LOCUS       NM_001355173            3664 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus potassium voltage-gated channel, shaker-related
            subfamily, beta member 2 (Kcnab2), transcript variant 6, mRNA.
ACCESSION   NM_001355173 XM_006538583
VERSION     NM_001355173.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3664)
  AUTHORS   Yee JX, Rastani A and Soden ME.
  TITLE     The potassium channel auxiliary subunit Kvbeta2 (Kcnab2) regulates
            Kv1 channels and dopamine neuron firing
  JOURNAL   J Neurophysiol 128 (1), 62-72 (2022)
   PUBMED   35788155
  REMARK    GeneRIF: The potassium channel auxiliary subunit Kvbeta2 (Kcnab2)
            regulates Kv1 channels and dopamine neuron firing.
REFERENCE   2  (bases 1 to 3664)
  AUTHORS   Ohanyan V, Raph SM, Dwenger MM, Hu X, Pucci T, Mack G, Moore JB
            4th, Chilian WM, Bhatnagar A and Nystoriak MA.
  TITLE     Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvbeta
            Proteins
  JOURNAL   Circ Res 128 (6), 738-751 (2021)
   PUBMED   33499656
  REMARK    GeneRIF: Myocardial Blood Flow Control by Oxygen Sensing Vascular
            Kvbeta Proteins.
REFERENCE   3  (bases 1 to 3664)
  AUTHORS   Kilfoil PJ, Chapalamadugu KC, Hu X, Zhang D, Raucci FJ Jr, Tur J,
            Brittian KR, Jones SP, Bhatnagar A, Tipparaju SM and Nystoriak MA.
  TITLE     Metabolic regulation of Kv channels and cardiac repolarization by
            Kvbeta2 subunits
  JOURNAL   J Mol Cell Cardiol 137, 93-106 (2019)
   PUBMED   31639389
  REMARK    GeneRIF: Kvbeta2 subunits regulate the expression of myocardial Kv
            channels and confer redox sensitivity to Kv current and cardiac
            repolarization.
REFERENCE   4  (bases 1 to 3664)
  AUTHORS   Chapalamadugu KC, Tur J, Badole SL, Kukreja RC, Brotto M and
            Tipparaju SM.
  TITLE     Physiological role of Kvbeta2 (AKR6) in murine skeletal muscle
            growth and regulation
  JOURNAL   Acta Physiol (Oxf) 224 (2), e13083 (2018)
   PUBMED   29704886
  REMARK    GeneRIF: Genetic deletion of Kvbeta2 leads to decreased skeletal
            muscle size along with isotype switching from fast to slow fiber
            type.
REFERENCE   5  (bases 1 to 3664)
  AUTHORS   Chen N, Koopmans F, Gordon A, Paliukhovich I, Klaassen RV, van der
            Schors RC, Peles E, Verhage M, Smit AB and Li KW.
  TITLE     Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the
            presence of two Caspr2 isoforms with overlapping interactomes
  JOURNAL   Biochim Biophys Acta 1854 (7), 827-833 (2015)
   PUBMED   25707359
REFERENCE   6  (bases 1 to 3664)
  AUTHORS   Coleman MP, Buckmaster EA, Ogunkolade BW, Tarlton A, Lyon MF, Brown
            MC and Perry VH.
  TITLE     High-resolution mapping of the genes Kcnb3 and Ly63 on distal mouse
            chromosome 4
  JOURNAL   Mamm Genome 7 (7), 552-553 (1996)
   PUBMED   8672149
REFERENCE   7  (bases 1 to 3664)
  AUTHORS   Uebele VN, England SK, Chaudhary A, Tamkun MM and Snyders DJ.
  TITLE     Functional differences in Kv1.5 currents expressed in mammalian
            cell lines are due to the presence of endogenous Kv beta 2.1
            subunits
  JOURNAL   J Biol Chem 271 (5), 2406-2412 (1996)
   PUBMED   8576199
REFERENCE   8  (bases 1 to 3664)
  AUTHORS   Autieri MV, Kozak CA, Cohen JA and Prystowsky MB.
  TITLE     Genomic organization and genetic mapping of the neuroimmune gene
            I2rf5 to mouse chromosome 4
  JOURNAL   Genomics 25 (1), 282-284 (1995)
   PUBMED   7774930
REFERENCE   9  (bases 1 to 3664)
  AUTHORS   Arai M, Prystowsky MB and Cohen JA.
  TITLE     Expression of the T-lymphocyte activation gene, F5, by mature
            neurons
  JOURNAL   J Neurosci Res 33 (4), 527-537 (1992)
   PUBMED   1484386
REFERENCE   10 (bases 1 to 3664)
  AUTHORS   Cohen JA, Arai M, Prak EL, Brooks SA, Young LH and Prystowsky MB.
  TITLE     Characterization of a novel mRNA expressed by neurons in mature
            brain
  JOURNAL   J Neurosci Res 31 (2), 273-284 (1992)
   PUBMED   1573677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY198829.1, DN173203.1, CV784053.1, AL611985.22, CX768025.1,
            CK627448.1, AK143166.1, CX224114.1 and AI835117.1.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_001355173.2.
            
            On Sep 11, 2017 this sequence version replaced XM_006538583.3.
            
            Transcript Variant: This variant (6) differs in the 5' UTR and
            contains an alternate in-frame exon in the central coding region,
            compared to variant 1. The encoded isoform (3) is longer than
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.16401.1,
                                           SRR1660815.102861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BY198829.1         3-30
            29-82               BY198829.1         32-85
            83-668              DN173203.1         1-586
            669-707             CV784053.1         331-369
            708-755             AL611985.22        141014-141061       c
            756-1172            CV784053.1         370-786
            1173-1750           CX768025.1         59-636
            1751-1762           AL611985.22        133423-133434       c
            1763-2348           CK627448.1         1-586
            2349-2432           AK143166.1         2236-2319
            2433-2433           CX224114.1         609-609
            2434-3647           AK143166.1         2321-3534
            3648-3664           AI835117.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.08 cM"
     gene            1..3664
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /note="potassium voltage-gated channel, shaker-related
                     subfamily, beta member 2"
                     /db_xref="GeneID:16498"
                     /db_xref="MGI:MGI:109239"
     exon            1..149
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            150..282
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1357
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /note="isoform 3 is encoded by transcript variant 6;
                     voltage-gated potassium channel subunit beta-2;
                     neuroimmune protein F5; K(+) channel subunit beta-2"
                     /codon_start=1
                     /product="voltage-gated potassium channel subunit beta-2
                     isoform 3"
                     /protein_id="NP_001342102.1"
                     /db_xref="GeneID:16498"
                     /db_xref="MGI:MGI:109239"
                     /translation="MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGK
                     SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNI
                     IKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP
                     DPNTPMEAGDPFSSFKSRTFIIEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVA
                     RQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIP
                     PYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVS
                     SVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPYSKKDYRS"
     exon            283..324
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            325..368
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..406
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..486
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            487..531
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..576
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..620
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            621..707
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..755
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..841
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..962
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1057
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1178
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1267
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..3648
                     /gene="Kcnab2"
                     /gene_synonym="F5; I2rf5; Kcnb3; kv-beta-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcgtggc cgagggagtc ccacgaggta aagatgctgc gggcggaacc tgccggagcg
       61 agcgggattc gggggtgcta aagtcgcaag ggcagggcag gaaggaagat ccggaacggg
      121 gcgtgggatc cggagctgga ggcccccagg attccccctc tgtgaaaagg cacgctgatc
      181 tgtctggata agtgtggccg gccccatgta tccggaatca accacggggt ccccagctcg
      241 actctccctg cggcagacag gctcccccgg gatgatctac agtactcgtt atgggagtcc
      301 caaaagacag ctccagtttt acaggaatct gggcaaatct ggccttcggg tctcctgcct
      361 ggggcttgga acatgggtga ccttcggggg ccagatcacg gatgagatgg cagagcacct
      421 aatgaccttg gcctacgata atggcatcaa cctgttcgat acggcggagg tctacgctgc
      481 tggaaaagct gaagtggtat tagggaacat cattaagaag aagggatgga gacggtccag
      541 ccttgtcatc accaccaaga tcttctgggg tggaaaagcg gagactgaga gaggcctttc
      601 caggaagcac ataattgaag gactgaaagc gtccctggag cggctgcagc tggagtacgt
      661 ggatgtggtt tttgccaacc gcccagaccc caacacgccc atggaagcag gggacccatt
      721 tagttccttc aagtcacgga cattcatcat tgaagagacc gtgcgggcca tgacccatgt
      781 catcaaccag gggatggcca tgtactgggg cacatcacgc tggagctcca tggagatcat
      841 ggaggcctac tcggtggctc ggcagttcaa cctgatcccg cccatctgcg agcaagcgga
      901 atatcacatg ttccagaggg agaaggtgga ggtccagctg ccagagctgt tccacaagat
      961 aggagtaggt gccatgacct ggtcccctct ggcgtgcggc atcgtctcag ggaagtatga
     1021 cagcgggatc ccaccctact ccagagcctc cctgaagggc taccagtggt tgaaggacaa
     1081 gatcctgagt gaggagggtc gccgccagca ggccaagctg aaggaactgc aggccattgc
     1141 cgaacgcctg ggctgcaccc taccccagct ggccatagcc tggtgcctga ggaatgaggg
     1201 tgtcagctcc gtgcttctgg gtgcttccaa tgcagaacaa cttatggaga acattggagc
     1261 aatacaggtc cttccaaaat tgtcgtcttc catcgtccac gagatcgaca gcattctggg
     1321 caataaaccc tacagcaaaa aggactatag atcctaagtc tactccccac ccctcgtgcc
     1381 ccacccggac agttcccggt tccctcctcg tctctgttcg ctcgcttctg ctgttccaaa
     1441 gccaaatgca gagtgtggtt cacatccaaa gggaaatcac tatgcccaga cgtgacaggg
     1501 aatcgacctc caaagtcacc gccagatgcc gcctgccgct tcttcactgg atactgtccg
     1561 acaacggatg ccaggggatg gcatcagtta gggggacatc cagaggctcc cgcccaagcc
     1621 caccacctct gcttatcctt caagaagaaa cacttgcccc cagccatggc ccttcacgga
     1681 aattctagaa gccatggccg ggtggaggtc tcatccttag agcaggaggg gccgccaaga
     1741 gcccatctca aaagaggggt gtgcaccctt ctcccagagt cctggtggtt agagcagggc
     1801 cctccctctt tccatggaca ccaggtactt tgctcaaggc tggcctggat cccattcttc
     1861 ctaggtcttg acctgcccca catacccacc gagccttggc tgacatagct acccagctgg
     1921 cccttggccc ccaccctccc ccttgctggc agggccaggg attccagctg gctttcccag
     1981 catcttccaa ctgctgagcc ccacagcagg caagctcagc aggcttggat ggagcccatc
     2041 ggagtatgcc tctcaagaca gacactcgtg ggcaagtgtg gcagctggcc ccaccgcagg
     2101 caggtggcag caggcttgca agaccatatt gctctcacag accttccaat acctctgctg
     2161 taccggggca gtgggctcat gatgtgggct ttgcccagat gaagcactta gagctatgtt
     2221 gcaagccagg gaactacggg agcagctcca gtaatagtct ccgtgtttta agaatagatc
     2281 ccagagcttc tccctggaaa aatggctagg accacccatt cccttctgcg taccctcatg
     2341 ctggcctagg gcaggatggg gagaggaagt agtggaaagg ataggcagcc ctttatcact
     2401 gggataaatc ctgcatggat gttgatgcca gggagcctgc gggattggtc agtacacact
     2461 gcctggaggc cccatcccat ggttttgtga tgctctgggg gacagggtcc tacccagctg
     2521 cctccctagg agaccagcct cctgccctgc tgcacagacc atggccagct cccaggcaca
     2581 agtcctagat gcttagcacc ctagctttgc cttctgtagc tgctattaca aggctgctcc
     2641 ttgctgctct taaggctggg cagaggtgag gacaggggtg ggggttgggg gggtttatgg
     2701 ggaggagaca ggaagaaagg cagacaaacc cccccccgaa aaccctgagc tctctaacct
     2761 tcgctgctca tagtgctgac cctaagacct cagaagcagc tctgtgtgtg gggggatgga
     2821 gaccatgggc tctggtattt ccatgcctgg ctagcagagc cagctttctg gacagggccc
     2881 tgcagtggcc cagcaggaag taccagacct gtccacacag ctggccttgg ccctgcttgt
     2941 taggtgggcc aggcatgcag ggatgcccac agtgggagct actgcctgcc tgtgaaccac
     3001 acctcagagc taagctcctg ctggtgatgt gcaagagaca ggaaaacagg ctgccgggct
     3061 aaggcccata ggatttagcc cacaggagcc ctagatgcaa aagacatgtt aaccaagtgt
     3121 ttctgagagg ttgtcttcca cacccactct cgaagcgtca gggatttgct tcttaaactt
     3181 ctgcggaggg gtttggcttg ggaggccatg tagagcaagt acagacagcc tgttagtggg
     3241 agcttgcccc caggccctca aagggtgtaa ggccagctcc ttcctccatg gcctctcctt
     3301 cctttagccc agctgcctgc aggccagccc aagccagctt ctcttcacct tgaagtagtc
     3361 tgccaggcct ggtgcaggag gagggccatg tagagagagg atctggcact cggagcccaa
     3421 ggtcccaagg cacagcagcg cacctgtgtg cctgctctcc tcatgtacat acataacgtg
     3481 ctttctctcc ccgttttttg tttgtttttt tttaaacgag cgtggctcct cgctaactgc
     3541 accccaccag gccgacagca aacgcctcca gcttcccgac agactcagac caaggtgcgg
     3601 ccccgtattt atggaatggc aaataaaacc cgagcccttt ggtctccaaa aaaaaaaaaa
     3661 aaaa
//
