LOCUS       NM_001112739            4336 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus potassium voltage gated channel, Shaw-related
            subfamily, member 1 (Kcnc1), transcript variant 1, mRNA.
ACCESSION   NM_001112739
VERSION     NM_001112739.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4336)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4336)
  AUTHORS   Page,C.E. and Coutellier,L.
  TITLE     Kv3.1 Voltage-gated Potassium Channels Modulate Anxiety-like
            Behaviors in Female Mice
  JOURNAL   Neuroscience 538, 68-79 (2024)
   PUBMED   38157976
REFERENCE   3  (bases 1 to 4336)
  AUTHORS   Oh,H., Lee,S., Oh,Y., Kim,S., Kim,Y.S., Yang,Y., Choi,W., Yoo,Y.E.,
            Cho,H., Lee,S., Yang,E., Koh,W., Won,W., Kim,R., Lee,C.J., Kim,H.,
            Kang,H., Kim,J.Y., Ku,T., Paik,S.B. and Kim,E.
  TITLE     Kv7/KCNQ potassium channels in cortical hyperexcitability and
            juvenile seizure-related death in Ank2-mutant mice
  JOURNAL   Nat Commun 14 (1), 3547 (2023)
   PUBMED   37321992
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4336)
  AUTHORS   Richardson,A., Ciampani,V., Stancu,M., Bondarenko,K., Newton,S.,
            Steinert,J.R., Pilati,N., Graham,B.P., Kopp-Scheinpflug,C. and
            Forsythe,I.D.
  TITLE     Kv3.3 subunits control presynaptic action potential waveform and
            neurotransmitter release at a central excitatory synapse
  JOURNAL   Elife 11, e75219 (2022)
   PUBMED   35510987
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4336)
  AUTHORS   Bee,S., Ringland,A. and Coutellier,L.
  TITLE     Social impairments in mice lacking the voltage-gated potassium
            channel Kv3.1
  JOURNAL   Behav Brain Res 413, 113468 (2021)
   PUBMED   34274375
REFERENCE   6  (bases 1 to 4336)
  AUTHORS   Stubbs,L., Rinchik,E.M., Goldberg,E., Rudy,B., Handel,M.A. and
            Johnson,D.
  TITLE     Clustering of six human 11p15 gene homologs within a 500-kb
            interval of proximal mouse chromosome 7
  JOURNAL   Genomics 24 (2), 324-332 (1994)
   PUBMED   7698755
REFERENCE   7  (bases 1 to 4336)
  AUTHORS   Grissmer,S., Ghanshani,S., Dethlefs,B., McPherson,J.D.,
            Wasmuth,J.J., Gutman,G.A., Cahalan,M.D. and Chandy,K.G.
  TITLE     The Shaw-related potassium channel gene, Kv3.1, on human chromosome
            11, encodes the type l K+ channel in T cells
  JOURNAL   J Biol Chem 267 (29), 20971-20979 (1992)
   PUBMED   1400413
REFERENCE   8  (bases 1 to 4336)
  AUTHORS   Lesage,F., Attali,B., Lazdunski,M. and Barhanin,J.
  TITLE     Developmental expression of voltage-sensitive K+ channels in mouse
            skeletal muscle and C2C12 cells
  JOURNAL   FEBS Lett 310 (2), 162-166 (1992)
   PUBMED   1383027
REFERENCE   9  (bases 1 to 4336)
  AUTHORS   Perney,T.M., Marshall,J., Martin,K.A., Hockfield,S. and
            Kaczmarek,L.K.
  TITLE     Expression of the mRNAs for the Kv3.1 potassium channel gene in the
            adult and developing rat brain
  JOURNAL   J Neurophysiol 68 (3), 756-766 (1992)
   PUBMED   1432046
REFERENCE   10 (bases 1 to 4336)
  AUTHORS   Yokoyama,S., Imoto,K., Kawamura,T., Higashida,H., Iwabe,N.,
            Miyata,T. and Numa,S.
  TITLE     Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells.
            Primary structure and functional expression from cDNAs
  JOURNAL   FEBS Lett 259 (1), 37-42 (1989)
   PUBMED   2599109
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ130517.1, AC020786.20, AK162964.1, AC090652.32 and BB750064.1.
            
            On Dec 27, 2013 this sequence version replaced NM_001112739.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162964.1, SRR7974084.1843.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-464               CJ130517.1         2-465
            465-1343            AC020786.20        12149-13027         c
            1344-3456           AK162964.1         1-2113
            3457-3457           AC090652.32        29347-29347
            3458-3933           AK162964.1         2114-2589
            3934-4336           BB750064.1         46-448
FEATURES             Location/Qualifiers
     source          1..4336
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.1 cM"
     gene            1..4336
                     /gene="Kcnc1"
                     /gene_synonym="C230009H10Rik; Kcr2-1; KShIIIB; Kv3.1; KV4;
                     NGK2; Shaw"
                     /note="potassium voltage gated channel, Shaw-related
                     subfamily, member 1"
                     /db_xref="GeneID:16502"
                     /db_xref="MGI:MGI:96667"
     exon            1..1780
                     /gene="Kcnc1"
                     /gene_synonym="C230009H10Rik; Kcr2-1; KShIIIB; Kv3.1; KV4;
                     NGK2; Shaw"
                     /inference="alignment:Splign:2.1.0"
     CDS             1211..2968
                     /gene="Kcnc1"
                     /gene_synonym="C230009H10Rik; Kcr2-1; KShIIIB; Kv3.1; KV4;
                     NGK2; Shaw"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium voltage-gated channel subfamily C member 1;
                     voltage-gated potassium channel subunit Kv4; voltage-gated
                     potassium channel subunit Kv3.1; voltage-gated potassium
                     channel KCNC1"
                     /codon_start=1
                     /product="voltage-gated potassium channel KCNC1 isoform 1"
                     /protein_id="NP_001106210.1"
                     /db_xref="CCDS:CCDS52252.1"
                     /db_xref="GeneID:16502"
                     /db_xref="MGI:MGI:96667"
                     /translation="MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHS
                     HFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVE
                     PCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDS
                     PDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPI
                     VNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKN
                     SLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVL
                     GHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFW
                     WAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQ
                     KLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGE
                     VAKAALANEDCPHIDQALTPDEGLPFTRSGTRERYGPCFLLSTGEYACPPGGGMRKDL
                     CKESPVIAKYMPTEAVRVT"
     exon            1781..2714
                     /gene="Kcnc1"
                     /gene_synonym="C230009H10Rik; Kcr2-1; KShIIIB; Kv3.1; KV4;
                     NGK2; Shaw"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2903
                     /gene="Kcnc1"
                     /gene_synonym="C230009H10Rik; Kcr2-1; KShIIIB; Kv3.1; KV4;
                     NGK2; Shaw"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..4336
                     /gene="Kcnc1"
                     /gene_synonym="C230009H10Rik; Kcr2-1; KShIIIB; Kv3.1; KV4;
                     NGK2; Shaw"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4086..4091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnc1"
                     /gene_synonym="C230009H10Rik; Kcr2-1; KShIIIB; Kv3.1; KV4;
                     NGK2; Shaw"
                     /note="hexamer: AATATA"
     polyA_site      4109
                     /gene="Kcnc1"
                     /gene_synonym="C230009H10Rik; Kcr2-1; KShIIIB; Kv3.1; KV4;
                     NGK2; Shaw"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgcccgt gtccggagag ccgcgggctg gacgcggacc gcgcgaacga gcaagcgagc
       61 aggcagcgga gcagcagccc ggaggcagca gcggcgcggc ggcggcggtg gcggcggtgg
      121 ccgctccgcg cctcgcctcc ctggcctcgc cagtctcgct gcgccgcgcc cggacctgcc
      181 acccccgcct accgggcccg acctcggcag cgcccctcgc ctcggctgcc agcgccaccc
      241 gccctcctag agcagagagc ggagtgcggg gcgcagagac accggagcca gtgcccgccg
      301 gccccgccaa gcaaacccgg ccgggagaac cttcgctcgg cccagcgcag ctccgcagcc
      361 gtccgggagc tgtcccttca gcaccgccgc ggaagcctga gtcccaacgc agcccagcgg
      421 aacccctgac ccagcccgag cgcacaaggt gctgcgctca gcggccgccc cgcggggcag
      481 caccctggtg cccctaccca ggggacccgc catcccctcc gggaggcggg gagaaggaac
      541 gaggagggag gtcaggcagc ttcacccgcc accgagggga gtaggcagat aggcaaggag
      601 agccgaaggg gaccggtcac gcagggagga gagcaagccg catccgtccc caccgcaccg
      661 ggagcgcgct gcagcgacca ccgcagagcc aagcgcggat ttctcgtaac cccctctttc
      721 ccagctgggg ctggtctatc ggtccggccc ccgaaacgga gcagctgacc ttcccctaaa
      781 aagctttgtg tcggtttctc cattttcccg ctgagatgat accgggagcc cggccccccc
      841 atcctctctc ccctcctccc gggcctcgcc gctgagcgcc gccccactcc cttcctccct
      901 ccctctttac ctccctcctc tcttccactg cctcctccgc agccaggcca gctccctctc
      961 acactaggcg ccttaaagac cctagggagc ccgtgcacac acccctggac ccgcacctgc
     1021 ctgacagctc cccctgaggg agcttggctc gttggttggg gtgggtggcc agagccgcgg
     1081 tcctctgtgc cccccgacgg ctggggggag gggggaagag gccctgcgcc cccctccccg
     1141 tcgccaactc cccctggcgg cagctcccat gggtgtcgct gggccgcgcc atgcctaagg
     1201 gggcgccgcg atgggccaag gggacgagag cgagcgcatc gtgatcaacg tgggcggcac
     1261 gcgccaccag acgtaccgct cgacgctgcg cacgctgccc ggcacgcggc ttgcctggct
     1321 ggcagagccg gacgcccaca gccacttcga ctatgacccg cgtgccgacg agttcttctt
     1381 cgaccgccac ccgggcgtct tcgctcacat cctgaactat taccgcaccg gcaagcttca
     1441 ctgcccggcc gacgtgtgcg ggccgctcta cgaggaggag ctggccttct ggggcatcga
     1501 cgagacggac gtggagccct gctgctggat gacctatcgc cagcaccgag acgctgagga
     1561 ggcgctggac agctttggcg gtgcgccctt ggacaacagc gccgacgacg cggacgccga
     1621 cggccccggc gactcgggcg acggcgagga cgagctggag atgaccaaga gattggcact
     1681 cagtgactcc ccagatggcc ggcctggcgg cttctggcgc cgctggcaac cgcgcatctg
     1741 ggcgctgttc gaggacccct actcatcccg ctacgcgcgg tatgtggcct ttgcctccct
     1801 cttcttcatc ctggtctcca tcacaacctt ctgtctggag actcacgagc gcttcaaccc
     1861 catcgtgaac aagaccgaaa tcgagaacgt tcgaaacggc acccaagtgc ggtactaccg
     1921 ggaagcagag acggaggcct tcctcaccta catcgagggc gtctgcgtgg tctggttcac
     1981 cttcgagttc ctcatgcgtg tcgtcttctg ccccaacaag gtggaattca tcaagaactc
     2041 cctcaatatc attgactttg tggccattct ccccttctac ctggaggtgg gcctaagcgg
     2101 cctgtcctca aaagccgcca aggacgttct gggcttcctg cgcgtcgtcc gcttcgtgcg
     2161 catcctgcgc atcttcaagc tgacccgcca cttcgtgggc ctgagggtcc tgggccacac
     2221 gctccgtgcc agcaccaacg agttcctgct gcttatcatc ttcctggccc tgggagtgct
     2281 catctttgcc accatgatct actacgccga gaggataggg gcacagccca atgaccccag
     2341 cgccagcgaa cacacacact ttaaaaacat ccccatcggc ttctggtggg ctgtggtcac
     2401 catgacgaca ctgggctatg gagacatgta tccccagacg tggtctggaa tgctggtggg
     2461 agccttgtgt gctctggctg gtgtgctgac cattgccatg ccggtgcctg tcatcgtgaa
     2521 caattttggg atgtactact ctttagccat ggctaagcag aaactaccaa agaaaaaaaa
     2581 gaagcatatt ccgcggccac cacagctggg atctcccaat tattgtaaat ctgtcgtaaa
     2641 ctctccacac cacagtactc agagtgacac atgcccgctg gcccaggaag aaattttaga
     2701 aattaacaga gcagattcca aactgaatgg ggaggtggcg aaggccgcgc tggcgaacga
     2761 agactgcccc cacatagacc aggccctcac tcccgatgag ggcctgccct ttacccgctc
     2821 gggcacccgc gagagatacg gaccctgctt cctcttatca accggggagt acgcgtgccc
     2881 acctggtgga ggaatgagaa aggatctttg caaagaaagc cctgtcattg ctaagtatat
     2941 gccgacagag gctgtgagag tgacttgacc aggcggcttg gccgaggaca ctggtggcta
     3001 ttaagcatct gggtggacct gcagcccctc ctcaccctcg gacagagtaa attcacgcca
     3061 tgcaggtttg ccggacgagt ccgagtggcc caggcattgt actaagacgg acgtagcttt
     3121 ttctacggcc catggtaact gaccgtagag gattcgccct tctttctttt catttttttc
     3181 tttttttaga agttaccttt tatttgggga gggggggtca aggggagcct tagcatgact
     3241 tgcatgaagt taaacagaaa aacgcagcta aaccaagccc accagcccct gctgtgactg
     3301 tatgaccacc ctaaccatca ccaacaatgg agagaaaagc aagagtccct tattttcttt
     3361 cagcactctt tgacacatgg tgtctggagt caaactgtac cggtgctcgg tagaaacctg
     3421 tacatttctg ggagtggggg tggggcgggg gggggggtca gggaacaagg atggggctgt
     3481 agagcggatt gctttttgta cacaagacct agaggaaagg ttccaaaacg gcagtcagtc
     3541 atcggtcaca ttgacctcac cttcattgcc caccactcac gtggaaaacc aagaactctg
     3601 ctctgaatag gattgtggaa attcacactg ccaccctctt ccacctctgt ctggcatgct
     3661 tgtgacccaa cgggcctctc cccaagaccc ggacagcggc tagtttaggt tgattctctc
     3721 atcttggtgt gtagctccaa tgtgaccaag tttcataaca aattgttcat agttacacca
     3781 tatggatttt ccagtgtcat tctaaagcca ggatgtagag tccctgcagt ccagggccac
     3841 cagaggggtg gcctcccctc caccttcatc aaggcgagaa ctggcactgt atgcaattta
     3901 gtacttcaga gtaaaaaaat aaataaagaa aataaaataa agaaaaaaaa ctgcatgccc
     3961 aatgttatgc aaagagattc gagcatgaaa taaattttgt aacatggttt ctgtctagtc
     4021 gaaagcagat ttgtttttct gaagcgattg gaggtttgca gagacccgct tctgcatctc
     4081 gaataaatat agtattttcc caacagaaac agaggacagt agcttggctt tggtctgatt
     4141 ctaaaattag tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtaaagatg
     4201 atatttttga aaaacacatg cttgagttga aaaaaatagc aacatctcga gctctcagtg
     4261 cgacatttcc tggaaagaca gcaacctccc cttcccaggc cctggccctg gaaataaaga
     4321 gctgactttt gatctg
//
