LOCUS       NM_008418               3738 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus potassium voltage-gated channel, shaker-related
            subfamily, member 3 (Kcna3), mRNA.
ACCESSION   NM_008418
VERSION     NM_008418.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3738)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3738)
  AUTHORS   Liu,L., Xu,W., Li,K., Hu,Y., Shen,L., Zhang,H. and Wang,Y.
  TITLE     Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell
            proliferation through JAK2/STAT3 signaling pathway
  JOURNAL   Arch Biochem Biophys 746, 109719 (2023)
   PUBMED   37591369
  REMARK    GeneRIF: Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell
            proliferation through JAK2/STAT3 signaling pathway.
REFERENCE   3  (bases 1 to 3738)
  AUTHORS   Huffstetler,C.M., Cochran,B., May,C.A., Maykut,N., Silver,C.R.,
            Cedeno,C., Franck,E., Cox,A. and Fadool,D.A.
  TITLE     Single cannabidiol administration affects anxiety-, obsessive
            compulsive-, object memory-, and attention-like behaviors in mice
            in a sex and concentration dependent manner
  JOURNAL   Pharmacol Biochem Behav 222, 173498 (2023)
   PUBMED   36455670
REFERENCE   4  (bases 1 to 3738)
  AUTHORS   Zhang,Q., Liu,L., Hu,Y., Shen,L., Li,L. and Wang,Y.
  TITLE     Kv1.3 Channel Is Involved In Ox-LDL-induced Macrophage Inflammation
            Via ERK/NF-kappaB signaling pathway
  JOURNAL   Arch Biochem Biophys 730, 109394 (2022)
   PUBMED   36100082
  REMARK    GeneRIF: Kv1.3 Channel Is Involved In Ox-LDL-induced Macrophage
            Inflammation Via ERK/NF-kappaB signaling pathway.
REFERENCE   5  (bases 1 to 3738)
  AUTHORS   Kolling,L.J., Tatti,R., Lowry,T., Loeven,A.M., Fadool,J.M. and
            Fadool,D.A.
  TITLE     Modulating the Excitability of Olfactory Output Neurons Affects
            Whole-Body Metabolism
  JOURNAL   J Neurosci 42 (30), 5966-5990 (2022)
   PUBMED   35710623
REFERENCE   6  (bases 1 to 3738)
  AUTHORS   Folander,K., Douglass,J. and Swanson,R.
  TITLE     Confirmation of the assignment of the gene encoding Kv1.3, a
            voltage-gated potassium channel (KCNA3) to the proximal short arm
            of human chromosome 1
  JOURNAL   Genomics 23 (1), 295-296 (1994)
   PUBMED   7829094
REFERENCE   7  (bases 1 to 3738)
  AUTHORS   Lesage,F., Attali,B., Lazdunski,M. and Barhanin,J.
  TITLE     Developmental expression of voltage-sensitive K+ channels in mouse
            skeletal muscle and C2C12 cells
  JOURNAL   FEBS Lett 310 (2), 162-166 (1992)
   PUBMED   1383027
REFERENCE   8  (bases 1 to 3738)
  AUTHORS   Grissmer,S., Dethlefs,B., Wasmuth,J.J., Goldin,A.L., Gutman,G.A.,
            Cahalan,M.D. and Chandy,K.G.
  TITLE     Expression and chromosomal localization of a lymphocyte K+ channel
            gene
  JOURNAL   Proc Natl Acad Sci U S A 87 (23), 9411-9415 (1990)
   PUBMED   2251283
REFERENCE   9  (bases 1 to 3738)
  AUTHORS   Wei,A., Covarrubias,M., Butler,A., Baker,K., Pak,M. and Salkoff,L.
  TITLE     K+ current diversity is produced by an extended gene family
            conserved in Drosophila and mouse
  JOURNAL   Science 248 (4955), 599-603 (1990)
   PUBMED   2333511
REFERENCE   10 (bases 1 to 3738)
  AUTHORS   Chandy,K.G., Williams,C.B., Spencer,R.H., Aguilar,B.A.,
            Ghanshani,S., Tempel,B.L. and Gutman,G.A.
  TITLE     A family of three mouse potassium channel genes with intronless
            coding regions
  JOURNAL   Science 247 (4945), 973-975 (1990)
   PUBMED   2305265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121825.3.
            
            On Oct 3, 2022 this sequence version replaced NM_008418.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR13422601.1175846.1, BC137667.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3738              AC121825.3         17160-20897
FEATURES             Location/Qualifiers
     source          1..3738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.59 cM"
     gene            1..3738
                     /gene="Kcna3"
                     /gene_synonym="Kca1-3; Kv1.3; Mk-3"
                     /note="potassium voltage-gated channel, shaker-related
                     subfamily, member 3"
                     /db_xref="GeneID:16491"
                     /db_xref="MGI:MGI:96660"
     exon            1..3738
                     /gene="Kcna3"
                     /gene_synonym="Kca1-3; Kv1.3; Mk-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1840
                     /gene="Kcna3"
                     /gene_synonym="Kca1-3; Kv1.3; Mk-3"
                     /note="MK3; voltage-gated potassium channel subunit Kv1.3;
                     Voltage-gated potassium channel protein Kv1.3 (RGK5)
                     (RCK3) (KV3)"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 3"
                     /protein_id="NP_032444.2"
                     /db_xref="CCDS:CCDS17730.1"
                     /db_xref="GeneID:16491"
                     /db_xref="MGI:MGI:96660"
                     /translation="MTVVPGDHLLEPEAAGGGGGDPPQGGCGSGGGGGGCDRYEPLPP
                     ALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFF
                     DRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREE
                     ERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDY
                     PASPSQDVFEAANNSTSGAPSGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATF
                     SRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHS
                     KGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAV
                     VTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQA
                     QYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTAT
                     CTTNNNPNSCVNIKKIFTDV"
     regulatory      3712..3717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcna3"
                     /gene_synonym="Kca1-3; Kv1.3; Mk-3"
                     /note="hexamer: AATAAA"
     polyA_site      3738
                     /gene="Kcna3"
                     /gene_synonym="Kca1-3; Kv1.3; Mk-3"
                     /note="major polyA site"
ORIGIN      
        1 agacagagcc tcgcggcagc cgcagcaaca ggcggcgggg ccgggctcgt agggcagagg
       61 cggcggtggg gcggggagct ccaggaggag cgactcgggc cggcagccgc cagcagggaa
      121 ggaaagcacc gccgcctccc gcgctcgacc gccgcagccc tccacccatc accgcgccca
      181 ccctgcaccg gaccccgcag gaggcggcgc gcgcatcctg cagagccccg gccacgccga
      241 gctgccgcca gacatgaccg tggtgcccgg ggaccacctg ctggagccag aggcggcggg
      301 aggcggtggc ggggacccgc ctcagggagg ctgtggcagt ggcggcggcg gtggcggctg
      361 cgaccgctac gagccactgc cacccgcgct gcccgccgcg ggcgagcaag attgctgcgg
      421 cgagcgtgtg gtcatcaaca tctctgggct gcgcttcgag acgcagctca agaccctctg
      481 ccagttcccc gagacactgc tgggcgaccc caagcggcgc atgcggtact ttgacccact
      541 ccgcaatgag tacttcttcg accgcaaccg acccagcttc gacgccatcc tctactacta
      601 ccagtccggg ggccgcattc gccggccggt caacgtgccc atcgacatct tctccgagga
      661 gatccgcttt taccagctgg gtgaggaggc catggaaaag ttccgtgagg atgagggctt
      721 cctgcgggag gaggagcgac ccctgccccg ccgtgacttc cagcgccagg tgtggctgct
      781 cttcgaatat ccggagagct ccgggccggc ccggggcatt gccattgtgt cagtgctggt
      841 cattctcatc tccattgtca tcttctgctt ggagacgctt cccgagtttc gcgatgagaa
      901 agactatccc gcctccccgt cgcaggacgt gtttgaggct gccaacaaca gcacgtcggg
      961 ggccccttct ggagcctcca gcttctcgga ccccttcttc gtggtggaga ccttgtgcat
     1021 catctggttc tcctttgagc ttctggtgcg gttctttgct tgccccagta aagccacctt
     1081 ctccagaaat atcatgaact tgatagacat tgtggccatc attccttatt ttatcactct
     1141 gggcactgag ctggctgaac gacaaggtaa tgggcagcag gccatgtcgc tggccatcct
     1201 gagagtcatc cgcctagtaa gggttttccg catcttcaag ctctcccgcc attctaaggg
     1261 gctgcagatc ctaggacaga cgctgaaggc ttccatgcgg gagctggggc tgctcatatt
     1321 cttcctcttc attggggtca tccttttctc cagtgcagtc tactttgctg aggcagacga
     1381 cccttcttcg ggttttaaca gtatcccgga tgccttctgg tgggcagtag taaccatgac
     1441 aactgttggt tatggtgata tgcacccagt gaccatagga ggcaagattg tgggctctct
     1501 ttgtgccatc gcaggtgtct tgaccattgc attgccagtt cctgtgattg tttccaactt
     1561 caactacttc taccaccggg agacagaagg ggaagagcaa gcccagtaca tgcacgtggg
     1621 cagttgccag cacctctcct cttcagccga ggagctccga aaagcccgga gtaactccac
     1681 tctgagtaag tcggagtata tggtgatcga agaggggggt atgaaccaca gcgccttccc
     1741 gcagaccccc ttcaaaacgg gcaactccac agccacttgc accacgaaca ataaccccaa
     1801 ctcctgtgtc aacatcaaga agatattcac tgatgtctaa tatatgatac ggttgccaat
     1861 tctgtgccca gtattgtgtg gaacatgccc ccttggtctg tgtatgccct tgatttatac
     1921 atttccagac cactcatcaa ggaaagtaca agaagtgagg aagcacactt cattctccct
     1981 attgcttcat actgaaacag gtgcctgttt ttgcaagtgg gctgcattct ctcagctctt
     2041 tttttctctc tctccctgtc tcttaatttt gtgaccaaca aacttacatt aagcgtggtt
     2101 tttttgtgtg agccctacag ccacatcctg agaggaagtg aaactataga gtcagagtaa
     2161 ctgtttaacc tcaaaatcaa aagatagttg tttctttact aagtaaagga ggcggaacct
     2221 aaatgaagct cctgactggt ggacttttca atattatttc cggactagtt attgtaacta
     2281 cctaacctct ggatatgtgg gtggaaagtc taactagagc gttgacgcgt aagcccacta
     2341 taaatttatt ttgtttttga ctgatctttc agtttgaatc tctcccctaa ggacttaagg
     2401 ttcacaataa ttttgaacca aaagggaaat gccccgaatg tcctgatctg gctattaact
     2461 cttcaaagtt tgcaaagcat tttgaaaaca ttagacacag attccaatga agttgtgagt
     2521 tcatgcccca gccaatatct acgaaagtct agaaactcat tttcagtgct gccgggagaa
     2581 acaacagaaa ttcctgatgc atccgagaga taagcttctg cagtatcaca ggaagattaa
     2641 agtgtcagac accccttcca gcggaagtta ctaattcgga cctgactgat gcagttccca
     2701 tagcaacccg tgtttcctgg gaaacccgaa aaaggttgtc atggcatctt ttgctctcta
     2761 gccccacccc caccccaggc cctgccgttt ctacagtaac ctttccagat ggttcctact
     2821 tacatgattt cataagaaaa aaacactatt tgaataaacc acacaaatta agtgtaagac
     2881 tatatagagg ttaaatgaat cacaaaatgc ttttttacat tttatataaa tcattgctgt
     2941 tatcccataa tgactggatc aaaaaggaaa ttatcatctt tggaacgtta cacgtaaggc
     3001 atgatctgaa ttaaatgtca gttgtttggt agcaattttt aaagatggtt ctgtacagtt
     3061 ttcattaaga aatggcaagc caacagataa aatgagaaca acaatataaa catggtctgt
     3121 acataagcca gtgagagtca gtgtacccaa agtattacta caagatacct tcagagttcc
     3181 tcaatttaaa agaaaaaaaa gaaaaagaaa aacatccaga tcccacaaca ggactgtcac
     3241 catcacagca ctggaaaagc agaatcaacc tcaaacatat ggaggatgca caatttaatg
     3301 agtggattac aaaaaggagg ttcaggaaat gatcagactt gaaagaacac ctgcaagtta
     3361 cagccacatg ctgagagctg ccagcagaca gacagaatca ggtgagccct gtcctatgtg
     3421 atccctacaa gtagtctatt gtgcagggaa ccagggacat ttctgttcat aactaggttt
     3481 atatttgcaa agcagacagt tttatattac atgccagttg cctttagaaa gattaagaaa
     3541 ttcttcccat tttccccatg tttctggtta tcttttggtt tccatgttta tggcaaaggg
     3601 atgcagaaaa ttcccctctg agcagctttc tcccaagctg aactgaaaag tactccattg
     3661 ctttaaccaa ccctcttggc ttctgaacaa tttgtttccc cctttaaact gaataaaagg
     3721 caaatgctac aactgcta
//
