LOCUS       NM_008417              11582 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus potassium voltage-gated channel, shaker-related
            subfamily, member 2 (Kcna2), mRNA.
ACCESSION   NM_008417
VERSION     NM_008417.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11582)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 11582)
  AUTHORS   Liang,Y., Sharma,D., Wang,B., Wang,H., Feng,X., Ma,R., Berkman,T.,
            Char,S., Bekker,A. and Tao,Y.X.
  TITLE     Transcription factor EBF1 mitigates neuropathic pain by rescuing
            Kv1.2 expression in primary sensory neurons
  JOURNAL   Transl Res 263, 15-27 (2024)
   PUBMED   37607607
  REMARK    GeneRIF: Transcription factor EBF1 mitigates neuropathic pain by
            rescuing Kv1.2 expression in primary sensory neurons.
REFERENCE   3  (bases 1 to 11582)
  AUTHORS   Oh,H., Lee,S., Oh,Y., Kim,S., Kim,Y.S., Yang,Y., Choi,W., Yoo,Y.E.,
            Cho,H., Lee,S., Yang,E., Koh,W., Won,W., Kim,R., Lee,C.J., Kim,H.,
            Kang,H., Kim,J.Y., Ku,T., Paik,S.B. and Kim,E.
  TITLE     Kv7/KCNQ potassium channels in cortical hyperexcitability and
            juvenile seizure-related death in Ank2-mutant mice
  JOURNAL   Nat Commun 14 (1), 3547 (2023)
   PUBMED   37321992
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11582)
  AUTHORS   Cifuentes-Diaz,C., Canali,G., Garcia,M., Druart,M., Manett,T.,
            Savariradjane,M., Guillaume,C., Le Magueresse,C. and Goutebroze,L.
  TITLE     Differential impacts of Cntnap2 heterozygosity and Cntnap2 null
            homozygosity on axon and myelinated fiber development in mouse
  JOURNAL   Front Neurosci 17, 1100121 (2023)
   PUBMED   36793543
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11582)
  AUTHORS   Eom,K., Lee,H.R., Hyun,J.H., An,H., Lee,Y.S., Ho,W.K. and Lee,S.H.
  TITLE     Gradual decorrelation of CA3 ensembles associated with contextual
            discrimination learning is impaired by Kv1.2 insufficiency
  JOURNAL   Hippocampus 32 (3), 193-216 (2022)
   PUBMED   34964210
  REMARK    Erratum:[Hippocampus. 2024 Sep;34(9):504. doi: 10.1002/hipo.23627..
            PMID: 39091150]
REFERENCE   6  (bases 1 to 11582)
  AUTHORS   Lesage,F., Attali,B., Lazdunski,M. and Barhanin,J.
  TITLE     Developmental expression of voltage-sensitive K+ channels in mouse
            skeletal muscle and C2C12 cells
  JOURNAL   FEBS Lett 310 (2), 162-166 (1992)
   PUBMED   1383027
REFERENCE   7  (bases 1 to 11582)
  AUTHORS   Migeon,M.B., Street,V.A., Demas,V.P. and Tempel,B.L.
  TITLE     Cloning, sequence and chromosomal localization of MK6, a murine
            potassium channel gene
  JOURNAL   Epilepsy Res Suppl 9, 173-80 (1992)
   PUBMED   1285906
REFERENCE   8  (bases 1 to 11582)
  AUTHORS   Wei,A., Covarrubias,M., Butler,A., Baker,K., Pak,M. and Salkoff,L.
  TITLE     K+ current diversity is produced by an extended gene family
            conserved in Drosophila and mouse
  JOURNAL   Science 248 (4955), 599-603 (1990)
   PUBMED   2333511
REFERENCE   9  (bases 1 to 11582)
  AUTHORS   Betsholtz,C., Baumann,A., Kenna,S., Ashcroft,F.M., Ashcroft,S.J.,
            Berggren,P.O., Grupe,A., Pongs,O., Rorsman,P., Sandblom,J. et al.
  TITLE     Expression of voltage-gated K+ channels in insulin-producing cells.
            Analysis by polymerase chain reaction
  JOURNAL   FEBS Lett 263 (1), 121-126 (1990)
   PUBMED   1691985
REFERENCE   10 (bases 1 to 11582)
  AUTHORS   Chandy,K.G., Williams,C.B., Spencer,R.H., Aguilar,B.A.,
            Ghanshani,S., Tempel,B.L. and Gutman,G.A.
  TITLE     A family of three mouse potassium channel genes with intronless
            coding regions
  JOURNAL   Science 247 (4945), 973-975 (1990)
   PUBMED   2305265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044342.1, AC121825.3 and AI607461.1.
            
            On Jan 21, 2012 this sequence version replaced NM_008417.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044342.1, ERR3363660.2153505.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AK044342.1         2-319
            319-319             AC121825.3         84299-84299
            320-608             AK044342.1         321-609
            609-11558           AC121825.3         85022-95971
            11559-11582         AI607461.1         3-26                c
FEATURES             Location/Qualifiers
     source          1..11582
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.61 cM"
     gene            1..11582
                     /gene="Kcna2"
                     /gene_synonym="Akr6a4; Gm10672; Kca1-2; Kv1.2; Mk-2"
                     /note="potassium voltage-gated channel, shaker-related
                     subfamily, member 2"
                     /db_xref="GeneID:16490"
                     /db_xref="MGI:MGI:96659"
     exon            1..193
                     /gene="Kcna2"
                     /gene_synonym="Akr6a4; Gm10672; Kca1-2; Kv1.2; Mk-2"
                     /inference="alignment:Splign:2.1.0"
     exon            194..521
                     /gene="Kcna2"
                     /gene_synonym="Akr6a4; Gm10672; Kca1-2; Kv1.2; Mk-2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..11582
                     /gene="Kcna2"
                     /gene_synonym="Akr6a4; Gm10672; Kca1-2; Kv1.2; Mk-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             682..2181
                     /gene="Kcna2"
                     /gene_synonym="Akr6a4; Gm10672; Kca1-2; Kv1.2; Mk-2"
                     /note="MK2; voltage-gated potassium channel subunit Kv1.2"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 2"
                     /protein_id="NP_032443.3"
                     /db_xref="CCDS:CCDS17733.1"
                     /db_xref="GeneID:16490"
                     /db_xref="MGI:MGI:96659"
                     /translation="MTVATGDPVDEAAALPGHPQDTYDPEADHECCERVVINISGLRF
                     ETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV
                     NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSG
                     PARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGGGVTFHTYSNSTIGYQQSTSF
                     TDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAE
                     KPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFF
                     LFIGVILFSSAVYFAEADERDSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGS
                     LCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSA
                     STISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV"
     regulatory      4299..4304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcna2"
                     /gene_synonym="Akr6a4; Gm10672; Kca1-2; Kv1.2; Mk-2"
                     /note="hexamer: AATAAG"
     polyA_site      4326
                     /gene="Kcna2"
                     /gene_synonym="Akr6a4; Gm10672; Kca1-2; Kv1.2; Mk-2"
                     /note="major polyA site"
     regulatory      11563..11568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcna2"
                     /gene_synonym="Akr6a4; Gm10672; Kca1-2; Kv1.2; Mk-2"
                     /note="hexamer: AATAAA"
     polyA_site      11582
                     /gene="Kcna2"
                     /gene_synonym="Akr6a4; Gm10672; Kca1-2; Kv1.2; Mk-2"
ORIGIN      
        1 gtggcgcggt gcggcgcggt gcggctgcgg gcggcggccg ggcgctccgt acgcgccgcc
       61 cgcgggactg cagagtcggc tcccggctgg ccgcccgcac cccgccgcca ccaccgccac
      121 cgcccgctgt ccgggttctg cctgtgctgg ctgccaccca ggaacatgga ggctctggta
      181 cccatctgca agggcaacgt cacacctccg gaggacagcc aggaggactc aggcttttgc
      241 tgagctgtgc atcttgcctc cttccttcca aaggcttcag acccaagctc cactctcctc
      301 ctcaagtcgt ggtgcgcgcc cctggccaag catctcactg tccctcgagc cccatccagt
      361 cctagagcac acctccagga cctgccctcc tgctcagaat gactcaccat tatttccagc
      421 tcaagtgaga agatgtgacg gggactgagc tgcctatttg tgtatctgtg ccatcagatc
      481 tgctcttcga agaagagtac ctcaggctcc tgcctggcca gccgagtggg gctgtgtctc
      541 caactcacaa agggctctgg ggctttcctg cagaagctca gacttatgct tctgtgtttc
      601 ctggggccgt tatcagcacc gagttccctg ctgcaggcag ctggaaggca ttaaagtaaa
      661 gcacacttct cagccccaat tatgacagtg gctaccggag acccagtgga cgaggctgct
      721 gccctccctg ggcacccaca agacacctat gacccagagg cagaccatga atgctgtgag
      781 agagtggtca tcaacatctc aggcctgcgg ttcgaaactc agctaaagac cttagcccag
      841 ttcccagaga ccctcttagg ggaccccaag aaacggatga ggtacttcga tcccctccga
      901 aatgagtact tttttgatcg caaccgccct agctttgatg ccattttgta ctactatcag
      961 tctgggggca ggttgaggcg acctgtgaac gtgcccttag atatcttctc ggaagaaatc
     1021 cggttttatg agctaggaga agaagcaatg gagatgtttc gggaggatga aggctacatc
     1081 aaggaagaag agcgtcctct gcctgaaaat gagtttcaga gacaggtgtg gcttctcttt
     1141 gaataccctg agagctcagg gcctgccagg attatagcca ttgtatctgt gatggtcatt
     1201 ctgatctcca tcgtcagctt ctgtctggaa accttgccca tcttccggga tgagaatgag
     1261 gacatgcatg gtggcggggt gaccttccac acctattcca acagcaccat cgggtaccag
     1321 cagtccacct ccttcaccga ccctttcttc attgtagaga ctctctgcat catctggttc
     1381 tcctttgagt ttctggttag attctttgcc tgtcccagca aagctggctt cttcaccaac
     1441 atcatgaaca tcattgacat tgtggctatc atcccttact ttatcaccct ggggacagag
     1501 ttagctgaga agccagagga cgcccagcaa ggccagcagg ccatgtcact ggccattctc
     1561 cgtgtcatcc ggttggtaag agtctttagg attttcaagt tgtccagaca ctccaaaggt
     1621 ctacagattc taggtcagac cctcaaagct agcatgaggg aattgggcct cctgatattc
     1681 ttcctcttca ttggggtcat cctcttctct agtgctgtct attttgcaga agctgatgag
     1741 agagattccc agttccccag catcccggat gctttctggt gggcagtcgt ctccatgaca
     1801 actgtaggct atggagacat ggttccaact accattgggg ggaagatagt gggttctctg
     1861 tgtgcaattg caggtgtgtt aaccattgcc ttaccagtcc ctgtcatagt gtctaatttc
     1921 aactacttct accaccggga gacagaggga gaggagcagg cccagtactt gcaagtgaca
     1981 agctgtccaa agatcccgtc ctcccctgac ctaaagaaaa gtagaagtgc ctctaccata
     2041 agtaagtctg attacatgga gatacaggag ggagttaaca acagcaatga ggactttaga
     2101 gaggagaact taaaaacagc caactgtacc ttggctaaca caaactatgt gaatattacc
     2161 aaaatgttaa ctgatgtctg attgaagcct actaatgtac tcacagctca acaggactga
     2221 tgcagatgtt gcataatagc ctgcattgta gtcagtgttc tacagtgttc tacagcatct
     2281 ggttctgcat ggaaagcaat agttcgtgca agtgactttt gatcttttga tttttgattt
     2341 agaacacaga atatttatca tggctttcat gaaatcttca tcaccgactt acaggtttcc
     2401 aaagaggaga gtcacccatg gagccagcat ctcagaaagg cacaatgcag ccccctcaca
     2461 cccacacaca acctaccata gcaacactat cctatcttcc tacctaaaca tgagcacacc
     2521 tgggaggtgc attccctcca ccccacccct accaccctat ttcagcccat ctgccccttc
     2581 acagaggaac ataccattgt ggcttagttc taaagtctgg tgactactca aaggtcattc
     2641 tcggttttgt gttgagaaga acacacagtc ctgtgtgttg gaactacttt ctgtgtcaca
     2701 ggctggggtt tgtgaattgc agttgccaac tagatgctcc ggaggcttat gtttcgtaac
     2761 ggaaaaatgc tgcattctgc tttttctctg cagtgtcgat gtgagggaag cccagggggg
     2821 tgggggaggg acagttaata tgaccaaata tgaattgcca agtttcacat ttgttccctt
     2881 aggcctatgg ggagaagcta cctaattcag ggacttctca gcttcagata ccattttgca
     2941 agcttcaggg tcaccgaatg tgtttgattt cttcttttac tctggagttt gcaagacatc
     3001 tgctttcctg gtggtgtggc ccagctccac tgacactgca gtggagtata ccagtcatgc
     3061 aatagaactg catgggtgtt cactgcatga atctcaatat ttaaaacaca ggagataacc
     3121 tattttccta gtagccgata cagtattcct acttagagta ttaatagcct tgggatggta
     3181 ttgaacaggg gtttttcaca tcaaaaggca aaagcccttc atcagggtaa aacaaataga
     3241 ctatttggaa tggggaacca aaacttctgg ctggccctct cagcccacct ctggtctttc
     3301 actgggaaca cagaccctgc cacaccagga gaataaacag aaaagtcaga gtgtaaacac
     3361 tcacatgact gaactttggg gattaatcta gtcgtgggca tgactacaca gcttaccagg
     3421 gtcctgaaga caggcaggtc tgtgggttca atgtatataa atatatatca gctctctctc
     3481 tctctctctc tctctctctc tctctctctc tctttctctc tctctctcgt gttcctctag
     3541 caagctatag aaaaaattgc atttgaacat tgtatatgct tatgcaatat cttgacacag
     3601 ggcaatttat gcatgtgttt gactatgtgc actagaatat atatatatat atatatatat
     3661 atatatatat atatatatat acatacacaa gtgtgtgtat atacattata catacacata
     3721 tatatatatt cattctctgg agttcagatt caggagcaga tctattactc ggtgggttgg
     3781 tggtgtaaga aacccaatgg gtacagtaaa cccactgggc ctgggtttgc tgtcattgcc
     3841 tcagacatgc tccagtgttc atggattcct agatattaga attgtctttc tgccctccat
     3901 gtgctgcagc ttcagtttcc cacggctgaa gcttgtctta ctgagtgcac aagggtccta
     3961 tagccctcac agctccagct atcctgggcc aggcccaccc aggcctcctc cctagaatcc
     4021 atcccattaa tcatctccat tattatcctc tgccccattt gattctctat catttggttc
     4081 tacatccatc attttcatga acctgtccat aggcggatcc tctgctttga aaccaaggag
     4141 taaaactcct tgggaccgga ttctgctaat ctacacttaa aggaagcctc ctattggtgg
     4201 aaatttccta attccagaac caagggatgg attccctaaa tgacccaaag catcattttg
     4261 attactaaac tcagactctc tctccctagc atactgataa taagagctgc cctttaaaaa
     4321 aagaaagaaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa ggaaggaagg
     4381 aaggaagaaa gaaagaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa
     4441 agagaaaaga aaagaaaaga aaagaaaaga aaagaaaaga aaaagaagga tgggtaaaga
     4501 attaatcctc accccaagaa caaataaaga atggatgagc actgtgcagc cttgaagtag
     4561 agagtgtgat gtgttgtccc taggaagaga gtggggaagg cctttgcttc cccatactgg
     4621 gtgtctttgc cttttaacac agtggcttaa attctcacaa acacaatgaa ctgtggtcag
     4681 gctgttcagt attgattcca gtctaggtct tgctgttcac tagatggtac ctacagttgt
     4741 ctttggggag ggggcaccag ctcagggtgc tagcccaggg tgctcattag ttcctggtca
     4801 cccatatccc caggtgactg cagggcatcc catgccaggc acaaagcctc tgtgcttctc
     4861 ttcttctcct ttgtgggagg tggtgctgaa tttcatgaca tggggtggaa gggacaaact
     4921 tgggatagta gaaggttaag gcaaaccata cataaggtct agaccaaggg aagttagtta
     4981 ttcacaaaag ccttggcctg ggaaccataa aatgtccaca cccatgcatg cacatgcatc
     5041 ataaaataaa tgatagatta ttgtcacata caaatataaa atacacagca cacatgcaaa
     5101 atgcacacca gccaaaataa tatgaggcat aggcagaaaa gatagacaaa gcatgtatat
     5161 gccgcataag catgcaatgt gcataccaac atagaatagc tgcaagagat atatttgccc
     5221 cgtgtgcaaa tgcacagcat gcaactcaga tgcaaaatat acaaatccaa ctgggggtcg
     5281 gggacaatgg atatacatgc aagttacata agtgatgctt tgttattgtt tctgcacaca
     5341 agctcagctt atatacacag tgcaccaaac tatgctaggt acaccaaaac aaaaaacaaa
     5401 aacaaaaaaa ataaataaac aaacagtacc catgcccatg aatccacaca aaatgtaggc
     5461 attgaatcat cattgactgc ctctgcttcc acatctaaaa attgataaat gaaggcaagg
     5521 gatcagattt aattgctttt ccttgcccat atcaatatcc ctcaatattc tccaaggagc
     5581 ctcttctttg gcatccaacc tcattcctga gacataactc ctgaggtttc aagtggaaag
     5641 atgtggcacc atatcgagca ctggaacctc tgggttttct acctttcgcc ttcctgcaag
     5701 aatccctcag ggtgaaagct gtgggaactg caagagctgg caacctcttg tgggctccct
     5761 tgctatccct tttctttcaa agaaaatcta cactgaggac ccgaactcct ctccaagtgt
     5821 ctgggatctc cagatttctc cctattgtct tgaagcagtg atggtccaag aaactatagg
     5881 attctgaacc ctgaatcagg ttgaaatgcc ccgattttct ttgagccaaa agatcttatt
     5941 aacactcttt ccaaagtagt gttgtctgga tccaggtcag aaagttggat ctatagactt
     6001 agctcttaaa atgctttcct tgctcgtggc atttcactta ctcttaggca tgagtccaat
     6061 gacgacaact cttgattcat tcaatctaga cttgttctcc ccttacttcc caacccaggc
     6121 tcccagggaa ctcaggcttc ccattcaagt gttgtgcctt gacaaaatcg cagaccagtt
     6181 tagctgaagt aaaatgtggt gggggacatt aatctacggc tagaggagca gttagcaatt
     6241 tttagagagc ctggtatttg tcttctattc taacactaaa tttaaatact tggcaatatt
     6301 acccaccatt acagagccca ggggcttcat cctgctagta ttaccagctg gggcctctgc
     6361 attttggcaa aggctttata caaaatagaa gttaaaagtt gcatccagtc ttggatcaag
     6421 ttttgtgggc tctgcttcta tatccctgag tatcttaacc ctctgttcag gcctctatag
     6481 aggaggcaat gagcagataa tggacatgtg gttcaaaact tgtacactta acacactgag
     6541 acttgagttt ccaaagcaag atatcaattt ccaccatagc ttcatgaggc ctctgtggcc
     6601 tcagacattt gtaaaagttg tagtttctgg gaggttggac aggaaagagt ccaggaaaag
     6661 tagagaaatt atcaggaaga aaaggcaaca gagctgttga atttcagagt aaatttatca
     6721 ggagccaagt tttcattgat taattaaaat taattcagga acccaaattt aatttagtta
     6781 tggctctgtg cctttctaga acttcagtgg tgtgttagag tcaagtctta gtgagaaaag
     6841 tcagagcttc tgaagatcct caggcaggga attcaatgct acccatagtc gtgggaagga
     6901 gttagaaaca catcttcccc agagaaaaac tatgggaagt acaaacaaca tgtggaggcc
     6961 atgaggggag tgcagtcctc tgacgtgtta gcctaggata gagggtgacc tcagagctct
     7021 tcctcttcca gtctgcatgg ggggaatggg atggctaagg cctgtgaggg ttctgatgtg
     7081 tagggtactc caggttacac aatagaggtt ccttttgata aagtgttcat catccaggtt
     7141 cgaactcatg cccttcactc attcacatca ttagctacct gagtcaacca ggtgtatatg
     7201 ctgggagctg tcttggtagt tatagtgacc attatttata ccctcagact tggcccttat
     7261 tgagaccagc acacacacac acacacacac acacacacac acacagagag agcagaaagc
     7321 agggaaggag aggtaaggga tcccttgcac actcctcagc taacctagtc tacttttccc
     7381 tcctttctgc tccccttttc cctaaaactc agctccatct ctcatagttt gtgtctaacg
     7441 ttcttaaaga ggaaatgtgc aataaaagca atagtgactg ttttctttag caatagctct
     7501 ttcaaaaatc ttgctctcag gactgaaaag tgatagatga tacatacatc atcagatacg
     7561 cccttgacct ctggacatct gttcacggtt tctgtacttc ttcttcctac atggtcatat
     7621 gaatgattcc tgtctgctga ggtccgacct ccctctggaa tgaacatata cacagaggtg
     7681 cagtgtgcac tcaaggaagg cccacaagaa ggctttcttt tgacattctg tcttcttttt
     7741 tcatatactt ttttcatgta cctctgtgtg tgtgtctgaa cccctctccc actgccttgc
     7801 ctttctacct tttcttcagc agtaccctag aaacctttag ggactgaaac ctcacatctg
     7861 agtgacctta tgccagcctg tcttgttgaa tttgtgtctg tctgtcaggt gtaatggaag
     7921 tctgtaggag agtgcttacc aatagataag aataaagcat cctgagccat tacagaagat
     7981 cttttccatg cactagaaac cattacttga ttctttcaca gccctctcca gggaaatgaa
     8041 taccaaggaa tgtagccatg gggtgtacgg atgggatcag ttactcaggc agagttggga
     8101 atcgccctct gactctcatt cacaataggc tgacttgagc aactagagag actccatcag
     8161 agcttcagag ctttgggtag aggtgaacag gcacagaggc atgggtcgtc aagggatatc
     8221 attagtgaaa taagccccac ctcccactac aggatgcacc tgtgcaaaaa tagtttttat
     8281 atttcccagg gttttggaaa ggaccccttt cttgaaacat ctgtgaggtg agctattaac
     8341 attcagactg gacaggaaag gctggcaacc ccaggagccc attccattcc ttctcaatct
     8401 actttgctcc acacaccttt gcatagccta acgttggaaa atctcaagga ggagggtgtc
     8461 ctggatgctt tgcgatcctg gttatttgag gagaaatggg aaaatgtgtg gttcagcctt
     8521 tgtgattgga aagtaggatt ccctcttgcc ttagttaagt aaagcattgg gaggtgacag
     8581 aagaccttgc atggctcaga gtcagccttc taaatctcag tgcttggtgc ctggaaacag
     8641 aggtgaagca gacaaaaagg acaggctgaa tgatgctagc taaagtagat ctggaagagg
     8701 gctaaagggc acggcgtggc atatcagatg ctgctgctcc taccacttgc cacttcctac
     8761 taaatgtata gaaagacagt ataattcttg tcaatcaagg ttttagtcca ttggtcctga
     8821 gttattagag gttttccata tatacatata cctgtgtata tatgtatagt atatgtatat
     8881 atgtatgcca ttatttcaaa aatcatccac aaataggcgg tgacaaatct cctcagtttc
     8941 actaatgtgg aatacatttg acattctaag gaatacgctg catttacttg aattttaaca
     9001 tgaccttctt tgcattcttt tcacctcccc agttctgctc ttttccgctt aaaaacttgt
     9061 ctagcaggca tttattcaaa caaaagaaca ggctcagggt cacctctttc ccttccctgc
     9121 cagagggaaa ggtcgattct tttcccttcc tgcctcaagg atcaaaggga atcgagatcc
     9181 cagggccagg tgctttctta gcctttattc tgtccgcctt ggttggctgt aacctaatct
     9241 ctaaagacta gaagagttat gcccaactct gtagctctag gggagtggga cactcagaga
     9301 cttggctcag cactggtcta tttagcttcc tcttggtcag tgttagagtc ctagggttgg
     9361 ctttcatgaa ttctgaaata tcctccatga aagggaggtg gggcggggat gggctttgtg
     9421 gcctttggta gaactaaatc acatgtagct gagtctgatc aaatgaaaga acagagggct
     9481 gggcctagag caactaaaac ccacttgtgt ctttggagat gagctgtaga ctgctgggtg
     9541 ggatcctaaa tatgccctcc attctgtctt gcctagcagt gttaaagtca tggggaaaca
     9601 cttttctagg cctcatcatc tcctttattc tgtgtgcact ttacttagaa gtgggtggga
     9661 gggattcctc actagtatct gaagcagttg aggtgataca ggggtggctg tcatttcccc
     9721 cacattccca gaagctcgac aatctggtca agtgagccat catccagtag gagaagcctt
     9781 taaccttgac tgagcgtgac cagccactaa gtgctgcggt tgaagcagcc tgtctctatg
     9841 gccatttctc gtcctgcatg agccctagca tggaaactaa tctaacttcc cgtgctcctc
     9901 ctcactccta aaatagtcag atatgttcca gctgagtgtg ccgctgagaa gcccttgcat
     9961 cattctcctg acggatgcat agggcaggtg tgattacata atactgtgga cagctgctgc
    10021 agcagctaca taattaaggg gagtagagaa gtggctgggt gataggacct taggtagtta
    10081 cccagaggac tatatgctgt gtctctgggt ccttgggaga ggcctccagg ccctgcttct
    10141 ccttgaaaat gactccctag acgcggctgc cttgtttgtc agactgcata aacactcggg
    10201 gatgcagaga aagaaaagga ggagcttagg ggagatgcta ttcaggggca tgcttggcta
    10261 gcagacaact accgtattag ccattaatgt gactgagttc tggacttaca aagtgtagag
    10321 actctgacct gccaagtgag gctaaaagga gcacacgagt tcaaggctaa gacctggaat
    10381 agaaaagcaa gaggagaggc ctggatggct ttggcaaggg tgagcctcag ctcctgagag
    10441 tttgaacatg ctccgtgctt gccccagttc tgccttcacg tgggagccgg cgacccagtt
    10501 tccttttgtt gtcgtgcttg gatggtttct tcatttgaag ggctccggga agctggaaag
    10561 gcccatgatt gagctccagc ctgctgagca aacaatgccc cagccaaatt ggcctcttcc
    10621 tgggtttctg cagtcatgca cccctctctc cactgagggt aatcttggaa cagccaggac
    10681 gaatggtgcc agaaagcaag gaggattctc ttgtttccat tacagacaga gctgtaaagc
    10741 tcataagtga gggctgttgt gtgcttatgt gcttattata taggctggag aacatatcta
    10801 tatataatat attgtatata ttatatatgt gtgtataaat atatatgttt atatttatac
    10861 acacactgtg gaaatggccg ctcacttagg ctcatgcagc acagactaat taggatttca
    10921 ccggcttctt tgctgttcat gcatgactct gcatgactct gcagctgcct tcccgtgtcc
    10981 tgtctctaaa aaaaaatcac tgaaaactca aagaggagcg gaagatccat aagcctcttt
    11041 gagatcaata gggaaaaagg aactccaagg cttatagcaa agcttcctaa ggatgatgct
    11101 gaaagggaac gtgggtctcc atggtgataa gagacagaga accaatgaga gctgaaggcg
    11161 gagcaggact tgtgtggagg actcatggga actgggagtc atttaactat ttgtttgctt
    11221 catgaaaatt tagacaccag ctgtaactgc attgcacagg gtgtatagat gttatcattc
    11281 ttgctgacat attctggaag ctttcagccc caccaacact gccccaccca ggacttctgc
    11341 agctgagagt tcctgtgtca gtagggtctg atatatgtac atagattata catatatgtg
    11401 tacatatgtg cctcaatgaa cattgcctgt tcaccttatc atgggtgtac atagacttca
    11461 tagagctcca cagtcttttg taaatattga cacaagtaaa taagtatata aatatatatt
    11521 actgaggatt tattttaaca tcattctgtg tgaaatgaca aaaataaaat ttttgacaga
    11581 ca
//
