LOCUS       NM_001379643            5531 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus potassium voltage gated channel, Shaw-related
            subfamily, member 2 (Kcnc2), transcript variant 4, mRNA.
ACCESSION   NM_001379643 XM_006513685
VERSION     NM_001379643.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5531)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5531)
  AUTHORS   Russell,N.X., Burra,K., Shah,R.M., Bottasso-Arias,N.,
            Mohanakrishnan,M., Snowball,J., Ediga,H.H., Madala,S.K. and
            Sinner,D.
  TITLE     Wnt signaling regulates ion channel expression to promote smooth
            muscle and cartilage formation in developing mouse trachea
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (6), L788-L802 (2023)
   PUBMED   37873566
REFERENCE   3  (bases 1 to 5531)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 5531)
  AUTHORS   Bedogni,F., Cobolli Gigli,C., Pozzi,D., Rossi,R.L., Scaramuzza,L.,
            Rossetti,G., Pagani,M., Kilstrup-Nielsen,C., Matteoli,M. and
            Landsberger,N.
  TITLE     Defects During Mecp2 Null Embryonic Cortex Development Precede the
            Onset of Overt Neurological Symptoms
  JOURNAL   Cereb Cortex 26 (6), 2517-2529 (2016)
   PUBMED   25979088
REFERENCE   5  (bases 1 to 5531)
  AUTHORS   Kraushar,M.L., Viljetic,B., Wijeratne,H.R., Thompson,K., Jiao,X.,
            Pike,J.W., Medvedeva,V., Groszer,M., Kiledjian,M., Hart,R.P. and
            Rasin,M.R.
  TITLE     Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical
            Ribosome Signature and mRNA Translation to Specify Neocortical Cell
            Subtypes
  JOURNAL   J Neurosci 35 (31), 10911-10926 (2015)
   PUBMED   26245956
REFERENCE   6  (bases 1 to 5531)
  AUTHORS   Roe,M.W., Worley,J.F. 3rd, Mittal,A.A., Kuznetsov,A., DasGupta,S.,
            Mertz,R.J., Witherspoon,S.M. 3rd, Blair,N., Lancaster,M.E.,
            McIntyre,M.S., Shehee,W.R., Dukes,I.D. and Philipson,L.H.
  TITLE     Expression and function of pancreatic beta-cell delayed rectifier
            K+ channels. Role in stimulus-secretion coupling
  JOURNAL   J Biol Chem 271 (50), 32241-32246 (1996)
   PUBMED   8943282
REFERENCE   7  (bases 1 to 5531)
  AUTHORS   Lock,L.F., Gilbert,D.J., Street,V.A., Migeon,M.B., Jenkins,N.A.,
            Copeland,N.G. and Tempel,B.L.
  TITLE     Voltage-gated potassium channel genes are clustered in paralogous
            regions of the mouse genome
  JOURNAL   Genomics 20 (3), 354-362 (1994)
   PUBMED   8034307
REFERENCE   8  (bases 1 to 5531)
  AUTHORS   Haas,M., Ward,D.C., Lee,J., Roses,A.D., Clarke,V., D'Eustachio,P.,
            Lau,D., Vega-Saenz de Miera,E. and Rudy,B.
  TITLE     Localization of Shaw-related K+ channel genes on mouse and human
            chromosomes
  JOURNAL   Mamm Genome 4 (12), 711-715 (1993)
   PUBMED   8111118
REFERENCE   9  (bases 1 to 5531)
  AUTHORS   Klocke,R., Roberds,S.L., Tamkun,M.M., Gronemeier,M., Augustin,A.,
            Albrecht,B., Pongs,O. and Jockusch,H.
  TITLE     Chromosomal mapping in the mouse of eight K(+)-channel genes
            representing the four Shaker-like subfamilies Shaker, Shab, Shaw,
            and Shal
  JOURNAL   Genomics 18 (3), 568-574 (1993)
   PUBMED   7905852
REFERENCE   10 (bases 1 to 5531)
  AUTHORS   Ghanshani,S., Pak,M., McPherson,J.D., Strong,M., Dethlefs,B.,
            Wasmuth,J.J., Salkoff,L., Gutman,G.A. and Chandy,K.G.
  TITLE     Genomic organization, nucleotide sequence, and cellular
            distribution of a Shaw-related potassium channel gene, Kv3.3, and
            mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1
  JOURNAL   Genomics 12 (2), 190-196 (1992)
   PUBMED   1740329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153500.3 and AC121610.2.
            
            On Apr 10, 2020 this sequence version replaced XM_006513685.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.58513.1, SRR9219379.114.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-532               AC153500.3         126502-127033
            533-1250            AC153500.3         128172-128889
            1251-2178           AC121610.2         34490-35417         c
            2179-2343           AC121610.2         32371-32535         c
            2344-5531           AC121610.2         24721-27908         c
FEATURES             Location/Qualifiers
     source          1..5531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 60.3 cM"
     gene            1..5531
                     /gene="Kcnc2"
                     /gene_synonym="B230117I07; KShIIIA; Kv3.2"
                     /note="potassium voltage gated channel, Shaw-related
                     subfamily, member 2"
                     /db_xref="GeneID:268345"
                     /db_xref="MGI:MGI:96668"
     exon            1..532
                     /gene="Kcnc2"
                     /gene_synonym="B230117I07; KShIIIA; Kv3.2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..1250
                     /gene="Kcnc2"
                     /gene_synonym="B230117I07; KShIIIA; Kv3.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             552..2480
                     /gene="Kcnc2"
                     /gene_synonym="B230117I07; KShIIIA; Kv3.2"
                     /note="isoform 1 is encoded by transcript variant 4;
                     potassium voltage-gated channel subfamily C member 2;
                     voltage-gated potassium channel Kv3.2; shaw-like potassium
                     channel; voltage-gated potassium channel KCNC2"
                     /codon_start=1
                     /product="voltage-gated potassium channel KCNC2 isoform 1"
                     /protein_id="NP_001366572.1"
                     /db_xref="GeneID:268345"
                     /db_xref="MGI:MGI:96668"
                     /translation="MGKIESNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPQG
                     DCLTAAGDKLQPLPPPLSPPPRPPPLSPVPSGCFEGGAGNCSSHGGNGGNGGSDHPGG
                     GREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTY
                     RQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRKLQPR
                     MWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSPVL
                     QYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEV
                     GLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIF
                     LALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQ
                     TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPLAS
                     SPTFCKTELNMACNSTQSDTCLGKENRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRR
                     SSTRDKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRSLNNIAGLAGNALRLSPVTSP
                     YNSPCPLRRSRSPIPSIL"
     exon            1251..2178
                     /gene="Kcnc2"
                     /gene_synonym="B230117I07; KShIIIA; Kv3.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2343
                     /gene="Kcnc2"
                     /gene_synonym="B230117I07; KShIIIA; Kv3.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..5531
                     /gene="Kcnc2"
                     /gene_synonym="B230117I07; KShIIIA; Kv3.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5469..5474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnc2"
                     /gene_synonym="B230117I07; KShIIIA; Kv3.2"
                     /note="hexamer: AATAAA"
     polyA_site      5502
                     /gene="Kcnc2"
                     /gene_synonym="B230117I07; KShIIIA; Kv3.2"
                     /note="major polyA site"
     regulatory      5512..5517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnc2"
                     /gene_synonym="B230117I07; KShIIIA; Kv3.2"
                     /note="hexamer: ATTAAA"
     polyA_site      5531
                     /gene="Kcnc2"
                     /gene_synonym="B230117I07; KShIIIA; Kv3.2"
                     /note="major polyA site"
ORIGIN      
        1 actgtagctg tgtgctcagg caagcggtgg tgaagaacag ctctagcaga ggacgctttc
       61 gggcgggggt ggggggagca ccaaatctgt ggatccaaat ctaagctgag agccttcact
      121 ttccactggg tgagcccccc tgtccttcgg tcagcctccg ctccagacac agccagccga
      181 cccgaaggtc tgcggcgggg tcgggctgtg ccagctggac ccgccccgag ctccatggtt
      241 cgcccagccc cgcgcgatgg tgactctggg tgcggagggt ggctatggga gagccagcag
      301 atcgcagcag cgtgaaggca gggagcgcgg cgggcggcag gcggggactg tctccccgac
      361 ctcagcaccc agagaagcgg atcaaccacc tgaaccccga aaaaacgcca acaagtagtt
      421 tctcctttga ggagggcggc tcagctggtc gcagagactc tgtccgactg caggaagaac
      481 ctcgtccaca gggagaccca agcagatcca ctttactccc ggtctcctta agtcatgtct
      541 gagccacaga gatgggcaag atcgagagca acgagagggt gatcctcaat gtcgggggta
      601 ccaggcacga aacctaccgc agcaccctca agaccctgcc tggaactcgc ctggcccttc
      661 ttgcctcctc tgaacctcag ggcgactgcc tgactgcggc cggggacaag ctgcaaccgc
      721 tgccccctcc gctgtctccg ccgccacgac cgcctccctt gtcccctgtc cccagcggct
      781 gcttcgaggg cggcgcaggc aactgcagtt cgcacggtgg caacggcggc aacggcggca
      841 gcgaccaccc tgggggaggc cgcgaattct tcttcgatcg ccacccagga gtattcgcct
      901 atgtgctcaa ttactaccgc acgggcaagc tgcactgccc cgccgacgtg tgcgggccgc
      961 tcttcgagga agagctggct ttctggggca tcgatgagac cgacgtggag ccctgctgct
     1021 ggatgaccta caggcagcac cgggacgcgg aggaggccct ggacatcttt gagacacccg
     1081 acctcatcgg gggcgaccct ggtgatgatg aggacctagc ggccaagaga ttgggcattg
     1141 aggatgctgc ggggctggga ggacccgatg gcaagtcagg ccgctggagg aagctgcagc
     1201 ctcgcatgtg ggctcttttt gaggacccct actcatctag agccgctagg tttattgctt
     1261 ttgcttcttt gttcttcatt ttggtttcca tcacaacctt ttgcctggag acacatgaag
     1321 ctttcaatat tgttaaaaac aagacggagc ccgtcatcaa tggcaccagc ccggtcctcc
     1381 agtacgaaat cgaaacggat cccgccctga cgtacgtgga aggagtatgt gtggtgtggt
     1441 ttacgtttga atttttagtc cgaattgttt tctcacccaa taaacttgaa ttcatcaaaa
     1501 atctcttgaa catcattgac tttgtggcca tcctcccctt ctacctagag gtgggactca
     1561 gcgggctgtc ctccaaagcg gccaaagatg tgctcggctt tctcagggtg gttaggtttg
     1621 tgaggatcct gagaatcttc aagctcaccc gccatttcgt aggtctgagg gtgctcggac
     1681 atactcttcg ggcgagcacc aacgaatttt tgttgctgat catcttcctg gcgctgggag
     1741 ttttgatatt cgctacgatg atctactacg ctgagagagt aggggctcag cccaatgacc
     1801 cttcagctag tgagcacacg cagttcaaaa acatccccat tggtttctgg tgggccgtag
     1861 tgaccatgac taccttaggt tacggggata tgtaccccca aacatggtca gggatgttgg
     1921 tgggggcctt gtgtgccctg gccggagtgc tgacaatagc catgcctgtg cctgtcattg
     1981 tcaacaattt tggaatgtac tactccttgg caatggcgaa gcagaaactt ccaagaaaga
     2041 gaaagaagca tattcctcct gcccctctgg caagctcgcc tacattttgc aagacagaat
     2101 tgaacatggc ttgcaacagt acccagagtg acacatgtct gggcaaagaa aaccggcttc
     2161 tggaacataa cagatcagtg ttatcaggtg acgacagtac aggaagtgag ccgccattat
     2221 cacctccaga aaggctccct atcagacgct ctagtaccag agacaaaaac agaagagggg
     2281 aaacgtgttt cctgttgacg acaggtgatt acacgtgcgc ttctgatgga ggaatcagga
     2341 aaggatatga aaaatcccga agcttaaaca acatagcggg cttggcaggc aatgctctga
     2401 gactctctcc agtaacgtcc ccctacaact ctccgtgtcc tctgaggcgc tctcggtctc
     2461 ccatcccatc tatcttgtaa accaaactgc atcaatcggc taaattctat caatacaacc
     2521 aactactgtt taccctgtaa tggaaacaat caactgtaga gtttctccag gctccattag
     2581 taacagtgta gctcctgcat gatattacta tttgaagtca gaaatgctac gcaagtagct
     2641 aaaacatctt atcctggctt taaagatgat ctaaagtagt gctactactc aagacaagtt
     2701 gccccagttt ccttttgcaa tacagtgacc aatagtgtca gatattggcc agtgcactaa
     2761 tgcataagcc atatcttcag ggagacttta atagtgtgct tctaaatgcc agccaccttt
     2821 ctggaccttc atttcttgtg actccaaacc attctgaaga tgtctgggat cctatctaga
     2881 tcgcatagga catgactttg gtcagttcat tggcatggac catcttgtct gtatcacctg
     2941 aatacaatgt tgtagagtcc tgggactgga tggctcagga tacatgtact tgcttcaaac
     3001 catcctgcaa atgtgaaatc gctgggagcc tgttctgcat gttgaattgt ggggcaggga
     3061 ggggtgcctt tctccttgct attccccacc ccttctttga tagaagtatt tactttaaat
     3121 accttaattt ttcgattgat ttcttttttt ttttttataa aaaacaaaca aatgctgtat
     3181 tggtgttctg aatgtttttg gttgtttgta tacacagata actgcaaaga ggttgtcatt
     3241 actggttaca cgcaagccga ggccagatct cttacttaat gacttgggga aggcacaaaa
     3301 catgaaagaa aggtaacagc taaccaggct tgcattgttt agccaagaat cgctgcttgg
     3361 tactagagcc attccccccc ccccccttta agtcctagaa tttgtcatta tttttagagg
     3421 tagagtgcca aatattaccc aaagcttttg tctttttttt tcttgcctct ttatttttat
     3481 ttattatttt gtgtgaacat taaaagttac tggtgttcac cggaggcttt tttgactagc
     3541 cttaagattt gcatcaaagg actaaccaga attttcaggc tgtgtttaat caggtgcttc
     3601 gtcccgtgtg ttgtctccat ctgtctgtct tagctccctg tcttaactct atatgctgtc
     3661 tccatagagg gtagacgtgc cctgattgtc tctttgaact ccctacctcc tacccatgtc
     3721 ttcttgtatg caaaactaat gatgctgtgt agactaccta gattaatagg cactgtgaat
     3781 atttttttcc atgagcagga ccgaagcagc aattcaccat agttctctgt tccttatggc
     3841 agtgctggtt tctactgcct agcaatcagc attcaccagt acgttccagg aaccatccct
     3901 agggagtctt ttttatttat ttatttattt tcagtctgga gggaagatag tctgtttaca
     3961 catccctacc aaatgctgta gcaatagtgt atctgatatt ttgggtatgc gaaggaagga
     4021 aaatgccata atataatctc agcctagact ttaactttca atgaattgat ccttacgcgt
     4081 gttgatgaat tcctgattct catgtttatt tttgatagaa aggcaattgt cacttgtgtt
     4141 attggataga gacgtgtgtt agtctccatt cccaagccct agagcatgag ctgcatgtca
     4201 agagatcttg tacagcaatg catttaccca gacgtaaata ctcgaaattt agagactcca
     4261 cgattctttt gataacacca ttcgtagaat gctgtgagta ctcagagatt tacggtaagg
     4321 aattaacatg ctgtctggtg ctgctgttat tgactgcagt gttgtacaga atttatcatg
     4381 gatttttgac tgctgaaaaa aaaggacatt gagatttagc cattccaagg attgtaccag
     4441 aaaacttctg ctaccgaatg taacccgatg tgacccgttt gtttccagaa gaggtcccgc
     4501 atcttatgag gcatttaaag cttataaaag ggactgtggc tggaactgag atggtgctcg
     4561 ccatgggaat attctgcttg tcgacagacc tgagtccacg gaacagctgt aaataccaac
     4621 cgtgtgcatg gacctgccca ctctcaccgt ctcatagaca gtgagacgcc acagacatca
     4681 gacggtgaga cgtcagacgg tgagacgcca cattcatggt cagcgtctgt ggggcttcaa
     4741 ggaatgcccg caaggctctg aatggctcct ctcaggctca cggtggtttt ggagtgaatt
     4801 acagagggca gtgaatccga tgtagtatag gtctgttttc atttctctta tttgtacatt
     4861 acgtgttgga tatccaaaca ctgattgcct cattttcttg caaaccgctt atagatcagc
     4921 gtgtcgactg tgttgtaaac ttctagtgtc tacatagaaa tctaaccatt tcttggtcac
     4981 gtgttcattt agttctggaa ggctgttact atctagaaga aagtcatcaa cagtgttcat
     5041 agttttaagt cttttgtcct tgttacctca attataaata ttaaaaagta taaattctgg
     5101 caatgagaat atttttttat taaatgatta aggaaaatgt cagtatatag tagaatatta
     5161 tcaaattata tcctaaaatg tctattttgc ataaaagaga tattcttcaa ccaattactt
     5221 tttttttttg tgagctttgt ggctaacgaa gcgtgcattt gtccttatca ctgctgtagt
     5281 tgaaactgta taagagtttt tcatcttgct taatcaatat ttccagaatc taatagttcc
     5341 cctgggattc tgaatatact atatagccta actataaccc ccctgtatcg tgtacctttt
     5401 gtgaccatct caaggtgcat gcctaacctt ctgataagcc aatggacatg ttactaactg
     5461 aagtgaagaa taaaagtcaa ctgatctggg gatagacttg aatcctatgt gattaaatga
     5521 ttcataccct t
//
