Voltage-gated potassium channel genes are clustered in paralogous
            regions of the mouse genome
  JOURNAL   Genomics 20 (3), 354-362 (1994)
   PUBMED   8034307
REFERENCE   8  (bases 1 to 3815)
  AUTHORS   Chabala,L.D., Bakry,N. and Covarrubias,M.
  TITLE     Low molecular weight poly(A)+ mRNA species encode factors that
            modulate gating of a non-Shaker A-type K+ channel
  JOURNAL   J Gen Physiol 102 (4), 713-728 (1993)
   PUBMED   7903683
REFERENCE   9  (bases 1 to 3815)
  AUTHORS   Lesage,F., Attali,B., Lazdunski,M. and Barhanin,J.
  TITLE     Developmental expression of voltage-sensitive K+ channels in mouse
            skeletal muscle and C2C12 cells
  JOURNAL   FEBS Lett 310 (2), 162-166 (1992)
   PUBMED   1383027
REFERENCE   10 (bases 1 to 3815)
  AUTHORS   Pak,M.D., Baker,K., Covarrubias,M., Butler,A., Ratcliffe,A. and
            Salkoff,L.
  TITLE     mShal, a subfamily of A-type K+ channel cloned from mammalian brain
  JOURNAL   Proc Natl Acad Sci U S A 88 (10), 4386-4390 (1991)
   PUBMED   2034678
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC139325.1 and AK033805.1.
            
            On May 9, 2015 this sequence version replaced NM_008423.1.
            
            Summary: This gene encodes a multipass transmembrane protein that
            comprises a subunit of voltage-gated rapidly inactivating A-type
            potassium channels. [provided by RefSeq, May 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033805.1, SRR1660819.7259.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2115              BC139325.1         1-2115
            2116-3815           AK033805.1         1601-3300
FEATURES             Location/Qualifiers
     source          1..3815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.53 cM"
     gene            1..3815
                     /gene="Kcnd1"
                     /gene_synonym="1110037K09Rik; Kca2-1; Kv4.1; mShal1; Shal;
                     Shal1"
                     /note="potassium voltage-gated channel, Shal-related
                     family, member 1"
                     /db_xref="GeneID:16506"
                     /db_xref="MGI:MGI:96671"
     exon            1..1205
                     /gene="Kcnd1"
                     /gene_synonym="1110037K09Rik; Kca2-1; Kv4.1; mShal1; Shal;
                     Shal1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2040
                     /gene="Kcnd1"
                     /gene_synonym="1110037K09Rik; Kca2-1; Kv4.1; mShal1; Shal;
                     Shal1"
                     /note="potassium voltage-gated channel subfamily D member
                     1; voltage-gated potassium channel subunit Kv4.1"
                     /codon_start=1
                     /product="A-type voltage-gated potassium channel KCND1"
                     /protein_id="NP_032449.1"
                     /db_xref="CCDS:CCDS29974.1"
                     /db_xref="GeneID:16506"
                     /db_xref="MGI:MGI:96671"
                     /translation="MAAGVATWLPFARAAAVGWLPLAQQPLPPAPEVKASRGDEVLVV
                     NVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDAESGEYFFDRDPDMFRHVLNFYRTGR
                     LHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGEGP
                     ALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGTPRWPS
                     KEQSCGDRFPTAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYY
                     IGLFVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLT
                     MAIIIFATVMFYAEKGTSKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSIC
                     SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYK
                     QNGGLEDSGSGDGQMLCVRSRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSL
                     GGRTSRSTSVSSQPMGPGSLFSSCCSRRVNRRAIRLANSTASVSRGSMQELDTLAGLR
                     RSPAPQTRSSLNAKPHDSLDLNCDSRDFVAAIISIPTPPANTPDESQPSSPSGGGGSG
                     GTPNTTLRNSSLGTPCLLPETVKISSL"
     exon            1206..1368
                     /gene="Kcnd1"
                     /gene_synonym="1110037K09Rik; Kca2-1; Kv4.1; mShal1; Shal;
                     Shal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1452
                     /gene="Kcnd1"
                     /gene_synonym="1110037K09Rik; Kca2-1; Kv4.1; mShal1; Shal;
                     Shal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1551
                     /gene="Kcnd1"
                     /gene_synonym="1110037K09Rik; Kca2-1; Kv4.1; mShal1; Shal;
                     Shal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1802
                     /gene="Kcnd1"
                     /gene_synonym="1110037K09Rik; Kca2-1; Kv4.1; mShal1; Shal;
                     Shal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..3815
                     /gene="Kcnd1"
                     /gene_synonym="1110037K09Rik; Kca2-1; Kv4.1; mShal1; Shal;
                     Shal1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3202..3207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnd1"
                     /gene_synonym="1110037K09Rik; Kca2-1; Kv4.1; mShal1; Shal;
                     Shal1"
                     /note="hexamer: AATAAA"
     polyA_site      3235
                     /gene="Kcnd1"
                     /gene_synonym="1110037K09Rik; Kca2-1; Kv4.1; mShal1; Shal;
                     Shal1"
                     /note="major polyA site"
ORIGIN      
        1 ctccaagcct ccaccatcct ggcggtagcc acattctcct aaacaaaaca tccccaagtc
       61 tccgtgggcc tggggagctg caggatggcg gcaggtgtgg ccacatggct accatttgca
      121 agggccgcag cagtgggctg gctgccctta gcccagcagc ccctaccccc tgcaccggag
      181 gtgaaggcat cccgagggga tgaggttctg gtggtgaatg tgagtggtcg gcgctttgag
      241 acctggaaaa acacactgga tcgctaccca gacacattgc tgggcagctc ggagaaggaa
      301 ttcttctatg atgctgaatc tggcgagtac ttctttgatc gtgacccaga catgttccgg
      361 cacgtgctga acttttatcg cactggccgg ctgcactgcc ccaggcagga gtgcatccag
      421 gcctttgatg aggagctggc cttctatggc ttggtcccag agctggttgg tgactgctgt
      481 cttgaagagt acagggaccg taagaaggaa aacgcagagc gcctggcaga agatgaggag
      541 gctgagcagg ccggggaagg tccagccctt ccagcaggca gctccctgcg acagcgactc
      601 tggagggcct ttgagaaccc ccacacgagc actgcagccc tggttttcta ctatgtgact
      661 ggcttcttca tagctgtgtc agtcattgcc aacgtcgtgg agaccatccc atgtcgtggt
      721 accccacgat ggccctccaa agagcagtcg tgtggtgacc gcttccctac agcctttttc
      781 tgtatggaca cagcctgtgt actcatattc acaggggagt acctgctgcg gctcttcgca
      841 gcccccagcc gttgtcgctt cctgcggagt gtgatgagcc ttatcgatgt ggtggccatc
      901 ctaccctact atattgggct gttcgtgccc aagaatgatg atgtctctgg tgcctttgtc
      961 accctccgtg tgttccgggt cttccgaatc ttcaagttct ccaggcactc gcagggcctg
     1021 aggattctgg gctacaccct caagagctgt gcctctgagc taggctttct cctcttttcc
     1081 ctcaccatgg ccatcatcat ctttgccact gtcatgttct atgctgagaa gggcacgagc
     1141 aagaccaact tcacaagcat ccctgctgcc ttctggtata ccattgtcac catgaccaca
     1201 cttgggtatg gagatatggt acctagcacc attgcaggca aaatttttgg gtccatctgc
     1261 tcacttagcg gtgtcttggt cattgccttg cctgtgccag tcattgtatc caacttcagc
     1321 cgcatctacc accagaacca gcgtgctgac aagcgccggg cacagcagaa agtgcgcctg
     1381 gcaagaatcc gtttggcaaa gagtggtacc accaatgcct tcctgcagta taagcaaaat
     1441 gggggcctcg aggacagtgg cagtggcgac ggacaaatgc tgtgcgttag gagccgctct
     1501 gcttttgaac aacagcatca ccatctgctg cattgtctgg agaagactac gtgtcacgag
     1561 ttcacagacg agctaacttt cagtgaggcc cttggagcag tctcactggg tggtcgcacc
     1621 agccgcagta cctcagtatc atcccaacca atggggcctg ggagcctgtt ctcatcctgc
     1681 tgctctcgaa gggtcaatcg cagagccatc cgccttgcca actctactgc ctctgtcagc
     1741 cgtggcagca tgcaggagct agacacacta gcaggtcttc ggaggagccc tgcccctcaa
     1801 acccgctcaa gcctcaatgc caagccccac gacagccttg acctgaactg tgacagccgg
     1861 gacttcgtgg ccgccatcat cagtatcccc accccccctg ccaacacgcc agatgaaagt
     1921 caaccttcct cccctagtgg tggtggcggc agtggtggca cacccaacac cactctcagg
     1981 aactccagct tgggtactcc gtgcctcctc cctgagactg tcaagatctc ttccctgtga
     2041 ggaacgggcc tgcccattca gagggccttc tttattcttg ggaactcctt tccaaagcca
     2101 tattttgggg gaggcaaaga ggggcagacc tgggaactcc ctgtgccgcc tgacaagaac
     2161 tatgcaatgg agtttcatgg aatggcccac ctggtgggaa cgtaggtagg gaatgaggaa
     2221 cttccctcag tccagacagt ttttctagtg ggagcttgaa gcatgggact ccataggtcc
     2281 ctggcctcct tggcccagca tgctgggact ggcctgtctc tcctagttgg cctcttgcat
     2341 gcctcttccc ttgggccctc agaggcagct taaagctttc tatagtctga catttgaggt
     2401 ctgtctggtc tgacaagagt taagagttcc tcttctcttt ggttgtgttg tgcaagtttg
     2461 ggagttcagg gaagagaacc ctcatctcca atttagcctc gaggggcaag gttttgccct
     2521 tcaacaggcc cagcatttcc cggatttgga agcttggaat gcaaccctgg gctggcttaa
     2581 tgggctgtgg cctctgtagt gacctgctac cctcatgctt tggctgaggg ggtcaggctg
     2641 cttctcccaa cacagagata gcacaaacac taccacccct tttccctggc tagctgctgg
     2701 aagtgagttc ccaccacctg tcttctgctg ggcctccagc aaactctagc aatagcagct
     2761 gctgccatac caatatgcaa agccttggac caatttgctg cagcatatac atctgctctg
     2821 atcagatggg ccacatctaa ctactctctt ctctgatgtg ctttcttctt gggttggtct
     2881 ggagtctgga cctgctgaga taagagacta acatccagca agagctggac tgggtggtga
     2941 gatcatgggc tggtttcata ttcttgggca gaagtccaga agtagtgtgg gcagaggact
     3001 gaactgttcc tgacccctgg gagagataga agatatcgcc tccttctctg ctgtaactcc
     3061 tttgcacact gtcttctcct ccctcttggg tcaccttctg gatctatgct ctcgactgaa
     3121 tctcatgtca tctcaggttc cctgtctcca gctctgtccc tctgaagctg gcagctgaca
     3181 aagatgaagt tttcatcagt caataaagcc taagaggaga gatgtggact gagcatctac
     3241 tgactctgtg gattgacttt gagggctggg tttggctgag gggttaagaa cactatggtc
     3301 tcaatttctt tcagtcgaag agaaattcaa cagtgaaggg actggtgtgg gtagatgggt
     3361 ggctagtgct ctattttcga agatgtggat tatggagaaa tgaaaaaggg tgctttgaag
     3421 agtttgtctc tgtaggcagt gaagccagcc agagggtcct aagcctgctg gaccttagat
     3481 actaatctgt tccagatcct tcattgctag aaggagaagc caagatttag agcaccatgg
     3541 agttactttg aggagcaact taagcccatg cttcctgata gcaaaaaacc tatacatttt
     3601 tttctgagtt tggtaataac cccctttctc atggatagtg cctctgctgt tctcttctgg
     3661 ataccagcta caccaggcta gtatgtgagt gagttgtgga gagccctgtg gagaccaatc
     3721 ttggattcag atcgacacat tttagtcctt tgtgagagac tcactctttg tgtcacgttg
     3781 ctaatgtgaa atagaaacag taatttcttt attca
//
