LOCUS       NM_001356447            4340 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus potassium voltage gated channel, Shaw-related
            subfamily, member 4 (Kcnc4), transcript variant 1, mRNA.
ACCESSION   NM_001356447 XM_006502476
VERSION     NM_001356447.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4340)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4340)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4340)
  AUTHORS   Turzo,M., Metzger,K., Lasitschka,F., Weigand,M.A. and Busch,C.J.
  TITLE     Inhibition of overexpressed Kv3.4 augments HPV in endotoxemic mice
  JOURNAL   BMC Pulm Med 20 (1), 260 (2020)
   PUBMED   33032555
  REMARK    GeneRIF: Inhibition of overexpressed Kv3.4 augments HPV in
            endotoxemic mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4340)
  AUTHORS   Kaczmarek,L.K. and Zhang,Y.
  TITLE     Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release,
            and Neuronal Endurance
  JOURNAL   Physiol Rev 97 (4), 1431-1468 (2017)
   PUBMED   28904001
  REMARK    Review article
REFERENCE   5  (bases 1 to 4340)
  AUTHORS   Boscia,F., Pannaccione,A., Ciccone,R., Casamassa,A., Franco,C.,
            Piccialli,I., de Rosa,V., Vinciguerra,A., Di Renzo,G. and
            Annunziato,L.
  TITLE     The expression and activity of KV3.4 channel subunits are
            precociously upregulated in astrocytes exposed to Abeta oligomers
            and in astrocytes of Alzheimer's disease Tg2576 mice
  JOURNAL   Neurobiol Aging 54, 187-198 (2017)
   PUBMED   28390823
  REMARK    GeneRIF: KV3.4 channel subunits are precociously upregulated in
            cultured astrocytes exposed to Ab oligomers.
REFERENCE   6  (bases 1 to 4340)
  AUTHORS   Brooke,R.E., Moores,T.S., Morris,N.P., Parson,S.H. and Deuchars,J.
  TITLE     Kv3 voltage-gated potassium channels regulate neurotransmitter
            release from mouse motor nerve terminals
  JOURNAL   Eur J Neurosci 20 (12), 3313-3321 (2004)
   PUBMED   15610163
REFERENCE   7  (bases 1 to 4340)
  AUTHORS   Vullhorst,D., Jockusch,H. and Bartsch,J.W.
  TITLE     The genomic basis of K(V)3.4 potassium channel mRNA diversity in
            mice
  JOURNAL   Gene 264 (1), 29-35 (2001)
   PUBMED   11245975
REFERENCE   8  (bases 1 to 4340)
  AUTHORS   Lock,L.F., Gilbert,D.J., Street,V.A., Migeon,M.B., Jenkins,N.A.,
            Copeland,N.G. and Tempel,B.L.
  TITLE     Voltage-gated potassium channel genes are clustered in paralogous
            regions of the mouse genome
  JOURNAL   Genomics 20 (3), 354-362 (1994)
   PUBMED   8034307
REFERENCE   9  (bases 1 to 4340)
  AUTHORS   Klocke,R., Roberds,S.L., Tamkun,M.M., Gronemeier,M., Augustin,A.,
            Albrecht,B., Pongs,O. and Jockusch,H.
  TITLE     Chromosomal mapping in the mouse of eight K(+)-channel genes
            representing the four Shaker-like subfamilies Shaker, Shab, Shaw,
            and Shal
  JOURNAL   Genomics 18 (3), 568-574 (1993)
   PUBMED   7905852
REFERENCE   10 (bases 1 to 4340)
  AUTHORS   Ghanshani,S., Pak,M., McPherson,J.D., Strong,M., Dethlefs,B.,
            Wasmuth,J.J., Salkoff,L., Gutman,G.A. and Chandy,K.G.
  TITLE     Genomic organization, nucleotide sequence, and cellular
            distribution of a Shaw-related potassium channel gene, Kv3.3, and
            mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1
  JOURNAL   Genomics 12 (2), 190-196 (1992)
   PUBMED   1740329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124727.4.
            
            On Dec 21, 2022 this sequence version replaced NM_001356447.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784644.375492.1,
                                           SRR17784648.531422.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2087              AC124727.4         79846-81932         c
            2088-3024           AC124727.4         69149-70085         c
            3025-3228           AC124727.4         67075-67278         c
            3229-4340           AC124727.4         59948-61059         c
FEATURES             Location/Qualifiers
     source          1..4340
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..4340
                     /gene="Kcnc4"
                     /gene_synonym="Kcr2-4; KSHIIIC; Kv3.4"
                     /note="potassium voltage gated channel, Shaw-related
                     subfamily, member 4"
                     /db_xref="GeneID:99738"
                     /db_xref="MGI:MGI:96670"
     exon            1..2087
                     /gene="Kcnc4"
                     /gene_synonym="Kcr2-4; KSHIIIC; Kv3.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1398..3290
                     /gene="Kcnc4"
                     /gene_synonym="Kcr2-4; KSHIIIC; Kv3.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium voltage-gated channel subfamily C member 4;
                     voltage-gated potassium channel subunit Kv3.4;
                     voltage-gated potassium channel KCNC4"
                     /codon_start=1
                     /product="voltage-gated potassium channel KCNC4 isoform 1"
                     /protein_id="NP_001343376.1"
                     /db_xref="GeneID:99738"
                     /db_xref="MGI:MGI:96670"
                     /translation="MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGG
                     TRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGGGAGSSGSSGGGGGGGGCEFFFDR
                     HPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEE
                     ALDIFESPDGGGGGAGPGDEAGDDERELALQRLGPHEGGSGPGAGSGGCRGWQPRMWA
                     LFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIHRVGNITSVRFR
                     REVETEPILTYIEGVCVMWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVG
                     LSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFL
                     ALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKT
                     WSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPPQLES
                     PIYCKSEETSPRDSTYSDTSPPAREEGVVERKRADSKQNGDANAVLSDEEGAGLTQPL
                     ALAPTPEERRALRRSGTRDRNKKAAACFLLSAGDYACADGSVRKETCQDALSSNYAHA
                     EVLTLS"
     exon            2088..3024
                     /gene="Kcnc4"
                     /gene_synonym="Kcr2-4; KSHIIIC; Kv3.4"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3228
                     /gene="Kcnc4"
                     /gene_synonym="Kcr2-4; KSHIIIC; Kv3.4"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..4340
                     /gene="Kcnc4"
                     /gene_synonym="Kcr2-4; KSHIIIC; Kv3.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4306..4311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnc4"
                     /gene_synonym="Kcr2-4; KSHIIIC; Kv3.4"
                     /note="hexamer: AATAAA"
     polyA_site      4340
                     /gene="Kcnc4"
                     /gene_synonym="Kcr2-4; KSHIIIC; Kv3.4"
                     /note="major polyA site"
ORIGIN      
        1 actggctgct agcgggttac gcgcctccgc tgggctggga tgcgcggatg aaggctgagc
       61 tctgctgccc gagctccgca acgccccagg tcggccttgc gcctcgcagc gccgcgccca
      121 ccccgccccg cggagggtgc gccctggtca ggcgaggccg agaggaaaag gcgccacttg
      181 gagcgtcgca tcctctgtca tcgcgggagg gagtcgcaga gccctttgag ccccattcct
      241 ctggcgccca ggcgctccct tccctagacc acctcgcgcc cgcccctagc agggagccaa
      301 ggccggcgcc ccgcccggag atgggcagac gcgcagatgg cgcggctccc ggcggcgcca
      361 gatctcagga acccggcgcc ggggcgctgc gctgaggctc cctcttggcg cggcccagga
      421 agcctgcagg tgtccttggc cattcggcca ccgcccggga cactccgcca gcacccggtg
      481 cctggctctt cagagcagcc ccgccctcca ggctctgcgc cgcgcaggac gccccgtctg
      541 aaccccccct cgtcccggcg cggcccccgc agcgctgcat ccagcccggc gcagctcccg
      601 gccacggacg caggacccag gctcgctgct gcgggcgcgc ttgttttcct gccgcctggt
      661 cctgagcaac ccccacccgc tggtccgtct cgctcgactc aaccccgccc gccatcggtg
      721 ctccgcgctg gatttatgaa tggggggaac gggccacatg cccgccaccg ccgcctcgag
      781 ttgaccgcac actgcccggc cccgcagagc tctggctacc gtaggagcat ccgcccggcc
      841 ccggtagccg ctccgaggac ttgttgctgt tacgctgctg cctccgccgc tgccgccgcc
      901 cggagaaacc ctgccgcctt cgggctcgcc gcgttctagg agccaaaggg tggcccgtgt
      961 gagtgtgagc gcgcgcgccg cggaccctcg cagtgctctg ggactgtgcg cttctctgcc
     1021 tttctggggt cgggggggcg tgtccccggc ccagagcatc cttgtgcttg cccctacctc
     1081 ctgggacccc ggaccctttg gtttgagtcc tcgacccagg tcttcacctc ctgcctccac
     1141 taggttctgc ctgcctaaat cccaaccacc tgtgcaccac agaaagccaa ctcttcctgc
     1201 tccgcgcccc gggggggttg ggggggaggc aggggcagag ccactccgca gaaggggccg
     1261 ctaccacctc ctgcctcctc ctcctcctcc acctcctcct tgtcgtctcc tccccctccc
     1321 cgttctgacg ctgcctcctt gggaagggtg tttggagggc agcggccgcc ccaagccgga
     1381 gccccgcagc gcttcttatg atcagctcgg tgtgtgtctc ctcctaccgc gggcgcaagt
     1441 cggggaacaa gcctccgtcc aaaacatgtc tgaaggagga gatggccaag ggcgaggcgt
     1501 cggagaagat catcatcaac gtgggcggca cgcgacatga gacctaccgc agcaccctgc
     1561 gcaccctacc gggcacccgc cttgcctggt tggcggatcc cgacggcggg ggtcggccag
     1621 agtcggatgg cggcggtgca ggcagcagcg gcagcagcgg cggcggcggc ggcggcgggg
     1681 gctgtgagtt cttctttgat cggcacccgg gtgtttttgc ctatgtgctc aactactacc
     1741 gtacgggcaa gctgcattgc cccgcagacg tctgtgggcc tctctttgag gaagagctca
     1801 ccttctgggg tatcgatgaa acagatgtgg aaccctgctg ctggatgacc taccggcagc
     1861 accgcgatgc tgaggaggca ctggacatct tcgagagccc ggacgggggc gggggtggcg
     1921 cagggccagg cgacgaggct ggcgacgatg agcgggagtt ggccttgcag cgcctgggcc
     1981 cccatgaagg aggctctggc cctggtgctg ggtccggagg gtgccgtggc tggcagcccc
     2041 gaatgtgggc gctcttcgag gatccctact catcccgggc ggccagggtg gtagcctttg
     2101 cctctctctt cttcatcttg gtctccatta ccaccttctg cctggagacc catgaggcct
     2161 tcaacattga ccgaaacgtg acggagattc atcgggtagg gaatatcacc agcgtgcgct
     2221 tccggcggga ggtagaaaca gagcccattc ttacctacat cgagggtgtg tgcgtgatgt
     2281 ggttcactct agagttcctg gttcgcattg tgtgctgccc tgatacgctg gactttgtca
     2341 agaacttgct caacatcatc gactttgtgg ccatcttacc cttttacctg gaggtgggat
     2401 tgagtggttt gtcttccaag gcagctcgcg atgtgctggg tttcctgcgt gtggtacgct
     2461 ttgtacgcat cctgcggatc ttcaagctca cacgccactt tgtggggctg cgtgtgctag
     2521 gccacactct ccgggccagc actaatgagt tcctgttgct tatcatcttc ttggccctgg
     2581 gtgtgctcat cttcgccacc atgatctatt atgccgagcg aattggggcc aggccatctg
     2641 acccacgggg caacgaccac accgacttca agaacatccc catcggtttc tggtgggctg
     2701 tggtcaccat gacaacgctt ggctatgggg acatgtatcc caagacgtgg tcaggaatgt
     2761 tggtgggtgc gctgtgtgcg ctggctggtg tgctgaccat tgccatgccc gtgcctgtca
     2821 tcgtcaataa ctttggtatg tactactccc tggctatggc caagcagaag ctgcccaaga
     2881 agcgaaagaa gcacgtacca cggccacccc agctcgaatc gcccatttac tgcaagtctg
     2941 aggagacttc accccgggac agcacctaca gtgacaccag cccccctgcc cgggaagagg
     3001 gtgtggtcga gaggaaacgg gccgactcta agcagaatgg cgatgctaat gcggtgctgt
     3061 ctgatgagga gggagctggc ctcactcagc ccttggcctt ggcccccacc cctgaagagc
     3121 gtcgggccct gagacgctca ggcacgcggg acagaaacaa gaaggcagct gcctgcttcc
     3181 tgctcagtgc tggggactat gcctgtgctg atggcagtgt ccggaaagag acctgccaag
     3241 acgccctctc gtccaactat gcccacgctg aagtcctcac cctctcttag agtggcgcca
     3301 acgtgagaaa gacagacaga cagacagaca gaaagccaga ggcttaggaa aactctggaa
     3361 cccaggcacg aatcttttgc tgggaaagac tcagatatcc ttgtttgcac aagactggtg
     3421 gaaaaacctc ccatgcgact ctcagggccc agagccatct gggtctgata ctctgttcta
     3481 ctgtacattg aagagacata tatgcacata tagtatctat attcatacat actatatact
     3541 cttgtgtgta gtgcacgtgc tactggtggt ctgtcttcat cgttaggcta tgtctcccaa
     3601 gtcctcttcc caccctgttt cccctcctcc cttccttcat ggattgtttc ttctgaccac
     3661 gtgtatggga tatcccagga aatgtgtccc tgggacctgc ccctccagct gggtggtccc
     3721 aggctgctct cacttgggga tgtttcccct gccagcaggt ggcctgttga agtcagttga
     3781 aggcaagatt gccctccggg gtcactgctt cactagccca accccacccc agattggggt
     3841 tctacctccc accccacacc ccagtttgtg gggcatttct aggggctctt ttgcagcctc
     3901 tgtcactcct tccaatgccc cttctgtgtc tgtgataggg ggaatttcat ttcttttgtg
     3961 tgtctccttt gtccatttct tttcaaagat gctgctgggc agatggaagg ggatctgttt
     4021 gcccatctgg ctcaggggtc tgagaagggg acacctcggg cgagaggaga ccagttgcaa
     4081 tactgtactt cctggccagt ggccagagga tgcgtgcaat agcagaggcc gggtgacccc
     4141 ttcagccttg gcctctgccc ctccctcagc ccttcctgcc catccttggt attggtcagt
     4201 ccttttctaa agctgtcctc ttgtgtgtgt gtctgaggca cgcctaggct gggcccactg
     4261 tgccctgtct gcatgccctc aactgtcatg ctgtgctcga gtaccaataa agacatccga
     4321 gtgtcctgct gctcctctga
//
