LOCUS       NM_001410072            5924 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus potassium voltage-gated channel, shaker-related,
            subfamily, member 6 (Kcna6), transcript variant 2, mRNA.
ACCESSION   NM_001410072 XM_006505639
VERSION     NM_001410072.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5924)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5924)
  AUTHORS   Perumal,N., Yurugi,H., Dahm,K., Rajalingam,K., Grus,F.H.,
            Pfeiffer,N. and Manicam,C.
  TITLE     Proteome landscape and interactome of voltage-gated potassium
            channel 1.6 (Kv1.6) of the murine ophthalmic artery and neuroretina
  JOURNAL   Int J Biol Macromol 257 (Pt 1), 128464 (2024)
   PUBMED   38043654
  REMARK    GeneRIF: Proteome landscape and interactome of voltage-gated
            potassium channel 1.6 (Kv1.6) of the murine ophthalmic artery and
            neuroretina.
REFERENCE   3  (bases 1 to 5924)
  AUTHORS   Peck,L.J., Patel,R., Diaz,P., Wintle,Y.M., Dickenson,A.H.,
            Todd,A.J., Calvo,M. and Bennett,D.L.H.
  TITLE     Studying Independent Kcna6 Knock-out Mice Reveals Toxicity of
            Exogenous LacZ to Central Nociceptor Terminals and Differential
            Effects of Kv1.6 on Acute and Neuropathic Pain Sensation
  JOURNAL   J Neurosci 41 (44), 9141-9162 (2021)
   PUBMED   34544832
REFERENCE   4  (bases 1 to 5924)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5924)
  AUTHORS   Vysotskaya,Z., Chidipi,B., Rodgers,J.L., Tang,X., Samal,E.,
            Kolliputi,N., Mohapatra,S., Bennett,E.S. and Panguluri,S.K.
  TITLE     Elevated potassium outward currents in hyperoxia treated atrial
            cardiomyocytes
  JOURNAL   J Cell Physiol 233 (5), 4317-4326 (2018)
   PUBMED   29139549
  REMARK    GeneRIF: we are investigating the effects of hyperoxia on atrial
            electrophysiology using whole-cell patch-clamp electrophysiology
            experiments along with assessment of Kv1.5, Kv4.2, and KChIP2
            transcripts and protein profiles using real-time quantitative
            RT-PCR and Western blotting.
REFERENCE   6  (bases 1 to 5924)
  AUTHORS   Abbott,C. and Chambers,D.
  TITLE     Analysis of CAG trinucleotide repeats from mouse cDNA sequences
  JOURNAL   Ann Hum Genet 58 (2), 87-94 (1994)
   PUBMED   7979162
REFERENCE   7  (bases 1 to 5924)
  AUTHORS   Lock,L.F., Gilbert,D.J., Street,V.A., Migeon,M.B., Jenkins,N.A.,
            Copeland,N.G. and Tempel,B.L.
  TITLE     Voltage-gated potassium channel genes are clustered in paralogous
            regions of the mouse genome
  JOURNAL   Genomics 20 (3), 354-362 (1994)
   PUBMED   8034307
REFERENCE   8  (bases 1 to 5924)
  AUTHORS   Klocke,R., Roberds,S.L., Tamkun,M.M., Gronemeier,M., Augustin,A.,
            Albrecht,B., Pongs,O. and Jockusch,H.
  TITLE     Chromosomal mapping in the mouse of eight K(+)-channel genes
            representing the four Shaker-like subfamilies Shaker, Shab, Shaw,
            and Shal
  JOURNAL   Genomics 18 (3), 568-574 (1993)
   PUBMED   7905852
REFERENCE   9  (bases 1 to 5924)
  AUTHORS   Lesage,F., Attali,B., Lazdunski,M. and Barhanin,J.
  TITLE     Developmental expression of voltage-sensitive K+ channels in mouse
            skeletal muscle and C2C12 cells
  JOURNAL   FEBS Lett 310 (2), 162-166 (1992)
   PUBMED   1383027
REFERENCE   10 (bases 1 to 5924)
  AUTHORS   Migeon,M.B., Street,V.A., Demas,V.P. and Tempel,B.L.
  TITLE     Cloning, sequence and chromosomal localization of MK6, a murine
            potassium channel gene
  JOURNAL   Epilepsy Res Suppl 9, 173-80 (1992)
   PUBMED   1285906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124756.4 and AC079438.30.
            
            On Jul 27, 2022 this sequence version replaced XM_006505639.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.185655.1,
                                           SRR9219382.131679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate :: translation inferred from conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5433              AC124756.4         128417-133849       c
            5434-5545           AC124756.4         108265-108376       c
            5546-5853           AC124756.4         101602-101909       c
            5854-5924           AC079438.30        209569-209639       c
FEATURES             Location/Qualifiers
     source          1..5924
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 61.72 cM"
     gene            1..5924
                     /gene="Kcna6"
                     /gene_synonym="Kv1.6; MK1.6"
                     /note="potassium voltage-gated channel, shaker-related,
                     subfamily, member 6"
                     /db_xref="GeneID:16494"
                     /db_xref="MGI:MGI:96663"
     exon            1..5433
                     /gene="Kcna6"
                     /gene_synonym="Kv1.6; MK1.6"
                     /inference="alignment:Splign:2.1.0"
     exon            5434..5545
                     /gene="Kcna6"
                     /gene_synonym="Kv1.6; MK1.6"
                     /inference="alignment:Splign:2.1.0"
     exon            5546..5924
                     /gene="Kcna6"
                     /gene_synonym="Kv1.6; MK1.6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5906..5911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcna6"
                     /gene_synonym="Kv1.6; MK1.6"
                     /note="hexamer: AATAAA"
     polyA_site      5924
                     /gene="Kcna6"
                     /gene_synonym="Kv1.6; MK1.6"
                     /note="major polyA site"
ORIGIN      
        1 agagctgaga gctgagcctg ctgctgctgt tgctgctgct gctgctgctg ctgctgctgt
       61 tgctgctgct ggggctgctg cgggtgcagg caaggcttga agcggtgggg aggtgggtct
      121 ccgcgcttcg gcgcccggga aggcccaggg cgattccgag gcctctagaa cagctagctc
      181 ctggggaaga aggtggcggc tgcaatcgcg accttggcca gacctagttc ggtggtggac
      241 gtagggcgga ggcggaggcc gagcccgggc aggagtcttt ggtgagccag agggaggcgc
      301 atctggcgct taggtaccag cggcaaccca gagtcgtgtg cagctggaga agcgcagtag
      361 gacctggtga gagccagcag gtctggaggg cggacctgtg ggtcctgagc ccagttttag
      421 gcaccatcga gagctaagcc acgcgtcttt tcgggcagcc agtttcacgc gcgcgacagt
      481 ttgcgggttc caggcatctc agaaatcctg agcacggagg cgcggctatt gagagccaga
      541 gccacttccc agacctagcc tggcagaggg accagctgca gggctcaccg acctaaccgc
      601 caggtcagag cacgggcccc accctaaagg agggcacagc cgaagctgtg aagcgggtgc
      661 cgctctctgg agctcgtgtc gtgggcgccg tcctagtggc ggggagcgca ccgccgaggt
      721 gacatgagat cggagaaatc cctgacgctg gcggcgccgg gggaggtccg tgggccggag
      781 ggggagcaac aggatgcggg tgagttccag gaggccgagg gcggcggcgg ctgctgtagt
      841 agtgagaggt tggtgatcaa catctccggg ctgcgcttcg agacgcagct gcgcaccctg
      901 tcgctgttcc ctgacacgct gctaggagac cctggccgca gagtccgttt ctttgacccc
      961 ttgaggaacg agtacttctt tgaccgcaac cgacccagct tcgacgctat cctttattac
     1021 tatcaatctg gaggtcgcct gcgcaggcct gttaatgtgc ccctggacat ttttatggaa
     1081 gagatccgct tctatcagtt gggagaggaa gccctggcgg ccttccggga ggatgagggt
     1141 tgcctgcccg aaggtggcga ggatgagaaa ccactcccct cccagccttt ccagcgacag
     1201 gtctggcttc tctttgagta cccggagagt tccgggcccg cccgaggcat cgccatcgtc
     1261 tcagtattgg tcatcctcat ctccatcgtc atcttttgcc tggagacctt gcctcaattc
     1321 cgtgcagatg ggcgcggtgg aagcaacgag ggtagtggga cccgcttgtc tccggcctcc
     1381 aggagccacg aggaagaaga tgaggatgaa gattcctatg catttcctgg tagcattccc
     1441 tctggggggt tggggactgg aggaacatct tcacttagta ctctcggggg ttctttcttc
     1501 acagacccct tcttcttggt ggaaactctg tgtatcgtct ggttcacgtt tgagctcctg
     1561 gtgcgcttct ctgcctgtcc cagcaaggcg gccttctttc gcaatatcat gaacatcatt
     1621 gacttggtgg ccattttccc ctactttatc accttgggca ccgagctagt gcaacgtcac
     1681 gagcagcagt ctgtgagtgg tggcagtggt cagaatgggc agcaggccat gtccctagcc
     1741 atcctcaggg tgatccgcct ggtccgggtg ttccgaatct tcaagctctc ccgccattcc
     1801 aaggggctgc agatcctggg taagacctta caggcgtcca tgcgggagct cgggctgctc
     1861 atcttcttcc tcttcatcgg agtcatcctc ttttccagcg ctgtctactt cgcagaggct
     1921 gatgatgttg actcgctctt ccctagcatc ccagatgcct tctggtgggc tgtggttaca
     1981 atgaccacgg taggttatgg ggacatgtac cccatgacgg tagggggcaa gattgtgggc
     2041 tcactgtgcg ccattgctgg ggtcctcacc attgcattac cggtaccggt cattgtctcc
     2101 aatttcaact acttctacca ccgagagacg gagcaggagg agcaaggcca gtatacccac
     2161 gtcacttgtg ggcagcccac tccggacttg aaggcaacgg acaatgggct tggcaaacct
     2221 gactttgccg aggcttcacg ggaacgccgg cccagctacc ttccgactcc acatcgagct
     2281 tatgcggaga aaaggatgct caccgaggtt tgatggatgc gggcaggcct gcaggaaaac
     2341 aggagctctg agcaagtcat ctctcaggct tccttctcat gctcactact tccgccttag
     2401 ctccagagga cctcgaaccc ccctcccccc taacacagta catggcatct tggaccaaat
     2461 atctggactg tagactgttg ctcgatcctc gcagcattcg aggtttctcc atcttagtga
     2521 cattttggaa atttcaacgg tgccacccaa tcatgcccat cagtcacgtg gatgagatgc
     2581 acgtttctga ctgatcttcc ctcaagactg agttttcatg cctgggtctt gtaatatctc
     2641 taggaatggt gacaccagta gaataggaag cagctacact caggtccctt ctttagtgtc
     2701 ctttgctttg ggtcatgcac cttccttact tagcttctgg tcacttggtc actggcagaa
     2761 tctggagaat ggaaaagatt tcagcttggc attttagtgc ccaagccatc ttctgactgg
     2821 tagagctatt agctgcacgg ctttgaaaga tatggctaaa tttggatgga attagagaaa
     2881 atactaccca actggattat ttgaaggaca tgaaggtcag ttttagacca atgggggccg
     2941 gtggatttct ctagttgtga tctgtcacag gagatgctgg caggggtcta cattagtcct
     3001 caccactctg attccatgac ttccttgcgc ttccaggaag aaacttggca ctttctcaga
     3061 gccaagttct ttttatgtgc aagcgccttc gtgtgcagag gaactggaaa atagaactac
     3121 agagacagga gaaaaggctg accagagcca aaggactggc tggaccacat atctgaagca
     3181 aggtgccact taagcagaga ctgtcactta gaacaggcag agggactctg ctgcagacag
     3241 cagccaattc ctccagatta gctcagacct ctttaagata tcctccaccc tttttcctgg
     3301 gaatctgacc taggattgca aatggatttg tttttataaa gcaacctcag ctgtaaccta
     3361 cagacaggtg agttcacaca ttgaatgcca gcatagcttt cctcttatgc cacaggcaac
     3421 agcctttggt tgggagccag ggaagggcac ggtcattttg ttggcagcct ctctcttaga
     3481 ggattttgct gagtcaagca aacgtttgtc tgctcagctc ttcctttgga gctgcattgg
     3541 gcctgctaag gtaactcggt cgttcctact tggaccaagc catcttctcc cattgtgaaa
     3601 tcactgccac cctcccagct gcccactgcc ccctccccca gtaacattgc cattcagttt
     3661 tgcctttgat aaactgtgat acactcttct cagttctcat gggtacagct ctgaaactca
     3721 aaggactgtt aacatgtttt taattttcta ttgatgcttt aagactcttc gaagggaatg
     3781 gcttttcaaa agattttttt tttccctgaa gaacaactta ggaaggagtg accttgatgg
     3841 ttggcttgag aggccactgt ggctccactc tgagttttgc cacagcttta cagggtaact
     3901 ctggtgtcat ggtccctctt tgtgcctcag ttccccccac ccattaaatg agaacattaa
     3961 tgtcttcgcc tccttacctc atggggaatt atcaataaac tcacccagga gggtggggag
     4021 gatgctatgc aaatgtgtga attatagtaa tggccttgag ttttagttca ctatactgcc
     4081 tgcctatctc tcaaaggcat ggcctttcct cagaactttc taccatggat ccaaagccta
     4141 agactaggcc atcgtagacc atcagctctc taagtcgctc cctgccatct tgggctgggt
     4201 ctctccatcc tttctctcac ccgtcagaaa aggagtgtat tcttgcatta gacttggtgg
     4261 ccagaagtca ccttatctgg gagcttaact tctccaagcc tgcaacatag taaaaggctg
     4321 agatggttga gactcagaga tctattctaa ggccagtaag aaagtacttt ctgtttccaa
     4381 tgattttagt tactccatgc ccaccccagt ggccaaaggg atgtctccag ctgagggtgg
     4441 atggggggac atgtgtgcat ggacctctgt gtatgtatag attgtcaccc tcatcactgt
     4501 ccctgtcctt atgcaaacat tgccttttca agtcagagca tgcctgaaag taaaaggttt
     4561 gtggagagcc aggctctcca gggactctgg ttgctgtagc aaccttccag actgttctct
     4621 ctactgattt gggtatcaag ggagaacaga ctacatatcc cagcttctca cacgggaaca
     4681 cctccaatct attggtttag gcattggcag aactaaaata aggactcagg acctttggca
     4741 atgtggaggg agtagattcc caacacttcc tgcctagacc tttcttcctg gttccctgta
     4801 tggtcatgga agccgccaca tcttactccg agtcttcaga aacttgaatg cttaaaacct
     4861 gcccaattca gccagaagca aggttaaggt tttcaaagga agacctcaga gaggggtata
     4921 aaatgtcccc tccatcgcag ccagactggg ccttgaggac acagatgaca ccaatctggg
     4981 atgtcatggt attctcatct caggcgcagg ttcttcccag ccctaagaga gatcaagaag
     5041 gatgaaactc ctccctccca gggagcaaca ctgctcctgg caaaattaca gaagtgattc
     5101 ttaagatgtc agacagaaac tgagaggctg tgactatcaa gtttttgtgg agaattttgt
     5161 ccagtgagct ctccctgctt ctgagcctcc atgtggatga tgtaaccgtg tcatcaagag
     5221 accatgcacc accttgtgct gcctcaacag ctggatcaat aggaccacag ctgctcaaga
     5281 aggtggggtt caagccatct cgatgactga cgtaagccag tgggggctcc cagaggatac
     5341 tctgggactg ccaatttctg cttgggatga ggacagccct cctgcctagc atcccagagg
     5401 agcaagggac agctggcctt tcttgcctct gaggcaggtt ctcactatat agccccaatt
     5461 gcactggatc tcacggtgta gaccaggttg gccttggaca tgcagaggtc catctccttc
     5521 tgcctcctga gtactggaac tgaagggttg tgctgcacga ggccactctg gaaaacctat
     5581 gcatccaaag agtacccgat cttgaacttc tctggaggat gagacccccg cctccccact
     5641 gaataactca gccggacagc ccctggtggc cttccacaag cagtgactga gacggaagga
     5701 aaaggaaaag gctgagatgg gggggggggc tccttgccag tgaacgatgg gattctgagt
     5761 gttggggtgg ggccagagga ggagaaggag agttgctggt ctgatcaaag gagaggaggt
     5821 gttaggatga tctgggatcg gaagaattcc tgagtgtgct gcagagtcgc ccaggcactc
     5881 gctggctgag gaagagtaac taataaataa atgacagtct caga
//
