LOCUS       NM_008420              11153 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus potassium voltage gated channel, Shab-related
            subfamily, member 1 (Kcnb1), mRNA.
ACCESSION   NM_008420 NR_045278 XR_104758 XR_107444
VERSION     NM_008420.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11153)
  AUTHORS   Bortolami,A., Forzisi Kathera-Ibarra,E., Balatsky,A., Dubey,M.,
            Amin,R., Venkateswaran,S., Dutto,S., Seth,I., Ashor,A.,
            Nwandiko,A., Pan,P.Y., Crockett,D.P. and Sesti,F.
  TITLE     Abnormal cytoskeletal remodeling but normal neuronal excitability
            in a mouse model of the recurrent developmental and epileptic
            encephalopathy-susceptibility KCNB1-p.R312H variant
  JOURNAL   Commun Biol 7 (1), 1713 (2024)
   PUBMED   39738805
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11153)
  AUTHORS   Forzisi-Kathera-Ibarra,E., Jo,C., Castillo,L., Gaur,A., Lad,P.,
            Bortolami,A., Roser,C., Venkateswaran,S., Dutto,S., Selby,M.,
            Sampath,H., Pan,P.Y. and Sesti,F.
  TITLE     KCNB1-Leptin receptor complexes couple electric and endocrine
            function in the melanocortin neurons of the hypothalamus
  JOURNAL   FASEB J 38 (20), e70111 (2024)
   PUBMED   39436109
REFERENCE   3  (bases 1 to 11153)
  AUTHORS   Smith,C.C., Nascimento,F., Ozyurt,M.G., Beato,M. and
            Brownstone,R.M.
  TITLE     Kv2 channels do not function as canonical delayed rectifiers in
            spinal motoneurons
  JOURNAL   iScience 27 (8), 110444 (2024)
   PUBMED   39148717
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11153)
  AUTHORS   Kang,S.K., Hawkins,N.A., Thompson,C.H., Baker,E.M.,
            Echevarria-Cooper,D.M., Barse,L., Thenstedt,T., Dixon,C.J.,
            Speakes,N., George,A.L. Jr. and Kearney,J.A.
  TITLE     Altered neurological and neurobehavioral phenotypes in a mouse
            model of the recurrent KCNB1-p.R306C voltage-sensor variant
  JOURNAL   Neurobiol Dis 194, 106470 (2024)
   PUBMED   38485094
REFERENCE   5  (bases 1 to 11153)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 11153)
  AUTHORS   Williamson,C.M., Dutton,E.R., Abbott,C.M., Beechey,C.V., Ball,S.T.
            and Peters,J.
  TITLE     Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1,
            Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal
            imprinting region of mouse chromosome 2 are not monoallelically
            expressed
  JOURNAL   Genet Res 65 (2), 83-93 (1995)
   PUBMED   7781998
REFERENCE   7  (bases 1 to 11153)
  AUTHORS   Klocke,R., Roberds,S.L., Tamkun,M.M., Gronemeier,M., Augustin,A.,
            Albrecht,B., Pongs,O. and Jockusch,H.
  TITLE     Chromosomal mapping in the mouse of eight K(+)-channel genes
            representing the four Shaker-like subfamilies Shaker, Shab, Shaw,
            and Shal
  JOURNAL   Genomics 18 (3), 568-574 (1993)
   PUBMED   7905852
REFERENCE   8  (bases 1 to 11153)
  AUTHORS   Lesage,F., Attali,B., Lazdunski,M. and Barhanin,J.
  TITLE     Developmental expression of voltage-sensitive K+ channels in mouse
            skeletal muscle and C2C12 cells
  JOURNAL   FEBS Lett 310 (2), 162-166 (1992)
   PUBMED   1383027
REFERENCE   9  (bases 1 to 11153)
  AUTHORS   Pak,M.D., Covarrubias,M., Ratcliffe,A. and Salkoff,L.
  TITLE     A mouse brain homolog of the Drosophila Shab K+ channel with
            conserved delayed-rectifier properties
  JOURNAL   J Neurosci 11 (3), 869-880 (1991)
   PUBMED   2002364
REFERENCE   10 (bases 1 to 11153)
  AUTHORS   Wei,A., Covarrubias,M., Butler,A., Baker,K., Pak,M. and Salkoff,L.
  TITLE     K+ current diversity is produced by an extended gene family
            conserved in Drosophila and mouse
  JOURNAL   Science 248 (4955), 599-603 (1990)
   PUBMED   2333511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591854.18, BC061501.1 and AL591711.22.
            
            On or before Dec 30, 2011 this sequence version replaced
            NR_045278.1, NM_008420.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061501.1, M64228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL591854.18        65805-65823         c
            20-3744             BC061501.1         1-3725
            3745-11153          AL591711.22        168717-176125       c
FEATURES             Location/Qualifiers
     source          1..11153
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 87.22 cM"
     gene            1..11153
                     /gene="Kcnb1"
                     /gene_synonym="Kcr1-1; Kv2.1; Shab"
                     /note="potassium voltage gated channel, Shab-related
                     subfamily, member 1"
                     /db_xref="GeneID:16500"
                     /db_xref="MGI:MGI:96666"
     exon            1..762
                     /gene="Kcnb1"
                     /gene_synonym="Kcr1-1; Kv2.1; Shab"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2769
                     /gene="Kcnb1"
                     /gene_synonym="Kcr1-1; Kv2.1; Shab"
                     /note="voltage-gated potassium channel subunit Kv2.1"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily B
                     member 1"
                     /protein_id="NP_032446.2"
                     /db_xref="CCDS:CCDS17096.1"
                     /db_xref="GeneID:16500"
                     /db_xref="MGI:MGI:96666"
                     /translation="MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEV
                     LWRTLDRLPRTRLGKLRDCNTHDSLLQVCDDYSLEDNEYFFDRHPGAFTSILNFYRTG
                     RLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREG
                     EEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLD
                     EFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVT
                     IFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLL
                     ILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKI
                     VGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNM
                     KDAFARSIEMMDIVVEKNGEGVAKKDKVQDNHLSPNKWKWTKRALSETSSSKSFETKE
                     QGSPEKARSSSSPQHLNVQQLQDMYSKMAKTQSQPILNTKEMAPQSQPQEELEMGSMP
                     SPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPEATRFSHSPLASLSGKSGGSTAPEV
                     GWRGALGASGGRLMETNPIPEASRSGFFVESPRSSMKTHNPMKLRALKVNFLEGDPTP
                     LLPALGLYHDPLRNRGGAAAAVAGLECASLLDKPVLSPESSIYTTASARTPPRSPEKH
                     TAIAFNFEAGVHQYIDTDTDDEGQLLYSVDSSPPKSLHGSTSPKFSLGARTEKNHFES
                     SPLPTSPKFLRPNCVYASEGLPGKGPGAQEKCKLENHTSPDVHMLPGGGAHGSTRDQS
                     I"
     exon            763..11153
                     /gene="Kcnb1"
                     /gene_synonym="Kcr1-1; Kv2.1; Shab"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11131..11136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnb1"
                     /gene_synonym="Kcr1-1; Kv2.1; Shab"
                     /note="hexamer: AATAAA"
     polyA_site      11153
                     /gene="Kcnb1"
                     /gene_synonym="Kcr1-1; Kv2.1; Shab"
                     /note="major polyA site"
ORIGIN      
        1 ccgtgtccgc tttcgctttc tgcctcgcag ccgtcgggat ggaggtgaga cggtagccgc
       61 gacgcccgcc ctcgcgcacc cctgcaccac agcggcctgc agagctcccc gccccccgcc
      121 cccgcggcag cgggccttgc cgtcgagtga cagcggcctg ggggggcagg gggggcgggg
      181 gcggccagac cagcgatgcc ggcgggcatg acgaagcatg gctcgcgctc caccagctcg
      241 ctgccgcccg agcccatgga gatcgtgcgc agcaaggcgt gctcgcgccg ggtgcgcctc
      301 aacgtcgggg gcctggcgca cgaggtgctg tggcgcactc tggaccgcct gcctcgcacg
      361 cggctgggca agctccggga ctgcaacacg cacgactctc tgctccaggt gtgcgacgac
      421 tacagcctcg aggacaacga gtacttcttc gaccgccacc ctggcgcctt cacctctatt
      481 ctcaatttct accgcaccgg ccggctgcac atgatggagg agatgtgcgc gctgagcttc
      541 agccaggagc tggactactg gggcatcgat gagatctacc tggagtcctg ctgccaggcc
      601 cgctaccacc aaaagaagga gcagatgaac gaggagctga agcgggaggc tgagacgctg
      661 cgggagcggg agggcgagga gttcgacaac acgtgctgtg ctgagaagag gaagaaactt
      721 tgggacctgc tggagaagcc caactcatcg gtggccgcca agatcctggc catcatctcc
      781 atcatgttca ttgtcctctc caccattgcc ctgtcactca acacactgcc tgagctacag
      841 agcctggacg aattcggcca gagcacggac aacccgcagc tggcacacgt ggaggctgtg
      901 tgcatcgcgt ggttcaccat ggagtacttg ctgaggttcc tgtcctcgcc caagaaatgg
      961 aagttcttta agggccccct caacgccatt gacttactgg ccatcctgcc ctactacgtc
     1021 accatcttcc tcacagaatc caacaagagc gtgctgcagt tccagaatgt gcgccgtgtg
     1081 gtccagatct tccgcatcat gcgcatcctg cgcatcctga agttggcccg ccactccacc
     1141 ggtctgcagt ccttgggctt cacgctgcgc aggagctaca acgagctggg cttgctcatc
     1201 ctcttcctcg ccatgggcat catgatcttc tccagcctgg tcttctttgc cgagaaggat
     1261 gaggatgaca ccaagttcaa aagcatcccc gcctctttct ggtgggctac catcaccatg
     1321 acgaccgttg gttacggaga catctaccct aagactctcc tggggaaaat cgtggggggc
     1381 ctctgttgca ttgccggtgt cctggtgatt gccctcccca ttccaattat cgtcaataac
     1441 ttctccgagt tctacaagga gcagaagcgc caggagaaag ccatcaagcg gagagaggct
     1501 ctggagagag ccaagaggaa cggcagcatc gtgtccatga acatgaagga tgccttcgcc
     1561 cggagcatcg agatgatgga catcgtggtg gagaaaaatg gagagggcgt ggctaagaag
     1621 gacaaggtgc aggataacca cctgtctccc aacaagtgga aatggaccaa gagggcgctc
     1681 tccgagacca gctcgagcaa gtcctttgaa accaaggagc agggatctcc tgagaaggcc
     1741 aggtcctcgt ctagtccgca gcacttgaac gtccagcagc tgcaagacat gtacagcaag
     1801 atggccaaga cccagtctca acccatcctc aacaccaagg agatggcgcc gcagagccag
     1861 ccgcaggaag aactggagat gggcagcatg cccagccccg tggcccctct gcccacgcgc
     1921 acagagggcg tcatcgacat gcgcagcatg tctagcatcg acagcttcat cagctgcgcc
     1981 acggacttcc ctgaagccac cagattctcc cacagtcctc tggcatccct ctccggcaag
     2041 tctgggggca gcacagcccc ggaggtgggc tggcgggggg ctctgggtgc cagcggcggg
     2101 agactcatgg agaccaaccc catccccgag gccagccgct ctggtttctt cgtggagagc
     2161 ccccggagtt ccatgaagac ccacaacccc atgaagctgc gagcgctcaa ggttaacttc
     2221 ctggagggcg atcccacccc gctgctaccg gctctgggct tgtatcacga tcctcttagg
     2281 aacagaggag gcgcagcggc tgcagtcgcc ggactggagt gtgcctccct cttagacaag
     2341 cccgtgctga gcccggagtc ctccatctac accacagcaa gtgccaggac gccccctcgc
     2401 tccccagaga aacacacagc aatagcgttc aacttcgagg cgggggtcca ccagtacata
     2461 gacaccgaca ctgatgacga gggtcagctg ctctacagcg tggactccag tcctcccaag
     2521 agtctccacg ggagtaccag ccccaagttc agccttggag ctagaacaga aaagaaccac
     2581 ttcgagagct ccccgttgcc cacctcccct aagttcttaa ggccgaactg tgtctacgcc
     2641 tcagaagggt tacctgggaa aggtcccggg gcccaagaga aatgcaagct ggagaaccac
     2701 acctcccccg atgtgcacat gctgcctggg ggaggagcac acgggagcac tcgggatcag
     2761 agtatctgag ctccctacca cagagggtat ttgcaggaga catcgaggag gagggatgct
     2821 tggcctgcct gccgctgagt tctgcgtgaa ctcggagacc caaggacccc acacacacac
     2881 aattttcccc acccccgcag agccccagcg acaggagaga ccctgagagc cacgacaagt
     2941 ctgtggacac caactaggat ggggaccaca cctaacagct tcttccttag atggcaggag
     3001 cagagctgac agccacatac tcctagtctc ctttagaggc tctgtctgcc tctgagtgcg
     3061 tcatcgccat ctctcatggc gtcagctgag gcaggtgttg gagcaagggg ttgctagtga
     3121 gagagtgggc tggccaagca gtagtgggtg tcccccctct tgttagaggg gtacagagga
     3181 cacttgatcc tgagggagtc tccacttcat cagccacact cctagggcat aacgcttaaa
     3241 caagcagcgg ctcaaatgat tcagtattct gtggtatctg gggctttagt ctgagaagct
     3301 gtcaggagga gctgacaatt taaactcaat cctttctgct cacctggcaa tccagaaagg
     3361 gttccaacag ttggcacgca gccaagggga tataagccag ggctgtcaca ggaatgcggg
     3421 tcccaaacag ggctagcccg gactgaaaag ataagcgtca aatatgcaaa cgagatagat
     3481 tattcaaaaa gactgtgtgt gactgaaaaa caacattaaa aaaataataa atttcatttt
     3541 ctacatgaaa aaaaaaagaa aaaagaaaag aaaaatcctt cactgaactg ccctgtgaag
     3601 aattgtgact actttctgct gtggtgtggt agggaacaca cctactatga gaggaagttc
     3661 tctctctctt tttttttctt tctttttttg tttcctgtag tattcaagct aaaaaataat
     3721 aataataata agttaataaa aaaagcactt tatgtttttc taatctaggt tctaccaggg
     3781 acagtgtcaa gatctcgcac tttaaaacaa gcactatttc ccctgggccg taagctggcc
     3841 ctgcacttgg ggtattactt gtgcccattt ctggccacag tgggtctacc gttaccacat
     3901 cagagtccgg ggcttttccg tgacccctca ggatcacccc tcatccctca tgggacagga
     3961 gaggtcctca ggtttcggag gcagggatct cttaaagcct gcgtacaaga gacacacaac
     4021 gtctcagaag ggcgcagcaa gagttgggtg tcgggtgttg taccgctctt tcttgtcaac
     4081 cggccattgt gtgttctatg ttactgtctg tcccaaaagc ccgacgctcc tccctgaggc
     4141 catctaggca gacggcacag ccaaaagcaa taagtaccca tgtgtatccc tcgaggttcc
     4201 cgtgcacttc ctggtgtcag tcttcctgtc caagcgttga cctggcgtcg tcccgcctgc
     4261 ttgtgaccca gtggcacagt attgttggcc cttcctcagt gacaccagtc tgcgcaaatg
     4321 ctctagttac ggcgatgttg ttggtcagcc tgtctctggt acaatagggc aatgtggttt
     4381 tcttactata gtgtgagtgg gtaatgtccc aaatgctgta gtgtcctcct ccctgtcctc
     4441 agaacagtga cgggcatgtc ttcctgatga agcaaagaca ataatggtca cctgtcctca
     4501 gtatcgtgtg tggctggtcg gcccagcagt ccgatggcat gatccacccg tcagcacacg
     4561 tagcacatca cgatcttctg ccttctcttg tttccatagc tgcggtcagg ccacctgtcc
     4621 caggtaggat gctaaaggct catcccacca cccttaaaca aagtgttcat gacgcttctc
     4681 agcatctcca aagacctggg tcccccctcc ctccagaggg cacagcttgg tattttgctg
     4741 ttttcatgaa gaaaataaga agttgactct gcctcaccat ccgtcctcag agctttctca
     4801 aaacaggagc aaaggggctg agacagtgcc gggtcacgtg caccagcggc atcctggaga
     4861 caggaagcag gggggcgggg ctccacggcc ccctgctgag ctctgcctgg cgctggggcc
     4921 tgtgtgtgac cggtgatcga tgatcgtggg acctttctgc tgaccatctt ccatgtctgt
     4981 cttttgtgtt gctcataagt cacccatcag cacaaatgtg aaaattcagg gaaacaaaca
     5041 aatgcttttt gataaaaagt aaatagttgt gatttccgat tcagatattt ttagagctat
     5101 ctgtaaaaaa aaaaaaacct cctactgatg atatagtcta ttttacatat caggaagtaa
     5161 acacgtctta acatagccat aaatagccag aaggaagtta ccgcccccct tctttaaacc
     5221 aaggcatttc attggttggt taagccgacg gcgggtgtac agtgtagaaa tgattgcttt
     5281 cttttttaag aaccacttgg tgcgactttt cttgtaacca aaggcccttt ctgccttgtg
     5341 taggacctgg ctgtccctcc ctcttgtgtt ttgtctgact ttaaagtagc attataccga
     5401 gaaaatgatg aatccagaat acctttccta gctgcatagg cagagtctga cagaactcct
     5461 atagagacaa ccatcaaaac agtatagacg aagcaaaaga agagttttcc attttggttt
     5521 ttgttggcgt tttttttttt tttcctttca cttatatttg tgtgaactgt gggaatatag
     5581 cttcccccac acaagtgtaa ctcaagttag aatattataa atttttctac caaccctcca
     5641 tgggctaaaa aggaacacag agtctcaggc cgcatgtacc tgacccgggt acatgtgttt
     5701 acacgcactg ggaaatcttg ggttgccaag atgaagatga atctgacaga tgggtctcag
     5761 cagtgaagac aagagccagg ggatggggac agaggccact tgaacatggt ggtccacctg
     5821 gcctgaccca accagagcaa aaggaagtga gatacccaaa taactccagg ggctggaggc
     5881 ggagatctcc cggtccggtt atgaaatcaa caggactatc aaaaagccag ctgaatcgga
     5941 gtcccagcat ccaccacgtc atcagaaaag gccaggcgtc ggactgctgt gcgcacctgt
     6001 cgcaccggga aagccttact gtggacaagg tgaggacaag ccagttcttt tgccttttca
     6061 tttttggatg tttccaaagc agcagatctg gggcaacaga tctctctctg gtattctacc
     6121 ttaagcacat ttagatgaga gagagagtaa aggaggagag aatatttgtc atcgaggaga
     6181 gaggaaacgc caaagtaatg aggaagccac ccttaacctg ctccactcac cctgacagtt
     6241 gctgggaata ggagctcttt ttcctcccaa gtctcacctt ctcttcatct cctctgtgtt
     6301 ctgtagctgc agccttgtct ctgtcccttc tcccgagaag atccacatct ctaaggagga
     6361 aacaagacgc aacagcatcc tcttctatac aactgtaatg tattgtcaat atttataatt
     6421 atgtatttgt ctgactctgg tcatggctgg aatgtctagt ccttgaacaa ggacatattt
     6481 aaagttcatc acagaaaagg gtccctaaag ccaggtatct ctatatagat aggtaggtat
     6541 agatatataa atagatctct tttccttgtt tctctgccaa ctttgtctcg agtaaaataa
     6601 ccacagcctg cactgaatca aagggggatg ggtacacaga aaagcttcta gaacatcctc
     6661 gtttggagac agactttgtg tatgtgtatc tgacaggttg gcaggaggaa gatgggggct
     6721 ccgaggcccc cagcaggaca acagaacact ctagccttgg gcgtttccta acctattatt
     6781 gtttatatga caacccccaa atactttcat gtctctaggc cagggccgcc caaagcagcc
     6841 caggccacac ctggaaagaa gacttacctc tgcatttcct gttgccattt ttctggccct
     6901 agaagcatct atatcctagg acgtccacac atctcagagt agtctatttt tttgttcaga
     6961 taaaatatat acatatatgt atttttagta tatttataat agggcaattg agtctaattt
     7021 cttttgtaac agagtgatat cttggggatt ttattgttgc tcatttgcat agctggtctt
     7081 ttctgctgtc attccttccc actgtccctt gggctggttt tttggttttg ttttgttttg
     7141 ttggattcca gttgtctgga gatgggaaaa gactggggtt taatatcctg gaagatggag
     7201 ttcctagcaa tgggtgggtg atgggggtct gggagagcaa ctctgtgtct ttcctcatca
     7261 ggtctatgtc ccctggctgt cactcttaag aatccaggta tgcaggagca agccaggtga
     7321 agacgggtgc aattgggacc tgggctgccg ggagctcaga cagagctcgg acgcttgctt
     7381 cccttcccaa atcttaaagg actgtgcttt ctggttacca gaaatattag aatcaagacc
     7441 ctcctgcaag caaacttgtc tctgagctca ggagcattcc tgagtccctc ctggctagat
     7501 tgtccccaag tccagctatc ctgcttccca gggccaccaa ctggatccaa ggaccagggt
     7561 gtgtgcaggc tccagcaaat ctcagaagaa tgtgctgtgt gtctccattc catttctcac
     7621 agtcttacca aaaatcagtg gccagacagc cttgtagcca aacgctgagg agtgacagac
     7681 agcccaaagc tgtgatccac ccagcccctc gaagcggcac caaggtgaga cttgaggcaa
     7741 gggtggcagt attttttcag cttctgcttt tccaagtctc cagtctttgg tcagttctga
     7801 acatccaagt ctccagttct tggtcagtcc tgaacatcca ttggaaacaa ttttgagcct
     7861 aggctcaggt ggtggacaga ctccacatgg agtgaagggg tctgccaacc atcaccttcc
     7921 atgggacaag aaaagccaat cagatcacct cccatgccca accagtcacc tacctgcctc
     7981 agctctggac tctgagctct gccagcacca gaaatttgag tcaagccaga tcagccctat
     8041 cagacagcga tggtgttccc actgaaagaa ccccaagagg atgcagccca aatgcaaatt
     8101 taatattctg gtggttggat tgtctttcct cccccttggg tttgttctgt tgtgtggtgt
     8161 tggggaccta actagggcct tggctgtgtc agacaagtgc tccaccctgc gctacatctg
     8221 cagcccctga atgtattaat ttggaatgtg gttctgatca gtttctccca tccctaaaat
     8281 tcctggtaat ctggtttgtt ccagagccaa ataaaacaga caagattttg tgtgcgtgtg
     8341 tgtgtgtgtg tgtgtgtgtg attatgtgtg tgtgattatg tgtggtatgc atgcacatgc
     8401 aatatgtgca tatgtgtgca tatgtgtgtg tgcaactttt gcataagaac aaaatttaaa
     8461 attgctgtca tgttgtttct gaagtttcct gcccagctaa gtaaacacag gctatcttcc
     8521 caaaaaagag agggtacctc tgaccttctc tccttgtcct agaattcctc tcaaaatttc
     8581 cagatggtga cttgaactga atttggaagg ggctgttagt cgtttgggcc gtcctctccg
     8641 cgtctagccc tacctctgtc cgtctcagcc aaggccctga agaaacctaa aagccagcag
     8701 aagagcatgg gcaggaagtt ggcccaaaga agtagcctct caacatgaat tgtccatttc
     8761 agctcaaagt agcaaagccc tttctcagca gggtgggtgg gttatatgct catagaacac
     8821 ggcgcatgat gggtaagagg atccagacta cccagtgtgt cccaggtatt cccagggagg
     8881 ctgagtagtg cacaaatagg ccttggcatt accacaaaac gggactggaa actcaaagca
     8941 attctttctt ggagtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttttca
     9001 cagctttcat gcacatgtgg gtgtctgcac aggtgtcttg aacattctgg gtccaggttc
     9061 aagcctcata gagaaggatt cagagcagag ctactgggac ctcaggttat aggatcgggc
     9121 catcccagaa ggcaccagcg caggagggct gcagcagagg gctcagcatc ctaagccggc
     9181 tcttgctatt tttctgaccc tgccaaccat ttatccaacc catttccaat ggtctaacaa
     9241 ggaccactta gggaagagaa gtacgctgcc ctttccccgg ccagtaaagg gccaaccccg
     9301 caggctcgcc tgtggttggc cactgcattg gtgcttcagc cccttcccct atactctgtg
     9361 ccctcaaaga gactcagcga tcatcccaca agccagccac ccactgccca accaattcca
     9421 aatggcacca ttccaaaagg gctttttttt ccttgttaaa taaaagtaaa acctagtcaa
     9481 ggtgttcaaa ggtctctgcc caagagataa atctagaaaa ctaaaaacag cagaggtaat
     9541 tataatccaa ctttacgagg gaaacaaggc tccagctgcc tccaagagga aagcccgctc
     9601 tcccacatcc atacccaaag ggaatctgtc tgtctccatc tccctcattg gatatagggc
     9661 gtggggaaga ggtagtgtgt gaacttcaga gtgagcccaa acctaggtgg ttttgaaagg
     9721 caaggtagac cagtaagcca gagttacccg aaccactatc ttctaaaact aaattaaata
     9781 ggaactggtt taccaaatct cagcccatgg aggtgtttcc catgacactg cggttacaga
     9841 gcagctgtgg gaaatgtggg gttgcccgat tctatcccac ttagatgtgc gaaactcggt
     9901 ttggataggc agggatgtac cacagaagac agcccccagg gtctaactca acagcccagc
     9961 tcccagtctc ggggtttccc caaggtttga accgcttgag gccaccgggc atccaagagc
    10021 cagatgtgga tacagggagt gcagggcagc tgacctcttt ctctctgggg cccatttggc
    10081 ttgagtcgaa gctaaagggc aaggggtccc ccttttctac actggcggga actcatggcc
    10141 ttctgtccgc gtgctgatgg cacagagcag tcatccagcc tgtgttctgg ggtgtgtgca
    10201 tgtgagggtg gtaagttccg gaggatgagt ggaagaaggc agtactggat tctcacctgg
    10261 ctgggggtgt tgctcgctgg gaaggaaaac gtggaagtcc ctgtttctct gaagtgtccc
    10321 cacgaatgtc atctcgccta tgaccatatt tagagtcaca gtgatgccca catttgatgt
    10381 tggcagcctc aagctgagag gggtcatgat ctactcaaag cccccacccc caccctgagg
    10441 ctggtcagca ccggctgtca tccttcttgt tcctacttaa gttcacaggg agtcacatgg
    10501 agaccacatt ggctatccag tagtccaagc caagggtccg aggtgggggt ggggtatatg
    10561 ggacttgact agagcaggga catgggagcc agtgtctacc actggatctc attacctgag
    10621 ctgtaagaac caatggcccc tctttttatc tgagcctgga aggcccccct tacaataatg
    10681 acaagcaccc caatcccatc agctcagact ctctgtcccc tccccccagg accccagagt
    10741 gtaaggcccg ggttcttctg ccagcaaagc cattcggatt gctccatctt tcaaggaggc
    10801 caagccaacc atattagcca tactccacca gggtcttcac cactcttctt tgggttgtgt
    10861 tcatgggtcc tgttcaacct tcatcagtag aaggctctag cccttcctgt ccatgtgaca
    10921 gtgcacatca gcgtgcatgt cttatacgtg cacatgagtg cacacacaag gaaaccaaca
    10981 aaactccagt gtcgtcttct gcatgtggtg agagggactt gtgaccccta tgtgacctcc
    11041 agctgctgtc ctgtcttgta taaaaaaaaa aaaatcacat gtttaagaat tttcaagcaa
    11101 atggtccctt aatgaagtct gcagcgttca aataaaagat ccggagaaaa caa
//
