LOCUS       NM_001357358            2955 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus potassium voltage-gated channel, shaker-related
            subfamily, beta member 1 (Kcnab1), transcript variant 3, mRNA.
ACCESSION   NM_001357358 XM_006501056
VERSION     NM_001357358.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2955)
  AUTHORS   Lee,Y., Yeo,I.S., Kim,N., Lee,D.K., Kim,K.T., Yoon,J., Yi,J.,
            Hong,Y.B., Choi,B.O., Kosodo,Y., Kim,D., Park,J. and Song,M.R.
  TITLE     Transcriptional control of motor pool formation and motor circuit
            connectivity by the LIM-HD protein Isl2
  JOURNAL   Elife 12, e84596 (2023)
   PUBMED   37869988
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2955)
  AUTHORS   Diaz Del Moral,S., Barrena,S., Hernandez-Torres,F., Aranega,A.,
            Villaescusa,J.M., Gomez Doblas,J.J., Franco,D., Jimenez-Navarro,M.,
            Munoz-Chapuli,R. and Carmona,R.
  TITLE     Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac
            Troponin-T Lineage Reveals Novel Functions of WT1 in Heart
            Development
  JOURNAL   Front Cell Dev Biol 9, 683861 (2021)
   PUBMED   34368133
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2955)
  AUTHORS   Ohanyan,V., Raph,S.M., Dwenger,M.M., Hu,X., Pucci,T., Mack,G.,
            Moore,J.B. 4th, Chilian,W.M., Bhatnagar,A. and Nystoriak,M.A.
  TITLE     Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvbeta
            Proteins
  JOURNAL   Circ Res 128 (6), 738-751 (2021)
   PUBMED   33499656
  REMARK    GeneRIF: Myocardial Blood Flow Control by Oxygen Sensing Vascular
            Kvbeta Proteins.
REFERENCE   4  (bases 1 to 2955)
  AUTHORS   Tur,J., Chapalamadugu,K.C., Katnik,C., Cuevas,J., Bhatnagar,A. and
            Tipparaju,S.M.
  TITLE     Kvbeta1.1 (AKR6A8) senses pyridine nucleotide changes in the mouse
            heart and modulates cardiac electrical activity
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (3), H571-H583 (2017)
   PUBMED   27986658
REFERENCE   5  (bases 1 to 2955)
  AUTHORS   Tarantino,L.M. and Bucan,M.
  TITLE     Dissection of behavior and psychiatric disorders using the mouse as
            a model
  JOURNAL   Hum Mol Genet 9 (6), 953-965 (2000)
   PUBMED   10767319
  REMARK    Review article
REFERENCE   6  (bases 1 to 2955)
  AUTHORS   Downen,M., Belkowski,S., Knowles,H., Cardillo,M. and
            Prystowsky,M.B.
  TITLE     Developmental expression of voltage-gated potassium channel beta
            subunits
  JOURNAL   Brain Res Dev Brain Res 117 (1), 71-80 (1999)
   PUBMED   10536234
REFERENCE   7  (bases 1 to 2955)
  AUTHORS   Giese,K.P., Storm,J.F., Reuter,D., Fedorov,N.B., Shao,L.R.,
            Leicher,T., Pongs,O. and Silva,A.J.
  TITLE     Reduced K+ channel inactivation, spike broadening, and
            after-hyperpolarization in Kvbeta1.1-deficient mice with impaired
            learning
  JOURNAL   Learn Mem 5 (4-5), 257-273 (1998)
   PUBMED   10454353
REFERENCE   8  (bases 1 to 2955)
  AUTHORS   Jones,J.M., Bentley,E., Meisler,M.H. and Darling,S.M.
  TITLE     Genetic mapping of the voltage-gated shaker potassium channel beta
            subunit Kcnab1 to mouse chromosome 3
  JOURNAL   Mamm Genome 9 (3), 260 (1998)
   PUBMED   9501317
REFERENCE   9  (bases 1 to 2955)
  AUTHORS   Butler,D.M., Ono,J.K., Chang,T., McCaman,R.E. and Barish,M.E.
  TITLE     Mouse brain potassium channel beta1 subunit mRNA: cloning and
            distribution during development
  JOURNAL   J Neurobiol 34 (2), 135-150 (1998)
   PUBMED   9468385
REFERENCE   10 (bases 1 to 2955)
  AUTHORS   Fink,M., Duprat,F., Lesage,F., Heurteaux,C., Romey,G., Barhanin,J.
            and Lazdunski,M.
  TITLE     A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK)
            expression
  JOURNAL   J Biol Chem 271 (42), 26341-26348 (1996)
   PUBMED   8824288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113458.10, AC134550.5 and AC113279.7.
            
            On Apr 5, 2022 this sequence version replaced NM_001357358.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR2680377.1167055.1,
                                           SRR1660817.234299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               AC113458.10        170733-171051       c
            320-363             AC134550.5         58636-58679
            364-401             AC134550.5         87410-87447
            402-481             AC134550.5         89814-89893
            482-526             AC134550.5         91733-91777
            527-571             AC134550.5         94293-94337
            572-615             AC134550.5         96265-96308
            616-702             AC134550.5         111564-111650
            703-788             AC134550.5         148409-148494
            789-909             AC134550.5         149167-149287
            910-1004            AC134550.5         150393-150487
            1005-1125           AC134550.5         156747-156867
            1126-1214           AC134550.5         163502-163590
            1215-2955           AC113279.7         5829-7569
FEATURES             Location/Qualifiers
     source          1..2955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 30.15 cM"
     gene            1..2955
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /note="potassium voltage-gated channel, shaker-related
                     subfamily, beta member 1"
                     /db_xref="GeneID:16497"
                     /db_xref="MGI:MGI:109155"
     exon            1..319
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1304
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     voltage-gated potassium channel subunit beta-1; K(+)
                     channel subunit beta-1; voltage dependent potassium
                     channel subunit beta-1"
                     /codon_start=1
                     /product="voltage-gated potassium channel subunit beta-1
                     isoform 3"
                     /protein_id="NP_001344287.1"
                     /db_xref="CCDS:CCDS89632.1"
                     /db_xref="GeneID:16497"
                     /db_xref="MGI:MGI:109155"
                     /translation="MLAARTGAAGSQISEDNSKFRKQSGLSSGGKDRSPKKAPENAKD
                     SSLSPTGQSQLRARQLALLREVEMNWYLKLCELSSEHTTAHTTGMPHRNLGKSGLRVS
                     CLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGW
                     RRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPM
                     EEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREK
                     VEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEG
                     RKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVL
                     PKMTSHVVNEIDNILRNKPYSKKDYRS"
     exon            320..363
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..401
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..481
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..526
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..571
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..615
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..702
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..788
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..909
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1004
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1125
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1214
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..2955
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2934..2939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /note="hexamer: AATAAA"
     polyA_site      2955
                     /gene="Kcnab1"
                     /gene_synonym="Akr8a8; Kvbeta1.1; mKv(beta)1"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcttag cctcttccca gacaggcaga taggaacttc caggatgctg gcagcccgca
       61 caggcgctgc agggagtcag atctccgaag acaacagcaa gttcagaaag cagtctggcc
      121 tttcttcagg ggggaaagac agatctccca agaaagcccc cgagaatgcc aaagacagca
      181 gcctcagccc aaccgggcaa agccagctca gggcaaggca gctggccctg ctgcgggagg
      241 tggagatgaa ctggtaccta aagctctgcg agctgtccag cgagcacacc acggcacaca
      301 ccaccgggat gccgcacagg aatcttggga aatcaggact cagagtttca tgcttgggtc
      361 ttggaacatg ggtgacattt ggaggtcaaa tctcagatga ggttgctgaa cggctgatga
      421 caattgccta cgaaagtgga gttaatctct tcgacacagc tgaggtctat gctgctggga
      481 aggctgaggt gattctggga agcatcatca agaagaaagg ctggaggagg tccagcttgg
      541 tcatcacaac caaactctac tggggtggaa aagctgagac agaaagggga ctgtcaagaa
      601 agcacatcat tgaaggactg aaaggctccc tccagaggct gcaactggaa tacgtggatg
      661 tggtctttgc aaatcgccca gacagcaaca ctcccatgga agaaatcgtt cgagccatga
      721 cgcacgtgat caaccaaggc atggccatgt actggggcac ctcgaggtgg agcgcgatgg
      781 agatcatgga agcctactct gtcgcacggc agttcaacat gatcccgcct gtctgtgagc
      841 aagctgagta ccatcttttc cagagagaga aggtggaggt ccagctgccg gagctctacc
      901 ataaaatagg agttggtgca atgacatggt ctccacttgc ttgtggaatt atttcaggaa
      961 aatatggaaa tggggtgcca gaaagttcta gagcttcact gaagtgctac cagtggttga
     1021 aggaaagaat cgtaagtgaa gaagggagaa aacagcaaaa caagctgaaa gacctctctc
     1081 caatcgctga gcgcctgggg tgcacgctac ctcagctggc tgtggcgtgg tgcctgagaa
     1141 atgagggtgt gagttctgtg ctcctgggat catccactcc ggaacaactc attgaaaacc
     1201 ttggtgccat tcaggtcctc cctaagatga catctcacgt ggtgaacgag attgataaca
     1261 tactgcgcaa caagccctac agcaaaaagg actatagatc ataaggcaat gcatgagcca
     1321 cttaagctgc atgggtaaag tcatgatggg taggcagtgc agaacggcct taccagccac
     1381 tcttttcaat cacttagcag tttgctgctc aacctctagt gtcccaggat tctctgaggt
     1441 ttctgctgtt gctaccactg tgcaccctga attctgaaca catctgaaaa ttcacaagcc
     1501 agaaaatcca ttctattttc ttatcttgga ctggtcccct accctggcac tggtctgtgt
     1561 acctcatgtt tttgcaatgg aaagaatgct ggggtagggg aatctattat cttcagaaga
     1621 aggctgtaca tatatatttt tttcaaaaga acaaatttca caagatacag tatatgacct
     1681 gcataggaaa caggatatcc tcactcttta gtcttgctcg ggagaacaaa ctgaactaga
     1741 tttttccccc catatttcat attcacacta gcaagtttta tgtcacctga tattcaaata
     1801 aaatttctag atatttgctt tcactatctc taaagttata ttgttgcctg gccctgtaca
     1861 atttaactgg ggtgtctctc agggttctaa catatccatt tgcatagtta taaaggcatg
     1921 actatcccaa gatacataat agatacataa tgctgattta taaaaaggtc acaatgttat
     1981 ggaaacagct ttaaataaaa tgttaagtgt tcatttttta ctttctatta aagcctacat
     2041 ttactttcaa ttgcttgtag gcacaacttc tgttgaggct aaatatttga ctttaaaaat
     2101 acatacatgt tcagttttgt aattaaacct ataaataccc agaaaggcaa gtgttcaatt
     2161 taccattggg acattatcat ataatgcttg gaattttctg aagttattaa catgaaaaca
     2221 aatcataggc gatgttaaga aaaagacaaa aaaacatttt ttttctcatt cctcggcaca
     2281 tgctagatga cttaacttgc ccaaagaaaa agcaaaatat tcaagaagct cctggttcga
     2341 attgtatcac accctacacc atatgcatga aagctctttg catggaataa aggggcctag
     2401 ctttgcactc agaatctgag atacacttag ctctgcctct acgggctaat tcccctcact
     2461 gtatcccact tgagaaaaac tgtaaaacta tatatactgt gtggctatct gtaaatacgg
     2521 ataagacaca aggggttttt gttgttgttt tgttttctgt aaaggtgggg tcattttcta
     2581 actcttattt gtctaactat agatgggcaa cattctactt catctagtta gcaagttctc
     2641 catcacttta agatttacac aagaaatata cgaacttaaa atcattttcg gatatgtacc
     2701 acatggttaa gttctaaatc ttaaactatc agtgaaagat accaagaaat atgattgtga
     2761 ctacctagct agcctccagc aggcaacttg ggagtttcac ccgtgaatat ctgaataatg
     2821 atagagatga gctaactttc catctattca ctgtaaatgt aatccactga actactgtac
     2881 gtataaatga gtggagtgct gtctaaataa aaatcaattt atttgcttag agtaataaag
     2941 gcatctgcaa tctca
//
