LOCUS       NM_010596               3494 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus potassium voltage-gated channel, shaker-related
            subfamily, member 7 (Kcna7), mRNA.
ACCESSION   NM_010596
VERSION     NM_010596.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3494)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3494)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   3  (bases 1 to 3494)
  AUTHORS   Finol-Urdaneta,R.K., Struver,N. and Terlau,H.
  TITLE     Molecular and Functional Differences between Heart mKv1.7 Channel
            Isoforms
  JOURNAL   J Gen Physiol 128 (1), 133-145 (2006)
   PUBMED   16801386
  REMARK    GeneRIF: Kv1.7 channels from mouse heart muscle have two putative
            translation initiation start sites that generate two channel
            isoforms with different functional characteristics, mKv1.7L (489
            aa) and a shorter mKv1.7S (457 aa).
REFERENCE   4  (bases 1 to 3494)
  AUTHORS   Bardien-Kruger,S., Wulff,H., Arieff,Z., Brink,P., Chandy,K.G. and
            Corfield,V.
  TITLE     Characterisation of the human voltage-gated potassium channel gene,
            KCNA7, a candidate gene for inherited cardiac disorders, and its
            exclusion as cause of progressive familial heart block I (PFHBI)
  JOURNAL   Eur J Hum Genet 10 (1), 36-43 (2002)
   PUBMED   11896454
REFERENCE   5  (bases 1 to 3494)
  AUTHORS   Kashuba,V.I., Kvasha,S.M., Protopopov,A.I., Gizatullin,R.Z.,
            Rynditch,A.V., Wahlestedt,C., Wasserman,W.W. and Zabarovsky,E.R.
  TITLE     Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a
            member of the voltage-gated potassium channel gene family
  JOURNAL   Gene 268 (1-2), 115-122 (2001)
   PUBMED   11368907
REFERENCE   6  (bases 1 to 3494)
  AUTHORS   Kalman,K., Nguyen,A., Tseng-Crank,J., Dukes,I.D., Chandy,G.,
            Hustad,C.M., Copeland,N.G., Jenkins,N.A., Mohrenweiser,H.,
            Brandriff,B., Cahalan,M., Gutman,G.A. and Chandy,K.G.
  TITLE     Genomic organization, chromosomal localization, tissue
            distribution, and biophysical characterization of a novel mammalian
            Shaker-related voltage-gated potassium channel, Kv1.7
  JOURNAL   J Biol Chem 273 (10), 5851-5857 (1998)
   PUBMED   9488722
REFERENCE   7  (bases 1 to 3494)
  AUTHORS   Lock,L.F., Gilbert,D.J., Street,V.A., Migeon,M.B., Jenkins,N.A.,
            Copeland,N.G. and Tempel,B.L.
  TITLE     Voltage-gated potassium channel genes are clustered in paralogous
            regions of the mouse genome
  JOURNAL   Genomics 20 (3), 354-362 (1994)
   PUBMED   8034307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151602.4.
            
            On Mar 10, 2007 this sequence version replaced NM_010596.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY779767.1, AF032099.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1056              AC151602.4         183449-184504       c
            1057-3494           AC151602.4         179082-181519       c
FEATURES             Location/Qualifiers
     source          1..3494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.3 cM"
     gene            1..3494
                     /gene="Kcna7"
                     /gene_synonym="Kv1.7"
                     /note="potassium voltage-gated channel, shaker-related
                     subfamily, member 7"
                     /db_xref="GeneID:16495"
                     /db_xref="MGI:MGI:96664"
     exon            1..1056
                     /gene="Kcna7"
                     /gene_synonym="Kv1.7"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..3494
                     /gene="Kcna7"
                     /gene_synonym="Kv1.7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcagatag tctcgggtgg ctcatgactg tcacccgggc aatccgaagg atgaggcaga
       61 ggattgccac aagttcgcgg tcagcttaaa tgacaggctg aggagactgt ctaaataaca
      121 aacaaacaaa taaatagcca tgatgccata cgcctgcaat cccagcattt gggaggtgga
      181 ggcaggagga tcataaattc aaggtcagtt cagctacata agacctcggg tcatgaatcc
      241 aaaagccaaa caaataaaat agatgactac aagggaaagc tcaagagatc cacggaaaag
      301 cgccgggtgg cagtgtttcc acaggtgtgg gaacggcaga gggcgcccct agccccgcgg
      361 gggtaacacc gccccctccc ccgcgccctg gccggacttt ccatgctatt tttacccgcc
      421 gacaccggac acccgactgg ggtggctgcg gcgtcggggc cacacgtccg ttcaccggtc
      481 gcccgggctg tgcgcgccat ggagccacgg tgcccgccgc cctgcggctg ctgcgagcgg
      541 ctggtgctca acgtggccgg gttgcgcttc gagacccgcg cgcgcacgct cggccgcttc
      601 ccggacacgc tgctggggga cccggtgcgc cgcagccgct tctacgacgg cgcgcgccgc
      661 gagtatttct tcgaccgaca ccggcccagc ttcgatgcgg tgctctacta ctaccagtcg
      721 ggcggccggc tgagacggcc ggcgcacgtg cccctcgacg tcttcctgga ggaggtgtcc
      781 ttctacgggc tgggcgcggc ggcgctggcg cggctgcggg aggacgaggg ctgcgcggtg
      841 ccgcccgagc ggccgctgcc ccgccgcgcc tttgcgcgtc agctctggct gctcttcgaa
      901 tttcctgaga gctcgcaggc tgcgcgcgtg ctcgccgtgg tctccgtact cgtcatcctg
      961 gtctccatcg tggtcttttg cctcgagaca ctgccagact tccgcgacga ccgcgatgac
     1021 ccggggctcg cgcccgtagc cgctgctact ggcccgttcc tcgcccgact gaatggctcc
     1081 agtcccatgc caggagcccc tccccgacag cccttcaacg atccattctt tgtggtggag
     1141 accctgtgta tctgctggtt ctcctttgag ctgctggtgc gtctggtggc ctgccctagc
     1201 aaagctgtgt tcttcaagaa tgtgatgaac ctaattgact tcgtggccat cctgccttac
     1261 ttcgtggccc tgggcacgga gttagcccgg cagcggggtg tgggccagcc ggctatgtcc
     1321 ctggccatcc taagggtcat ccgattggtg cgtgtcttcc gcatcttcaa gctctccagg
     1381 cattcgaagg gtctacagat cttgggtcag acactgcggg cttccatgcg tgagctaggt
     1441 ctcctcatct tcttcctctt cattggcgtg gtcctctttt ccagcgcagt ctactttgct
     1501 gaagtggacc gggtggacac ccatttcacc agcatcccgg agtccttttg gtgggcagtg
     1561 gtcaccatga ccacggttgg ctatggggac atggcacccg tcaccgtggg tggcaagatc
     1621 gtgggctctc tgtgtgccat tgcaggtgtg ctcaccatct ctctgcctgt gcctgtcatt
     1681 gtctctaact ttagctactt ttaccaccgg gagacagagg gcgaagaggc agggatgtac
     1741 agccatgtgg acacacagcc ctgcggtacc ctggagggca aggctaatgg ggggctggtg
     1801 gactctgagg tgcctgaact cctcccacca ctctggcccc ctgcagggaa acacatggtg
     1861 actgaggtgt gagggtcaac tggggtctcc agggagcagt ggggtgggag ggaggaggga
     1921 aggcagggtc aggtgctggg ttaaggacta agatggtaac aaaagggtac agattcttaa
     1981 tctgaaggca tgtcacatgg tggctcctag ggggacctta tgtgacagga attgccagga
     2041 tttgggttgt gtccagggct ccccccattg attgcgcaat gtggtagagc tgtgcaaatg
     2101 tccaggggct ctatgggtag cactgtaaga gacttggcca tagattgtga gtttcctagg
     2161 tgttcgtggg gtcccactgg gggcaagtgt ggtcccgtta acacttgata ggtactaata
     2221 gaactttggg tcctctaggg ccaagtcggc tcctgtaggt ctctggagca ctgttaaaga
     2281 gtgtgagctt gtggctacat ggtcacacac agaggttatg tggtgataca tagcagattg
     2341 tgtggattca tgtttcttct aggactcaag ttattttaga ttctgtgagc tctggagtca
     2401 tgcagacagg atgtgatcac tctgggtcct gatggaaaaa gggttagggt ataaaagata
     2461 gacagaggca gagactcaga taaagggaca gagacacccc cacacacaca cacaacacac
     2521 aattctctgt gttgtgcagg gttataggac tggaatcatt ttagggccat gcaaagctga
     2581 gatgtgtgac cccatgtgtc tccgaacagt tgagtctgat gacttctacg gtctcatggg
     2641 acttgtgtta ctgtgagtcc tgtggaactt ttggttgaat ttgactgtat gtgagggcca
     2701 ttttaaacag tagatcaggg tcacagcaca gataaaacta actacaaggg agcaagcatg
     2761 ggcacgtgga tgtgtgtggc ccgttgaaca agtttactca gggttatgca ttgtagagct
     2821 ggtagtgtct gtatctctgg gtccccctgc ccgaagcacc tagaaagacg atgggaacta
     2881 gtaacctgcc tgtcttgctc atgtgggacc catatttcta tgttgtccca tgctgtagta
     2941 caaagattca gaggctggtt ggagccacaa ggaaagaaaa cacagtaggg caagagtagg
     3001 tacttgggaa aagatgtggc aggggacaga gatctagaag aaagaaagat ggagagaagg
     3061 agcaggagga gcaggggagg gggaaagagg gaagggaagg agggagagac agagcaggta
     3121 aagaggaaga gatgtggggg ggggggggag aaggacctgg agcccaaggg tcatcctctc
     3181 tattctctga gtcataacag actctaagcc atggcgtcag catcccttag agccaaggaa
     3241 ggtcaccaca ctcctggagg tgctctgtgt ttcctaggac agaaacccaa ggctgtagtg
     3301 tgctgtggct tccctcaagg ttacccagca cgtcatagga ccaaggctgg tgccaggtgg
     3361 cctgcctgtg acacccccac aacttctggt gtgcaggtat tgcctgaggc cactggtcct
     3421 gtgtcctttg tttttatccc ttaaaacagg gtccctcttt gtagtgttgg ctgtcctgga
     3481 actcactacg taga
//
