LOCUS       NM_010599               2537 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus potassium voltage-gated channel, shaker-related
            subfamily, beta member 3 (Kcnab3), mRNA.
ACCESSION   NM_010599
VERSION     NM_010599.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2537)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2537)
  AUTHORS   Ding,J., Wang,C., Huang,G.Q., Zhang,J.W., Zhai,Q.X., Chen,Z.H.,
            Zhang,Y.X. and Guo,Y.X.
  TITLE     Functional characterization of a KCNAB3 genetic epilepsy with
            febrile seizures plus adult mouse model
  JOURNAL   Transl Pediatr 11 (10), 1615-1623 (2022)
   PUBMED   36345448
REFERENCE   3  (bases 1 to 2537)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 2537)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2537)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2537)
  AUTHORS   Schilling,K. and Oberdick,J.
  TITLE     The treasury of the commons: making use of public gene expression
            resources to better characterize the molecular diversity of
            inhibitory interneurons in the cerebellar cortex
  JOURNAL   Cerebellum 8 (4), 477-489 (2009)
   PUBMED   19554387
REFERENCE   7  (bases 1 to 2537)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   8  (bases 1 to 2537)
  AUTHORS   Downen,M., Belkowski,S., Knowles,H., Cardillo,M. and
            Prystowsky,M.B.
  TITLE     Developmental expression of voltage-gated potassium channel beta
            subunits
  JOURNAL   Brain Res Dev Brain Res 117 (1), 71-80 (1999)
   PUBMED   10536234
REFERENCE   9  (bases 1 to 2537)
  AUTHORS   Leicher,T., Bahring,R., Isbrandt,D. and Pongs,O.
  TITLE     Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel
            A-type potassium channel
  JOURNAL   J Biol Chem 273 (52), 35095-35101 (1998)
   PUBMED   9857044
REFERENCE   10 (bases 1 to 2537)
  AUTHORS   Fink,M., Duprat,F., Lesage,F., Heurteaux,C., Romey,G., Barhanin,J.
            and Lazdunski,M.
  TITLE     A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK)
            expression
  JOURNAL   J Biol Chem 271 (42), 26341-26348 (1996)
   PUBMED   8824288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049316.1 and AK083134.1.
            
            On Apr 15, 2009 this sequence version replaced NM_010599.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049316.1, AK083134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1468              AK049316.1         2-1469
            1469-1469           AK083134.1         1471-1471
            1470-2537           AK049316.1         1471-2538
FEATURES             Location/Qualifiers
     source          1..2537
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.51 cM"
     gene            1..2537
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /note="potassium voltage-gated channel, shaker-related
                     subfamily, beta member 3"
                     /db_xref="GeneID:16499"
                     /db_xref="MGI:MGI:1336208"
     exon            1..666
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1639
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /note="kv-beta-3; K(+) channel subunit beta-3"
                     /codon_start=1
                     /product="voltage-gated potassium channel subunit beta-3"
                     /protein_id="NP_034729.3"
                     /db_xref="CCDS:CCDS24890.1"
                     /db_xref="GeneID:16499"
                     /db_xref="MGI:MGI:1336208"
                     /translation="MQVSIACTEQNLRSRSSEDRLCGPRPGPGGGNGGPVGGGHGNPP
                     GGGGPSSKSRAAVVPRPPAPAGALRESTGRGTGMKYRNLGKSGLRVSCLGLGTWVTFG
                     SQISDETAEDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVITTKI
                     FWGGQAETERGLSRKHIIEGLQGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVI
                     NQGLALYWGTSRWSAAEIMEAYSMARQFNLIPPVCEQAENHFFQREKVEMQLPELYHK
                     IGVGSVTWSPLACGLITSKYDGRVPDTCKATVKGYQWLKEKVQSEEGKKQQARVMDLL
                     PTARQLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLMEHLGSLQVLSQLTPQTVVEI
                     DALLGNKSHSKK"
     exon            667..710
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     exon            711..748
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     exon            749..828
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     exon            829..873
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     exon            874..918
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     exon            919..962
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1049
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1135
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1256
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1351
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1472
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1561
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..2537
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2514..2519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /note="hexamer: AATAAA"
     polyA_site      2532
                     /gene="Kcnab3"
                     /gene_synonym="C330022D06Rik; Kcnab4; mKv(beta)4"
                     /note="major polyA site"
ORIGIN      
        1 gttaatgagc tgggcttgct gccgacgcgg ctgggagcac agcggtcccg cagcggttcc
       61 agctgaagtg gcacccgtct tttgctaccc cttgttcctg ggtagctatc cttgaagacc
      121 gtcctcgact tttctttatc cttacccgtt tatcctccca atcccttcat cacagctccc
      181 agcacccgaa tacccaccac tccgggcgac cccacggttt tcctttccca ccgcaagacc
      241 cgcgacctcc aacagcccgc ccccgcgggc ccgatcccgt ttggcggctc tagctgcagc
      301 cttctcagcc ttcccgctct ccctgcgatc gcgctattac caccacaccg gtgtctgccc
      361 tcggacttcc cggctccctc ctcccgctcc ctcggagccc cctcccccgc cctggccatc
      421 cggcatgcag gtgtctatcg cgtgtaccga gcagaacctt cgcagccgga gcagtgagga
      481 ccgtctctgt ggaccccggc ccggtcctgg gggcggtaat ggagggccag tgggcggagg
      541 gcatgggaac cctccggggg gtggaggacc gagctcgaag tcacgagctg cagtggtccc
      601 tagaccccca gcacctgctg gggcccttcg agagagcacc ggccgaggca ctggcatgaa
      661 atacaggaac ctagggaagt ctgggctccg ggtgtcctgt cttggccttg gtacctgggt
      721 cacgtttggc tctcagatct cagatgagac agcagaagat ctcctgacag ttgcctatga
      781 gcacggcgta aacctgtttg acactgctga agtgtacgcg gcaggaaagg ctgaaagaac
      841 ccttggcaat attctcaaga gcaaaggctg gaggagatca agctatgtta tcaccaccaa
      901 gattttttgg ggtggacagg cagaaacaga gcgtggcttg agtcgcaaac acatcattga
      961 aggcttgcaa ggatccctgg accgcctcca gctggaatac gttgatatag tatttgccaa
     1021 tcgttcagat cctaatagtc ctatggagga gattgtgaga gccatgacct atgtcatcaa
     1081 ccagggcctg gccctatact gggggacatc cagatggagt gctgcagaaa tcatggaggc
     1141 ctactccatg gccagacagt tcaatctgat ccctcctgtg tgcgagcaag cggagaacca
     1201 cttctttcag agggagaagg tggagatgca gctgcctgag ctctaccaca aaattggtgt
     1261 tggctcagtc acttggtccc ccctggcgtg cggcctcatt actagcaagt atgatgggcg
     1321 agttccggat acttgcaaag ccactgtcaa gggctaccag tggctcaaag aaaaagttca
     1381 gagtgaggaa ggcaagaagc aacaagccag agtgatggat cttctcccaa ctgctcgcca
     1441 gctaggctgc accgtggccc aactagctat agcctggtgt ctccgaagcg agggtgtcag
     1501 ctctgtttta ctgggggtgt ccagtgcaga gcagctgatg gaacatctgg gctccctaca
     1561 ggtgctgagt cagctgacgc cgcaaacggt ggtggaaata gatgcgctct tggggaacaa
     1621 atcgcattcc aagaagtagt ccgttggggg cgcggggacc caatgcggag tgattgtacc
     1681 ctctggaaag ccactttcct gcatcctgca atcagctccg gacccccacc aaccaaaccc
     1741 tgctcccacg cagcgccgcg gcagaatcag ggtagctccg ccctccaacg agtcccggct
     1801 tcgagtagcg attcgcatga acaaagccat atcctttcac catggggcac cgagagagaa
     1861 agtagatctc ccacccagcc tctacgcccc tactgttcct agggctaggc cttctcgcta
     1921 atctagggca tgagccttct cctctctgcc atttggtctt gcaccgctcc gctcatttct
     1981 tccccctatt gctgaaaccc agaaaacata gagcagctaa aagaaacatt gagactatct
     2041 caaaaatggg ccttgaaatg tcatcaaggg ggcaagaacc tacactggga acggggcttt
     2101 gtagtatttg tttaatagaa gccaggctgg ccctggcaga aagtaattat aatctttgga
     2161 atgcagactc ctgcctcctg cctggaggtg gaagacttaa atctagaact agagtcacac
     2221 tttgtgttta cagagagggg ataaagttgg ggaagacaaa tgttgacaaa ggcagaaaga
     2281 aatgtactgg ctgtgtcgca gaaatggcaa ggtggccctt agaaaacaaa gtgctctgga
     2341 ggatttagtg cgtttggcca ctggcaaaga cggggttgta aaaggtctgg gggaaaactt
     2401 gggcttgaac tggactttgt atgtagcagc agatgacttc agtcgtcttc ctggcaataa
     2461 acctaaagca ataaagatgg cccctctgct gtaagacctc ccagggatct gtaaataaaa
     2521 atctcagctt gatcctc
//
