LOCUS       NM_008422               5490 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus potassium voltage gated channel, Shaw-related
            subfamily, member 3 (Kcnc3), transcript variant 1, mRNA.
ACCESSION   NM_008422
VERSION     NM_008422.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5490)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5490)
  AUTHORS   Xu,P., Shimomura,K., Lee,C., Gao,X., Simpson,E.H., Huang,G.,
            Joseph,C.M., Kumar,V., Ge,W.P., Pawlowski,K.S., Frye,M.D.,
            Kourrich,S., Kandel,E.R. and Takahashi,J.S.
  TITLE     A missense mutation in Kcnc3 causes hippocampal learning deficits
            in mice
  JOURNAL   Proc Natl Acad Sci U S A 119 (31), e2204901119 (2022)
   PUBMED   35881790
  REMARK    GeneRIF: A missense mutation in Kcnc3 causes hippocampal learning
            deficits in mice.
REFERENCE   3  (bases 1 to 5490)
  AUTHORS   Richardson,A., Ciampani,V., Stancu,M., Bondarenko,K., Newton,S.,
            Steinert,J.R., Pilati,N., Graham,B.P., Kopp-Scheinpflug,C. and
            Forsythe,I.D.
  TITLE     Kv3.3 subunits control presynaptic action potential waveform and
            neurotransmitter release at a central excitatory synapse
  JOURNAL   Elife 11, e75219 (2022)
   PUBMED   35510987
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5490)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5490)
  AUTHORS   Zhang,Y., Varela,L., Szigeti-Buck,K., Williams,A., Stoiljkovic,M.,
            Sestan-Pesa,M., Henao-Mejia,J., D'Acunzo,P., Levy,E., Flavell,R.A.,
            Horvath,T.L. and Kaczmarek,L.K.
  TITLE     Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1
            to regulate trafficking of the cell survival protein Hax-1
  JOURNAL   Nat Commun 12 (1), 1731 (2021)
   PUBMED   33741962
  REMARK    GeneRIF: Cerebellar Kv3.3 potassium channels activate TANK-binding
            kinase 1 to regulate trafficking of the cell survival protein
            Hax-1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5490)
  AUTHORS   Cabib,S., Oliverio,A., Ventura,R., Lucchese,F. and
            Puglisi-Allegra,S.
  TITLE     Brain dopamine receptor plasticity: testing a diathesis-stress
            hypothesis in an animal model
  JOURNAL   Psychopharmacology (Berl) 132 (2), 153-160 (1997)
   PUBMED   9266612
REFERENCE   7  (bases 1 to 5490)
  AUTHORS   Wymore,R.S., Korenberg,J.R., Kinoshita,K.D., Aiyar,J., Coyne,C.,
            Chen,X.N., Hustad,C.M., Copeland,N.G., Gutman,G.A., Jenkins,N.A. et
            al.
  TITLE     Genomic organization, nucleotide sequence, biophysical properties,
            and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4
            to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to
            mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13
  JOURNAL   Genomics 20 (2), 191-202 (1994)
   PUBMED   8020965
REFERENCE   8  (bases 1 to 5490)
  AUTHORS   Goldman-Wohl,D.S., Chan,E., Baird,D. and Heintz,N.
  TITLE     Kv3.3b: a novel Shaw type potassium channel expressed in terminally
            differentiated cerebellar Purkinje cells and deep cerebellar nuclei
  JOURNAL   J Neurosci 14 (2), 511-522 (1994)
   PUBMED   8301351
REFERENCE   9  (bases 1 to 5490)
  AUTHORS   Haas,M., Ward,D.C., Lee,J., Roses,A.D., Clarke,V., D'Eustachio,P.,
            Lau,D., Vega-Saenz de Miera,E. and Rudy,B.
  TITLE     Localization of Shaw-related K+ channel genes on mouse and human
            chromosomes
  JOURNAL   Mamm Genome 4 (12), 711-715 (1993)
   PUBMED   8111118
REFERENCE   10 (bases 1 to 5490)
  AUTHORS   Ghanshani,S., Pak,M., McPherson,J.D., Strong,M., Dethlefs,B.,
            Wasmuth,J.J., Salkoff,L., Gutman,G.A. and Chandy,K.G.
  TITLE     Genomic organization, nucleotide sequence, and cellular
            distribution of a Shaw-related potassium channel gene, Kv3.3, and
            mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1
  JOURNAL   Genomics 12 (2), 190-196 (1992)
   PUBMED   1740329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157653.2.
            
            On Jul 22, 2020 this sequence version replaced NM_008422.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.844061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1307              AC157653.2         62298-63604         c
            1308-2415           AC157653.2         57788-58895         c
            2416-2607           AC157653.2         55481-55672         c
            2608-5490           AC157653.2         49305-52187         c
FEATURES             Location/Qualifiers
     source          1..5490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.85 cM"
     gene            1..5490
                     /gene="Kcnc3"
                     /gene_synonym="Kcr2-3; KShIIID; Kv3.3"
                     /note="potassium voltage gated channel, Shaw-related
                     subfamily, member 3"
                     /db_xref="GeneID:16504"
                     /db_xref="MGI:MGI:96669"
     exon            1..1307
                     /gene="Kcnc3"
                     /gene_synonym="Kcr2-3; KShIIID; Kv3.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..2744
                     /gene="Kcnc3"
                     /gene_synonym="Kcr2-3; KShIIID; Kv3.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium voltage-gated channel subfamily C member 3;
                     voltage-gated potassium channel subunit Kv3.3;
                     voltage-gated potassium channel KCNC3"
                     /codon_start=1
                     /product="voltage-gated potassium channel KCNC3 isoform 1"
                     /protein_id="NP_032448.2"
                     /db_xref="CCDS:CCDS39942.1"
                     /db_xref="GeneID:16504"
                     /db_xref="MGI:MGI:96669"
                     /translation="MLSSVCVWSFRGRQGTGKQQPQPVPTPQPPESSPPPLPPPQQQQ
                     CSQPGTAASPAGAPLSCGPGGRRAEPCPGLPAVAMGRHGGGGGDSGKIVINVGGVRHE
                     TYRSTLRTLPGTRLAGLTEPEAAARFDYDPGTDEFFFDRHPGVFAYVLNYYRTGKLHC
                     PADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDSSANANANAG
                     GAHDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPAGGAGGAGGTWWRRWQPR
                     VWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAP
                     PENITNVEVETEPFLTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCVAILP
                     FYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFL
                     LLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYG
                     DMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPR
                     PPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVNVAGAYPPGPHTHPGL
                     LRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIETNRADPRPNGDPAAAALAHEDCPAID
                     QPAMSPEDKSPITPGSRGRYSRDRACFLVTDYAPSPDGSIRKGYEKSRSLSSIVGLSG
                     VSLRLAPLATPPGSPRATRRAPPTLPSIL"
     exon            1308..2415
                     /gene="Kcnc3"
                     /gene_synonym="Kcr2-3; KShIIID; Kv3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2607
                     /gene="Kcnc3"
                     /gene_synonym="Kcr2-3; KShIIID; Kv3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..5490
                     /gene="Kcnc3"
                     /gene_synonym="Kcr2-3; KShIIID; Kv3.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5468..5473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnc3"
                     /gene_synonym="Kcr2-3; KShIIID; Kv3.3"
                     /note="hexamer: AATAAA"
     polyA_site      5490
                     /gene="Kcnc3"
                     /gene_synonym="Kcr2-3; KShIIID; Kv3.3"
                     /note="major polyA site"
ORIGIN      
        1 cttttttttt cgaggcagag tctcatgcag cccaggctgg cctctatctc actttgtagc
       61 atgaccttga acgcctgatc ccccttcctt cacggtacct ggctctttcc catacctggc
      121 tctgaggtct ccattttcgc tgtgctgctg agttaggcat ttttagggtc cccttgacgc
      181 cccgccctct cctaggtagg atccaatccc tgagctttct gtgcaacccc acctcctcta
      241 gctaggctgg gtcggagtct gcctagccgt ggccccgccc agtcgctcag cccaatcagc
      301 tcgtgccctc cctccacctg cccaatcaca ccctcccatc cattcatcgc ctcctcctgt
      361 ccaatcacgt ctgcctctct acccgggccc cgcccccgag accctgcccc ctcccagccc
      421 cgcctccctg tccaatgctc agttcagtgt gcgtctggtc gttccgcggg cgccagggga
      481 ccggcaagca gcagcctcag ccggtgccaa cgccgcagcc gcctgagtcc tcaccgccgc
      541 ctctgccgcc gccgcagcag cagcagtgct ctcagcccgg cactgccgcc tccccggcgg
      601 gtgccccgct ttcctgcggg cctgggggcc ggcgtgccga gccatgcccc gggctgccgg
      661 cggtggccat ggggcggcac ggcggcggcg gcggcgacag cggtaagatc gtgatcaacg
      721 tgggcggcgt gcgccatgag acgtaccgct ccacgttgcg caccctgcca gggaccagac
      781 tggccgggct gaccgagccc gaggcggccg cgcgctttga ctacgacccg ggcacggacg
      841 agttcttctt cgaccgtcac ccgggcgtct tcgcctacgt gctcaactac taccgcaccg
      901 gcaaactgca ctgcccggcc gacgtgtgcg ggccgctctt cgaggaggag ctgggcttct
      961 ggggcataga cgagacggac gtggaggcct gctgctggat gacctatcgc cagcaccgtg
     1021 acgctgagga ggcactggac tctttcgagg ccccggactc ctcggccaac gccaacgcca
     1081 acgccggagg cgcgcacgat gcgggactgg acgacgaggc gggcgcagga ggcggcggcc
     1141 tggacggggc aggcggcgag ctcaagcgtc tgtgttttca ggacgcgggc ggaggtgccg
     1201 gaggacctgc cgggggcgcg ggcggcgcgg gcggcacctg gtggcggcgc tggcagcccc
     1261 gtgtgtgggc gctttttgag gacccctact cgtcgcgggc tgccaggtat gtggccttcg
     1321 cctccctatt ctttatcctc atctccatca ccaccttctg cctggagaca cacgagggct
     1381 tcatccacat cagcaacaag acggtgacgc aggcctcccc aatccctggg gctcccccgg
     1441 agaatatcac caacgtggag gtggagacgg aacccttctt gacctacgtg gaaggcgtgt
     1501 gtgtggtctg gttcaccttt gagtttctca tgcgggtcac cttctgccca gataaggtgg
     1561 agtttctcaa aagcagcctg aacatcatcg actgcgtggc catcttgccc ttctacttgg
     1621 aagtgggcct gtcaggtctc agctccaaag ctgccaagga cgtgctgggc ttcctgcgtg
     1681 tcgtccgctt cgtgcgcatc cttcgtatct tcaagctgac ccgtcacttc gtggggctgc
     1741 gtgtgctggg ccacacgctc cgggccagca ccaacgaatt cttgttactc atcatcttcc
     1801 tggctctggg ggtcctcatc tttgccacca tgatctacta tgccgaacgc atcggggctg
     1861 atcctgacga catcctgggc tccaaccaca cctacttcaa gaacatcccc atcggcttct
     1921 ggtgggctgt ggtcaccatg acgacactgg gctatggaga catgtatccc aagacgtggt
     1981 ctgggatgct ggttggggca ctgtgtgccc tggctggtgt gctgaccatt gccatgcccg
     2041 tgcctgtcat tgtcaacaac ttcggcatgt actattcact ggctatggcc aagcagaaat
     2101 tgccaaagaa gaaaaacaaa catattccca ggcccccgca gcctggctca cccaactact
     2161 gcaagcctga ccccccgcct ccacccccac cacaccccca ccacggcagc ggtggcataa
     2221 gcccaccgcc gcccatcacc cctccttcca tgggggtgaa tgtggccggg gcctacccac
     2281 ctggacccca cacacacccc gggctgctca ggggtggtgc tgggggcctg ggaatcatgg
     2341 gattgcctcc tctgccagcc cctggtgagc cctgcccatt ggctcaagaa gaggtgattg
     2401 aaaccaacag ggcagacccc cgtcccaatg gagaccctgc agcagccgca ctggcccatg
     2461 aggactgccc tgccatcgac cagccagcca tgtctccaga agacaagagc ccaatcactc
     2521 ccggaagccg gggtcgctac agccgggacc gagcttgctt ccttgtcaca gactatgccc
     2581 cttcccctga tggctccatc cgaaaaggtt acgagaagtc ccgcagcctg agcagcattg
     2641 tgggcctgag cggggtgtcc ctgcgcctcg cgcccctcgc caccccccct ggctctcccc
     2701 gggccacgcg ccgagctccc ccgaccctgc cctccatcct ctagcgcagc cctcccccct
     2761 gtggggggac tgggggtgat gggaaggtga aaaggagctg ggagtagggc tggggaaagg
     2821 gttctttttt taaaaaaaaa aaagtcaata atatgcaaaa gagacgatgc cagcagacac
     2881 ccccggggcc tctcactccc catacactag aaaacccagg atagaggggg cagggccgga
     2941 gcctgtaccc catctccctc ccccttccaa aaaaaaaaaa aaaagcaaac ctcaggtctc
     3001 catgagccat aggacacccc tcccatcgac tcctgtaaat aactaaaagc tgattccatc
     3061 ttggggcacc cactccagtt tgcatgcctc cccgaccccc tcttcagcaa taagccgcca
     3121 ggagctgtgt gcaaagagtt ggaggggagg ctgctgggag cctctaaggt cggagctagc
     3181 atttttaggg gtcttcctgg tcacccgccc cccaaagggc aacccaccca tcactaattg
     3241 attcaggaaa aacaaaaacc tctaggaaca cgtaggaaaa ggaagacagg ttaatcagcc
     3301 gcagccccga ggagctcagc ttgggggtgg gggggttctg ccagctgctc ttgggcttgg
     3361 aggacgccag ctggtgcatt ccacccacgc ccgcctccag ggatctgctc cctctattcg
     3421 ctgcatggac ttggccctcc aggcccagaa ccctctaccc actgcagtct ccactctatc
     3481 ccaagaggtg agactagtac cctagactta aggagacaga acctggcacc ctgcactccc
     3541 acaccccacg gactccggcg ccccccactc ctcacctcca tcactccatc catcccccac
     3601 tggcctggac tgcaccacag agtttttcca ctcttccctt gcacctccgc tcacttccag
     3661 ccttcggggt tctgacagtc ctcaagaccc tgacattgcc tagacacccc tatatcccca
     3721 accccagacg gccccaactc cctgacatca cactcctctg tcccctggcg cctctggcgc
     3781 aagaccttcc cggacaagct ccgtctgtct gattacagag agctcccatc ccattccagt
     3841 attactgtct aggcagcccc ctcctcaccg ccctctcccc ccccacccca tggtgccaaa
     3901 acacactttc ttcatggcca ccagagtttc ccagagcgtg ggactcccgt tccctcttcg
     3961 tgtgctgaag tttgcaaagt gcacagacga ccaagtgttt taaacttgtg tgctctttgc
     4021 aggctcacac ccggctggtg cgtcctggca gcgcagcagt tgggtgttgc cactgaaagc
     4081 aagtctaaga caggatggga cccaatgcta aaagcgcttg cttaatgtgc taaggtccca
     4141 gggttcaaac tccagcaacc cctcttcccc tactggtggg caaagaggac atacccacct
     4201 cggctaggat ctcagcctgc ccttcccagc ttccttgccc actacgtgcc acattctcgg
     4261 atggaaaact ttctcaaatc tcgtcttggc tccaggatgc tacctccccc aagcccagag
     4321 accacactgg tcccagaatc cttagcgaac tatccccttt ggagctgggt ggtcggcaga
     4381 attagcaatc ccttgttccc accgcctcag ggaaacctcc cgctgtcacc agagttgtcg
     4441 gtgggggtgt ccttgggccc aattcttgat gcaacaattc ctatgcaagg gacattttga
     4501 gtccctcccg caccccccgc cttccctcgg gaccttaaac tctggtgaga caggggttga
     4561 ggagtggggt gggatctggt aggggcaggg caaagggcta ggggactcta gacaccaggg
     4621 tatgggctga ggactcctaa tattgccaaa ggattcaact tatttaacaa cccctattat
     4681 ccccgccccc ctgtccctta aaagagacga atggggcggg gaaaggggta agagtccttt
     4741 ttgaagggta ccaaccactt cccactgttt tcccctgctc tccagttccc tacacatatc
     4801 cagcttttta gttaagcatt tttaaaaagc taccgtcatt ataaacgtct acaaaacgtg
     4861 atttttgccc ctccacatcc cccaatttac caaacagtgt gggattaggg gagggagagc
     4921 caggtcctgg tctccctttt ccccacggcc gccagggtgc ctgcaactgc acgcatgcgc
     4981 tgcatgacgc gcccccccca catacacacg catgcgtcgc gcacccctcc tgcgctgggg
     5041 ggggacgcgc ggacttgggg gcggggcgat ggggaggaat gattggcaga ggggaagggg
     5101 gtctttctga gctcaatggc tcctctcctt ccccacacac tcacagcaat aagtttctct
     5161 acttctagtg ggcggacggg cctagcctga cctggcgcgg gaggggctgg ccaatgggcg
     5221 ctctcaggga tgggggcggg tcctgagtct gggggagggg aggtctgcaa ctctggtgct
     5281 aatggcgggt cttcctggcc cacccgcagg cagggaggaa ggagtcggca ggctcctccc
     5341 ccaagcctcc cccacgccca cccagggtgc atgaaccacc cacgcagaag ctgccgcatg
     5401 tcaaccctcc cccccacaaa gaaacagtgt catgcccctt cccacctgcc ctcccactcc
     5461 ccagcccaat aaatgatacc ttttcattta
//
