LOCUS       NM_021275               4844 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus potassium voltage-gated channel, shaker-related
            subfamily, member 4 (Kcna4), mRNA.
ACCESSION   NM_021275
VERSION     NM_021275.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4844)
  AUTHORS   Li,Y., Wang,J.Z., Deng,Y.M., Wang,K., Yang,L. and Long,C.
  TITLE     Amyloid-beta Protein Precursor Regulates Electrophysiological
            Properties in the Hippocampus via Altered Kv1.4 Expression and
            Function in Mice
  JOURNAL   J Alzheimers Dis 92 (4), 1241-1256 (2023)
   PUBMED   36872774
  REMARK    GeneRIF: Amyloid-beta Protein Precursor Regulates
            Electrophysiological Properties in the Hippocampus via Altered
            Kv1.4 Expression and Function in Mice.
REFERENCE   2  (bases 1 to 4844)
  AUTHORS   Gonzalez-Alvarado,M.N., Rotger,C., Berger,L., London,B., Haase,S.,
            Kuhbandner,K., Lee,D.H. and Linker,R.A.
  TITLE     Functional role of endogenous Kv1.4 in experimental demyelination
  JOURNAL   J Neuroimmunol 343, 577227 (2020)
   PUBMED   32247877
  REMARK    GeneRIF: Functional role of endogenous Kv1.4 in experimental
            demyelination.
REFERENCE   3  (bases 1 to 4844)
  AUTHORS   Toib,A., Zhang,C., Borghetti,G., Zhang,X., Wallner,M., Yang,Y.,
            Troupes,C.D., Kubo,H., Sharp,T.E., Feldsott,E., Berretta,R.M.,
            Zalavadia,N., Trappanese,D.M., Harper,S., Gross,P., Chen,X.,
            Mohsin,S. and Houser,S.R.
  TITLE     Remodeling of repolarization and arrhythmia susceptibility in a
            myosin-binding protein C knockout mouse model
  JOURNAL   Am J Physiol Heart Circ Physiol 313 (3), H620-H630 (2017)
   PUBMED   28646025
REFERENCE   4  (bases 1 to 4844)
  AUTHORS   Li,J., Zhang,W., Yang,H., Howrigan,D.P., Wilkinson,B., Souaiaia,T.,
            Evgrafov,O.V., Genovese,G., Clementel,V.A., Tudor,J.C., Abel,T.,
            Knowles,J.A., Neale,B.M., Wang,K., Sun,F. and Coba,M.P.
  TITLE     Spatiotemporal profile of postsynaptic interactomes integrates
            components of complex brain disorders
  JOURNAL   Nat Neurosci 20 (8), 1150-1161 (2017)
   PUBMED   28671696
REFERENCE   5  (bases 1 to 4844)
  AUTHORS   Kim,G.E., Ross,J.L., Xie,C., Su,K.N., Zaha,V.G., Wu,X., Palmeri,M.,
            Ashraf,M., Akar,J.G., Russell,K.S., Akar,F.G. and Young,L.H.
  TITLE     LKB1 deletion causes early changes in atrial channel expression and
            electrophysiology prior to atrial fibrillation
  JOURNAL   Cardiovasc Res 108 (1), 197-208 (2015)
   PUBMED   26378152
REFERENCE   6  (bases 1 to 4844)
  AUTHORS   Wymore,R.S., Negulescu,D., Kinoshita,K., Kalman,K., Aiyar,J.,
            Gutman,G.A. and Chandy,K.G.
  TITLE     Characterization of the transcription unit of mouse Kv1.4, a
            voltage-gated potassium channel gene
  JOURNAL   J Biol Chem 271 (26), 15629-15634 (1996)
   PUBMED   8663090
REFERENCE   7  (bases 1 to 4844)
  AUTHORS   Marine,J.C., Gilbert,D.J., Bellefroid,E.J., Martial,J.A.,
            Ihle,J.N., Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of fifteen unique mouse KRAB-containing zinc
            finger loci
  JOURNAL   Mamm Genome 7 (6), 413-416 (1996)
   PUBMED   8662221
REFERENCE   8  (bases 1 to 4844)
  AUTHORS   Wymore,R.S., Korenberg,J.R., Kinoshita,K.D., Aiyar,J., Coyne,C.,
            Chen,X.N., Hustad,C.M., Copeland,N.G., Gutman,G.A., Jenkins,N.A. et
            al.
  TITLE     Genomic organization, nucleotide sequence, biophysical properties,
            and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4
            to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to
            mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13
  JOURNAL   Genomics 20 (2), 191-202 (1994)
   PUBMED   8020965
REFERENCE   9  (bases 1 to 4844)
  AUTHORS   Klocke,R., Roberds,S.L., Tamkun,M.M., Gronemeier,M., Augustin,A.,
            Albrecht,B., Pongs,O. and Jockusch,H.
  TITLE     Chromosomal mapping in the mouse of eight K(+)-channel genes
            representing the four Shaker-like subfamilies Shaker, Shab, Shaw,
            and Shal
  JOURNAL   Genomics 18 (3), 568-574 (1993)
   PUBMED   7905852
REFERENCE   10 (bases 1 to 4844)
  AUTHORS   Lesage,F., Attali,B., Lazdunski,M. and Barhanin,J.
  TITLE     Developmental expression of voltage-sensitive K+ channels in mouse
            skeletal muscle and C2C12 cells
  JOURNAL   FEBS Lett 310 (2), 162-166 (1992)
   PUBMED   1383027
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX293548.5.
            
            [WARNING] On Jul 16, 2024 this sequence was replaced by
            NM_021275.5.
            
            On Mar 23, 2010 this sequence version replaced NM_021275.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036112.1, SRR9219379.49594.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-483               BX293548.5         124997-125479       c
            484-4844            BX293548.5         117564-121924       c
FEATURES             Location/Qualifiers
     source          1..4844
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 56.12 cM"
     gene            1..4844
                     /gene="Kcna4"
                     /gene_synonym="Kv1.4"
                     /note="potassium voltage-gated channel, shaker-related
                     subfamily, member 4"
                     /db_xref="GeneID:16492"
                     /db_xref="MGI:MGI:96661"
     exon            1..483
                     /gene="Kcna4"
                     /gene_synonym="Kv1.4"
                     /inference="alignment:Splign:2.1.0"
     exon            484..4844
                     /gene="Kcna4"
                     /gene_synonym="Kv1.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3391..3396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcna4"
                     /gene_synonym="Kv1.4"
                     /note="hexamer: AATAAA"
     polyA_site      3430
                     /gene="Kcna4"
                     /gene_synonym="Kv1.4"
     regulatory      4377..4382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcna4"
                     /gene_synonym="Kv1.4"
                     /note="hexamer: ATTAAA"
     regulatory      4388..4393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcna4"
                     /gene_synonym="Kv1.4"
                     /note="hexamer: AACAAA"
     polyA_site      4394
                     /gene="Kcna4"
                     /gene_synonym="Kv1.4"
                     /note="major polyA site"
     polyA_site      4406
                     /gene="Kcna4"
                     /gene_synonym="Kv1.4"
ORIGIN      
        1 gcccccgccc gtgcgcgctg gcagcctggg gaggcgtgtg ctgctcctgc agccagctag
       61 agagcaagac tgggatggat actggagaag gaatgcaggc ttaacaagtg atcgctgctg
      121 tctaggattt tgagtctttt tcggagaacc ttgacttccg ttcccagccc atgtctgctg
      181 tgccgaactc cagaggaacc agaaatctcc ggggtctacc ttggggcgtc cccaatctcc
      241 acctctgggc tccagtaacg aggactctgc aataccccct agccccctgg ccaagacaac
      301 cgaacttgtt ccgtggatat ttgggatcct ccacctgcca aacctgagcg attttttttg
      361 tactgcgccc ccacccccaa tgattctgcc cctcctccag ctgttgcagc gtggaaaagg
      421 ggaaacaaat caccgggggg gatttttttc gtctattttt atttttcgca cttgctggga
      481 atggtgaagt gcttcttgtg aatgattcta gccaaaggat gctcttcatt tcctgctttc
      541 tatggagacc tcagtgttga gtttgcctct gctggaactg cgtctaccac cttctctacc
      601 ttccaaggtc tttgcctcta tctacaacct ggcattgtct gtgggtccat gaaggcttgg
      661 atgaccttag agggaaggtc tgggagtcca ccctcataga ctaagcagca atggctgggc
      721 atattttaag ccgcatttta acatgggtca agccatcagt agaaggcaag tgctaagact
      781 aaagacttat ttgaatttta tttaaattag atggactggg ccttggccaa tttccatgca
      841 agaaaaagta tatttcattt tctaggcaca acttctgagt gtcagatact tgctgtcttt
      901 gagtcttgtg gcgtcatcac cggacagcat cccagacaga cttccagatt tgaacatcta
      961 ccccccaaca cgtaggtgta tgggagacca catcatttca tgacttatgt ttgaggaaca
     1021 ctaggctgtt gtctagacga ggcaagctct ggaaagcaac gccgagtctc tgagaagagg
     1081 gagcataggc tgtgctgatt taaaaacaga aaatgcaaag ttggactgaa aatatcccac
     1141 gtcttctaag caatctgctt aaggcttcca aacttacctt aatttggtaa gaaaataagc
     1201 tgccctattt ttctttcttc ttctcttaca actggaagca gccatttccc caaaccacca
     1261 ccatggaagt ggcgatggtg agtgccgaga gctcagggtg caacagccat atgccttatg
     1321 gttatgcagc ccaggccagg gcccgagagc gggagagact cgctcactcc agggcagctg
     1381 cagctgctgc tgtcgcagct gccacggctg ctgtcgaagg cactgggggt tctggtggag
     1441 gcccccacca ccatcatcag acacgtgggg cctactcctc ccatgatcct caaggtagcc
     1501 gtggaagtag aaggaggagg cgtcagcgaa ctgagaagaa gaaactccac cacaggcaga
     1561 gcagttttcc tcattgctca gacctgatgc ccagtggctc tgaagagaag atcctgaggg
     1621 agctaagcga ggaagaggaa gacgaggagg aggaagagga ggaggaggag gagggaaggt
     1681 tttactatag tgaagaagac catggggatg ggtgttcgta cacagacctg ctgccacagg
     1741 atgatggggg tggtggcggc tacagttcag tccgctatag tgactgctgt gaacgtgtgg
     1801 tgataaatgt gtctggtcta cgcttcgaaa cccaaatgaa aactttggcc cagtttccag
     1861 aaactctgtt gggagaccct gagaagagga ctcagtactt cgaccctttg cgcaatgagt
     1921 atttttttga tcggaaccga cccagctttg atgccatttt gtattattac cagtcaggag
     1981 gccgcctgaa gagaccagtc aatgtcccct ttgatatctt caccgaggag gtgaagttct
     2041 atcagttggg agaggaagcc ctgctcaagt tccgggagga tgagggcttt gtgagagaag
     2101 aggaggacag ggctctgcca gaaaatgaat ttaaaaaaca gatttggctt ctctttgaat
     2161 atccagagag ttctagccct gccaggggta tagccattgt gtctgtcctg gtcatcttaa
     2221 tctctattgt catattttgc ctggaaacct tgccggagtt cagggatgat agggacctta
     2281 ttatggccct cagtgcaggc gggcacagca gattgctgaa tgacacctcg gcaccccacc
     2341 tggagaactc agggcacaca atattcaatg accctttctt catcgtggag acagtgtgta
     2401 ttgtgtggtt ttcctttgag tttgtggttc gatgctttgc ttgtcccagc caagcactct
     2461 tcttcaaaaa catcatgaac atcattgata tcgtctccat tttgccttac ttcatcactc
     2521 tgggcactga cctggcccaa cagcaggggg gtggcaatgg ccagcagcag caggccatgt
     2581 cctttgccat ccttaggatc attcgtctgg tccgagtatt ccggatcttc aagctctcca
     2641 gacactccaa aggcctgcag atcctgggcc acaccctaag agccagcatg cgggaactgg
     2701 gccttcttat ctttttcctc ttcatcgggg ttatcctctt ttccagcgct gtgtattttg
     2761 cagaggcgga tgaacccact acccatttcc aaagcattcc agatgcgttt tggtgggctg
     2821 tggtaaccat gacaactgtg ggctatgggg acatgaagcc catcacagtc gggggaaaga
     2881 ttgtggggtc cctgtgtgcc attgcgggtg tcttaaccat tgctttgcct gtgccggtga
     2941 ttgtgtctaa ctttaactat ttctaccaca gagagactga aaatgaagaa cagacccagc
     3001 tgacacaaaa cgcagtcagt tgtccatacc taccttctaa tttgctcaag aaatttcgga
     3061 gctccacttc ttcttccctg ggggacaagt cagagtatct agagatggaa gaaggggtca
     3121 aggaatcatt atgtggaaag gaggagaagt gtcagggaaa gggagatgag agcgagacag
     3181 ataaaaacaa ctgttctaat gcaaaggctg tggagactga tgtgtgaatt gttctctcca
     3241 cctgccactg tccccccatc tccaaatata ttcatacata gagaatgcag ttatgaaaat
     3301 gagatatgca aacgattgca ctgcatacag taatatgctg tttaatggta atacatggca
     3361 taattgtgac taaacgtgta ttgcatatca aataaatgat acatcttgga gaagagggag
     3421 gcattaaaaa cagcagatct atctttatat tttttaatag aatgcaagaa ttttgcacat
     3481 aatgggaaaa atgttaatag taaaggtggt tctgaggaga gtgagtgtgt gtgtgtgaga
     3541 gagcgagaga gtgtgtgtac ctgggtatgt aagtaaattg tcaacactgt tgggaattgt
     3601 gccgtgatgg aaaaagttgg cattctgaag tatttactat gtaagaacta atgaatttga
     3661 gcagtctttt accagtgttt taataacatc tcctatgtct ttggattctg tagttgtttt
     3721 ttagaaatta taagaattac tgtgtagaaa aaagagaaag taaattattt aatagaatat
     3781 aggtcacaat ttaatcttgg atttaattaa agtttatttt taactggaaa ttaacttttg
     3841 aaaaggctgc aggggccttt agaaattgat tatattttat tattaatttt ggggagatat
     3901 aatagcaaat gcctaacatt ctggaggaaa tgtaacaagt tttgttcaca ggtcttaaaa
     3961 ctggattttt ttttcttttg cactactttc tatgccgaag cccgagagag acttcatact
     4021 atgaatgttt actaatgcac caatcagttc aatgacaatc attggaagaa tgggttcttc
     4081 gtctcattta ttgttctctt cctttcgtga gactaatggc cacacaaata acagcacatg
     4141 attcctgctt taaaatccga acaactcatc tacaaaggga ctatgaagta acgttcagca
     4201 gccgaatctt ttgaaattgg tttgttacga tgatgcttca gaaaccatac tattttcaat
     4261 actcttctgc cttttaagtc cagaataatt taaccaaagt tattgcatgc acagagagaa
     4321 ttcttggaga aataaggcac ccagcagcta cagcaattat ggcttaagat ctttttatta
     4381 aatatgcaac aaaatgctag atttaagtcc cttttgtgta tgtgtgtgtg tgtctgtgtg
     4441 tgtctgtgtg tgcagctgca aaaacaaaac agaacacgaa atgtggggat tcgcctcaaa
     4501 tgctaaagca ctctgctaaa tcagagttag ggaagaatgg ttttagagca tttggtttcc
     4561 caatggtcat tgtaaatcat tatcatcttt atcacagggg cttcctgagg attatacttc
     4621 catttacctc acaatagcta ttcttgagtt tggagtagga acaaggaatg caccacgaac
     4681 aactgtagca ccataaaata cagctcagaa cactcagtat aaacacatag gaggcattac
     4741 taaacaattc attaaaacaa aacaaaatct tctttataaa tggttgccct gagcattggg
     4801 aagaaatccc atgtccacta tttcagtcca tagcaaacgt gaac
//
