LOCUS       NP_001397001             529 aa            linear   ROD 01-JUL-2024
DEFINITION  potassium voltage-gated channel subfamily A member 6 [Mus
            musculus].
ACCESSION   NP_001397001 XP_006505702
VERSION     NP_001397001.1
DBSOURCE    REFSEQ: accession NM_001410072.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 529)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 529)
  AUTHORS   Perumal,N., Yurugi,H., Dahm,K., Rajalingam,K., Grus,F.H.,
            Pfeiffer,N. and Manicam,C.
  TITLE     Proteome landscape and interactome of voltage-gated potassium
            channel 1.6 (Kv1.6) of the murine ophthalmic artery and neuroretina
  JOURNAL   Int J Biol Macromol 257 (Pt 1), 128464 (2024)
   PUBMED   38043654
  REMARK    GeneRIF: Proteome landscape and interactome of voltage-gated
            potassium channel 1.6 (Kv1.6) of the murine ophthalmic artery and
            neuroretina.
REFERENCE   3  (residues 1 to 529)
  AUTHORS   Peck,L.J., Patel,R., Diaz,P., Wintle,Y.M., Dickenson,A.H.,
            Todd,A.J., Calvo,M. and Bennett,D.L.H.
  TITLE     Studying Independent Kcna6 Knock-out Mice Reveals Toxicity of
            Exogenous LacZ to Central Nociceptor Terminals and Differential
            Effects of Kv1.6 on Acute and Neuropathic Pain Sensation
  JOURNAL   J Neurosci 41 (44), 9141-9162 (2021)
   PUBMED   34544832
REFERENCE   4  (residues 1 to 529)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 529)
  AUTHORS   Vysotskaya,Z., Chidipi,B., Rodgers,J.L., Tang,X., Samal,E.,
            Kolliputi,N., Mohapatra,S., Bennett,E.S. and Panguluri,S.K.
  TITLE     Elevated potassium outward currents in hyperoxia treated atrial
            cardiomyocytes
  JOURNAL   J Cell Physiol 233 (5), 4317-4326 (2018)
   PUBMED   29139549
  REMARK    GeneRIF: we are investigating the effects of hyperoxia on atrial
            electrophysiology using whole-cell patch-clamp electrophysiology
            experiments along with assessment of Kv1.5, Kv4.2, and KChIP2
            transcripts and protein profiles using real-time quantitative
            RT-PCR and Western blotting.
REFERENCE   6  (residues 1 to 529)
  AUTHORS   Abbott,C. and Chambers,D.
  TITLE     Analysis of CAG trinucleotide repeats from mouse cDNA sequences
  JOURNAL   Ann Hum Genet 58 (2), 87-94 (1994)
   PUBMED   7979162
REFERENCE   7  (residues 1 to 529)
  AUTHORS   Lock,L.F., Gilbert,D.J., Street,V.A., Migeon,M.B., Jenkins,N.A.,
            Copeland,N.G. and Tempel,B.L.
  TITLE     Voltage-gated potassium channel genes are clustered in paralogous
            regions of the mouse genome
  JOURNAL   Genomics 20 (3), 354-362 (1994)
   PUBMED   8034307
REFERENCE   8  (residues 1 to 529)
  AUTHORS   Klocke,R., Roberds,S.L., Tamkun,M.M., Gronemeier,M., Augustin,A.,
            Albrecht,B., Pongs,O. and Jockusch,H.
  TITLE     Chromosomal mapping in the mouse of eight K(+)-channel genes
            representing the four Shaker-like subfamilies Shaker, Shab, Shaw,
            and Shal
  JOURNAL   Genomics 18 (3), 568-574 (1993)
   PUBMED   7905852
REFERENCE   9  (residues 1 to 529)
  AUTHORS   Lesage,F., Attali,B., Lazdunski,M. and Barhanin,J.
  TITLE     Developmental expression of voltage-sensitive K+ channels in mouse
            skeletal muscle and C2C12 cells
  JOURNAL   FEBS Lett 310 (2), 162-166 (1992)
   PUBMED   1383027
REFERENCE   10 (residues 1 to 529)
  AUTHORS   Migeon,M.B., Street,V.A., Demas,V.P. and Tempel,B.L.
  TITLE     Cloning, sequence and chromosomal localization of MK6, a murine
            potassium channel gene
  JOURNAL   Epilepsy Res Suppl 9, 173-80 (1992)
   PUBMED   1285906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124756.4 and AC079438.30.
            
            On Jul 27, 2022 this sequence version replaced XP_006505702.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.185655.1,
                                           SRR9219382.131679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate :: translation inferred from conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 61.72 cM"
     Protein         1..529
                     /product="potassium voltage-gated channel subfamily A
                     member 6"
                     /note="voltage-gated potassium channel subunit Kv1.6"
                     /calculated_mol_wt=58543
     Region          1..35
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61923.1)"
     Region          41..170
                     /region_name="BTB_POZ_KCNA6"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in potassium
                     voltage-gated channel subfamily A member 6 (KCNA6);
                     cd18407"
                     /db_xref="CDD:349714"
     Site            order(41,74,77,79..80,82,84)
                     /site_type="other"
                     /note="putative beta subunit interface [polypeptide
                     binding]"
                     /db_xref="CDD:349714"
     Site            order(42,46,48..55,58,78,81,85,87..88,90..91,94,98,101,
                     105,107,111,115..116,119)
                     /site_type="other"
                     /note="putative tetramer interface [polypeptide binding]"
                     /db_xref="CDD:349714"
     Site            172..193
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     Region          203..238
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     Region          259..468
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Site            263..284
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     Site            296..316
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     Site            338..358
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     Region          360..373
                     /region_name="S4-S5 linker.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     Site            374..395
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     Region          422..427
                     /region_name="Selectivity filter.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     Site            437..465
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     Region          488..513
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     Site            511
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000305;
                     propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     Region          527..529
                     /region_name="PDZ-binding. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61923.1)"
     CDS             1..529
                     /gene="Kcna6"
                     /gene_synonym="Kv1.6; MK1.6"
                     /coded_by="NM_001410072.1:724..2313"
                     /db_xref="GeneID:16494"
                     /db_xref="MGI:MGI:96663"
ORIGIN      
        1 mrseksltla apgevrgpeg eqqdagefqe aeggggccss erlvinisgl rfetqlrtls
       61 lfpdtllgdp grrvrffdpl rneyffdrnr psfdailyyy qsggrlrrpv nvpldifmee
      121 irfyqlgeea laafredegc lpeggedekp lpsqpfqrqv wllfeypess gpargiaivs
      181 vlvilisivi fcletlpqfr adgrggsneg sgtrlspasr sheeededed syafpgsips
      241 gglgtggtss lstlggsfft dpfflvetlc ivwftfellv rfsacpskaa ffrnimniid
      301 lvaifpyfit lgtelvqrhe qqsvsggsgq ngqqamslai lrvirlvrvf rifklsrhsk
      361 glqilgktlq asmrelglli fflfigvilf ssavyfaead dvdslfpsip dafwwavvtm
      421 ttvgygdmyp mtvggkivgs lcaiagvlti alpvpvivsn fnyfyhrete qeeqgqythv
      481 tcgqptpdlk atdnglgkpd faeasrerrp sylptphray aekrmltev
//
